Hepatoprotective effects of propolis ethanol extract on D-galactose-induced aging mice: A metabolomics and transcriptomics analysis focusing on insulin resistance pathways by Jinjia Liu, Songhao Tian, Jixiang Wang, Qing Sang, Wenting Su, Jinqiang Wu, Fenglei Zai

“…Histological analysis revealed that PEE mitigated liver damage. Mechanistically, PEE appeared to exert hepatoprotective effects by modulating the insulin resistance pathway, particularly through the PI3K-AKT/PP1 signaling axis, thereby enhancing glycogen synthesis in the damaged liver. …”
Get full text

Time-Dependence of Mechanical Property Alterations on Anthracite Coals Treated by Supercritical Carbon Dioxide by Wei Li, Bin Pang, Er-lei Su, Quanlin Yang, Qingquan Liu, Yuanping Cheng

“…The coal samples treated with Sc-CO2 for 240 h and 960 h show different damage modes from limited fractures to a complicated fracture network. …”
Get full text

Experimental Study on Energy Dissipation of Saturated Mudstone in Coal Mine under Impact Loading by Liangjie Guo, Yongyu Wang

“…The influence of blasting energy on blasting fragmentation and damage of reserved rock is important for safety and schedule of drill-blasting construction in coal mine. …”
Get full text

The Fluid-Solid Interaction Dynamics between Underwater Explosion Bubble and Corrugated Sandwich Plate by Hao Wang, Yuan Sheng Cheng, Jun Liu, Lin Gan

“…As the UNDEX bubble load is one of the severest damage sources that may lead to structure large plastic deformation and crevasses failure, the failure mechanisms of sandwich structures might not be accurate if only shock wave is considered. …”
Get full text

White Matter Injury in Central Nervous System Disorders by Zheng L, Wang X, Li P, Hao Y, Zhang H, Chen H, Zheng Z

“…Diseases of the CNS cause not only gray matter damage, which is primarily characterized by the loss of neurons, but also white matter damage. …”
Get full text

Il-6 signaling exacerbates hallmarks of chronic tendon disease by stimulating reparative fibroblasts by Tino Stauber, Greta Moschini, Amro A Hussien, Patrick Klaus Jaeger, Katrien De Bock, Jess G Snedeker

“…To dissect the underlying causalities, we combine IL-6 knock-out mice with an explant-based assembloid model of tendon damage to successfully connect IL-6 signaling to reparative fibroblast activation and recruitment. …”
Get full text

Productivity improvement through lean tools in cement industry – A case study by Md. Tanjid Hossen Irfan, Md. Rafiquzzaman, Yeasin Arafat Manik

“…The study aims to identify the main causes of production loss or low OEE, including motor damage, bearing damage, vibration, and lack of 5S practice. …”
Get full text

Oxidative Stress and DNA Methylation in Prostate Cancer by Krishna Vanaja Donkena, Charles Y. F. Young, Donald J. Tindall

“…Oxygen radicals are associated with different steps of carcinogenesis, including structural DNA damage, epigenetic changes, and protein and lipid alterations. …”
Get full text

Stem Cell-Based Therapeutic Approaches to Restore Sensorineural Hearing Loss in Mammals by Muhammad Waqas, Iram Us-Salam, Zainab Bibi, Yunfeng Wang, He Li, Zhongshou Zhu, Shuangba He

“…The hair cells that reside in the cochlear sensory epithelium are the fundamental sensory structures responsible for understanding the mechanical sound waves evoked in the environment. The intense damage to these sensory structures may result in permanent hearing loss. …”
Get full text

Moderate-intensity interval exercise exacerbates cardiac lipotoxicity in high-fat, high-calories diet-fed mice by Jing Geng, Xiaoliang Zhang, Yanjie Guo, He Wen, Dong Guo, Qi Liang, Siying Pu, Ying Wang, Mingchuan Liu, Zhelong Li, Wei Hu, Xue Yang, Pan Chang, Lang Hu, Yan Li

“…Moreover, inappropriate physical exercise may damage certain organs even though it leads to weight loss and overall metabolic benefits. …”
Get full text

Peridynamics analysis of crack propagation in concrete considering random aggregate distribution by Bin Geng, Ze Li, Yigong Zhao, Xiaoyan Zhang

“…For the first time, the Boundary Damage Ratio (BDR) is proposed to quantitatively describe the influence of cement mortar and aggregate on crack propagation, revealing the influence rules of random aggregate parameters on concrete damage provides a new method for studying concrete crack propagation. …”
Get full text

Advancements in Antioxidant-Based Therapeutics for Spinal Cord Injury: A Critical Review of Strategies and Combination Approaches by Yang-Jin Shen, Yin-Cheng Huang, Yi-Chuan Cheng

“…Spinal cord injury (SCI) initiates a cascade of secondary damage driven by oxidative stress, characterized by the excessive production of reactive oxygen species and other reactive molecules, which exacerbate cellular and tissue damage through the activation of deleterious signaling pathways. …”
Get full text

Glucose metabolism impairment in major depressive disorder by Fanhao Meng, Jing Wang, Long Wang, Wei Zou

“…These impairments may result from mechanisms including insulin resistance, hyperglycemia-induced damage, oxidative stress, astrocyte abnormalities, and mitochondrial dysfunction, leading to insufficient energy supply, altered synaptic plasticity, neuronal cell death, and functional and structural damage to reward networks. …”
Get full text

Economic Consequence of Human - Hippopotamus (Hippopotamus amphibious) Conflicts on Farming Livelihood in Rural Adamawa State, Nigeria by Celestine Lumbonyi, Patrick Boni, Ibrahim Lumbonyi, Amurtiya Michael

“…The study found that Groundnut, Cowpea, and maize were among the most severely damaged crops at their mid-stage of development based on land size. …”
Get full text

Retiming dynamics of harmonically mode-locked laser solitons in a self-driven optomechanical lattice by Xiaocong Wang, Benhai Wang, Wenbin He, Xintong Zhang, Qi Huang, Zhiyuan Huang, Xin Jiang, Meng Pang, Philip. St. J. Russell

“…We reveal that, after an abrupt perturbation, each soliton in the lattice undergoes damped oscillatory retiming within its trapping potential, while the retiming is strongly coupled to soliton dissipation. …”
Get full text

<i>Hylomecon japonica</i>: A Review About Botanical Aspects, Traditional Applications, Chemical Composition, and Pharmacological Properties by Yue Tian, Guangqing Xia, Junyi Zhu, Li Li, Hao Zang

“…It has a long medicinal history and has been traditionally used to treat various conditions, including wind–cold–dampness obstruction syndrome, rheumatic joint pain, traumatic injuries, excessive fatigue, weakness of the limbs, epigastric pain, and dysentery. …”
Get full text

Enhanced corrosion resistance of AM60 alloy with 2.0Ca via thermal oxidation and carbonization under an O₂/CO₂ atmosphere by S.Y. Liu, K. Tang, G.J. Liu, Z.H. Liu, X.Y. Lang, Y.F. Zhu, Q. Jiang

“…Magnesium and its alloys have the advantages of high specific strength and specific stiffness, excellent thermal conductivity and vibration damping performance. However, due to their low corrosion potential and loose corrosion product film, the corrosion resistance of Mg alloys is poor, which seriously limits their utilization scope. …”
Get full text

Dynamic Response of Graphitic Targets with Tantalum Cores Impacted by Pulsed 440-GeV Proton Beams by Pascal Simon, Philipp Drechsel, Peter Katrik, Kay-Obbe Voss, Philipp Bolz, Fiona J. Harden, Michael Guinchard, Yacine Kadi, Christina Trautmann, Marilena Tomut

“…The dynamic response of low-density graphitic foams is surprisingly favourable, indicating promising properties for the application as high-power beam dump material.…”
Get full text

Accuracy Assessment of Nonlinear Seismic Displacement Demand Predicted by Simplified Methods for the Plateau Range of Design Response Spectra by Pierino Lestuzzi, Lorenzo Diana

“…Alternative approaches using linear computation with increased damping ratio are common in other parts of the world. …”
Get full text

Numerical Investigation of Ultra-Wide Low-Frequency Wave Attenuation Using Seismic Metamaterials with Auxetic Slender Strips by Haosheng Liu, Hongbo Zhang

“…Seismic metamaterials are an emerging vibration-damping technology, yet concentrating the bandgap in the low-frequency range remains challenging due to the constraints imposed by lattice size. …”
Get full text