Pan-tumor analysis to investigate the obesity paradox in immune checkpoint blockade by Evan J Lipson, Ludmila Danilova, Elizabeth M Jaffee, Won Jin Ho, Mark Yarchoan, Yasser Ged, Jean Hoffman-Censits, Jennifer Durham, Sanjay Bansal, Chester Kao, Rajat Mohindra, Stephanie L Alden, Tanguy Y Seiwert, Soren Charmsaz, Howard L Li, Kabeer Munjal, Hua-Ling Tsai, Alexei Hernandez, Erin M Coyne, Rachel Garonce-Hediger, Laura Tang, Marina Baretti, Kathryn Howe, G Scott Chandler, Madelena Brancati, Aanika Warner, Ervin Griffin, Mari Nakazawa, Chris Thoburn, Jennifer Gizzi, Nicole E Gross, Elsa Hallab, Sarah S Shin, Aditi Guha

“…To interrogate mechanisms of divergent immune responses in obese and non-obese patients, we examined the relationship among obesity status, clinical responses, and immune profiles from a diverse, pan-tumor cohort of patients treated with ICI-based therapy.Methods From June 2021 to March 2023, we prospectively collected serial peripheral blood samples from patients with advanced or metastatic solid tumors who received ICI as standard of care at Johns Hopkins. …”
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Smoking relapse reasons among current smokers with previous cessation experience in Shanghai: A cross-sectional study by Ruiping Wang*, Lingzi Shenfan*, Yu Song*, Qingliang Wang*, Rui Zhang, Le Kuai, Bin Li

“…Introduction Quitting smoking can lead to substantial health gains, even later in life. Many smokers who attempt to quit experience several relapses before achieving sustainable cessation. …”
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Effect of Liuzijue Training on Balance and Respiratory Function of Stroke Patients in Recovery Stage by WANG Chen, ZHANG Peizhen, YANG Faming, YU Junwu

“…ObjectiveTo observe the effect of Liuzijue training on balance and respiratory function of stroke patients in recovery stage.MethodsA total of 63 stroke patients in recovery stage who were treated in the department of rehabilitation medicine of Haishu Rehabilitation Hospital (a teaching hospital of Ningbo college of Health Sciences) from January 2020 to March 2021, were recruited and randomly divided into control group and observation group, with 31 cases, 32 cases respectively. …”
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Geographical Differences in the Safety and Efficacy of Tofacitinib Versus TNFi: A Post Hoc Analysis of ORAL Surveillance by Bogdan Batko, Slawomir Jeka, Piotr Wiland, Agnieszka Zielińska, Maria Stopińska-Polaszewska, Marcin Stajszczyk, Magdalena Kosydar-Piechna, Mary Jane Cadatal, Jose L. Rivas

“…Methods Patients with RA in ORAL Surveillance (NCT02092467), who were aged ≥ 50 years with ≥ 1 additional CV risk factor, received tofacitinib 5 or 10 mg twice daily or TNFi; 45.9% were from either Poland or North America. …”
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Antihypertensive drug-related problems in Vietnamese ambulatory care by Hoang Hai Nguyen, Le Anh Thu Vu, Minh-Hoang Tran, Hong Tham Pham

“…We conducted a cross-sectional study targeting ambulatory prescriptions of Vietnamese patients with hypertension who either received standard therapy (using two or fewer medications, SdT) or standard plus add-on therapy (using more than two medications, SdT + add-on). …”
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Evaluation of the long-term effects of COVID-19 on pulmonary functions in recovered patients by K Naja, Durga Shankar Meena, Deepak Kumar, Naveen Dutt, Gopal K. Bohra, Ravisekhar Gadepalli, Mithu Banerjee, Mahendra K. Garg, Sanjeev Misra

“…After adjusting the confounding factors, the mean pulmonary function values were lower in the patients who required oxygen support, with a significant difference in FEV1, FVC, PEF and FEF 25–75% with P values of 0.025, 0.046, 0.028 and 0.007, respectively. 66.67% had abnormal HRCT findings. …”
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Development of ptxD/Phi as a new dominant selection system for genetic manipulation in Cryptococcus neoformans by Muthita Khongthongdam, Tanaporn Phetruen, Sittinan Chanarat

“…Taken together, the ptxD/Phi system provides a robust and versatile tool for genetic manipulation in C. neoformans, facilitating further research into its biology and pathogenicity.IMPORTANCECryptococcus neoformans is a type of fungus that can cause serious illnesses in people who have weakened immune systems, like those with HIV/AIDS. …”
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Evaluation of extracts from used Xpert MTB/RIF cartridges for detection of resistance to second-line anti-tuberculosis drugs in patients with multidrug-resistant tuberculosis in Et... by Tilahun Ketema, Mulualem Tadesse, Zegeye Bonsa, Getu Balay, Wakjira Kebede, Mekidim Mekonnen, Gemeda Abebe

“…The Xpert MTB/XDR assay is the WHO recommended method for detecting resistance to isoniazid and second-line anti-TB drugs when rifampicin resistance is detected. …”
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Prevalence of Diabetic Retinopathy in Patients with Cerebrovascular Accident: A Cross-sectional Study by (Col.) OK Radhakrishnan, Rutu K Rao, Varsha Manade, Swaranjali Gore, Shreya Gandhi, Khushboo Goyal, Tushar Agrawal

“…Aim: To assess the prevalence of DR among individuals who have experienced CVAs and to explore the relationship between DR and CVAs within the Indian population. …”
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Hubungan Obesitas dengan Hormon Testosteron pada Mahasiswa STIKes Indonesia Padang by Ibrahim , Fadil Oenzil, Arni Amir

“…<br />This research can provide information and knowledge about the occurrence of infertility due disruption of testosterone levels men who suffer from obesity.<br />Keywords: obesity, testosterone, adiponecty, enzym aromatase<br /><br /></p>…”
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Legality as a principle of court activity in respecting the rights, freedoms and interests of minors in cases of administrative offences by M. A. Sambor

“…The study focuses on the empirical aspect of the application by courts of the Constitution and laws of Ukraine regarding the observance of human rights and freedoms in proceedings on administrative offences involving certain categories of citizens who need additional protection – minors. Administrative law enforcement practice demonstrates that the courts of first instance and appellate courts, using their own legal consciousness, apply administrative penalties to minors which are not provided for by law, thereby neglecting the principle of legality in the activities of public authorities. …”
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A deep learning model for carotid plaques detection based on CTA images: a two stepwise early-stage clinical validation study by Zhongping Guo, Ying Liu, Jingxu Xu, Chencui Huang, Fandong Zhang, Chongchang Miao, Yonggang Zhang, Mengshuang Li, Hangsheng Shan, Yan Gu

“…ObjectiveTo develop a deep learning (DL) model for carotid plaque detection based on CTA images and evaluate the clinical application feasibility and value of the model.MethodsWe retrospectively collected data from patients with carotid atherosclerotic plaques who underwent continuous CTA examinations of the head and neck at a tertiary hospital from October 2020 to October 2022. …”
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Lack of Male-Female Differences in Disposition and Esterase Hydrolysis of Ramipril to Ramiprilat in Healthy Volunteers after a Single Oral Dose by Tom B. Vree, Erik Dammers, Ivan Ulc, Stefan Horkovics-Kovats, Miroslav Ryska, IJsbrand Merkx

“…There is a group of subjects who showed a t1/2β of approximately 80 h (15% CV), and two apparent groups with a longer t1/2βfor each formulation (124 h, 22.5% CV; 166 h, 21.6% CV, respectively, p = 0.0013). …”
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Elbow Injuries Among MLB Pitchers Increased During Covid-19 Disrupted Season, But Not Other Baseball Injuries by Chelsea Martin, Jozef Palasiewicz, Jesse Grullon, Ellen Shanley, Charles Thigpen, Daniel Kline, Stefan Kluzek, Gary Collins, Garrett Bullock

“… # Study Design A retrospective cohort study utilizing publicly available data # Methods MLB players who competed in 1+ seasons between 2015-2021 were included and stratified by position (pitcher, position player). …”
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The Performance of Equations That Estimate Glomerular Filtration Rate against Measured Urinary Creatinine Clearance in Critically Ill Patients by Hasan M. Al-Dorzi, Abdulmajeed A. Alsadhan, Ayman S. Almozaini, Ali M Alamri, Hani Tamim, Musharraf Sadat, Lolowa Al-Swaidan, Elwaleed Elhassan, Yaseen M. Arabi

“…In this substudy of the PermiT trial (https://clinicaltrials.gov/ct2/show/ISRCTN68144998), patients from King Abdulaziz Medical City-Riyadh who had CrCl24h-urine were included. We estimated GFR using Cockroft–Gault (CG), modification of diet in renal disease study (MDRD), chronic kidney disease epidemiology collaboration (CKD-EPI), and Jelliffe equations. …”
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Infectious keratitis following photorefractive keratectomy: a 13-year study at a tertiary center by Alireza Attar, Hossein Jamali, Julio Ortega-Usobiaga, Golnoush Mahmoudinezhad, Dagny Zhu, Mohammad Mohammadi

“…The study was conducted in two stages: the first stage assessed the incidence of post-PRK infectious keratitis among patients who underwent PRK at our center, while the second stage included all patients with post-PRK infectious keratitis, regardless of where their PRK was performed. …”
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Developing a comprehensive inventory to define harm reduction housing by Sofia Zaragoza, Joseph Silcox, Sabrina Rapisarda, Charlie Summers, Patricia Case, Clara To, Avik Chatterjee, Alexander Y. Walley, Miriam Komaromy, Traci C Green

“…Among its responses, Boston developed six low threshold harm reduction housing (HRH) sites geared towards supporting the housing needs of people who use drugs (PWUD) and addressing health and safety concerns around geographically concentrated tent encampments. …”
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Characteristics of the Approximate-Optimal Training Indicators of Goalkeepers in Modern Football by Igor Doroshenko, Andrii Svatyev, Valerij Shamardin, Bogdan Khorkavyy, Daria Vaniuk, Eduard Doroshenko

“…Material and methods. 14 athletes who are training at MFC “Metalurg” (Zaporizhzhya), playing the role – of goalkeeper: 3 athletes – MFC “Metalurg” (Zaporizhzhya), 3 athletes – MFC “Metalurg, U-19” (Zaporizhzhya), 2 athletes – MFC “Metalurg, U-17” (Zaporizhzhya), 2 athletes – MFC “Metalurg, U-16” (Zaporizhzhya), 2 athletes – MFC “Metalurg, U-15” (Zaporizhzhya), 2 athletes – MFC “Metalurg, U-14” (Zaporizhzhya). …”
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Combination of mentor-based and resident-based learning may benefit to improving the ability of clinical practice in resident training by Min Li, Tao Liu, Yiqiong Wen, Min Zhang, Wenye Zhu, Xuming Wang, Yunjiao Hou, Lin Li, Anju Zu, Shibo Sun

“…Methods Seventy-two residents who participated in standardized resident training (SRT) were recruited and randomly divided into the CMRL and MBL groups. …”
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Clinic evaluation of cognitive impairment in post-COVID syndrome: Performance on legacy pen-and-paper and new digital cognitive tests by Aysha Mohamed Rafik Patel, Gina Gilpin, Anna Koniotes, Catherine Warren, Cian Xu, Paul W. Burgess, Dennis Chan

“…Results: The overall sample had a mean ACE-III score of 91/100 (SD 6) with 15.7% (16/102) scoring at or below the cut-off score considered to represent objective cognitive impairment. Of the 20 individuals who also completed the LCCAB, 89.47% were impaired on at least one task, primarily in the domains of attention, executive function and processing speed. …”
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