HER-SAFE study design: an open-label, randomised controlled trial to investigate the safety of withdrawal of pharmacological treatment for recovered HER2-targeted therapy-related c... by Robin Chung, James C Moon, Alexander R Lyon, Charlotte H Manisty, Muhummad Sohaib Nazir, Malcolm Walker, Peter Kellman, Benjamin Dowsing, Daniel Chen, Jessica Artico, Mark Westwood, Hakim-Moulay Dehbi, Rebecca Roylance, Tom Crake, Peter Schmid, Arjun Ghosh, Maria Sol Andres, Joanna Pedra, Orla Worn

“…The study will recruit 90 participants who will undergo serial clinical assessment over 12 months with advanced cardiovascular imaging (CMR scans with automated analysis at baseline, 6 and 12 months), cardiac biomarker measurement (six time points over 12 months), plus complete heart failure QoL and medication disutility questionnaires. …”
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Oxygenation improvement and duration of prone positioning are associated with ICU mortality in mechanically ventilated COVID-19 patients by Silvia De Rosa, Nicolò Sella, Giacomo Bellani, Giuseppe Foti, Andrea Cortegiani, Giulia Lorenzoni, Dario Gregori, Annalisa Boscolo, Lucia Cattin, Muhammed Elhadi, Giorgio Fullin, Eugenio Garofalo, Leonardo Gottin, Alberto Grassetto, Salvatore Maurizio Maggiore, Elena Momesso, Mario Peta, Daniele Poole, Roberto Rona, Ivo Tiberio, Andrea Zanoletti, Emanuele Rezoagli, Paolo Navalesi, for the SIAARTI Study Group

“…Methods International registry including COVID-19 adult patients who underwent prone positioning. We measured the difference for arterial partial pressure of oxygen to inspired fraction of oxygen ratio (PaO2/FiO2), ventilatory ratio, and respiratory system compliance (Crs) between baseline supine position and at either the end of the first cycle of prone position (Delta-PP) or re-supination (Delta-PostPP). …”
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Trauma as a Public Health Moment: Addressing Vaccine Uptake in Trauma Patients by Grace E. Keegan, BS, Rachel Alexander, BS, Simi Ogunnowo, BS, Isaiah Brown, BS, Tanya L. Zakrison, MD, MPH, Lea E. Hoefer, MD

“…Conclusions:. Trauma patients who have experienced more discrimination in medical settings have lower rates of COVID-19 vaccination. …”
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The Relationship Between the Modified Glasgow Prognostic and SYNTAX Scores in Patients with Non-ST Elevation Myocardial Infarction by Ahmet KARADUMAN, Cemalettin YILMAZ, Mustafa Ferhat KETEN, Ismail BALABAN, Zeynep Esra GUNER, Mehmet CELIK

“…Methods: This study analyzed the cases of 295 patients with NSTEMI who had undergone coronary angiography. In an effort to determine the seriousness and scope of CAD in each patient, the Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score was calculated and then assessed. …”
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Transformations in the police organization in the early 1920s by V. A. Grechenko

“…In the first of the named documents, it was stated that persons who joined the police and investigation service are considered civil servants. …”
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Stress and Coping Strategies among Nurses and Midwives during Assisted Vaginal Delivery in Pregnant Women with COVID-19: A Cross-sectional Study by R Bagavathi, Binu Mathew, Shivangi Mudgal, Ranjana Kumari, Sapna Chopra

“…Design: A cross-sectional study was conducted among nurses and midwives who assisted vaginal delivery of COVID-19-affected pregnant women at a tertiary care hospital in East Central India. …”
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Enablers of and barriers to ART adherence among female sex workers in mid-western Uganda: a qualitative study by David Friday Apuulison, Brenda Nabawanuka, Michael Muhoozi, Julian Aryampa, Pauline Irumba, Edson Katsomyo, Moses Asiimwe, Joshua Epuitai, Pardon Akugizibwe, Wasswa George, John Rubaihayo

“…We conducted 30 in-depth interviews among FSWs who had been taking ART for at least six months. …”
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A Potential Protective Effect of Alcohol Consumption in Male Genital Lichen Sclerosus: A Case-Control Study by Joey El Khoury, Jessica Andraos, Anthony Kanbar, Rami Halabi, Serge Assaf, Anthony Mina, Sabine El Breidi, Charbel Dabal, Charbel El Hachem, Rodrigue Saad, Antoine Kassis, Maher Abdessater, Raghid El Khoury

“…Subjects enrolled were adult male patients who had a circumcision between January 2010 and December 2020 at our university hospital, with a confirmed LSc diagnosis on pathology. …”
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Heterogeneous association of health with patient and general practice characteristics by region, age and chronic condition: pooled cross-sectional study of patient-level data from... by Hugh Gravelle, Yan Feng, Vladimir Sergeevich Gordeev

“…Three concentration indices embodying different value judgements summarise income-related health inequality in the full sample and subsamples.Setting Primary care in England.Participants Over 1 million adult patients in 6426 general practices in 2015/2016 and 2016/2017.Primary outcome measures Patient-reported health (the 5-level EQ-5D version or EQ-5D-5L).Results Patients who are younger, male, more satisfied with their practice, have fewer chronic conditions and live in less-income or education-deprived areas report better health. …”
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Mechanical Thrombectomy System for the Treatment of Intermediate-Risk Acute Pulmonary Embolism: The CLEAR Study by Wenguang Zhang, Tao Hu, Song Ding, Zhouming Wang, Tao Zhang, Hongyao Hu, Xin Fang, Honggang Pang, Mingjin Guo, Bo Yu, Hui Zhuang, Nuofu Zhang, Baoshi Han, Qiguang Wang, Mingzhi Cai, Kuan Wang, Pingfan Guo, Bin Xu, Peiliang Fang, Shengxian Tu, Yi Jiang, Hongyu Shi, Zhenwen Yang, Xinwei Han, Hongyan Tian, Jun Pu, Xiaoming Zhang

“…Results: Of 127 patients at 15 centers with intermediate-risk acute PE who underwent mechanical thrombectomy with the Tendvia system (September 2021 to December 2022), 123 underwent analysis. …”
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KNOWLEDGE AND USE OF MODERN CONTRACEPTIVES AMONG MOTHERS OF REPRODUCTIVE AGE IN ENUGU STATE; SOUTHEASTERN NIGERIA by UCHENNA TERESA OKONKWO, HELEN NNADI, CHIOMA AKAEBE

“…Qualitative data indicated that the majority of married mothers of reproductive age who used any other modern contraceptive aside from the male condom often do so without the knowledge or consent of their spouses due to male dominance and some patriarchal values/beliefs. …”
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Advancing Objective Mobile Device Use Measurement in Children Ages 6–11 Through Built-In Device Sensors: A Proof-of-Concept Study by Olivia L. Finnegan, R. Glenn Weaver, Hongpeng Yang, James W. White, Srihari Nelakuditi, Zifei Zhong, Rahul Ghosal, Yan Tong, Aliye B. Cepni, Elizabeth L. Adams, Sarah Burkart, Michael W. Beets, Bridget Armstrong

“…Passive sensing applications objectively monitor time spent on a given device but are unable to identify who is using the device, a significant limitation in child screen time research. …”
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Perceived stress and family adaptability in head and neck cancer patients receiving radiotherapy: the chain-mediated effect of social support and family resilience by Xiaoru Li, Xiaoru Li, Xiaoru Li, Yu Zhu, Yu Zhu, Yu Zhu, Hongwei Wan, Hongwei Wan, Hongwei Wan

“…The aim of the present study was to investigate the relationship between perceived stress and family adaptability in patients with head and neck tumors and to analyze whether social support and family resilience play a mediating role in this relationship.MethodsThe convenience sample approach was utilized to recruit 316 patients with head and neck tumors who received radiation. Self-developed general information questionnaires, the Chinese Perceived Stress Scales, Social Support Rating Scale, the Shortened Chinese Version of the Family Resilience Assessment Scale, and Family Adaptability Scale were used to collect data. …”
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POSSIBILITIES OF DIAGNOSIS OF RADIATION INJURIES AND REHABILITATION OF PATIENTS AFTER COMBINED TREATMENT OF MALIGNANT TUMORS OF THE BREAST by A. V. Kondakov, M. E. Borodina, O. V. Andrianov, N. I. Rozhkova

“…The study included 259 women who had undergone combined treatment of breast cancer. …”
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Vascular endothelial growth factor inhibitors for retinopathy of prematurity by O.V. Zhukova, I.A. Mal’tseva, A.V. Zolotarev

“…Finally, our experience with intravitreal ranibizumab for threshold ROP and plus d isease in a patient who was followed-up for subsequent 9 years is described.…”
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Treatment with Sulodexide Downregulates Biomarkers for Endothelial Dysfunction in Convalescent COVID-19 Patients by Alejandro J Gonzalez-Ochoa MD, Gyozo Szolnoky MD, Ana G Hernandez-Ibarra MD, Jawed Fareed PhD

“…Conclusions Patients in the convalescent phase of COVID-19 who received sulodexide for eight weeks showed a reduction in TM, vWF, D-dimer, CRP, and IL-6 serum levels compared to placebo. …”
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Molecular characterization of a rare TP63 variant associated with split-hand/split-foot malformation 4 and incomplete penetrance: disruption of the p63-Dlx signaling pathway by Jianlong Zhuang, Yanqing Li, Yu’e Chen, Hegan Zhang, Shufen Liu, Manman Hu, Chunnuan Chen

“…Subsequently, WES identified a rare heterozygous variant of NM_003722.5: c.956G > A (p.Arg319His) in the TP63 gene in the proband, which was inherited from her father who also presented with limb deformities. However, both of the sister and grandfather of the proband had the same variant but exhibited normal limb morphology. …”
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Deep learning-based skin lesion analysis using hybrid ResUNet++ and modified AlexNet-Random Forest for enhanced segmentation and classification. by Saleem Mustafa, Arfan Jaffar, Muhammad Rashid, Sheeraz Akram, Sohail Masood Bhatti

“…Most likely all the patients who received wrong diagnosis and low-quality treatment die early. …”
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Secondhand Smoke Exposure and Smoking Attitudes and Behaviors Among Adolescents in the Gaza Strip: Findings From the 2019 Global Youth Tobacco Survey by Beesan Maraqa, Mahmoud Abu Mayaleh, Seya Arafeh, Kenana Altell, Ahmad Khleif, Abdallah Najjar, Bayyena Abu-Radwan

“…Background Secondhand smoke (SHS) exposure remains a critical public health concern, especially for adolescents, who are more susceptible to its harmful effects and may initiate smoking as a result. …”
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Comparative analysis of efficacy and quality of life between totally extraperitoneal sublay and intraperitoneal onlay mesh repair for ventral hernia by Miaofeng Wang, Wei Chen, Xiufeng Chu

“…A retrospective cohort study was conducted, encompassing 125 patients who underwent ventral hernia repair between May 2018 and November 2023. …”
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