Nuclear Factor-Kappa B Activity Regulates Brain Expression of P-Glycoprotein in the Kainic Acid-Induced Seizure Rats by Nian Yu, Qing Di, Hao Liu, Yong Hu, Ying Jiang, Yu-kui Yan, Yan-fang Zhang, Ying-dong Zhang

“…This study was aimed to investigate the effect of NF-κB activity on the seizure susceptibility, brain damage, and P-gp expression in kainic acid- (KA-) induced seizure rats. …”
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Effects of Thermal and Stress Cycles on the Mechanical Properties and Acoustic Emission Characteristics of Rocks by Xianwei Meng, Xinran Zhang, Mingbo Chi, Kun Du

“…Energy analysis indicates that basalt accumulates more total energy (Et) and elastic energy (Ee) compared to sandstone, with different pretreatments affecting energy dissipation (Ed) and damage severity differently in each rock type. These findings contribute to understanding the complex interactions between pretreatment methods and rock behavior in engineering applications.…”
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Infectious hematopoietic necrosis (review) by K. A. Balakhnina, V. P. Melnikov

“…In recent years, infectious hematopoietic necrosis (IHN) has caused significant damage to fish farms. In 2020, Estonia suffered heavy losses; more than 65 tons of rainbow trout died and were destroyed during the IHN outbreak with a mortality rate of 71%. …”
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Regulatory Role of CD4+ T Cells in Myocarditis by Daria Vdovenko, Urs Eriksson

“…In the presence of tissue damage and innate immune activation, however, activated self-antigen-loaded dendritic cells promote CD4+ effector T cell expansion and myocarditis. …”
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Dysfunction of G Protein-Coupled Receptor Kinases in Alzheimer's Disease by William Z. Suo, Longxuan Li

“…The increased cytosolic GRK2 appears to be colocalized with damaged mitochondria and neurofibrillary tangles. …”
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The Hydroalcoholic Extract Obtained from Mentha piperita L. Leaves Attenuates Oxidative Stress and Improves Survival in Lipopolysaccharide-Treated Macrophages by Mariana Oliveira Arruda, Saulo José Figueiredo Mendes, Simone Aparecida Teixeira, Ludmilla Santos Silva de Mesquita, Maria Nilce de Sousa Ribeiro, Stanley de Sousa Lima Galvão, Marcelo Nicolás Muscará, Elizabeth Soares Fernandes, Valério Monteiro-Neto

“…These effects may be beneficial when the excessive activation of macrophages contributes to tissue damage during infectious disease.…”
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Right Amygdalar and Temporofrontal Activation During Autobiographic, But Not During Fictitious Memory Retrieval by Hans J. Markowitsch, Alexander Thiel, Mechthild Reinkemeier, Josef Kessler, Adem Koyuncu, Wolf-Dieter Heiss

“…These data demonstrate that autobiographic memory retrieval uses (at least in non-brain damaged individuals) a network of right hemispheric ventral prefrontal and temporopolar regions and left hemispheric lateral temporal regions. …”
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CONCORDANCE OF TECHNOGENESIS WITH ECODEVELOPMENT by S. M. Sukhorukova, A. M. Pogorelyi, S. G. Vysotskiy

“…In order to coordinate technogenesis with ecodevelopment and guarantee ecologically sustainable development, refusal of market economy is required, because this will allow to introduce long-term economic responsibility for ecological damage and to take into account changes in environmental management efficiency by using natural science knowledge on the basis of forecasts of cyclic changes in the biosphere.…”
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Alcohol and Suicide: Neurobiological and Clinical Aspects by Leo Sher

“…Dopaminergic dysfunction may play an important role in the pathophysiology of suicidal behavior in alcoholism. Brain damage and neurobehavioral deficits are associated with alcohol use disorders and may contribute to suicidal behavior in persons with alcohol dependence or abuse. …”
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HEALTH MONITORING OF STRUCTURAL ELEMENTS USING CT-XRAY by F. Nateghi Alahi, S.S. Kamali

“…This means that with the advent of new damage detection techniques, authorities can make sure that these vital structural elements, such as road signs or traffic lights and so on, are safe. …”
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Inflammatory Response Mechanisms Exacerbating Hypoxemia in Coexistent Pulmonary Fibrosis and Sleep Apnea by Ayodeji Adegunsoye, Jay Balachandran

“…Patients with idiopathic pulmonary fibrosis commonly have obstructive sleep apnea, which potentiates the hypoxic stimuli for oxidative stress, culminating in systemic inflammation and generalized vascular endothelial damage. Comorbidities like pulmonary hypertension, obesity, gastroesophageal reflux disease, and hypoxic pulmonary vasoconstriction contribute to chronic hypoxemia leading to the release of proinflammatory cytokines that may propagate clinical deterioration and alter the pulmonary fibrotic pathway. …”
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Unified Failure Strength Criterion for Terrace Slope Reinforcement Materials by Xuan Fang, Jie Yang, Jia-Ming Na, Zhen-Yuan Gu

“…The results of this work can provide an important theoretical basis for the stability calculation of terrace slopes and LCSG dams.…”
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Swept Source Optical Coherence Tomography Angiography for Contact Lens-Related Corneal Vascularization by Marcus Ang, Yijun Cai, Anna C. S. Tan

“…This early clinical study suggests that the swept-source OCTA used may be useful for examining corneal vascularization, which may have potential for clinical applications such as detecting early limbal stem cell damage.…”
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Exogenous nitric oxide relieves iron-inhibitory effect on wheat seed germination by Shuqian Shi, Zhe Zhang, Rongrong Ma, Yihui Tao, Ziling Wang, Yingli Yang

“…Conclusively, exogenous NO treatment alleviates the inhibitory effects of Fe on wheat seed germination by enhancing endogenous NO synthesis, promoting starch decomposition, and alleviating oxidative damage.…”
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A Novel Method to Evaluate the Effect of Slope Blasting under Impact Loading by Wenhai Zhou, Zhenbao Li, Xin Wu, Shujiang Wang, Yaru Lv, Xiaoming Lou, Chaofei Du, Rui Liang

“…And the numerical model of slope blasting is established by embedding the evolution relationship of tensile and compressive damage into the elastoplastic constitutive material. …”
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Dysregulation in the microbiota by HBV and HCV infection induces an altered cytokine profile in the pathobiome of infection by Marcos Daniel Mendes Padilha, Francisco Tiago de Vasconcelos Melo, Rogério Valois Laurentino, Andrea Nazaré Monteiro Rangel da Silva, Rosimar Neris Martins Feitosa

“…This dysregulated microbiome induces a microenvironment conducive to the development of hepatic complications in patients with acute and chronic HBV and HCV infection, with subsequent dysregulation of cytokines IFN-α/β, TNF-α, IL-1β, TGF-β, IL-6 and IL-10, which alter the dysfunction and damage of the hepatic portal system. In view of the above, this review aimed to correlate the pathophysiological mechanisms in HBV and HCV infection, the dysregulation of the microbiome in patients infected with HBV and HCV, the most altered cytokines in the microbiome, and the most altered bacterial representatives in the pathobiome of infection.…”
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Inhibitory effects of oxyresveratrol on ERK and Smad1/2 phosphorylation and HSC activation in preventing carbon tetrachloride-induced rat liver fibrosis by Guliang Yang, Jianfeng Zhan, Yiwen Yang, Li Yuan, Peilei Wang, Chi-Tang Ho, Shiming Li

“…We demonstrated that rat liver oxidative damage induced by CCl4 was significantly alleviated after ORes feeding. …”
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Effects of Different Ratios of Fly Ash and River Sand on Mechanical Properties of Cemented Paste Backfill Materials by Jiang Li, Shenggen Cao, Yang Liu, Chiyuan Che, Changzheng Zhao, Shuyu Du, Kaifei Wang, Ruiting Ma

“…Based on Weibull distribution and prepeak correction factor, a damage constitutive model was established to describe the stress–strain process of CPB under load. …”
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Long-Term Statistical Analysis of Severe Weather and Climate Events in Greece by Vassiliki Kotroni, Antonis Bezes, Stavros Dafis, Dimitra Founda, Elisavet Galanaki, Christos Giannaros, Theodore Giannaros, Athanasios Karagiannidis, Ioannis Koletsis, George Kyros, Konstantinos Lagouvardos, Katerina Papagiannaki, Georgios Papavasileiou

“…Finally, societal impacts from weather hazards have increased in Greece over the past 14 years, with flash floods being the most frequent and damaging events, while public preparedness and effective risk communication remain low.…”
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Metabolic consequences of erastin-induced ferroptosis in human ovarian cancer cells: an untargeted metabolomics study by Kaylie I. Kirkwood-Donelson, Alan K. Jarmusch, Carl D. Bortner, Bruce Alex Merrick, Birandra K. Sinha

“…Erastin (ER), a ferroptosis inducer, kills tumor cells by generating and accumulating reactive oxygen species (ROS) within the cell, resulting in an iron-dependent oxidative damage-mediated ferroptotic cell death.MethodsWe have utilized human ovarian cancer cell lines, OVCAR-8 and its adriamycin-selected, multi-drug resistance protein (MDR1)-expressing NCI/ADR-RES, both equally sensitive to ER, to identify metabolic biomarkers of ferroptosis.ResultsOur studies showed that ER treatment rapidly depleted cellular glutathione and cysteine and enhanced formation of ophthalamate (OPH) in both cells. …”
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