Circ_0001084/miR-181c-5p/PTPN4 Axis Mitigates Cardiomyocyte Injury by Modulating the TLR4/NF-κB Pathway: Insights into Therapeutic Potential for Myocardial Reperfusion Injury by Deng H, Fan Q, Huang L, Ouyang W, Zhu W

“…Non-coding RNAs, including miRNAs, have been increasingly recognized for their roles in regulating cardiomyocyte responses to hypoxia/reoxygenation (H/R) injury. miR-181c-5p, in particular, has been implicated in inflammatory and apoptotic processes, suggesting its potential involvement in exacerbating cellular damage.Methods: This study combined bioinformatic and experimental techniques to investigate myocardial injury. …”
Get full text

Pengaruh Timbal (Pb) Terhadap Kadar MDA Serum Tikus Putih Jantan by Endrinaldi ., Asterina .

“…Pb toxicityinhibitsan enzyme that acts as an antioxidant and liver cell damage.<br />The purpose of this study was to observe the effect of lead (Pb) on levels of malondialdehyde (MDA) male whiterats. …”
Get full text

ECONOMIC ASPECT OF CRIMINAL LAW COUNTERACTION TO JUSTIFICATION OF ARMED AGGRESSION AGAINST UKRAINE: RISKS FOR THE STATE BUDGET IN THE LIGHT OF THE PRACTICE OF THE EUROPEAN COURT OF... by Andrii Lapkin, Daryna Yevtieieva, Daria Kukovynets

“…The empirical basis of the study was as follows: (1) statistical data on Ukraine's participation as a defendant in the ECHR and the expenses incurred by it for the compensation of damages in 2019-2023; (2) approximately 900 verdicts of Ukrainian courts under Article 4362 of the Criminal Code; (3) the survey results of 4015 law enforcement officers of Ukraine on countering the glorification of the Russian armed aggression in Ukraine; (4) the survey results of 16 Ukrainian judges on countering the glorification of the Russian armed aggression in Ukraine; (5) 46 ECHR judgments. …”
Get full text

Ilaser Submucous Destruction in the Treatment of Hemorrhoids by S. A. Frolov, D. V. Vyshegorodtsev, A. M. Kuzminov, Yu. L. Trubacheva, V. Yu. Korolik, I. S. Bogormistrov, I. A. Mukhin, A. N. Ryndin, A. A. Anarbaeva

“…The proposed method applying a fiber laser with a diode pump with a wavelength of 1940 nm makes it possible to affect transdermally the internal hemorrhoidal node without damaging the mucosa of the anal canal. The absence of postoperative wounds in the anal canal leads to a decrease in pain syndrome, and by day 7 there are no clinical manifestations of hemorrhoids. …”
Get full text

Coup (d'etat) in the Baltic States (1926, 1934): Similarities and Differences by Zenonas Butkus

“…The model enabled a more flexible reaction to the danger of extremist trends or serious blows to democracy; it also contributed to the protection from damaging impact of outward influences, which was especially noticeable in Estonia. …”
Get full text

Choroidal Thickness in Eyes with Band Atrophy of the Optic Nerve from Chiasmal Compression by Luiz Guilherme Marchesi Mello, Ana Claudia F. Suzuki, Giuliana Rovito de Mello, Rony Carlos Preti, Leandro C. Zacharias, Mário L. R. Monteiro

“…The choroid does not thin after the inner retinal layer becomes damaged due to CCL and may even be thicker in some areas with corresponding severe retinal neural loss. …”
Get full text

›Schreiben‹ als Differenz von Stille und Klang. Aspekte der musikalischen Form in Helmut Lachenmanns Schreiben. Musik für Orchester by Cosima Linke

“…Als ein zentrales ›Formproblem‹ von Schreiben sehe ich den Balanceakt im Spannungsfeld zwischen Kontinuität, Diskontinuität und Vernetzung und damit zwischen einer prozessualen, seriellen und strukturellen Form bzw. …”
Get full text

Hubungan Derajat Keasaman Cairan Lambung dengan Derajat Dispepsia pada Pasien Dispepsia Fungsional by Emil Prasetyo Muhammad, Arina Widya Murni, Delmi Sulastri, Saptino Miro

“…Gastric acid hypersecretion can increase the secretion of pepsin which can cause gastric mucosal damage in functional dyspepsia. The objective of this study was to determine the correlation of gastric juice acidity with dyspepsia level experienced by functional dyspepsia patients.This study was a analytic study with cross sectional design applied on 35 samples of functional dyspepsia patients with non-probability consecutive sampling technique at RSUP DR. …”
Get full text

SRT3025-loaded cell membrane hybrid liposomes (3025@ML) enhanced anti-tumor activity of Oxaliplatin via inhibiting pyruvate kinase M2 and fatty acid synthase by Xiaobin Wang, Shulin Li, Zichen Li, Zhuona Lin, Zhifeng Wang

“…This novel drug delivery system inhibits key metabolic pathways, which increase DNA damage and tumor cell apoptosis. The results indicate that 3025@ML is a promising therapeutic strategy for overcoming OXA’s compromised therapeutic effect and potentially improving cancer treatment outcomes.…”
Get full text

Fungsi Tiroid Pasca Radioterapi Tumor Ganas Kepala- Leher by Ade Chandra, Sukri Rahman

“…Tinjauan Pustaka : Hipotiroid merupakan efek samping yang paling sering ditemukan pasca radioterapi tumor ganas kepala dan leher. …”
Get full text

Hepatitis D virus infection triggers CXCL9-11 upregulation in hepatocytes and liver infiltration of CXCR3+ CD4 T cells by Jan-Hendrik Bockmann, Lena Allweiss, Annika Volmari, David da Fonseca Araújo, Matin Kohsar, Anastasia Hyrina, Janine Kah, Zhijuan Song, Josolyn Chan, Katja Giersch, Tassilo Volz, Marc Lütgehetmann, Jeffrey J. Wallin, Dmitry Manuilov, Meghan M. Holdorf, Simon P. Fletcher, Ansgar W. Lohse, Antonio Bertoletti, Julian Schulze zur Wiesch, Maura Dandri

“…Background &amp; Aims: The role of hepatocytes in producing chemokines and triggering liver inflammation and damage in chronic hepatitis D (CHD) is not fully understood. …”
Get full text

Association of IL-8 and CXCR2 with AST/ALT Ratio in Liver Abnormalities Screening during Oxidative Stress Injury Caused by VCM by Yiwen Dong, Xingang Wang, Weijiang Hu, Xin Wang, Hongying Bian, Wencui Zhang, null Feng Han, Ning Kang, Lin Zhang, Meng Ye

“…Liver impairment caused by VCM has been linked to irreversible damage such as fibrosis, necrosis, hepatocellular carcinoma, and liver angiosarcoma. …”
Get full text

Antagonistic Effects of Sublethal Concentrations of Certain Mixtures of Metal Oxide Nanoparticles and the Bulk (Al2O3, CuO, and SiO2) on Gill Histology in Clarias gariepinus by Amaeze Henry Nnamdi, Tam-Miette Dawarri Briggs, Oluwaseun Olusola Togunde, Henry Ebele Obanya

“…In single exposure, the gill alterations include high frequencies of erosion of gill lamella (EGL), hypertrophy (HPT), oedema (OD), and necrosis (N). Less damage was observed at the combination of the metal oxide nanoparticles of SiO + Al2O3, SiO + CuO and SiO + Al2O3 + CuO in equal (1 : 1—HAI, 2 and 6; 1 : 1 : 1—HAI, 6) and unequal ratios (1 : 2—HAI, 16 and 6; 2 : 1—HAI, 8 and 6). …”
Get full text

Clinical and endoscopical and morphofunctional scores in evaluation of development of gastroesophageal reflux disease in various age groups by M. A. Osadchuk, A. M. Zolotovitskaya, N. V. Kireyeva, S. N. Nikolenko, I. M. Kvetnoy

“…It results in more severe damage of esophageal mucosa with development of erosive esophagitis and extraesophageal manifestations. …”
Get full text

Perancangan Rencana Pemulihan Bencana Menggunakan NIST SP 800-34 Rev 1, NIST SP 800-53 Rev 5 dan SNI 8799 (Studi Kasus: Unit TI XYZ) by Hafizh Ghozie Afiansyah, Septia Ulfa Sunaringtyas, Amiruddin Amiruddin

“…According to Government Regulation Number 71 of 2019, to overcome the impact of service loss in data centers caused by disasters and threats, it is necessary to have a plan that aims to prevent loss and damage, namely a disaster recovery plan or DRP. This is supported by questionnaires and interviews with structural officials, unit heads, and students of the XYZ Institute, which state that services managed by the IT Unit XYZ are vital for the business processes of lectures, general administration, and student affairs. …”
Get full text

Nonspecific response of Lake Baikal phytoplankton to anthropogenic impact by A. A. Nikonova, S. S. Vorobyeva

“…This confirms cell membrane damages. In Lake Baikal surface water, we found a higher content of synthetic anionic surfactants (sodium alkylbenzene sulfonates), which are components of detergents and cause oxidation stress of hydrobionts (up to 30 ± 4 μg·L–1). …”
Get full text

Dispersion modelling of particulate matter concentrations of sand product plants in a mineral complex by Y. Zehtab Yazdi, N. Mansouri, F. Atabi, H. Aghamohammadi

“…PM2.5 and PM10 resulting from the sand and gravel mining activities could damage the workers in the mineral complex. They exceeded the 24-hour average permissible limits proposed by the United States Environmental Protection Agency about 1 and 33 µg/m3, respectively. …”
Get full text

Intracalvariosseous injection: an approach for central nervous system drug delivery through skull bone marrow with a preclinical research in strokeResearch in context by Wenqian Liu, Mo Yang, Nanxing Wang, Xiangrong Liu, Chaoyu Wang, Kaibin Shi, Fu-Dong Shi, Yuesong Pan, Mingjun Zhang, Zhiwei Sun, Yongjun Wang, Yilong Wang

“…Funding: This study was supported by The National Natural Science Foundation of China (No. 82425101); Beijing Municipal Science &amp; Technology Commission (No. Z231100004823036); Capital's Funds for Health Improvement and Research (2022-2-2045); National Key Research &amp; Development Program of China (2022YFF1501500, 2022YFF1501501, 2022YFF1501502, 2022YFF1501503, 2022YFF1501504, 2022YFF1501505).…”
Get full text

A socio-ecological model of the management of leprosy reactions in Indonesia and India using the experiences of affected individuals, family members and healthcare providers by Annisa Ika Putri, Ruth M. H. Peters, Kevin De Sabbata, Brittney S. Mengistu, Regitta I. Agusni, Medhi Denisa Alinda, Joydeepa Darlong, M. Yulianto Listiawan, Cita R. S. Prakoeswa, Stephen L. Walker, Marjolein B. M. Zweekhorst

“…Abstract Background Leprosy reactions (LR) are immune-mediated complications of leprosy that may be associated with severe and irreversible nerve damage. Non-medical aspects, such as financing, service provision, and healthcare resources in the management of LR are generally overlooked as studies tend to concentrate on clinical features and treatment. …”
Get full text

The Effect of Cirata Reservoir Sediment on Early Developmental Stage of Common Carp (Cyprinus carpio) Embryo by Yuni Pujihastuti, K. Nirmala, I. Effendi

“…Higher sediment supernatant concentration also resulted in lower hatching percentage of common carp larva. The damage of eggs and larval morphologies in treatments with sediment supernatant was likely caused by the presence Pb and organic matters which act in synergy. …”
Get full text