A microstructure-based numerical approach for uniaxial fatigue life-based non-uniaxial fatigue life prediction of hypo-eutectoid steels by Jonghoon Shin, Hyunki Kim, Minwoo Kang, Chungan Lee, Seunghyun Hong, Yoon Suk Choi

“…The proposed prediction procedure involves the generation of a statistically representative synthetic microstructure, the development of slip system-based fatigue constitutive models for the primary ferrite and pearlite phases constituting the hypo-eutectoid steel, the synthetic microstructure-based finite element simulations for uniaxial, torsional, and in-phase and out-of-phase axial plus torsional fatigue loading conditions using the developed constitutive models, the extraction of the cyclic increment of the fatigue indicator parameters (ΔFIP) from fatigue-simulated microstructures for the local fatigue damage quantification, the calibration of the uniaxial fatigue life prediction model by linking simulated uniaxial ΔFIPs to the uniaxial fatigue life data, and finally the prediction of the non-uniaxial fatigue life (through simulated non-uniaxial ΔFIPs) using the uniaxial fatigue-calibrated life prediction model. …”
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The pathogenesis of COVID-19: Hypercoagulation and D-dimer in thrombotic complications by Leonid DUBEY, Halyna LYTVYN, Olha DOROSH, Nataliya DUBEY, Olena KOZLOVA, Michal PRUC, Nina KUBIKOWSKA, Lukasz SZARPAK, Kavita BATRA, Francesco CHIRICO, Gabriella NUCERA, Svitlana DOAN, Uljana SHEVTSIV

“…In COVID-19, the inflammation and blood coagulation systems are excessively activated. SARS-CoV-2 damages endothelial cells and pneumocytes, which leads to disruption of hemostasis in SARS. …”
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Evolutionary Explanations of the “Actuarial Senescence in the Wild” and of the “State of Senility” by Giacinto Libertini

“…With the distinction between “damage resulting from intrinsic living processes”[4], alias “age changes”[5], and “age-associated diseases”[4,5], the same theory explaining IMICAW allows a rational interpretation of the first category of phenomena while another theory, the “mutation accumulation” hypothesis, gives an immediate interpretation for the second category.The current gerontological paradigm explaining the increasing mortality with increasing chronological age as consequence of insufficient selection should be restricted to the “age-associated diseases”. …”
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Oriented R-CNN With Disentangled Representations for Product Packaging Detection by Jiangyi Pan, Jianjun Yang, Yinhao Liu, Yijie Lv

“…This is because there are many unknown types of damaged samples in industrial object detection, the scale of the types varies greatly and the position changes are complex. …”
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Evaluation of the Antioxidant and Cytotoxic Activities on Cancer Cell Line of Extracts of Parasitic Plants Harvested in Tunisia by Imen Ben Attia, Paolo Zucca, Flaminia Cesare Marincola, Mariella Nieddu, Alessandra Piras, Antonella Rosa, Antonio Rescigno, Mohamed Chaieb

“…These data suggest that, despite the extreme climate conditions and the damage that can result, the studied desert parasitic plants can represent a novel and precious source of metabolites, with promising biological activities.…”
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Human Placental Mesenchymal Stem Cells for the Treatment of ARDS in Rat by Zurab Kakabadze, Nicholas Kipshidze, Teona Paresishvili, Nodar Kipshidze, Zurab Vadachkoria, David Chakhunashvili

“…The study has shown that HPMSCs are able to migrate and attach to damaged lung tissue, contributing to the resolution of pathology, restoration of function, and tissue repair in the alveolar space. …”
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Acute effects on hepatic biomarkers in the freshwater native fish Aequidens metae exposed to polycyclic aromatic hydrocarbons by W. Corredor-Santamaría, I.C. Calderón-Delgado, Z. Arbeli, J.M. Navas, Y.M. Velasco-Santamaría

“…Juveniles of Aequidens metae exposed to concentrations of polycyclic aromatic hydrocarbons close to those found in the environment showed health-compromising damage.…”
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Relationship between Plasma Aldosterone Levels and Left Ventricular Mass in Hypertensive Africans by Adewole Adebiyi, Olubayo Akinosun, Chibuike Nwafor, Ayodele Falase

“…Studies have suggested that the activity of the renin-angiotensin-aldosterone system play a major role in the target organ damage such as left ventricular hypertrophy occuring in hypertension. …”
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The Anti-Cytokine Storm Activity of Quercetin Zinc and Vitamin C Complex by Hayder B. Sahib, Omer Abid Kathum, Rafal Shakeeb Alanee, Rehab A. M Jawad, Ahmed Majeed Al-Shammari

“…LPS group C showed tissue damage in the lung and kidney, which significantly prevented by the pretreated complex in group B. …”
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Yiqi Fumai Lyophilized injection protects cardiac contractility in a rat model of heart failure with reduced ejection fraction by modulating SERCA2 by Yongwei Nie, Lu Chen, Yanxin Zhang, Yuqing Yao, Zizhuo Xue, Na Guo, Meixiu Wan, Zhi Li, Chunhua Liu, Dekun Li, Aichun Ju

“…Hematoxylin and Eosin (H&E) staining, Masson's trichrome staining, western blotting, and immunohistochemical analysis were performed to evaluate myocardial damage and investigate the underlying molecular mechanisms. …”
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ROS-regulated SUR1-TRPM4 drives persistent activation of NLRP3 inflammasome in microglia after whole-brain radiation by Yuan Chang, Yihua He, Di Wang, Kunxue Zhang, Yuzhen Zhang, Zhentong Li, Shuxin Zeng, Sheng Xiao, Suyue Pan, Kaibin Huang

“…Utilizing the mouse model of RIBI and irradiated BV2 cells, we further demonstrated that irradiation caused mitochondrial damage to microglia, leading to violent release of reactive oxygen species (ROS), which enhanced the transcription of SUR1, TRPM4, and NLRP3 inflammasome-related molecules. …”
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Posttraumatic stress disorder and associated factors in the aftermath of the 2015 earthquake in Nepal: A systematic review and meta-analysis. by Prayash Paudel, Asutosh Sah, Anil Khanal

“…The subgroup analyses revealed that the incidence of posttraumatic stress disorder after an earthquake varied significantly across studies in terms of the time of assessment, sex, age, marital status, ethnicity, educational level, disease history, bereavement, injury to the body, witnessing death, social support, loss of property and damage to one's house. However, stratified analyses could not fully explain the heterogeneity in the results. …”
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Preparation and Characterization of Auricularia cornea Ehrenb Polysaccharide-Zn Complex and Its Hypoglycemic Activity through Regulating Insulin Resistance in HepG2 Cells by Tingting Liu, Shanshan Zhang, Nan Wang, Xinle Xu, Hongcheng Liu, Dawei Wang, Yanrong Zhang

“…Therefore, it was speculated that the hypoglycemic effect of Auricularia cornea Ehrenb polysaccharide combined with zinc was related to the alleviation of liver cell damage caused by oxidative stress and the improvement of glucose metabolism of IR-HepG2 cells. …”
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The relationship of growth differentiation factor 15 with some biochemical parameters in cardiovascular disease patients in Babylon City by Hiba Resheed Behayaa, Zinah Abbass Ali, Seenaa Badr Mohammed, Suhayr A. Alqaysi

“…Though in cardiovascular damage, the level of GDF15 may rise, the natural effects of GDF15 may vary according to the stage of the disease. …”
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Experimental Study on Electric Resistivity Characteristics of Compacted Loess under Different Loads and Drying-Wetting Cycles by Yu Zhou, Guoyu Li, Wei Ma, Dun Chen, Fei Wang, Yuncheng Mao, Qingsong Du, Jun Zhang, Liyun Tang

“…The electrical resistivity of loess reflects plastic damage under uniaxial unloading-reloading tests, but it is deficient in representing the dissipated energy of loess. …”
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Exosomes derived from liver failure patients’ plasma stimulated mesenchymal stem cells alleviate acute liver failure by Zhuoran Wang, Jun Ling, Shaoli You, Bing Zhu

“…Apoptosis was assessed using the CCK-8 assay and flow cytometry. Liver tissue damage was examined by hematoxylin and eosin staining and immunohistochemistry. …”
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Concentrations, Deposition, and Effects of Nitrogenous Pollutants in Selected California Ecosystems by Andrzej Bytnerowicz, Pamela E. Padgett, Sally D. Parry, Mark E. Fenn, Michael J. Arbaugh

“…HNO3 vapor alone has a potential for toxic effects causing damage of foliar surfaces of pines and oaks. In addition, dry deposition of predominantly HNO3 has lead to changes in vegetation composition and contamination of ground- and stream water where terrestrial N loading is high. …”
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CRISPR-Based Programmable Nucleic Acid-Binding Protein Technology Can Specifically Detect Fatal Tropical Disease-Causing Pathogens by Md. Rashidur Rahman, Toma Rani Majumder, Md. Aminul Islam Apu, Alok K. Paul, Afrina Afrose, Biplab Kumar Dash

“…Furthermore, the discovery of programmable trans-cleavage Cas proteins like Cas12a and Cas13 that can collaterally damage reporter-containing single-stranded DNA or RNA upon formation of target Cas-gRNA complex has strengthened this technology with enhanced sensitivity. …”
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Microbubble dynamics in brain microvessels. by James H Bezer, Paul Prentice, William Lim Kee Chang, Sophie V Morse, Kirsten Christensen-Jeffries, Christopher J Rowlands, Andriy S Kozlov, James J Choi

“…These results present the first direct observations of ultrasound-driven microbubbles within brain tissue, and illustrate a range of microbubble behaviors that have the potential to lead to safe drug delivery or tissue damage.…”
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Unique laparoscopic emergency management of traumatic obstructed abdominal wall hernia: A case report and review of literature by Arwa M. Aljuhani, Ghaith A. Al Saied, Arjmand Reyaz, Mohammed A. Alkahlan, Ibrahim M. Aljohani, Muhammed M. Abukhater

“…This type of hernia is primarily caused by low- or high-energy blunt force trauma, resulting in damage to abdominal wall musculature while the skin is intact. …”
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