Influence of Mesalazine on Ferroptosis-Related Gene Expression in In Vitro Colorectal Cancer Culture by Joanna Słoka, Barbara Strzałka-Mrozik, Sebastian Kubica, Ilona Nowak, Celina Kruszniewska-Rajs

“…Ferroptosis is characterized by iron imbalance and the accumulation of lipid peroxides and reactive oxygen species (ROS), leading to cellular damage and death. Thus, the discovery of safe inducers of ferroptosis, offering new hope in the struggle against CRC, remains crucial. …”
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Comparative transcriptome analysis reveals the key role of photosynthetic traits in the formation of differences in photothermal sensitivity in tobacco by Yanfeng Zheng, Qiwei Yu, Anbin Lu, Xiue Chen, Kai Yang, Jingyao Zhang, Ying Huang, Renxiang Liu

“…However, this promotion also led to the increased production of harmful substances such as hydrogen peroxide and superoxide radicals, which can damage cellular structure and function. In the flavonoid biosynthesis pathway, genes such as FLS, CHI, and PAL were significantly upregulated, which enhanced the plant’s antioxidant capacity. …”
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Artesunate Restrains Maturation of Dendritic Cells and Ameliorates Heart Transplantation-Induced Acute Rejection in Mice through the PERK/ATF4/CHOP Signaling Pathway by Yuanyang Chen, Sihao Zheng, Zhiwei Wang, Xin Cai, Yanjia Che, Qi Wu, Shun Yuan, Xiaohan Zhong

“…Furthermore, the treatment alleviated the oxidative stress damage of BMDCs. Conclusion. ART can inhibit maturation of dendritic cells through the endoplasmic reticulum stress signaling pathway, thereby alleviating acute rejection in mice after heart transplantation.…”
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CHARACTERISTICS OF THE COURSE OF LEUCOCYTOCLASTIC VASCULITIS WITH SKIN LESIONS. ANALYSIS OF CLINICAL CASES by O.A. Borzykh, O.V. Belan, I.A. Mormol, Y.M. Avramenko, T. Іengalychev, T.M. Markina

“…Leukocytoclastic vasculitis of the skin (LCV) is an isolated cutaneous vasculitis without damage to internal organs. At present, vasculitis is considered a polyetiological disease. …”
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Structuring the genetic collection of sunflower by V. A. Gavrilova, I. N. Anisimova, N. V. Alpatieva, E. A. Porokhovinova

“…A set of 237 sunflower lines from VIR’s genetic collection was phenotyped for their morphological characters (plant height; branching type; shapes and sizes of the leaf, petiole, flower head, disk and ray florets; downy mildew damage rate) and genotyped with molecular markers. …”
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SCREENING OF THE CUCUMBER COLLECTION FOR RESISTANCE TO DOWNY MILDEW IN THE LOWER VOLGA REGION by E. H. Sukhanberdina, A. A. Grushin, T. M. Piskunova

“…During the years of study, 23 accessions, previously resistant to downy mildew, lost their resistance and suffered severe damage from the disease. Hence, it seems obvious that resistant accessions should be periodically retested for susceptibility to downy mildew. …”
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ABIOTIC STRESSORS AND THEIR EFFECT ON THE ACCUMULATION OF ASSIMILATES BY PLANTS AND THE YIELD OF VEGETABLE PEA by O. V. Putina, A. G. Besedin

“…., are spontaneous, and their impact causes significant damage to plants. This is also true for the common and leafless morphotypes of vegetable pea, which are most widely used in large-scale crop production.Objectives. …”
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An Aloe-Based Composition Constituting Polysaccharides and Polyphenols Protected Mice against D-Galactose-Induced Immunosenescence by Mesfin Yimam, Teresa Horm, Alexandria O’Neal, Ping Jiao, Mei Hong, Qi Jia

“…UP360 was found to improve the immune response as evidenced by stimulation of innate and adaptive immune responses, increase antioxidant capacity as reflected by augmented SOD and Nrf2, and preserve vital immune organs, such as the thymus, from aging-associated damage. The findings depicted in this report show the effect of the composition in activating and maintaining homeostasis of the immune system both during active infections and as a preventive measure to help prime the immune system. …”
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Ultrastructural studies distinguish skin diversities among Galápagos iguanas by Manuel Scimeca, Rita Bonfiglio, Giuliano Colosimo, Eleonora Candi, Glenn P. Gerber, Gregory A. Lewbart, Alessandro Mauriello, Gerry Melino, Christian Sevilla, Yufang Shi, Ying Wang, Gabriele Gentile

“…These skin characteristics may reduce the penetration power of UV rays into the superficial loose dermis, thereby attenuating potential UV-related damage such as DNA breaks and ROS generation. These findings offer insights into the adaptive strategies of these iguanas.…”
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A novel hybrid cooling system for a Lithium-ion battery pack based on forced air and fins integrated with phase change material by Mohanad F. Hassan, Abdul Hadi N. Khalifa, Ahmed J. Hamad

“…However, they face challenges, including thermal runaway and safety risks from thermal damage to an explosion. Therefore, effective cooling methods and strong thermal management systems ensure their safety and optimal performance. …”
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High-Affinity Anti-VISTA Antibody Protects against Sepsis by Inhibition of T Lymphocyte Apoptosis and Suppression of the Inflammatory Response by Tianzhu Tao, Lulong Bo, Teng Li, Longbao Shi, Hui Zhang, Bo Ye, Yuhai Xu, Qingqing Ma, Xiaoming Deng, Guorong Zhang

“…The effects of anti-VISTA mAb on the 7-day survival, lymphocyte apoptosis, cytokine expression, bacterial burden, and vital organ damage were determined. Furthermore, the effects of anti-VISTA mAb on CD3+ T cell apoptosis and macrophage activation were determined in vitro. …”
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Design, Synthesis, and Pharmacological Screening of Novel Porphyrin Derivatives by Ahmed A. Fadda, Rasha E. El-Mekawy, Ahmed El-Shafei, Harold S. Freeman, David Hinks, Manal El-Fedawy

“…These dyes were used as a model to study the free radical-induced damage of biological membranes and the protective effects of these porphyrins. …”
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Study on Interaction Mechanism of Natural Gas Pipe-Landslide System Reinforced by Micropile Groups Based on Model Test by Wei Guan, Honggang Wu, Daoyong Wu, Lin Tang, Hong Wei

“…The screw micropile cannot effectively resist the landslide thrust at a large load level, so the risk of pipeline damage is greater. The yield strength and ultimate strength of the perforated pipe micropile are greater than those of the screw micropile, and the perforated pipe micropile can still exert a certain residual resistance after reaching the ultimate bearing capacity, which has a beneficial effect on the reinforcement of the pipeline crossing the landslide system. …”
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Melatonin Enhances Maize Germination, Growth, and Salt Tolerance by Regulating Reactive Oxygen Species Accumulation and Antioxidant Systems by Wei-Qing Li, Jia-Yu Li, Shao-Jie Bi, Jia-Yue Jin, Zhong-Ling Fan, Zi-Lin Shang, Yi-Fei Zhang, Yan-Jie Wang

“…Moreover, exogenous melatonin alleviated NaCl-induced membrane damage and oxidative stress, and reduced Na⁺ content and excessively large quantities of reactive oxygen species (ROS). …”
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Modulation of the thiol redox proteome by sugarcane ash-derived silica nanoparticles: insights into chronic kidney disease of unknown etiology by Arthur D. Stem, Cole R. Michel, Peter S. Harris, Keegan L. Rogers, Matthew Gibb, Carlos A. Roncal-Jimenez, Richard Reisdorph, Richard J. Johnson, James R. Roede, Kristofer S. Fritz, Jared M. Brown

“…SiNPs have high potential for generation of reactive oxygen species (ROS), and their accumulation in kidney could result in oxidative stress induced kidney damage consistent with CKDu pathology. Methods In order to characterize the impact of sugarcane ash derived (SAD) SiNPs on human kidney proximal convoluted tubule (PCT) cells and identify potential mechanisms of toxicity, HK-2 cells were exposed to treatments of either pristine, manufactured, 200 nm SiNPs or SAD SiNPs and changes to cellular energy metabolism and redox state were determined. …”
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Rectus Abdominis Muscle Endometriosis: A Unique Case Report with a Literature Review by Marijana Turčić, Koviljka Matušan Ilijaš, Koraljka Rajković Molek, Petra Valković Zujić

“…Early diagnosis is essential to avoid delayed recognition, tissue damage, and to minimize the risk of recurrence or malignant transformation. …”
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Deep-Learning-Driven Insights into Nitrogen Leaching for Sustainable Land Use and Agricultural Practices by Caixia Hu, Jie Li, Yaxu Pang, Lan Luo, Fang Liu, Wenhao Wu, Yan Xu, Houyu Li, Bingcang Tan, Guilong Zhang

“…Nitrate leaching from soil presents a significant threat to soil health, as it can result in nutrient loss, soil acidification, and structural damage. It is crucial to quantify the spatial heterogeneity of nitrate leaching and its drivers. …”
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Urinary I-FABP, L-FABP, TFF-3, and SAA Can Diagnose and Predict the Disease Course in Necrotizing Enterocolitis at the Early Stage of Disease by Stepan Coufal, Alena Kokesova, Helena Tlaskalova-Hogenova, Barbora Frybova, Jiri Snajdauf, Michal Rygl, Miloslav Kverka

“…Therefore, we analyzed diagnostic and prognostic potential of the markers of early NEC pathogenesis, such as excessive inflammatory response (serum amyloid A (SAA)) and gut epithelium damage (intestinal and liver fatty acid-binding protein (I-FABP and L-FABP, respectively) and trefoil factor-3 (TFF-3)). …”
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L-Citrulline in Neonates: From Bench to Bed Side by Dwayne Mascarenhas, Atefeh Mohammadi, Randa Higazy, Julijana Ivanovska, Estelle Gauda, Bonny Jasani

“…Detoxification of endogenously produced superoxide radicals is inadequate in preterm infants due to immature antioxidants that leads to the production of peroxynitrite, a reactive oxygen-free radical that is cytotoxic and causes damage to organelles and cellular membranes, further disrupting the coupling of endothelial NO synthase enzyme and the generation of high levels of reactive nitrogen and oxygen species. …”
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Enhanced penetration and biofilm eradication by sophorolipid micelles encapsulating Honokiol: a comprehensive solution for biofilm-associated lung infections by Shiyu Lin, Xiaojuan Li, Wei Zhang, Gang Shu, Tim Tolker-Nielsen, Haohuan Li, Funeng Xu, Juchun Lin, Guangneng Peng, Li Zhang, Hualin Fu

“…In a murine model of pneumonia infected by S. aureus, HK-SL Ms significantly reduced the bacterial load in the lungs, decreased inflammatory factor levels, and repaired lung tissue damage. Conclusions HK-SL Ms offers a novel strategy for the clinical treatment of biofilm-associated infections by dispersing and removing S. aureus biofilms and preventing new infections. …”
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