Topical chlorhexidine 0.2% versus topical natamycin 5% for fungal keratitis in Nepal: rationale and design of a randomised controlled non-inferiority trial by Victor Hu, David Macleod, Helen Anne Weiss, Matthew J Burton, Simon Arunga, Astrid Leck, Sanjay Kumar Singh, Jeremy John Hoffman, Reena Yadav, Sandip Das Sanyam, Pankaj Chaudhary, Abhishek Roshan, Einoti Matayan

“…Secondary outcomes include epithelial healing time, scar/infiltrate size, ulcer depth, hypopyon size, perforation and/or therapeutic penetrating keratoplasty (corneal transplant), positive reculture rate (day 7) and quality of life (EuroQol-5 dimensions, WHO/PBD-VF20, WHOQOL-BREF).Ethics and dissemination The Nepal Health Research Council, the Nepal Department of Drug Administration and the London School of Hygiene and Tropical Medicine ethics committee have approved the trial. …”
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Efficacy of an intervention to increase therapeutic adherence in patients with secondary prevention for cardiovascular disease: a study protocol for a randomized controlled trial by Francisco Manuel Lidón-Muñoz, José Antonio Quesada, José Antonio Quesada, José Antonio Quesada, Vicente Francisco Gil-Guillén, Vicente Francisco Gil-Guillén, Vicente Francisco Gil-Guillén, Domingo Orozco-Beltrán, Domingo Orozco-Beltrán, Domingo Orozco-Beltrán

“…Furthermore, non-adherence is more pronounced in primary care.ObjectiveBased on our hypothesis that in patients undergoing cardiovascular secondary prevention, an intervention grounded in the application of the Chronic Care Model improves adherence to the three preventive drugs, this study aims to evaluate the efficacy of a health education intervention, which implements this model, to increase adherence in patients with cardiovascular disease.MethodsAn open-label randomized controlled trial will be conducted, selecting patients who meet inclusion criteria through consecutive non-probability sampling. …”
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Analysis Model of Giant Prawns Population (Macrobrachium rosenbergii) in Estuary Edge of Sembakung Waters, Nunukan, Indonesia by Agus Indarjo, Gazali Salim, Christine Dyta Nugraeni, Lukman Yudho Prakoso, Permana Ari Soejarwo, Rukisah Rukisah, Yen Thi Hong Pham, Achmad Daengs GS, Hariyadi Hariyadi, Abdul Jabarsyah

“…The sampling was by using a survey method with purposive judgment sampling based on a catch of 14 fishermen who used the bottom fish pot from Sembakung waters, Nunukan Regency (Indonesia). …”
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Seizures Following Carotid Endarterectomy: A Comprehensive Meta-Analysis of 69,479 Patients and Evidence-Based Recommendations for Perioperative Care by Kruthajn Rajesh, Helen Shen, Sonu M. M. Bhaskar

“…Male predominance was noted among patients who experienced seizures, and hypertension was the most common comorbidity. …”
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Tomographic features of lung damage associate with D-Dimer levels and further clinical outcome in patients with acute respiratory distress syndrome due to COVID-19 by Juan Antonio Suárez-Cuenca, José Fernando Flores-Zaleta, Leslie Andrea Corona-Rojas, Pablo Guzmán-Rullán, Luis Alfonso Camacho-Barajas, Uzziel Aguilera-Ontiveros, Alberto Melchor-López, Alejandro González-Mora, Perla Marlene Guzmán-Ramírez, Janicia Rodríguez-Solis

“…Patients diagnosed with ARDS due to COVID-19, without previous lung damage, clotting disorder and/or anticoagulants use, who were attended at the Intensive Care Unit and Internal Medicine Department from March to June 2020. …”
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Application of machine learning algorithms in predicting new onset hypertension: a study based on the China Health and Nutrition Survey by Manhui Zhang, Xian Xia, Qiqi Wang, Yue Pan, Guanyi Zhang, Zhigang Wang

“…Methods: We analyzed data from the 2011 China Health and Nutrition Survey cohort of individuals who were not hypertensive at baseline and had follow-up results available for prediction by 2015. …”
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A multicenter retrospective study of early cardiac toxicity in operable breast cancer patients receiving concurrent dual or mono anti-HER2 therapy with postoperative radiation ther... by Jing Yang, Meng-Yun Zhou, Bo Yu, Qing Lin, Yuan Yao, Hua-Ling Wu, Qi-Wei Zhu, Ming Ye, Hua-Ying Xie, Jian-Wei Wu, Gang Cai, Rong Cai, Wei-Xiang Qi, Jia-Yi Chen, Lu Cao

“…Dosimetric analysis showed that patients who developed subclinical cardiac events had increased mean heart dose (412.0 ± 249.6 vs. 347.2 ± 242.6 cGy, P-value = 0.010). …”
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A benchmark of deep learning approaches to predict lung cancer risk using national lung screening trial cohort by Yifan Jiang, Leyla Ebrahimpour, Philippe Després, Venkata SK. Manem

“…To evaluate our model’s general performance, we selected 253 out of 467 patients from a subset of the National Lung Screening Trial (NLST) who had CT scans without contrast, which are the most commonly used, and divided them into training and test cohorts. …”
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Statistical exploration of factors associated with birth of children having sickle cell traits among reproductive-age women in Nigeria by Gabriel Ogunde, Ayodele Shabi, Joshua O. Akinyemi

“…Results from the multilevel binary logistic regression revealed that women who were traditionalists (AOR = 1.77; 95% CI = 1.04–3.02) were more likely of having children with SCT. …”
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Contact patterns between index patients and their close contacts and assessing risk for COVID-19 transmission during different exposure time windows: a large retrospective observat... by Weibing Wang, Genming Zhao, Hao Pan, Bo Zheng, Chenyan Jiang, Yaxu Zheng, Huanyu Wu, Shenghua Mao, Ye Yao, Xiaohuan Gong, Sheng Lin, Bihong Jin, Dechuan Kong

“…Contact tracing should focus on individuals who had contact soon before or soon after the onset of symptoms (or positive RT-PCR test) in the index case.…”
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Autosomal Recessive Bestrophinopathy: Clinical and Genetic Characteristics of Twenty-Four Cases by Hassan Khojasteh, Mohsen Azarmina, Nazanin Ebrahimiadib, Narsis Daftarian, Hamid Riazi-Esfahani, Houra Naraghi, Hamideh Sabbaghi, Alireza Khodabande, Hooshang Faghihi, Afrooz Moghaddasi, Fatemeh Bazvand, Masoud Reza Manaviat, Hamid Ahmadieh, Narges Hassanpoor, Fatemeh Suri

“…Macular retinoschisis was observed in 46 eyes of 23 patients (95%) with cysts mostly located in the inner nuclear layer (INL) to the outer nuclear layer (ONL). Of the 18 patients who underwent FA, mild peripheral leakage was seen in eight eyes of four patients (22%). …”
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Non-support from the immediate boss is associated with stress and unsafety at work by Fredrik Iredahl, Elvar Theodorsson, Mike Jones, Tomas Faresjö, Åshild Faresjö

“…The main findings were associations between lack of support and feelings of unsafety at work (p < 0.001), higher long-term cortisol levels (p < 0.009), lack of support from colleagues (p < 0.001), and feelings of dejected/sad (p < 0.001) and high work pace (p = 0.03).ConclusionIndividuals who did not have the necessary support from their immediate boss and colleagues reported they felt more insecure at work and had higher biological long-term stress. …”
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Mortality in the families of children during the COVID-19 pandemic: evidence from a repeated cross-sectional study of children in the United States by Kao-Ping Chua, Rena M. Conti, Nora V. Becker

“…Moreover, we calculated the proportion of adult decedents who were the siblings of children. Results From January 2016 through February 2020, the median monthly proportion of families with ≥ 1 adult death was 0.000076 (7.6 per 100,000 families). …”
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Nutrition Awareness and Oral Health among Dental Patients in Palestine: A Cross-Sectional Study by Manal M. H. Badrasawi, Nour H. Hijjeh, Rana S. Amer, Reema M. Allan, Mohammad Altamimi

“…In this vein, this study was conducted to determine the level of awareness of nutrition information affecting oral health among dental patients who visit the private and university dental clinics in West Bank, Palestine. …”
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Clinical Characteristics and Outcome of Kidney Transplant Recipients Infected with COVID-19: A Retrospective Observational Study by Manzoor Ahmad Parry, Rayees Yousuf Sheikh, Raja Kaamil Qadri, Muzafar Maqsood Wani, Imtiyaz Wani, Mohammad Ashraf Bhat

“…Background: This study investigated the clinical characteristics and outcomes of kidney transplant recipients (KTRs) who contracted COVID-19. Methods: In this retrospective study, we analyzed data from 122 KTRs confirmed to have COVID-19. …”
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Mediation of endothelial activation and stress index in the association between vitamin B6 turnover rate and diabetic retinopathy: an analysis of the National Health and Nutrition... by Jie Yin, Juan Chen, Yuanyuan Chen

“…The mediating effect of log EASIX was also observed in individuals with diabetes who were aged≥60 years (proportion of mediation: 50.63%) or had a duration of diabetes ≥10 years (proportion of mediation: 71.83%).ConclusionThis study found a positive association between high levels of 4-PA/PLP and an increased risk of DR, with the relationship being partially mediated by log EASIX.…”
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Peran Dokter sebagai Saksi Ahli Di Persidangan by Rika Susanti

“…An expert witness is basically a person who has knowledge, experience and special skill as a basis in providing expertise which is caused a criminal. …”
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Impact of Late Ventricular Arrhythmias on Cardiac Mortality in Patients with Acute Myocardial Infarction by Takuma Takada, Koki Shishido, Takahiro Hayashi, Shohei Yokota, Hirokazu Miyashita, Hiroaki Yokoyama, Takashi Nishimoto, Tomoki Ochiai, Noriaki Moriyama, Kazuki Tobita, Shingo Mizuno, Futoshi Yamanaka, Masato Murakami, Yutaka Tanaka, Saeko Takahashi, Shigeru Saito

“…Moreover, independent predictors of in-hospital cardiac mortality among patients with AMI who had sustained VT/VF were higher peak CK-MB [Odds ratio (OR: 1.001, 95%confidence interval (CI): 1.000-1.002, p= 0.03)], higher Killip class (OR: 1.484, 95%CI 1.017-2.165, p= 0.04), and late VT/VF (OR: 3.436, 95%CI 1.115-10.59, p= 0.03). …”
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Triple Endobutton with Coracoacromial Ligament Transfer: A Modified Technique for Fixation of Acromioclavicular Joint Dislocation by Vikas Kesari, Jatin Prakash, Jyoti Garg, Divesh Jalan, Karan Maggo, Naval Bhatia

“…Materials and Methods: A prospective analysis was conducted on a cohort of patients with ACJ dislocation who were treated using the triple Endobutton and CAL transfer techniques. …”
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Systolic Blood Pressure, Cardiac Index and Eisenmenger Syndrome are Predictors of Mortality in Pulmonary Arterial Hypertension-associated with Congenital Heart Disease: An Analysis... by Muflihatul Baroroh Rochmat, Budi Yuli Setianto, Dyah Wulan Anggrahini, Lucia Kris Dinarti, Anggoro Budi Hartopo

“…Several baseline variables were selected as potential predictors of mortality, namely (1) clinical data: WHO-functional class, SaO2, 6-min walking distance, systolic blood pressure, and Eisenmenger syndrome; (2) laboratory data: hemoglobin and NT-pro BNP levels; (3) echocardiography data: pericardial effusion, defect size, and TAPSE; and (4) hemodynamic data: right atrial pressure, cardiac output and index, SvO2, and flow ratio. …”
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