Genetic characterization of Lynch syndrome germline variants in a LATAM cohort using a customized NGS gene panel by Cecilia Mathó, Cecilia Mathó, Santiago Chávez, Santiago Chávez, Rafael Sebastián Fort, Rafael Sebastián Fort, Adriana Della Valle, Florencia Neffa, José Roberto Sotelo-Silveira, José Roberto Sotelo-Silveira, Nora Artagaveytia, María Ana Duhagon, María Ana Duhagon

“…The mutational landscape aligns with findings in other populations while highlighting novel variants of clinical relevance. …”
Get full text

Barriers underlying care gaps in Singapore’s mental health landscape and suggestions for improvement from service providers’ perspectives: a qualitative approach by Siang Joo Seah, Charlotte Chao Min Tan, Mary Su-Lynn Chew, Jin Jin Lim, Dhiya Mahirah, Yi-Ching Lynn Ho, Sing Ai Lee, Ee-Lian Lee, Sungwon Yoon, Sungwon Yoon, Vicknesan Marimuttu, Ngar Yee Poon, Julian Thumboo, Julian Thumboo

“…Fragmentation of information systems hindered coordinated care implementation, while lengthy referral forms and complex referral routes created additional obstacles. …”
Get full text

Study of rheumatoid arthritis in older patients: a cross-sectional study by Ramesh Kumar Sah, A. B. Dey, P. Chatterjee, A. Chakrawarty, Uma Kumar, S. N. Dwivedi, C. J. Das

“…Results This study reported an average age of 63.67 years with a high female-to-male ratio of 4:1 in the RA cohort, while in the OA cohort, the mean age was 65.5 years with a low female-to-male ratio of 2:1 overall. …”
Get full text

Combination of Whole Body MRI and MY-RADS: A Promising Standardised Approach for Treatment Response Evaluation in Multiple Myeloma Patients by Dipu Bhuyan, Hrishikesh Choudhury, Baloy Jyoti Talukdar, Subhosree Dey, Sushant Agarwal, Aditi Das, Rishabh

“…The mean ADC seen on follow up was 0.71 +/- 0.08 x 10-3 mm2/sec in MY- RADS score 5 while it was 1.47 +/- 0.22×10-3 mm2/sec in MY-RADS score 1. …”
Get full text

Addressing Connectivity Challenges in Solar Home Systems: A Monitoring Solution for Rural Electrification by Carlos Cuenca-Enrique, Laura del-Rio-Carazo, Emiliano Acquila-Natale, Santiago Iglesias-Pradas

“…Results demonstrated the system’s ability to monitor key parameters, such as energy consumption, battery status, and solar energy generation, while maintaining connectivity in areas with intermittent mobile coverage. …”
Get full text

More is not always better: delta-downscaling climate model outputs from 30 to 5 min resolution has minimal impact on coherence with Late Quaternary proxies by L. Timbrell, L. Timbrell, J. Blinkhorn, J. Blinkhorn, M. Colucci, M. Colucci, M. Leonardi, M. Leonardi, M. Chevalier, A. V. Pozzi, M. Grove, E. Scerri, E. Scerri, E. Scerri, A. Manica

“…<p>Both proxies and models provide key resources to explore how palaeoenvironmental changes may have impacted diverse biotic communities and cultural processes. While proxies are thought to provide the “gold standard” in reconstructing the local environment, they only provide point estimates for a limited number of locations. …”
Get full text

Unlocking liver physiology: comprehensive pathway maps for mechanistic understanding by Luiz Ladeira, Anouk Verhoeven, Jonas van Ertvelde, Jian Jiang, Alessio Gamba, Julen Sanz-Serrano, Tamara Vanhaecke, Harm J. Heusinkveld, Ramiro Jover, Mathieu Vinken, Liesbet Geris, Liesbet Geris, Liesbet Geris, Bernard Staumont

“…These maps provide a foundation for creating computational models and mode-of-action ontologies while potentially extending their utility to systems biology and drug discovery applications.…”
Get full text

The impact of rainfall changes on soil bacterial and fungal communities in Pinus yunnanensis by Lin Wang, Lin Wang, Qiong Dong, Qiong Dong, Shaojie Zheng, Shaojie Zheng, Xingze Li, Xingze Li, Huiping Zeng, Huiping Zeng, Yu Chen, Yu Chen, Shunrou Shi, Shunrou Shi

“…Specifically, for soil bacteria, the Shannon, Chao1, and ACE (Abundance-based Coverage Estimator) indices were highest in GN and lowest in JS; for fungi, the Chao1 and ACE indices were highest in YJ and lowest in JS. …”
Get full text

Predicting Land Use Land Cover Dynamics and Land Surface Temperature Changes Using CA-Markov-Chain Models in Islamabad, Pakistan (1992&#x2013;2042) by Muhammad Farhan, Taixia Wu, Sahrish Anwar, Jingyu Yang, Syed Ali Asad Naqvi, Walid Soufan, Aqil Tariq

“…Cellular automata (CA) models are employed for simulating geographical distributions, while Markov-Chain models are utilized for simulating temporal changes. …”
Get full text

Comparative analysis of SD biosensor standard™ M10 HPV and seegene anyplex™ II HPV HR for detecting high-risk human papillomavirus: a concordance study by Abigail Rembui Jerip, Vaenessa Noni, Vanessa Kiah Anthony, Andy Cheong Shin Bong, Jaria Adam, Cheng Siang Tan

“…M10’s rapid, field-deployable design makes it suitable for resource-limited settings, while Anyplex provides enhanced genotyping capability in laboratory environments, allowing informed vaccine strategy. …”
Get full text

Integrated in-silico design and in vivo validation of multi-epitope vaccines for norovirus by Jingxuan Qiu, Yiwen Wei, Jiayi Shu, Wenjing Zheng, Yuxi Zhang, Junting Xie, Dong Zhang, Xiaochuan Luo, Xiulan Sun, Xin Wang, Sijie Wang, Xuanyi Wang, Tianyi Qiu

“…Specifically, broad-spectrum T-cell epitope vaccines were designed based on consensus sequences and optimized epitope screening, while broad-spectrum B-cell spatial epitope vaccines were constructed using high-throughput antigenicity calculations and epitope mapping. …”
Get full text

Quantification of Mars Entry Trajectory Uncertainty: Dynamic Adaptive Error Band Modeling and Multiscenario Performance Evaluation by Zhixian Luo, Yanmin Jin, Xiaohua Tong, Huan Xie, Yongjiu Feng, Sicong Liu, Xiong Xu, Peng Chen

“…This is achieved by fusing temporal linear interpolation and state-deviation adjustments to ensure that the time-varying covariance inherits the initial error characteristics while adapting to the trajectory dynamics. The geometric error band model constructs two-dimensional or three-dimensional (2-D/3-D) uncertainty boundaries using the trajectory&#x2019;s positional error covariances. …”
Get full text

Spatiotemporal dynamics of the normalized difference vegetation index and its multidimensional drivers in a rapidly urbanizing coastal city: A case study of Lianyungang, China (200... by Xue Li, Haihong He, Dewei Wang, Yiming Sun, Yichen Qin, Ke Wang, Yu Han, Jiabao Tang, Wenli Qiao

“…Land use remained the strongest factor (q = 0.306 in 2000 and 0.228 in 2020), while nighttime light (NTL) showed the sharpest increase (q = 0.082 to 0.194). …”
Get full text

Treatment of chronic hepatitis B: options, monitoring, special cases and adverse effects by Mateusz Litwin Litwin, Agnieszka Mikosińska, Jakub Parys, Patrycja Kałuziak, Aleksandra Witek, Martyna Kaźmierczak, Stanisław Jesionek, Marta Jajczak, Maciej Mossakowski

“…Additionally, it emphasizes the importance of monitoring treatment efficacy and safety, while also addressing the potential adverse effects associated with antiviral therapy. …”
Get full text

Cross-sectional investigation of pneumococcal vaccination patterns in HIV patients at a tertiary care hospital in Riyadh, Saudi Arabia by Reem Binsuwaidan, Enas Mosaffer Alghamdi, Ethar Abdullhameed Otaif, Maram Saud ALqutaym, Yahya Ali Mohzari, Ahmed Ali Alrashed, Rowdan Zeyan Alderaan, Ahmed Ajlan Alsheheri, Alaa Alhubaishi, Lina I Alnajjar

“…A significant proportion had not received any pneumococcal vaccinations (98.6 %), while only 2 patients (0.56 %) completed the full series of pneumococcal vaccines (PCV13-PPSV23), and 3 patients (0.84 %) received a single dose of PCV13. …”
Get full text

Impact of Dual Antibiotic Prophylaxis on 90-Day Surgical Site Infection Rates Following Posterior Spinal Fusion for Juvenile Scoliosis: A Single-Center Study of 296 Cases by Paolo Brigato, Davide Palombi, Leonardo Oggiano, Sergio De Salvatore, Alessandro Rogani, Sergio Sessa, Pier Francesco Costici

“…However, older age at surgery showed a protective trend, while higher preoperative ASA scores seemed to be a negative prognostic factor (respectively <i>p</i> = 0.051 and <i>p</i> = 0.08). …”
Get full text

How Does Vaccine-Induced Immunity Compare to Infection-Acquired Immunity in the Dynamics of COVID-19? by Indunil M. Hewage, Dylan Hull-Nye, Elissa J. Schwartz

“…Both local and global sensitivity analysis on the reproduction number reveal that the vaccine efficacy, waning of vaccine-induced immunity, vaccine coverage rate, coefficients of transmissibility, and the recovery rate for mild infections are the most sensitive parameters. …”
Get full text

Analytical Methods for Atmospheric Carbonyl Compounds: A Review by Xiaoshuai Gao, Xin Zhang, Yan Nie, Jiemeng Bao, Junling Li, Rui Gao, Yunfeng Li, Wei Wei, Xiaoyu Yan, Yongxin Yan, Hong Li

“…It was found that the direct sampling methods of atmospheric carbonyl compounds were applicable to low-molecular-weight carbonyl species with low reactivity, low boiling points, high polarity, and high volatility, while indirect sampling methods were suitable for a wider range and various types and phases of species. …”
Get full text

Development of a Conditional Generative Adversarial Network Model for Television Spectrum Radio Environment Mapping by Oluwatobi Emmanuel Dare, Kennedy Okokpujie, Emmanuel Adetiba, Olabode Idowu-Bismark, Abdultaofeek Abayomi, Raymond Jules Kala, Emmanuel Owolabi, Udeme Christopher Ukpong

“…The U-Net generator is a 3-channel input, 16-layer architecture while the PatchGan discriminator is a 6-channel input, 7-layer architecture. …”
Get full text

Large-scale screening of HIV-1 T-cell epitopes restricted by 12 prevalent HLA-A allotypes in Northeast Asia and universal detection of HIV-1-specific CD8+ T cells by Yan Ding, Jialai Yan, Ling Huang, Jinhong Yu, Yandan Wu, Chuanlai Shen, Anning Fang

“…Furthermore, the HLA-A cross-restriction for each epitope candidate was identified through peptide competitive binding assays using 12 transfected HMy2.CIR cell lines.ResultsA total of 45 epitopes demonstrated high affinity, while 31 epitopes displayed intermediate affinity. …”
Get full text