The Role of Hepatic Expression of STAT1, SOCS3 and PIAS1 in the Response of Chronic Hepatitis C Patients to Therapy by Sherif El-Saadany, Dina H Ziada, Hanan El Bassat, Wael Farrag, Hesham El-Serogy, Manal Eid, Manal Abdallah, Medhat Ghazy, Hoda A Salem

“…BACKGROUND: The underlying mechanisms of hepatitis C virus (HCV) resistance to treatment are unknown. Signal transducers and activators of transcription (STAT) proteins play a critical role in antiviral defense.…”
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Fire safety of a novel concept of ventilated façade integrating Phase Change Materials by Ovadiuc Emanuil-Petru, Calotă Răzvan, Năstase Ilinca, Simion Adrian, Anghel Ion

“…Ventilated facades represent a modern solution increasingly adopted in smart, low-energy building designs. A critical consideration in the implementation of these systems is ensuring fire resistance while simultaneously minimizing the risk of fire propagation. …”
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Transient Hemodynamic Changes upon Changing a BCPA into a TCPC in Staged Fontan Operation: A Computational Model Study by Fuyou Liang, Hideaki Senzaki, Zhaofang Yin, Yuqi Fan, Koichi Sughimoto, Hao Liu

“…Obtained results indicated that the presence of a low pulmonary vascular resistance and/or a low lower-body vascular resistance is beneficial to the increase in transpulmonary flow upon the BCPA to TCPC change. …”
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Immediate-Early Genes and Delayed Primary Response Genes Regulated by NmU in SKBR3 HER-2 Positive Breast Cancer Cell Line by Jessica Murphy, Sweta Rani

“…Rani et al. (2014), have associated the acquirement of resistance to HER2-treatment with Neuromedin U, but the mechanisms by which it works remain elusive. …”
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The Hippo pathway promotes platinum-based chemotherapy by inhibiting MTF1-dependent heavy metal response by Hui Chen, Yue Xu, Dingshan Chen, Di Xiao, Bing Yang, Wenqi Wang, Han Han

“…This resistance is mitigated by Hippo pathway-mediated phosphorylation of MTF1. …”
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Assessing Delayed Collapse Risks in Load-Bearing Reinforced Concrete Walls Exposed to Parametric Fires: A Numerical Investigation by Guergah Cherif, Baghdadi Mohamed, Dimia Mohamed Salah, Antonio Marcos de Oliveira Siqueira, Júlio César Costa Campos

“…Traditional prescriptive approaches assume a monotonically increasing temperature, while contemporary performance-based designs incorporate both heating and cooling phases for a more realistic fire resistance assessment. The critical aspect of this research is the modeling of the fire's cooling phase, which, though not commonly practiced in design offices, is essential for evaluating the risk of delayed structural collapse. …”
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Temporal–Spatial Dynamics and Collaborative Effects of Cropland Resilience in China by Liang Luo, Yetong Li, Wenjie Ma, Jianbo Rong, Jie Wei, Yong Cui, Tingting Qu

“…The study found the following: (1) The overall cropland resilience in China shows an upward trend, but there is uneven development among regions, particularly in the relatively lagging western areas. (2) There is a notable spatial imbalance in cropland resilience, primarily driven by intra-regional differences. (3) Stability of Grain Production; Total Grain Production; Fiscal Expenditure on Agriculture, Forestry, and Water; Soil–Water Harmony; and the Cropland Disaster Resistance Index are identified as key driving factors, with the influence of the Cropland Disaster Resistance Index notably increasing over time. (4) The study highlights the critical role of synergistic effects among these factors in enhancing cropland resilience, noting a significant strengthening of these synergies over time. …”
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Coexistence of Virulence Factors and Efflux Pump Genes in Clinical Isolates of Pseudomonas aeruginosa: Analysis of Biofilm-Forming Strains from Iran by Shahram Shahraki Zahedani, Hamed Tahmasebi, Mojdeh Jahantigh

“…Biofilm formation and efflux pumps (EPs) correlation play a critical role in the pathogenicity and antibiotic resistance of Pseudomonas aeruginosa. …”
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The Influence of Inflammation on Fibrinogen Turnover and Redistribution of the Hemostatic Balance to a Prothrombotic State in High On-Treatment Platelet Reactivity-Dual Poor Respon... by Grzegorz Biolik, Dariusz Gajniak, Maciej Kubicz, Damian Ziaja, Krzysztof Ziaja, Wacław Kuczmik

“…A high concentration of prothrombin fragment F1+2 together with higher activity of von Willebrand factor in critical limb ischemia shows more exaggerated fibrinogen turnover although the blood concentration of this factor was in normal range. …”
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Enhanced Antitumor Immune Response in 2′-5′ Oligoadenylate Synthetase-Like 1- (OASL1-) Deficient Mice upon Cisplatin Chemotherapy and Radiotherapy by Chan Kyu Sim, Jung Hoon Lee, In-Jeoung Baek, Sang-Wook Lee, Myeong Sup Lee

“…Thus, OASL1-deficient (Oasl1−/−) mice were more resistant to implanted tumor growth than wild-type (WT) mice. …”
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Genome-wide identification and characterization of transcription factors involved in defense responses against Sclerotinia sclerotiorum in Brassica juncea by Xu Yang, Shaomin Guo, Hairun Jin, Jinze Zhang, Lijing Xiao, Qingjing Ouyang, Xu Long, Zhongbin Yan, Entang Tian

“…Transcription factors (TFs) are recognized for their critical role in plant defense against S. sclerotiorum. …”
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Design and Analysis of a Serial Manipulator for Pick and Drop Objects for Material Handling at Uiri Metal Forming Workshop. by Behangana, Abert

“…The design process prioritized critical customer requirements, including maintainability, safety, usability, and adaptability. …”
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Flux pinning in superconducting multilayer 2H-NbSe2 nano-step junction by Minseong Kwon, Mingi Kim, Yoonji Gong, Heeyeon Lee, Young Duck Kim

“…We fabricated a high-quality multilayer 2H-NbSe _2 with a step junction, demonstrating supercurrent in clean limit below a critical temperature of 6.6 K and a high residual resistance ratio of 17. …”
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Relevant Elements of Standardisation of Federation’s Advisory Programs for Voluntary Sports Clubs by Marisa Moser, Matthias Buser, Siegfried Nagel

“…While research has discussed critical interfaces, little is known about what moderates the translation of advisory input to achieve change at club level (cf. …”
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Numerical Investigation of Load-Carrying Capacity of GFRP-Reinforced Rectangular Concrete Members Using CDP Model in ABAQUS by Ali Raza, Qaiser uz Zaman Khan, Afaq Ahmad

“…GFRP bars are lightweight having the high tensile strength and high corrosion resistance. An NLFEA model for the rectangular concrete specimens was developed using the commercial software ABAQUS Standard and calibrated for different materials and geometric parameters based on the previous experimental test results of the studied specimen. …”
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Influence of Aging and Immune Alterations on Susceptibility to Pneumococcal Pneumonia in the Elderly by Nathan Kang, Veedamali S. Subramanian, Anshu Agrawal

“…As the aging population grows, pneumonia is expected to become an increasingly critical health concern. In non-institutionalized elderly individuals, the annual incidence ranges from 25 to 44 per 1000, approximately four times higher than in those under 65. …”
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Adropin: a key player in immune cell homeostasis and regulation of inflammation in several diseases by Junmin Wang, Ning Ding, Chong Chen, Simin Gu, Jing Liu, Yanping Wang, Liubing Lin, Yiyuan Zheng, Yong Li

“…Its expression is regulated by various factors, including fat, LXRα, ERα, ROR, and STAT3. Adropin plays a critical role in glucose and lipid metabolism, as well as insulin resistance, by modulating multiple signaling pathways that contribute to the reduction of obesity and the improvement of blood lipid and glucose homeostasis. …”
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Fatigue Performance of Steel–UHPC Composite Bridge Deck System with Large Longitudinal Rib by Yi Zhou, Chuan Wei, Guoxi Liang, Dequan Zhou

“…The development of bridge deck systems with high fatigue resistance is increasingly gaining interest in the field of bridge deck design. …”
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Clinical and Biochemical Manifestations of Depression: Relation to the Neurobiology of Stress by Phillip W. Gold, Rodrigo Machado-Vieira, Maria G. Pavlatou

“…Aspects such as depression subtypes, inflammation, insulin resistance, oxidative stress, and prothrombotic states in critical brain circuits and periphery are critically appraised. …”
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Pomiędzy queerową subwersją a „middle-class mainstreaming”. O twórczości drag queen Mony Lizak by Magdalena Stoch

“…This article is a critical reflection on the stage and musical work of drag queen Mona Lizak. …”
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