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701
NeuTox 2.0: A hybrid deep learning architecture for screening potential neurotoxicity of chemicals based on multimodal feature fusion
Published 2025-01-01“…Chemically induced neurotoxicity is a critical aspect of chemical safety assessment. Traditional and costly experimental methods call for the development of high-throughput virtual screening. …”
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Cellular therapies in rheumatic and musculoskeletal diseases
Published 2025-06-01“…A substantial proportion of patients diagnosed with rheumatologic and musculoskeletal diseases (RMDs) exhibit resistance to conventional therapies or experience recurrent symptoms. …”
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704
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Wheat Leaf Rust Effector Pt48115 Localized in the Chloroplasts and Suppressed Wheat Immunity
Published 2025-01-01“…<i>Pt</i> acquires nutrients from host cells via haustoria and secretes effector proteins to modify and regulate the expression of host disease resistance genes, thereby facilitating pathogen growth and reproduction. …”
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706
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707
Selection of Superior Sugar Beet Genotypes using the Analysis of Quantitative and Qualitative Traits
Published 2024-11-01“…Consequently, sugar beet breeding has long been a critical domain of research and development, focusing on enhancing yield, quality, and resistance to diseases of this essential commodity. …”
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711
Sibling Species Composition and Susceptibility Status of Anopheles gambiae s.l. to Insecticides Used for Indoor Residual Spraying in Eastern Uganda
Published 2023-01-01“…Malaria remains one of the most critical disease causing morbidity and mortality in Uganda. …”
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712
GsMTx-4 venom toxin antagonizes biophysical modulation of metastatic traits in human osteosarcoma cells
Published 2025-03-01“…Importantly, mechanical preconditioning differentially impacts doxorubicin resistance, correlating with the Src-H3 acetylation axis. …”
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713
Soft Skills as Predictors of Students’ Life Self-Fulfillment
Published 2019-10-01“…Basic communication skills (communicative and personal potential), self-management skills (motivation to acquire knowledge, reflexive abilities) and effective thinking skills (ability to predict, innovativeness) increase the stability of the psychological system of the student’s personality, its ability to maintain stability, resistance to negative phenomena and freedom of behaviour. …”
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714
Performances of asphalt mastic incorporating with a home-made sustained-releasing salt storage additive
Published 2025-07-01“…The absence of intrinsic deicing capabilities in conventional asphalt mastic poses a critical challenge in cold-climate regions, where the accumulation of snow and ice can result in hazardous traffic conditions. …”
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715
From chaos to order: optimizing fecal microbiota transplantation for enhanced immune checkpoint inhibitors efficacy
Published 2025-12-01“…The integration of fecal microbiota transplantation (FMT) with immune checkpoint inhibitors (ICIs) presents a promising approach for enhancing cancer treatment efficacy and overcoming therapeutic resistance. This review critically examines the controversial effects of FMT on ICIs outcomes and elucidates the underlying mechanisms. …”
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716
The ENaC taste receptor’s perceived mechanism of mushroom salty peptides revealed by molecular interaction analysis
Published 2025-01-01“…Receptor extracellular arginine, glutamate, aspartate, and lysine residues were the critical amino acid residues recognized to bind salty peptides. …”
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Analysis of tumoral, stromal and glycolitic markers in the response basal cell carcinoma and Bowen disease to photodynamic therapy in real life
Published 2025-02-01“…Results: Tumor thickness was found to be a critical determinant of MAL-PDT response, with thicker nodular BCCs showing reduced response rates compared to thinner, superficial BCCs and BD lesions. …”
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Comparative growth kinetics and drug susceptibility of Mycobacterium tuberculosis lineages prevalent in Ethiopia: implications for tuberculosis treatment and management
Published 2025-02-01“…Sub-lineages 4.1.2.1 and 4.2.2.2 had MIC values matching WHO’s critical concentrations (except for rifampicin). Lineage 3 showed increased sensitivity to rifampicin, isoniazid, and streptomycin, requiring only half the standard concentration. …”
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720
Prevalence of Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae in Ethiopia: A Systematic Review and Meta-Analysis
Published 2021-01-01“…Background. Antimicrobial resistance especially caused by extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE) has become a global public health concern. …”
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