FOXP3 as a prognostic marker and therapeutic target in immunogenic cell death modulation for clear cell renal cell carcinoma by Jian Chen, Cheng Zhu, Yan He, Liping Huang, Weizhuo Wang, Shuaishuai Huang

“…Abstract Background Clear cell renal cell carcinoma (ccRCC) remains a challenging cancer type due to its resistance to standard treatments. Immunogenic cell death (ICD) has the potential to activate anti-tumor immunity, presenting a promising avenue for ccRCC therapies. …”
Get full text

The Function of SUMOylation and Its Role in the Development of Cancer Cells under Stress Conditions: A Systematic Review by Qi Zhao, Ying Ma, Zugui Li, Kexin Zhang, Minying Zheng, Shiwu Zhang

“…The prevention of tumor development, metastasis, recurrence, and radiochemotherapy resistance by attenuating SUMOylation requires further exploration. …”
Get full text

Looking beyond the ER, PR, and HER2: what’s new in the ARsenal for combating breast cancer? by Tryambak Pratap Srivastava, Ruby Dhar, Subhradip Karmakar

“…This intricate interplay is further complicated by the presence of constitutively expressed AR splice variants (AR-Vs) that drive resistance to AR-targeting therapies through structural rearrangements in the domains and activation of aberrant signaling pathways. …”
Get full text

C/EBPβ Regulates HIF-1α-Driven Invasion of Non-Small-Cell Lung Cancer Cells by Seung Hee Seo, Ji Hae Lee, Eun Kyung Choi, Seung Bae Rho, Kyungsil Yoon

“…These results indicate that C/EBPβ is a critical regulator for the invasion of NSCLC cells in the hypoxic tumor microenvironment. …”
Get full text

Multi-objective optimization of SUS430C steel turning process using hybrid machine learning and evolutionary algorithm approach by Nguyen Van-Canh, Nguyen Anh-Thang, Pham Ngoc-Linh, Nguyen Thuy-Duong

“…A hybrid approach combining Extreme Gradient Boosting (XGBoost) and Non-dominated Sorting Genetic Algorithm-II (NSGA-II) was employed to optimize three critical machining objectives: surface roughness (Ra), material removal rate (MRR), and tool wear (Vb). …”
Get full text

Oral Antibacterial Drug Prescribing in Primary Care Out-of-Hours Services: A Scoping Review by Sarah Khalid Al Hussain, Rhian Deslandes, Deborah Edwards, Karen Louise Hodson

“…Background/Objectives: The rapid spread of antimicrobial resistance (AMR) presents a critical threat to global health. …”
Get full text

The effect of abiotic factors on apricot yield in the Southern Urals by F. M. Gasymov

“…In the environments of the Southern Urals, critical winters (continuous frosts of –40°C) considerably damage generative buds, which results in having no apricot harvest in such years. …”
Get full text

ECC-Based Authentication Protocol for Military Internet of Drone (IoD): A Holistic Security Framework by Hyeon Choe, Dongsu Kang

“…The proposed protocol demonstrates strong resistance to various military threats, including DoS attacks, replay attacks, and man-in-the-middle attacks. …”
Get full text

Emerging roles of circular RNAs on the regulation of production traits in chicken by Guishuang You, Hong Long, Xiaoxu Shen, Huadong Yin, Shibin Zhang

“…This performance is determined by various production traits that are primarily influenced by multiple factors, including epigenetics—a critical aspect of gene regulation. Circular RNAs (circRNAs), a unique class of non-coding RNAs, have emerged as key epigenetic regulators. …”
Get full text

Investigation of Digital Light Processing-Based 3D Printing for Optimized Tooling in Automotive and Electronics Sheet Metal Forming by Szabolcs Szalai, Brigitta Fruzsina Szívós, Vivien Nemes, György Szabó, Dmytro Kurhan, Mykola Sysyn, Szabolcs Fischer

“…Despite some limitations in wear resistance, the findings highlight SLA technology’s potential for rapid prototyping and short-run manufacturing in the automotive and electronics sectors. …”
Get full text

Green Chemistry Within the Circular Bioeconomy to Harness Chestnut Burr Extract’s Synergistic Antimicrobial Activity Against <i>Helicobacter pylori</i> by Maria Lucia Schiavone, Roberta Barletta, Alfonso Trezza, Michela Geminiani, Lia Millucci, Natale Figura, Annalisa Santucci

“…By harnessing bioactive compounds from plant sources, this approach addresses the pressing issue of antibiotic resistance while promoting the responsible use of natural resources. …”
Get full text

Exploring the link between soil health and crop productivity by Yingying Xing, Xiukang Wang, Adnan Mustafa

“…Understanding the complex interactions of plants and soils in the face of global food security and environmental degradation challenges is critical to the future of sustainable agriculture. …”
Get full text

Germany’s stance on the Nord Stream 2 project: Internal and external determinants by F. А. Basov

“…Germany made significant diplomatic efforts not only to coordinate its position with other EU countries, but also to overcome the resistance to the project from the United States and Ukraine. …”
Get full text

Antimicrobial Susceptibility Testing for Colistin: Extended Application of Novel Quantitative and Morphologic Assay Using Scanning Electron Microscopy by Omar Zmerli, Sara Bellali, Gabriel Haddad, Rim Iwaza, Akiko Hisada, Erino Matsumoto, Yusuke Ominami, Didier Raoult, Jacques Bou Khalil

“…We present a SEM-AST technique enabling rapid detection of Colistin resistance through direct observation of morphological and quantitative changes in bacteria exposed to Colistin. …”
Get full text

Molecular determinants of Neu5Ac binding to a tripartite ATP independent periplasmic (TRAP) transporter by Parveen Goyal, KanagaVijayan Dhanabalan, Mariafrancesca Scalise, Rosmarie Friemann, Cesare Indiveri, Renwick CJ Dobson, Kutti R Vinothkumar, Subramanian Ramaswamy

Get full text

Sodium Butyrate: A Multifaceted Modulator in Colorectal Cancer Therapy by Alexandra Laura Mederle, Alexandra Semenescu, George Andrei Drăghici, Cristina Adriana Dehelean, Nicolae-Valentin Vlăduț, Dragoş Vasile Nica

“…<i>Conclusions</i>: NaB can modulate critical apoptotic and cell cycle genes, disrupt tumor cell proliferation, and overcome resistance mechanisms associated with anti-apoptotic regulators such as <i>MCL-1</i>. …”
Get full text

The Model of Disengagement of Talent with Meta-synthesis Method by Ali Asghar Mobasheri, Ali Nasr Isfahani, Hadi Teimouri

“…The organizational factors were categorized into five components: job-related factors (such as lack of autonomy, high work stress, lack of job security, insufficient feedback, mismatch between competencies and duties, and limited growth opportunities), cultural factors (inappropriate work environment, prevalence of bullying, political behaviors, individualism, melting pot mentality, and nepotism), structural factors (high formality, bureaucratic structures, centralized decision-making, and structural differentiation), managerial factors (managerial incompetence, Machiavellian tendencies, resistance to criticism, narcissism, and excessive focus on work), and process-related factors (weak compensation systems, poor communication processes, ineffective performance management, and inadequate talent management and succession planning). …”
Get full text

Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition by Antonino Glaviano, Hannah Si-Hui Lau, Lukas M. Carter, E. Hui Clarissa Lee, Hiu Yan Lam, Elena Okina, Donavan Jia Jie Tan, Wency Tan, Hui Li Ang, Daniela Carbone, Michelle Yi-Hui Yee, Muthu K. Shanmugam, Xiao Zi Huang, Gautam Sethi, Tuan Zea Tan, Lina H. K. Lim, Ruby Yun-Ju Huang, Hendrik Ungefroren, Elisa Giovannetti, Dean G. Tang, Tullia C. Bruno, Peng Luo, Mads Hald Andersen, Bin-Zhi Qian, Jun Ishihara, Derek C. Radisky, Salem Elias, Saurabh Yadav, Minah Kim, Caroline Robert, Patrizia Diana, Kurt A. Schalper, Tao Shi, Taha Merghoub, Simone Krebs, Anjali P. Kusumbe, Matthew S. Davids, Jennifer R. Brown, Alan Prem Kumar

“…Moreover, the article discusses the TME’s implications for resistance mechanisms and highlights the current therapeutic strategies toward TME modulation along with potential caveats.…”
Get full text

Lignin Metabolism Is Crucial in the Plant Responses to <i>Tambocerus elongatus</i> (Shen) in <i>Camellia sinensis</i> L. by Wenli Wang, Xiaogui Zhou, Qiang Hu, Qiuhong Wang, Yanjun Zhou, Jingbo Yu, Shibei Ge, Lan Zhang, Huawei Guo, Meijun Tang, Xin Li

“…Furthermore, the production of saccharides and the accumulation of anthocyanin glycosides in the flavonoid metabolic pathway are critical during this stress response. Further exploration of the roles of anthocyanin glycosides and lignin in tea tree resistance could provide a theoretical basis for understanding the defense mechanism of tea trees against <i>T. elongatus</i> damage.…”
Get full text

Short-term abstinence from alcohol and changes in cardiovascular risk factors, liver function tests and cancer-related growth factors: a prospective observational study by Gautam Mehta, Rajiv Jalan, Matteo Rosselli, James Maurice, Stewart Macdonald, Alexandra Cronberg, Tanya Khera-Butler, Colin Sumpter, Safa Al-Khatib, Anjly Jain, Christos Charalambous, Amir Gander, Cynthia Ju, Talay Hakan, Roy Sherwood, Devaki Nair, Kevin P Moore

Get full text