SETD2 loss-of-function uniquely sensitizes cells to epigenetic targeting of NSD1-directed H3K36 methylation by Ryan T. Wagner, Ryan A. Hlady, Xiaoyu Pan, Liguo Wang, Sungho Kim, Xia Zhao, Louis Y. El Khoury, Shafiq Shaikh, Jian Zhong, Jeong-Heon Lee, Jolanta Grembecka, Tomasz Cierpicki, Thai H. Ho, Keith D. Robertson

“…Depletion of NSD1 using a CRISPRi targeting approach promotes the loss of SETD2-mutant cells coincident with elevated levels of DNA damage and apoptosis. Surprisingly, only suppression of NSD1, but not related H3K36-methyltransferases, promotes synthetic lethality in these models. …”
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Outburst mechanism and hazard prevention technique of limestone aquifer under isolated island panels by Wei Wang, Wei Wang, Wei Wang, Yanjun Wu, Yanjun Wu, Yanjun Wu, Yongli Shi, Yongli Shi, Yongli Shi, Jingzhong Zhu

“…The theoretical results and engineering application in this study have significant implications for coal mining on other isolated islands affected by panel floor water damage.…”
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Melasma management: Unveiling recent breakthroughs through literature analysis by Darshan Kumar R, Richa Sood, Prashant Tiwari

“…These techniques offer precise targeting of melanin without causing significant epidermal damage, thus minimizing the risk of post-inflammatory hyperpigmentation. …”
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Numerical analysis model for the instantaneous grinding temperature of face gears with a worm grinding wheel by WANG Chao, GUO Hui, RUAN Yuhang, RAN Xiaoping, ZHAO Ning

“…ObjectiveThe thermal distribution during the grinding of face gears using a worm grinding wheel is complex, with the heat being concentrated primarily on the surface layer of the wheel teeth, which can lead to thermal deformation and damage. In order to improve the situation, a numerical computational model for the instantaneous grinding temperature of face gears with a worm grinding wheel was established to investigate the distribution and variation patterns of the grinding temperature.MethodsFirstly, based on the geometric contact characteristics between the face gear and the worm grinding wheel during the grinding process, a quadratic surface was employed to approximate the instantaneous contact region and derive a calculation formula for the instantaneous grinding contact area. …”
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RSM approach-based analysis of the physical behavior of dune sand reinforced with Washingtonia waste contributing to mortar cleaner production by Abdelhamid Khelifi, Messaouda Boumaaza, Ahmed Belaadi, Mostefa Bourchak, Tarek Djedid, Ibrahim M.H. Alshaikh, Djamel Ghernaout

“…These findings demonstrate the potential of this sustainable mortar for eco-construction applications, such as bending elements and repairing damaged structures in buildings, highways, and bridges.…”
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Review of the Generation of Fractures and Change of Permeability due to Water-Shale Interaction in Shales by Kerui Liu, Dangliang Wang, James J. Sheng, Jianfeng Li

“…Some believe that clay swelling causes formation damage, mainly impairing shale permeability. Others state that fractures can be induced because of clay swelling, leading to the enhancement of shale permeability. …”
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Innovations in Medical Education in Gastrointestinal Surgery Using Interactive Anatomical Tables by A. D. Kashtanov, E. O. Stetsyk, S. S. Dydykin, O. V. Kytko, E. M. Trunin, O. Yu. Aleshkina, A. N. Lavrentieva, A. N. Andreeva, D. S. Alekseeva, A. A. Muratova, A. Yu. Kharina, V. V. Tatarkin, A. S. Sokolova, V. N. Filatov, I. L. Samodova, E. A. Makeeva, E. S. Pekeldina, M. Yu. Kapitonova, T. S. Bikbaeva, I. A. Polkovova, B. A. Volel, T. M. Litvinova, E. N. Dudnik, N. V. Kireeva, K. V. Ivashkin, Yu. L. Vasil’ev

“…Traditional education based on dissection materials cannot fully provide for the massive training of students, as biological materials cannot be restored or preserved and are quickly damaged. 3D models are devoid of these limitations.Aim: to evaluate the effectiveness of digital dissection in the educational trajectory of clinical anatomy using interactive anatomical tables and the need of students for the active use of these aids.Materials and methods. …”
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Neuronal Plasticity Associated with Burn Injury and Its Relevance for Perception and Management of Pain in Burn Patients by Terence J Coderre, Manon Choinière

“…Recurrent inputs from damaged and redamaged tissue impinge on a nervous system that becomes an active participant in the initiation of changes in sensory perception and maintenance of long term sensory disturbances. …”
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Effect of Cultivar and Planting Date on Soybean Response to Dicamba by Wesley France, Jason Norsworthy, Trent Roberts, Jeremy Ross, Tom Barber, Edward Gbur

“…Off-target movement of dicamba has been blamed for damaging millions of hectares of soybean in the United States since registration of the herbicide for use in dicamba-resistant cotton and soybean. …”
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Comparative experimental anesthesia efficacy study of epidural injection at the sacrococcygeal space using ultrasound guidance versus blindness technique in Egyptian donkeys (Equus... by Mohamed A. Hamed, Hazem Hamouda, Mohammed Elmetwally, Foad Farrag, Mohamed Abdo Rizk, Mohamed M. A. Abumandour, Yamen Mohammed Hegazy, Alaa Samy

“…In conclusion, the ultrasound-guided technique of the epidural injection provided a number of benefits over the blind one, including the capacity to directly view the needle and distribute local anesthetic and avoid unintentional vascular damage, in comparison with traditional blind techniques. …”
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Single nucleotide polymorphism and expression of genes for immune competent cell proliferation and differentiation in radiation-exposed individuals by E. A. Blinova, V. S. Nikiforov, M. A. Yanishevskaya, A. A. Akleyev

“…And it predetermines early response in the case of genome damage. Later on modulations in gene transcription activity are also possible and could result in a carcinogenic effect. …”
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THE ROLE OF ARTIFICIAL INTELLIGENCE (AI) ON MRI BRAIN EXAMINATION WITH CLINICAL ISCHEMIC STROKE by Oktaviani Aulia WMS, Emi Murniati, Agustina Dwi Prastanti

“…It takes a short time to minimize the patient's brain damage. Purpose: Determine the role of AI in ischemic brain stroke MRI examination and find out the advantages and disadvantages of applying AI to ischemic brain stroke MRI examination. …”
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INTERNET COMMUNICATION: NEW CHALLENGES FOR THE YOUTH by D. N. Karpova

“…Besides above-mentioned personal security, special attention is paid to the problem of international cyber terrorism which can cause more damage not only to companies but the whole governments. …”
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Stability of a Roadway below a Coal Seam under Dynamic Pressure: A Case Study of the 11123 Floor Gas Drainage Roadway of a Mine in Huainan, China by Pingsong Zhang, Yuanchao Ou, Chang Liu, Binyang Sun, Chong Xu

“…The results of this study can provide guidance for devising suitable procedures for carrying out intelligent green safety mining and for warning about the hazards of roadway damage.…”
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DIC-Based Operational Modal Analysis of Bridges by Gongfa Chen, Zhihua Wu, Chunjian Gong, Jiqiao Zhang, Xiaoli Sun

“…A key issue in vibration-based damage detection for a bridge is to determine its modal parameters. …”
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Hybrid Method of Modal Analysis and Laser Shock Scanning to Visualize the Pyroshock Propagation in a Tension Joint by Yong-Woon Kim, Jae-Kyeong Jang, Jung-Ryul Lee, Hak-Seong Gim

“…In particular, it was confirmed that the pyrolock-induced shock at the near field can cause damage to the electronic equipment despite a smaller impulse than that of the explosive bolt-induced shock. …”
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Analysis of Various Types of Glomerulonephritis with Crescents at a Single Center by Tomo Nakakita, Kenichi Akiyama, Kazunori Karasawa, Yoei Miyabe, Takahito Moriyama, Keiko Uchida, Kosaku Nitta

“…Renal dysfunction at renal biopsy and the ratio of global sclerosis predicted renal prognosis, because it reflects the degree of irreversible renal damage. We also suspect that the formation of at least one crescentic lesion led to the development of these predictive factors, regardless of the type of glomerular disease and degree of crescent formation.…”
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The use of kinematic photogrammetry and LiDAR for reconstruction of a unique object with extreme topography: a case study of Dutchman’s Cap, Baltic seacoast, Lithuania by Birutė Ruzgienė, Lina Kuklienė, Indrius Kuklys, Dainora Jankauskienė, Dainora Jankauskienė, Sérgio Lousada, Sérgio Lousada, Sérgio Lousada, Sérgio Lousada, Sérgio Lousada

“…This area has been significantly eroded by the sea due to the climatic changes of the last few decades, which have caused substantial damage to the coastline. Quantitative measurements show that coastal erosion has led to a retreat of up to [X] meters over the last [Y] years. …”
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The transcriptional analysis of pepper shed light on a proviral role of light-harvesting chlorophyll a/b binding protein 13 during infection of pepper mild mottle virus by Weihong Lin, Shugen Zhang, Hao Zhang, Xiaomei Deng, Tong Jiang, Xifeng Chen, Laihua Dong, Qin Yan, Lianyi Zang, Yongping Xing, Zhenquan Wang, Qin Zhang, Kaitong Du, Huolin Shen, Junmin Zhang, Tao Zhou

“…Pepper mild mottle virus (PMMoV), a member of the genus Tobamovirus, causes severe damage on pepper worldwide. Despite its impact, the pathogenicity mechanisms of PMMoV and the pepper plant’s response to infection remain poorly understood. …”
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Pathomorphological Study of Coronary Atherosclerosis in Deceased Patients by Halina Pérez Álvarez, José Fernández-Brito Rodríguez

“…<strong>Background:</strong> atherosclerosis is a disease of the general metabolism, with damage to the vascular endothelium, which has led to multiple researches using the atherometric system. …”
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