Discharge against Medical Advice (DAMA) from an Emergency Department of a Tertiary Care Hospital in Saudi Arabia by Ashraf El-Metwally, Nesreen Suliman Alwallan, Ali Amin Alnajjar, Nida Zahid, Khalid Alahmary, Paivi Toivola

“…The outcomes of DAMA can have significantly damaging effects, causing possible relapses of disease, readmission, and increases in medical costs for the patient. …”
Get full text

Parkinson’s disease and other movement disorders in the context of the SARS-COV-2 pandemic by R. Kaladytė Lokominienė

“…The penetration of SARS-CoV-2 into the brain damaged by Parkinson’s disease can enhance the clinical burden of movement disorder and increase the deficit for substitutional dopaminergic therapy. …”
Get full text

An assessment of burden associated with problem joints in children and adults with moderate or severe haemophilia A: analysis of the CHESS-Paediatrics and CHESS II cross-sectional... by Paul McLaughlin, Hortensia De la Corte-Rodriguez, Tom Burke, Francis Nissen, Martynas Aizenas, Katya Moreno, Jamie O’Hara

“…Abstract Background Clinical research has offered many definitions and fragmented perspectives of joint morbidity in haemophilia. As joint damage, pain and mobility impairment can be present without clinical record of persistent bleeding, a person-centric joint morbidity characterisation remained a priority for the haemophilia community, giving rise to the ‘problem joint’ concept. …”
Get full text

Altered medial temporal lobe subregion volumes in systemic lupus erythematosus patients with neuropsychiatric symptoms by Z. Makdad Najeeb, P. C. Sundgren, A. Jönsen, K. Zervides, J. Lätt, T. Salomonsson, J. Nystedt, P. Nilsson, A. Bengtsson, G. Kuchcinski, L. E. M. Wisse

“…These findings are suggestive of neuronal damage in MTL subregions in NPSLE patients on a group level.…”
Get full text

Oxidative Stress and Risk of Dementia in Older Patients with Depression: A Longitudinal Cohort Study Using Plasma Biomarkers by Yoo-Jin Jang, Min-Ji Kim, Su-Jin Lee, Shinn-Won Lim, Doh-Kwan Kim

“…<i>Conclusions:</i> Nitrotyrosine, a biomarker that reflects nitrosative damage, emerged as a significant predictor of dementia risk in older patients with depression, highlighting its potential as an early biomarker of dementia. …”
Get full text

Inhibition of the mTOR Pathway Exerts Cardioprotective Effects Partly through Autophagy in CLP Rats by Wen Han, Hao Wang, Longxiang Su, Yun Long, Na Cui, Dawei Liu

“…Rapamycin alleviated the pathological damage of myocardial tissue, attenuated cardiac dysfunction (left ventricular ejection fraction (LVEF), p<0.05; fractional shortening (FS), p<0.05), and reduced HIF-1a expression (p<0.05). …”
Get full text

Comprehensive computational analysis of differentially expressed miRNAs and their influence on transcriptomic signatures in prostate cancer by Fahad M. Aldakheel, Hadeel Alnajran, Ayesha Mateen, Shatha A. Alduraywish, Mohammed S. Alqahtani, Rabbani Syed

“…This analysis uncovered their substantial impact on critical biological processes and molecular functions, such as cyclin-dependent protein kinase activity, mitotic DNA damage checkpoint signalling, stress-activated MAPK cascade, regulation of extrinsic apoptotic signalling pathway, and positive regulation of cell adhesion. …”
Get full text

Investigating Fire Collapse Early Warning Systems for Portal Frames by Ming Xie, Fangbo Xu, Zhangdong Wang, Li’e Yin, Xiangdong Wu, Mengqi Xu, Xiang Li

“…Combined with an ultrasonic experiment, the theoretical relationships between the transverse and longitudinal wave velocities and the elastic modulus of steel at high temperatures are verified, and the relationship between the transverse and longitudinal wave velocities and the overall damage of the portal frame is further constructed; then, a new early warning method for portal frame stability during a fire is proposed. …”
Get full text

Determination of HLA Tissue Type According to the Etiology of Patients with Chronic Renal Failure by Burcu KARAKUS TURAN, Fahri UCAR, Vural Taner YILMAZ, Yahya KILINC, Sule DARBAŞ ARAS, Huseyin KOCAK, Nurten SAYIN EKINCI, Bulent AYDINLI, Habibe Sema ARSLAN

“…Objective: Chronic kidney disease (CKD) is a prominent public health concern, is defined as functional and structural damage to the kidneys. This study aims to investigate the association between human leukocyte antigen (HLA) alleles individuals with CKD and the different etiological subgroups of diesease. …”
Get full text

Strength, Hydraulic, and Microstructural Characteristics of Expansive Soils Incorporating Marble Dust and Rice Husk Ash by Fazal E. Jalal, Sultani Mulk, Shazim Ali Memon, Babak Jamhiri, Ahsan Naseem

“…In an attempt to counter the treacherous damage of such soils in modern geotechnical engineering, efforts are underway to utilize environmentally friendly and sustainable waste materials as stabilizers. …”
Get full text

Assessment of the Effect of Flooding on Agricultural Lands in Kaharo Sub-County of Kabale District South Western Uganda. by Nyakiti, Dorcas Awino

“…Loss of life (52) was the major effect of flooding on agricultural lands in Kaharo sub county Kabale district (Table 4.2), 49% of the respondents recorded that damage to crops and food supplies were the effects of flooding in an area whereas 46% of the respondents mentioned that Famine was also an effect of flooding due to destruction of crops and other agricultural lands. …”
Get full text

The Impact of Sex Education Towards Moral Development Among Pupils in Kebisoni Sub-County Rukungiri District. by Kamagara, Annet

“…According to the findings, 100% of the respondents agreed that there are the impact of sex education towards moral development among pupils in the Kebisoni sub-county Rukungiri district and these included sexuality education is not damaging to children or adolescents, sexuality education open attitude towards sexuality among youth, provides a more robust framework for developing and measuring sex, children are aware of and recognize these relationships long before they act on their sexuality, provides adolescents with the information and skills they need to navigate relationships. …”
Get full text

Improving Growth Performance, Biochemical Parameters and Reducing Mortality due to Ascites in Broilers by Propranolol Inclusion by Shahriar Saidian, Somaya Farahmand, Mokhtar Fathi, Salar Saifi

“…Free radicals are produced in the body by damaging the cell membrane leading to cell death and ultimately tissue damage. …”
Get full text

Evolution of Green Technology, Technology Gap and International Trade A Comparative Study of Developing and Developed Countries by Mehrnoosh Patimar, Zahra Zamani

“…Green technology is a form of technology that aims to minimize the environmental damage caused by energy consumption by increasing energy efficiency. …”
Get full text

Editorial by Jörg Tremmel, Markus Rutsche

“…We should protect future generations from foreseeable damage if we have the power to do so. “We” is humankind in its entirety. …”
Get full text

Microscale bone interlocking enhances osseointegration strength on the rough surface of 3D-printed titanium implants: experimental and finite element analysis by Tianyu Shu, Haoyu Shi, Meng Li, Yu-Chia Lin, Ang Li, Dandan Pei

“…Microscale finite element analysis revealed that the rough surface of the SLM implants dispersed harmful strains at the bone-implant interface into the surrounding bone, thereby mitigating the risk of damage to the bone-implant interface. Conclusions The rough surface of 3D-printed titanium implants fosters microscale bone interlocking and alleviates peri-implant bone strain concentration, which is a promising biomechanical basis for osseointegration strength.…”
Get full text

Meta-analysis of the association between overexpression of RAD51 family genes and prognosis and clinical features in breast cancer by Yong-Cheng Liu, Jun Shen

“…Abstract The RAD51 family of genes play a crucial role in the repair of DNA damage, and increasing evidence suggests a close link between the aberrant expression of RAD51 family genes and the development of breast cancer. …”
Get full text

Plant growth promoting rhizobacteria in promoting sustainable agriculture by V. Dhayalan, K. Sudalaimuthu

“…Thus, excessive chemical fertilizer has been used to quickly turn out more outstanding food production, leading to more significant damages to soil ecosystem and human health. Henceforth, bio-fertilizers find the best alternatives to chemical fertilizers. …”
Get full text

Shengxue Busui Decoction activates the PI3K/Akt and VEGF pathways, enhancing vascular function and inhibiting osteocyte apoptosis to combat steroid-induced femoral head necrosis by Manting Liu, Jiexiang Ye, Runtian Wu, Dongqiang Luo, Tao Huang, Dandan Dai, Kexin Wang, Yanping Du, Junwen Ou

“…In vivo, SBD intervention significantly reduced bone structural damage and apoptosis, decreasing the rate of empty bone lacunae. …”
Get full text

Prediction of Heavy Metals Values for South-East of Baghdad Study Area by Eman Abdul Rahman, Muthaina Abdullah Mustafa

“…This study aims to estimate the damage and seriousness of heavy metals pollution in the soil surrounding these factories. …”
Get full text