Phase Ib/II study on the safety, tolerability, and preliminary efficacy of pegylated irinotecan (JK1201I) as second‐line monotherapy for patients with small‐cell lung cancer by Jieran Long, Xuefei Li, Lin Wu, Guohua Yu, Aimin Zang, Yanqiu Zhao, Jinsheng Shi, Ligong Nie, Xuan Zhao, Jian Fang

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Biofloc technology significantly reshapes water microbiome and improves survival rates in Japanese eel (Anguilla japonica) by Jiho Yang, Hyunjun Choi, Jun Seong Park, Yehyeon Cha, Ju-Ae Hwang, Seung-Yoon Oh

“…In this study, we observed the survival and growth rates of eels treated with BFT over 8 weeks and monitored changes in the gut and water microbiome using 16S rRNA amplicon sequencing (metabarcoding) and quantitative PCR. …”
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The associations of physical activity patterns and the triglyceride-glucose index in US adults: a secondary data analysis of NHANES (2007–2018) by JinYe Zhang, YiLin Yang, HaoNan Zheng, BoWen Bai, QianKun Yang, Li Zhang, YuTong Zhao, Jing Luo, Bin Yu

“…Additionally, a significant, non-linear, and negative relationship between weekly total PA and TyG index in non-inactive individuals was determined by RCS analysis (P for overall < 0.001, P for nonlinearity = 0.054). …”
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Elucidating the pharmacological foundations and mechanisms of the Sihai Shuyu formula in treating Graves’ disease through integrated serum metabolomics and network pharmacology wit... by Xiaoju Liu, Xingjia Li, Wenbin Huang, Yifan Cui, Fengyun Cheng, Guofang Chen, Guofang Chen, Xiaodong Mao, Chao Liu, Chao Liu, Shuhang Xu

“…A comprehensive analysis of the multi-level bioinformatic analysis, including protein-protein interactions (PPI) and functional pathways of the targets, was conducted, followed by verification through immunohistochemistry (IHC) to clarify SHSY’s pharmacological basis and action mechanisms in treating GD.ResultsAfter 8 weeks of treatment, SHSY significantly reduced serum T4 and TRAb levels in GD mice and enhanced the morphology of thyroid tissues. …”
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Nobiletin Attenuates Pathological Cardiac Remodeling after Myocardial Infarction via Activating PPARγ and PGC1α by Yufei Zhou, Ting Yin, Mengsha Shi, Mengli Chen, Xiaodong Wu, Kai Wang, Iokfai Cheang, Yanxiu Li, Hongcai Shang, Haifeng Zhang, Xinli Li

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Assessment of out-of-pocket (OOP) expenditures on essential medicines for acute and chronic illness: a comparative study across regional and socioeconomic groups in India by Ranjit Kumar Dehury, Imteyaz Ahmad, Manas Ranjan Behera, Janmejaya Samal, Varalakshmi Manchana, Jalal Mohammed, Parthsarathi Dehury, Deepanjali Behera, Nafisa Vaz e Desouza, Abhishek Dondapati

“…The details of the expenditures for the past four weeks were compared with those of medicines and healthcare expenses. …”
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The effect of groundwater depth on topsoil organic matter mineralization during a simulated dry summer in northwestern Europe by A. Françoys, A. Françoys, O. Mendoza, J. Hu, P. Boeckx, W. Cornelis, S. De Neve, S. Sleutel

“…<p>With climate change expected to intensify the occurrence and severity of droughts, the impacts of the groundwater table (GWT) depth and capillary rise on topsoil moisture may become critical drivers of biological activity. Consequently, the GWT depth could influence topsoil carbon (C) mineralization. …”
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Sex differences in murine MASH induced by a fructose-palmitate-cholesterol-enriched diet by Lakshmi Arivazhagan, Sofie Delbare, Robin A. Wilson, Michaele B. Manigrasso, Boyan Zhou, Henry H. Ruiz, Kaamashri Mangar, Ryoko Higa, Emily Brown, Huilin Li, Michael J. Garabedian, Ravichandran Ramasamy, Kathryn J. Moore, Edward A. Fisher, Neil D. Theise, Ann Marie Schmidt

“…Methods: Female and male C57BL/6J mice were fed a fructose-palmitate-cholesterol (FPC)-NASH diet vs. standard chow for 16 weeks (n = 40 mice). At sacrifice, plasma and liver were retrieved, the latter for single-nucleus RNA sequencing. …”
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Effects of a liquefied petroleum gas stove and fuel intervention on head circumference and length at birth: A multi-country household air pollution intervention network (HAPIN) tri... by Hina Raheel, Sheela Sinharoy, Anaité Diaz-Artiga, Sarada S. Garg, Ajay Pillarisetti, Kalpana Balakrishnan, Marilu Chiang, Amy Lovvorn, Miles Kirby, Usha Ramakrishnan, Shirin Jabbarzadeh, Alexie Mukeshimana, Michael Johnson, John P. McCracken, Luke P. Naeher, Ghislaine Rosa, Jiantong Wang, Joshua Rosenthal, William Checkley, Thomas F. Clasen, Jennifer L. Peel, Lisa M. Thompson

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