From gut to liver: Exploring the crosstalk between gut-liver axis and oxidative stress in metabolic dysfunction-associated steatotic liver disease by Mi Zhou, Jianyu Lv, Xinli Chen, Yujie Shi, Guanqun Chao, Shuo Zhang

“…Our analysis reveals several key findings: (1) Bile acid dysregulation can trigger oxidative stress through enhanced ROS production in hepatocytes and Kupffer cells, leading to mitochondrial dysfunction and lipid peroxidation; (2) Gut microbiota dysbiosis disrupts intestinal barrier function, allowing increased translocation of endotoxins like LPS, which activate inflammatory pathways through TLR4 signaling and promote oxidative stress via NADPH oxidase activation; (3) The redox-sensitive transcription factors NF-κB and Nrf2 serve as crucial mediators in the gut-liver axis, with NF-κB regulating inflammatory responses and Nrf2 orchestrating antioxidant defenses; (4) Oxidative stress-induced damage to intestinal barrier function creates a destructive feedback loop, further exacerbating liver inflammation and disease progression. …”
Get full text

Nano-curcumin Effects on Ischemic Stroke clinical outcomes and Interleukin-6 Levels: Pilot Randomized Clinical Trial by Zeinab Ehtiatkar, Alia Saberi, Samaneh Ghorbani Shirkouhi, Mozaffar Hosseininezhad, Shahrokh Yousefzadeh-Chabok, Yaser Moadabi, Ashkan Karimi, Haniyeh Shadrou Gharani, Sasan Andalib

“…Background: Accumulation of inflammatory factors in the stroke area results in brain tissue damage and a patient’s disability. It has been demonstrated that curcumin has neuroprotective effects. …”
Get full text

Indomethacin-Induced Gastric Ulcer in Rats: Gastroprotectivity of <i>Muscari neglectum</i> in Water by Menekse Soydan, Gulnur Arabaci, Necati Utlu, Mesut Bünyami Halici, Esra Aktas Senocak, Metin Kiliçlioglu

“…<b>Results:</b> The Gastric tissue examinations at biochemical, macroscopic and pathological levels showed that MN extracts effectively prevented indo-methacin-induced gastric mucosal damage. The 400 mg/kg dose exhibited the most effective antiulcer effect, with a 69% protective efficacy. …”
Get full text

Renoprotective Effect of Pitavastatin against TAA-Induced Renal Injury: Involvement of the miR-93/PTEN/AKT/mTOR Pathway by Marawan A. Elbaset, Bassim M. S. A. Mohamed, Passant E. Moustafa, Tuba Esatbeyoglu, Sherif M. Afifi, Alyaa F. Hessin, Sahar S. Abdelrahman, Hany M. Fayed

“…By altering the PTEN/AKT/mTOR pathway, pitavastatin may boost kidney antioxidant capacity and minimize oxidative damage. Statins have several benefits, including antioxidant and anti-inflammatory characteristics. …”
Get full text

Efficacy of CLT4A variants as immunoregulatory molecules among Vitiligo patients in Saudi Arabia by Amal F. Alshammary, Ghada BinSaif, Imran Ali Khan

“…In vitiligo, cytotoxic T-lymphocytes damage melanocytes, causing skin depigmentation. The Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) gene has been reported to be related to vitiligo and other autoimmune diseases. …”
Get full text

Purpurin suppresses Salmonella invasion of host cells by reducing the secretion of T3SS-1 effector proteins by Zhenxu Shi, Zhimin Guo, Siqi Li, Chenxiao Jiang, Jianfeng Wang, Xuming Deng, Hongtao Liu, Jiazhang Qiu

“…The results from animal experiments indicated that PPR exhibited significant efficacy in a mouse enteritis model caused by ST infection, increasing the survival rate of mice infected with a lethal dose by 50%, reducing spleen colonization in infected mice, and alleviating tissue damage resulting from ST infection. Therefore, PPR represents a promising antivirulence drug that targets the T3SS of ST and may serve as a hit compound for the development of novel antivirulence drugs for the treatment of ST.…”
Get full text

Myeloma cell-derived CXCL7 facilitates proliferation of tumor cells and occurrence of osteolytic lesions through JAK/STAT3 pathway by Yue Wang, Tianwei Lan, Qiongyan Zhang, Chi Zhou, Peng Liu

“…CXCL7 might be a crucial regulator of osteolytic damage in MM. Subsequently, the association between the expression level of CXCL7 and pathological fractures in patients was investigated, and the impact of CXCL7 on MM proliferation was confirmed both in vivo and in vitro. …”
Get full text

The antibacterial activity of clove Syzygium aromaticum extract and its effects on the survival rate of hybrid grouper Epinephelus fuscoguttatus ♀ × E. lanceolatus ♂ infected with... by Inem Ode, Sukenda, Widanarni, Dinamella Wahjuningrum, Munti Yuhana, Mia Setiawati

“…The conclusion of this research is that clove extract has antibacterial activity that can inhibit growth and cause cell morphological damage to V. alginolyticus. The application of clove powder at a dose of 15g kg-1 was able to improve the survival value which was a higher post-challenge test.   …”
Get full text

Seismic Performance and Flexural Capacity Analysis of Embedded Steel Plate Composite Shear Wall Structure with Fiber-Reinforced Concrete in the Plastic Hinge Zone by Junlong Li, Guoqiang He, Jianbo Tian

“…However, bending failure is prone to occur during strong earthquakes, and the single energy dissipation mechanism of the plastic hinge zone at the bottom leads to the concentration of local wall damage. To improve the embedded steel plate composite shear wall structure, the plastic hinge zone of the composite shear wall is replaced by fiber-reinforced concrete (FRC) and analyzed by ABAQUS finite element simulation analysis. …”
Get full text

CO2-Driven Hydraulic Fracturing Trajectories across a Preexisting Fracture by Qi Zhang, Jiehao Wang, Yufeng Gao, Shengfei Cao, Jingli Xie, Like Ma, Yuemiao Liu

“…Defining the trajectory of hydraulic fractures crossing bedding planes and other fractures is a significant issue in determining the effectiveness of the stimulation. In this work, a damage evolution law is used to describe the initiation and propagation of the fracture. …”
Get full text

Sjögren’s Syndrome: Concerted Triggering of Sicca Conditions by Zygmunt Mackiewicz, Justyna Mażul, Ieva Narkevičiūtė, Irena Dumalakienė, Irena Butrimienė, Rita Vilienė, Indrė Stankevičienė, Diana Mieliauskaitė

“…Cytometric analysis of the blood cells revealed a dropping amount of circulating natural killers and dendritic cells in patients with SS. …”
Get full text

Causal relationship between immune cells and risk of heart failure: evidence from a Mendelian randomization study by Wenjing Cao, Zefu Yang, Liumei Mo, Zhenhao Liu, Jiawei Wang, Zhenhong Zhang, Kui Wang, Wei Pan

“…BackgroundHeart failure (HF) is a clinical syndrome resulting from structural damage or dysfunction of the heart. Previous investigations have highlighted the critical involvement of immune cells in the progression of heart failure, with distinct roles attributed to different types of immune cells. …”
Get full text

Mine Geological Environment Monitoring and Risk Assessment in Arid and Semiarid Areas by Jiaqi Jin, Chicheng Yan, Yixuan Tang, Yilong Yin

“…Based on the above background, this thesis takes the coal mining area in the arid and semiarid regions as an example; applies the theories of ecology, coal mining subsidence, geodesy, and ecological restoration; uses remote sensing in synthetic aperture radar (SAR), geographic information system (GIS), and mathematical modelling to reveal the ecological evolution law of the mining area; measures the ecological damage of the mining area; and then proposes a reasonable ecological restoration strategy. …”
Get full text

Monacolin K as a Natural Alternative for Synthetic Statins by Julia Kozakiewicz, Aleksandra Okońska, Michał Ziemba, Kamil Kościelecki, Agnieszka Kalisz, Magdalena Krakowiak, Aleksandra Kaczmarek

“…In addition, there are also concerns about liver and/or kidney damage, headaches and/or dizziness, musculoskeletal symptoms and gastrointestinal disturbances in some people, especially when high doses of monacolin K are used. …”
Get full text

Exploring the Mesenchymal Stem Cell Secretome for Corneal Endothelial Proliferation by Bert Van den Bogerd, Nadia Zakaria, Steffi Matthyssen, Carina Koppen, Sorcha Ní Dhubhghaill

“…Specific identification of the underlying proteins using proteomics could render a bioactive protein that can be used for ex vivo expansion of cells or as an in vivo drug to treat early corneal endothelial damage.…”
Get full text

Exploiting somatic oncogenic driver alterations in a patient with Li-Fraumeni syndrome– paving the path towards precision medicine: a case report by Carolin Seeling, Sonja Dahlum, Ralf Marienfeld, Vera Jan, Brigitte Rack, Uwe Gerstenmaier, Ambros J. Beer, Regine Mayer-Steinacker, Wolfgang Thaiss, Thomas F. E. Barth, Thomas Seufferlein, Nadine T. Gaisa, Stephan Stilgenbauer, Wolfgang Janni, Reiner Siebert, Hartmut Döhner, Verena I. Gaidzik

“…It results from pathogenic/likely pathogenic heterozygous constitutional variants of the TP53 gene. Due to impaired DNA damage repair, conventional cytotoxic therapies or radiotherapy should be avoided whenever feasible to mitigate the high incidence of treatment-related secondary malignancies in these patients. …”
Get full text

Cell adhesion molecules involved in the leukocyte recruitment induced by venom of the snake Bothrops jararaca by Stella R. Zamuner, Catarina F. P. Teixeira

“…It has been shown that Bothrops jararaca venom (BjV) induces a significant leukocyte accumulation, mainly neutrophils, at the local of tissue damage. Therefore, the role of the adhesion molecules intercellular adhesion molecule-1 (ICAM-1), LECAM-1, CD18, leukocyte function-associated antigen-1 (LFA-1) and platelet endothelial cell adhesion molecule-1 (PECAM-1) on the BjV-induced neutrophil accumulation and the correlation with release of LTB4, TXA2, tumor necrosis factor-α, interleukin (IL)-1 and IL-6 have been investigated. …”
Get full text

Improving myocardial infarction diagnosis with Siamese network-based ECG analysis. by Vaibhav Gadag, Simrat Singh, Anshul Harish Khatri, Shruti Mishra, Sandeep Kumar Satapathy, Sung-Bae Cho, Abishi Chowdhury, Amrit Pal, Sachi Nandan Mohanty

“…<h4>Background</h4>Heart muscle damage from myocardial infarction (MI) is brought on by insufficient blood flow. …”
Get full text

Species classification of Tabanus (Diptera: Tabanidae) in Western Thailand: Integrating DNA barcoding and modern morphometrics by Tanasak Changbunjong, Thekhawet Weluwanarak, Sedthapong Laojun, Tanawat Chaiphongpachara

“…Given their role in disease transmission, accurate identification of horse fly species is critical but traditionally relies on morphological characteristics, requiring significant expertise and posing a high potential for error, especially with damaged specimens. To address the limitations of traditional morphological identification, this study highlights the importance of alternative techniques, including DNA barcoding and geometric morphometrics (GM). …”
Get full text

Systemic lupus erythematosus organ manifestation and disease activity in children based on Mexican systemic lupus erythematosus disease activity index score at East Java, Indonesia by Zahrah Hikmah, Anang Endaryanto, I Dewa Gede Ugrasena

“…Background: Disease activity in systemic lupus erythematosus (SLE) is associated with organ damage, outcome worsening, comorbidities, and mortalities in the patients. …”
Get full text