Sickle Cell Anemia, the First Molecular Disease: Overview of Molecular Etiology, Pathophysiology, and Therapeutic Approaches by Martin H. Steinberg

“…Sickle hemoglobin tetramers polymerize when deoxygenated, damaging the sickle erythrocyte. A multifaceted pathophysiology, triggered by erythrocyte injury induced by the sickle hemoglobin polymer, and encompassing more general cellular and tissue damage caused by hypoxia, oxidant damage, inflammation, abnormal intracellular interactions, and reduced nitric oxide bioavailability, sets off the events recognized clinically as sickle cell disease. …”
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Fatigue Properties of Plain Concrete under Triaxial Tension-Compression-Compression Cyclic Loading by Dongfu Zhao, Haijing Gao, Huixuan Liu, Penghe Jia, Jianhui Yang

“…To model this system, the relative residual strain was defined as the damage variant. Damage evolutions for plain concrete were established. …”
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Effect of Mesenchymal Stem Cell-Derived Exosomes on Retinal Injury: A Review of Current Findings by Raffaele Nuzzi, Paolo Caselgrandi, Alessandro Vercelli

“…In recent years, various studies have followed in the literature on the therapeutic effects of mesenchymal stem cells (MSC) on damage in retinal cells. The evidence that MSCs exert their regenerative and damage reduction effect in a paracrine way, through the release of soluble factors and exosomes, is now consolidated. …”
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Analysis of Automotive Suspension System Failures and Reliability Evaluation: A Study Based on V-SIM Simulation by Sławomir Kowalski

“…This article presents the factors that are conducive to the faster degradation of suspension system components with examples of typical system damage seen at diagnostic stations. Further in the article, the simulation of the deflection of the suspension system was conducted in the V-SIM 5.0 software, and the sample road consequences of damage to the system were presented. …”
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COMPUTATIONAL SCREENING TO IDENTIFY GENES INVOLVED IN DNA REPAIR IN ARABIDOPSIS THALIANA by James MORAN, Tim XING

“…The repair of damaged DNA is an essential function for living organisms. …”
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Nutritional and Pharmacological Effects on Oxidative Stress in Soft Tissue and Bone Remodeling by Benjamin M. Savasky, David P. Mascotti, Naren Patel, Edgardo Rodriguez-Collazo

“…Oxidative damage is the causal link to a multitude of pathologies, such as diabetes, arthritis, neuropathy, heart disease, and asthma. …”
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D-2-hydroxyglutarate impairs DNA repair through epigenetic reprogramming by Fengchao Lang, Karambir Kaur, Haiqing Fu, Javeria Zaheer, Diego Luis Ribeiro, Mirit I. Aladjem, Chunzhang Yang

“…Mechanistically, D-2-HG diminishes the chromatin interactions in the DNA damage regions via revoking CTCF binding. The hypermethylation of cytosine, resulting from the suppression of TET1 and TET2 activities by D-2-HG, contributes to the dissociation of CTCF from DNA damage regions. …”
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Verbal Memory Impairments in Children after Cerebellar Tumor Resection by Matthew P. Kirschen, Mathew S. Davis-Ratner, Marnee W. Milner, S. H. Annabel Chen, Pam Schraedley-Desmond, Paul G. Fisher, John E. Desmond

“…Anatomical MRI scans were used to quantify the extent of cerebellar lobular damage from each patient's resection. Patients exhibited significantly reduced digit span for auditory but not visual stimuli, relative to controls, and damage to left hemispheral lobule VIII was significantly correlated with this deficit. …”
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Effects of Sodium Sulfate Attack on Concrete Incorporated with Drying-Wetting Cycles by Fang Liu, Zhanping You, Rui Xiong, Xu Yang

“…It has been widely observed that sulfate attack can damage the durability of concrete. This research investigated the mass loss and damage degree of concrete under sodium sulfate attack incorporated with drying-wetting cycles. …”
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Gastric Cytoprotection as Basis of Gastrointestinal Mucosa Protection and Repair in Erosive Ulcerative Lesions of Various Aetiologies by K. V. Ivashkin, E. A. Izatullaev, V. R. Korneeva

“…Prostaglandins (PG) and SH-antioxidants are key mediators of gastroprotection in acute and chronic damage. SH-containing endogenous substances (L-cysteine, D,L-methionine, GSH) and exogenous molecules (methylmethionine-sulfonium chloride (MMSC), N-acetylcysteine) prevent damage due to the ability to absorb/neutralise free radicals released in xenobiotic-triggered cell damage, inhibit TNF-α expression, reduce the aspirin-induced leukocyte-endothelium adhesion and stimulate mucin release. …”
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Elastoplastic Modelling of an In Situ Concrete Spalling Experiment Using the Ottosen Failure Criterion by Lauri Kalle Tapio Uotinen, Topias Kalle Aleksi Siren

“…In conclusion, external heating is a potent way of inducing damage and thin concrete liner significantly reduces the amount of damage.…”
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Terahertz Spectroscopy and Imaging Detection of Defects in Civil Aircraft Composites by Mian Zhong, Bingwei Liu, Chen Li, Zhiqi Wang, Dongshan Wei, Bin Zhou, Xin Dai, Yajun Xu

“…To investigate the defect damage detection and its spectral characteristics and imaging of carbon-fiber-reinforced polymer composite laminates, defects from the low-velocity impact damage in composites were measured by the THz time-domain reflection imaging system. …”
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Local inflammation, lethality and cytokine release in mice injected with Bothrops atrox venom by S. F. Barros, I. Friedlanskaia, V. L. Petricevich, T. L. Kipnis

“…These results suggest that susceptibility to Bothrops a trox venom is genetically dependent but MHC independent; that IL-6, IL10, TNF-α, IFN-γ and NO can be involved in the mediation of tissue damage; and that the major venom component inducers of the lesions are haemorrhagins.…”
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Optimized Prediction of Weapon Effectiveness in BVR Air Combat Scenarios Using Enhanced Regression Models by Andre R. Kuroswiski, Annie S. Wu, Angelo Passaro

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Preparation, Characterization, and Evaluation of Humidity-Dependent Electrical Properties of Undoped and Niobium Oxide-Doped TiO2 : WO3 Mixed Powders by Pedro M. Faia, Juliano Libardi, Itamar Barbosa, Evando S. Araújo, Helinando P. de Oliveira

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The Effect of Slickwater on Shale Properties and Main Influencing Factors in Hydraulic Fracturing by Jiawei Liu, Xuefeng Yang, Shengxian Zhao, Yue Yang, Shan Huang, Lieyan Cao, Jiajun Li, Jian Zhang

“…Low differential pressure flowback can reduce the damage of the shale, and prolonging the time of shut-in has no obvious effect on the damage to porosity. …”
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Dynamic Response Simulation of Lining Structure for Tunnel Portal Section under Seismic Load by Guoqing Liu, Juntao Chen, Ming Xiao, Yang Yang

“…And then a simple elastic dynamic damaged constitutive model for concrete lining was built. …”
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Numerical Investigation of Pinned Fuse with Simple Replacing in Steel Eccentrically Braced Frames and Design Parameters Determination by Soroush Soltani, Mohammad Javaheri-tafti, Mohamad Vetr

“…However, repairing and regenerating damaged organs is a challenging and time-consuming process. …”
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Design and Control of Nonlinear Mechanical Systems for Minimum Time by J.B. Cardoso, P.P. Moita, A.J. Valido

“…This formulation is implemented in an optimum design code and it is applied to the nonlinear behavior dynamic response. Damping and stiffness characteristics plus control driven forces are considered as decision variables. …”
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Influences on the Seismic Response of the Gravity Dam-Foundation-Reservoir System with Different Boundary and Input Models by Denghong Chen, Chunping Hou, Feng Wang

“…Dynamic dam-foundation interaction is great important in the design and safety assessment of the dam structures. …”
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