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12421
Acupuncture mediates the “gut–testis axis” to improve asthenozoospermia
Published 2025-01-01“…Further validation was obtained by performing a fecal microbiota transplantation (FMT).ResultsAcupuncture improved the sperm quality; ameliorated testicular pathology; increased serum testosterone (T), follicle-stimulating hormone (FSH), and luteinizing hormone (LH) levels; and repaired gut and blood–testis barrier damage in asthenozoospermic mice. The abundances of Bacteroidota, Firmicutes, Faecalibaculum, and Dubosiella were associated with sperm motility, as shown by a gut microbiome analysis. …”
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12422
In vitro immunomodulatory effects of thymol and cinnamaldehyde in a pig intestinal epithelial cell line (IPEC-J2)
Published 2020-11-01“…This study evaluated the in vitro immune modulating effects of thymol and cinnamaldehyde blend (TCB) in a porcine gut epithelial cell line (IPEC-J2), with or without cellular damage caused by challenge with lipopolysaccharides. …”
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12423
Protective effects of apigenin in neurodegeneration: An update on the potential mechanisms
Published 2025-03-01“…Apigenin has been demonstrated to scavenge ROS, thereby reducing oxidative stress and mitigating the damage to neurons. Inflammation is another key feature of neurodegenerative diseases, and apigenin has been found to possess anti-inflammatory properties. …”
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12424
Metabolism: A Novel Shared Link between Diabetes Mellitus and Alzheimer’s Disease
Published 2020-01-01“…Thus, the brain may be more susceptible to oxidative damage than the rest of the body. Emerging evidence suggests that both oxidative stress and mitochondrial dysfunction are related to amyloid-β (Aβ) pathology. …”
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12425
Activated Human Umbilical Cord Blood Platelet-Rich Plasma Enhances the Beneficial Effects of Human Umbilical Cord Mesenchymal Stem Cells in Chemotherapy-Induced POF Rats
Published 2021-01-01“…The combined transplantation of HucMSCs and ucPRP resulted in more stem cells being retained in the ovaries of POF rats, the estrus cycle of the POF rats being restored, the levels of serum E2, AMH, and FSH improving, and damaged follicles beginning to grow. Finally, we confirmed that the potential mechanism of the combination of HucMSCs and ucPRP to rescue the ovarian function of POF rats is to promote ovarian angiogenesis and to promote the proliferation and reduce the apoptosis of ovarian granulosa cells. …”
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12426
Paeonol Attenuates Methotrexate-Induced Cardiac Toxicity in Rats by Inhibiting Oxidative Stress and Suppressing TLR4-Induced NF-κB Inflammatory Pathway
Published 2020-01-01“…MTX cardiac toxicity was induced at the end of the fifth day of the experiment, with or without paeonol pretreatment. MTX-induced cardiac damage is evidenced by a distortion in the normal cardiac histological structure, with significant oxidative and nitrosative stress shown as a significant increase in NADPH oxidase-2, malondialdehyde, and nitric oxide levels along with a decrease in reduced glutathione concentration and superoxide dismutase activity compared to the control group. …”
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12427
The Impact of Anti-Diabetics on Platelets Function and Cardiovascular Outcomes in Type 2 Diabetes Mellitus: A Narrative Review
Published 2025-01-01“…We realized various mechanisms responsible for enhanced platelet aggregation in T2DM, represented by immature, large, or activated platelets in the altered metabolic environment, against the background of vascular damage in DM. In parallel, analyzing the impact of anti-diabetics on platelet aggregation revealed that most of them are believed to have favorable protective effects against thrombotic disorders via reducing platelet activation and aggregation. …”
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12428
Olfactory Impairment and Recovery in Zebrafish (<i>Danio rerio</i>) Following Cadmium Exposure
Published 2025-01-01“…The exposed fish performed poorly, failing to reach food in five consecutive trials. However, lamellar damage was reduced after the recovery period, and their performance improved, becoming comparable to the control group. …”
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12429
Seepage Behavior of Earth Dams Considering Rainfall Effects
Published 2018-01-01“…In general, reservoir water levels sharply rise during this period and rock-fill dams are exposed to various types of damages such as soil erosion and piping related to seepage problems. …”
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12430
The diagnostic conundrum of late-onset developmental regression in child psychiatry: case series
Published 2025-01-01“… Background Developmental regression in children, in the absence of neurological damage or trauma, presents a significant diagnostic challenge. …”
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12431
Effects of hypoxia on the heart of the juvenile four-finger threadfin (Eleutheronema tetradactylum) based on physiological indicators and transcriptome analysis
Published 2025-02-01“…Histological analysis revealed structural damage in myocardial fibers under hypoxia, with increasing severity over time. …”
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12432
Phosphorylation of histone H3Ser10 in plant cell division
Published 2016-03-01“…It has been shown that this type of modification is required for activation of transcription, DNA damage repair, recombination and also for chromosome condensation and segregation. …”
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12433
H-NS controls the susceptibility of Escherichia coli to aminoglycosides by interfering its uptake and efflux
Published 2025-02-01“…Further studies displayed that the absence of hns caused damage to the bacterial outer membrane and increased the expression levels of porin-related genes, such as ompC, ompF, ompG, and ompN, thus obviously enhancing aminoglycosides uptake of strain EΔhns. …”
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12434
Dying to be famous: retrospective cohort study of rock and pop star mortality and its association with adverse childhood experiences
Published 2012-12-01“…Adverse experiences in early life may leave some predisposed to health-damaging behaviours, with fame and extreme wealth providing greater opportunities to engage in risk-taking. …”
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12435
Construction and application of optimized model for mine water inflow prediction based on neural network and ARIMA model
Published 2025-01-01“…In order to better predict the amount of water surging in mines and to provide an important basis for mine water damage prevention work, based on the time series data of mine water influx from January 2020 to February 2023 in Northern Guizhou Province Longfeng Coal Mine, the BP-ARIMA prediction model was established by combining the BP neural network model and ARIMA autoregressive sliding average model, It also predicted the mine influx for a total of 6 months from July 2022 to February 2023, and compared the prediction results with four models, namely, BP neural network model, ARIMA autoregressive sliding average model, traditional method of Large well method, and GM(1,1) grey model, and used the absolute relative error as the calculation of model accuracy. …”
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12436
Experimental Study on Mechanical Properties of Polypropylene: Steel Fiber Concrete and Loading Characteristics of Shaft Lining
Published 2022-01-01“…Combining the failure characteristics of the two shaft lining models, the following conclusions are obtained: The ultimate bearing capacity of PHSC shaft lining is hardly affected by fibers, but the hoop displacement is significantly reduced and the circumferential stability of shaft lining has been greatly improved, the initial cracks appeared late, the speed of crack’s propagation is reduced, and no obvious concrete peeling and separation appeared during damage. The comprehensive performance of SPHFRC shaft lining is excellent, which has better ductility and anti-deformation ability.…”
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12437
Chaotic spiral based reconfiguration scheme for the mitigation of power loss in solar photovoltaic (PV) systems
Published 2025-03-01“…The performance of photovoltaic (PV) arrays is significantly compromised by partial shading, which leads to reduced energy output and the formation of hotspots that can damage the modules. As the global shift towards renewable energy intensities, optimizing solar energy utilization has become a pressing concern. …”
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12438
Isolation and Antibiotic Sensitivity Testing of Pseudomonas aeruginosa Isolates from Patients with Chronic Suppurative Otitis Media in Baghdad
Published 2025-01-01“…P. aeruginosa has virulence factors that lead to damage to the middle ear mucosa. This study was conducted to identify Pseudomonas aeruginosa causing chronic suppurative otitis media and to determine its antibiotic sensitivity. …”
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12439
Continuous Consumption of Reused Palm Oil Induced Hepatic Injury, Depletion of Glutathione Stores, and Modulation of Cytochrome P450 Profiles in Mice
Published 2019-01-01“…It is therefore recommended that fresh rather than reused palm oil be used for cooking, and large-scale or long-term consumption be avoided to reduce the risk of liver damage and drug-interactions.…”
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12440
Evaluation of Small Intestinal Permeability in Patients with Overlap Syndrome (Autoimmune Hepatitis/Primary Biliary Cholangitis)
Published 2023-06-01“…We divided patients at the stage of liver damage. An increased small intestinal permeability was revealed: hepatitis stage — 0.19 [0.13; 0.30] (p < 0.001), liver cirrhosis stage — 0.18 [0.09; 0.30] (p < 0.05) compared with the control group. …”
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