Design, synthesis, structural characterization, in vitro anticancer activity, and in silico studies of some new hydroxylated and fluorinated-substituted hydrazone derivatives by Reşit Çakmak, Eyüp Başaran, Ömer Erdoğan, Suraj N. Mali, Semiha Köprü, Haya Yasin, Shailesh S. Gurav, Giray Topal

“…Today, due to improved lifestyles and increased survival, the number of new cancer cases and cancer-related deaths continues to increase. In this study, novel hydroxylated and fluorinated-substituted hydrazone derivatives bearing an aromatic nitro moiety (2a-d and 3a-d) were designed as potential anticancer drug candidates, synthesized for the first time, and evaluated for their anticancer activity against chondrosarcoma (SW1353), a common primary malignant cartilage-forming tumor, neuroblastoma (SH-SY5Y), a type of brain cancer, and healthy (L929) cell lines using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) method for 24 h. …”
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Double-Blind Clinical Trial of Arginine Supplementation in the Treatment of Adult Patients with Sickle Cell Anaemia by Renata M. N. Eleutério, Francisco O. Nascimento, Tamara G. Araújo, Marilena F. Castro, Tarcísio P. Almeida Filho, Pedro A. Maia Filho, José Eleutério, Darcielle B. D. Elias, Romélia P. G. Lemes

“…This was a randomized double-blind clinical study of adults with SCA with continuous use of HU at the State Blood Centre of Ceará. …”
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Penerapan Smart Sensor untuk Kendali pH dan Level Larutan Nutrisi pada Sistem Hidroponik Tanaman Pakcoy by Fitri Rahmah, Fitria Hidayanti, Mutma Innah

“…Abstract The application of smart sensors to control pH and nutrient level parameters in hydroponics plants aims to supply the nutrients of plants automatically and continuously. The working principle of a closed loop control system is designed to stabilize the pH parameters in the 6-7 values range, as well as the nutrient level parameters in the 18-20 cm height range. …”
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Silk Protein Gene Engineering and Its Applications: Recent Advances in Biomedicine Driven by Molecular Biotechnology by Ji X, Li Y, Wang J, Wang G, Ma B, Shi J, Cui C, Wang R

“…In conclusion, silk protein gene engineering, through continuous innovations in molecular biotechnology, has provided an effective pathway for the production of high-performance silk protein materials. …”
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Development and Validation of the Systemic Inflammatory Response Index-Based Nomogram for Predicting Short-Term Adverse Events in Patients With Acute Uncomplicated Type B Aortic In... by Wang Y, Wu X, Wang Y, Zhang Z, Liu X, Sun D, Liu X, Zhou T, Wang X

“…SIRI improved predictive accuracy, as shown by a continuous NRI of 0.521 (95% CI: 0.301– 0.743). Calibration curves and DCA further supported the clinical utility of the Clinical-SIRI model.Conclusion: The SIRI-based nomogram is a valuable prognostic tool for predicting short-term ARAEs in patients with acute uncomplicated Type B IMH.Plain Language Summary: This study introduces a novel nomogram that integrates the Systemic Inflammatory Response Index with clinical variables to enhance the prediction of adverse events in patients with Type B aortic intramural hematoma, a condition marked by highly variable clinical outcomes. …”
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Cancer mortality and sectors of employment: a cohort study in Italy by Stefania Massari, Lisa Bauleo, Claudio Gariazzo, Paola Michelozzi, Luca Dei Bardi, Nicolas Zengarini, Sara Maio, Massimo Stafoggia, Marina Davoli, Giovanni Viegi, Giulia Cesaroni, Alessandro Marinaccio, on behalf of the BIGEPI Collaborative Group

“…The large impact of occupational exposure on the burden of cancer continues to be a paramount public health concern that deserves more attention. …”
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Comprehensive overview of genotype distribution and prevalence of human papillomavirus in cervical lesions by Yang Liu, Chengquan Zhao, Tiannan Wang, Yuhong Ye, Terrel Jones, Xianxu Zeng

“…Women with atypical glandular cell (AGC) Pap test results showed a specific HPV genotyping pattern and extended HPV genotyping may be helpful for the clinical management of AGCs. Continual advancements in clinical guidelines integrating extended genotyping would increase diagnostic accuracy and refine strategies in clinical management.…”
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Effect of Whole Wheat Noodles on Biochemical Indexes and Histopathology of Type 2 Diabetic Rats by Li WU, Yuan ZHANG, Chunhong TANG, Huan YOU, Haijun CHANG, Shuai ZHANG

“…Methods: SD rats were fed continuously for 8 weeks and then randomly divided into normal and high-fat groups. …”
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“I believe it when there is an expert next to me:” a qualitative analysis on the perceptions and experiences of pregnant women to self-monitor blood pressure in Lombok, Indonesia... by Tigest Tamrat, Yuni Dwi Setiyawati, Maria Barreix, Nya’Jeumpa Madani, Antoine Geissbühler, Anuraj H. Shankar, Ozge Tuncalp

“…Conclusion For SMBP to be implemented in line with WHO recommendations, efforts are needed to strengthen counselling among women with HDPs, clarify protocols for SMBP and subsequent actions, and provide continued support to pregnant women. Considering varying levels of BP knowledge, future research should examine the implications of introducing SMBP among pregnant women with chronic hypertension versus those with newly onset gestational hypertension, as well as the potential conflation between BP and blood haemoglobin.…”
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Development of an Integrated Model of Planning and Management in Free Zones with an Emphasis on Environmental Pressures by Mohammad Javad Amiri, Vahid Moghaddamzadeh, Gholamreza Nabi Bidhendi

“…Conclusion The research outcomes are presented through two lenses: crisis management planning and contingency planning. The findings underscore the necessity of adjusting economic and social impacts for the integrated development of the Aras Free Zone's environment. …”
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THE ROLE OF N. I. VAVILOV AND VIR’S SCIENTISTS IN DESERT RECLAMATION by N. I. Dzyubenko, A. A. Kochegina

“…After the transfer of the Aral Experimental Station under the jurisdiction of the Republic of Kazakhstan, expeditions collecting desert plant genetic resources, their study and building up a collection of worldwide genetic resources of desert crops were continued. At the present level, to assess salt tolerance of alfalfa transcriptome analysis was applied. …”
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Serum IL-1<mml:math alttext="$eta $"> <mml:mi>&#x03B2;</mml:mi> </mml:math>, IL-2, and IL-6 in Insulin-Dependent Diabetic Children

“…Persistence of significant difference between the cases with IDDM monitored for a long time and controls in terms of IL-1<mml:math alttext="$eta $"> <mml:mi>&#x03B2;</mml:mi> </mml:math>, IL-2, IL-6, and TNF-<mml:math alttext="$alpha $"> <mml:mi>&#x03B1;</mml:mi> </mml:math> supports continuous activation during the late stages of diabetes.…”
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The protein structurome of Orthornavirae and its dark matter by Pascal Mutz, Antonio Pedro Camargo, Harutyun Sahakyan, Uri Neri, Anamarija Butkovic, Yuri I. Wolf, Mart Krupovic, Valerian V. Dolja, Eugene V. Koonin

“…Notwithstanding the continuing discovery of numerous orthornaviruses, it appears that all the protein domains conserved in large groups of viruses have already been identified. …”
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Consumer Anthropomorphism and Happiness: Analysis of the Brand Authenticity Effect by Mehdi Khademi Gerashi, Setare Mohammadian

“…This study aims to investigate the impact of brand anthropomorphism on consumer happiness, considering both emotional and cognitive aspects, and to examine the mediating role of brand authenticity across four dimensions: continuity, correctness, symbolism, and credibility.   …”
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Noninvasive oxygenation and ventilation strategies for viral acute respiratory failure: a comprehensive systematic review and meta-analysis by Fredy Leonardo Carreño-Hernández, Sergio Prieto, Daniela Abondando, Jairo Alejandro Gaitán, Yenny Rocío Cárdenas -Bolívar, Adriana Beltrán, Jorge Iván Alvarado-Sánchez, Joseph L. Nates

“…The included studies compared various oxygenation and ventilatory alternatives, such as high-flow nasal cannula (HFNC), continuous positive airway pressure (CPAP), or noninvasive mechanical ventilation (NIMV) with IMV. …”
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Biofloc technology significantly reshapes water microbiome and improves survival rates in Japanese eel (Anguilla japonica) by Jiho Yang, Hyunjun Choi, Jun Seong Park, Yehyeon Cha, Ju-Ae Hwang, Seung-Yoon Oh

“…Unlike flow-through systems (FTS), which depend on continuous water exchange and result in higher operational costs as well as limited microbiome stability, BFT operates without the need for constant water exchange. …”
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Socially interactive industrial robots: a PAD model of flow for emotional co-regulation by Fabrizio Nunnari, Dimitra Tsovaltzi , Matteo Lavit Nicora , Matteo Lavit Nicora , Sebastian Beyrodt , Pooja Prajod , Lara Chehayeb , Ingrid Brdar , Antonella Delle Fave , Luca Negri , Elisabeth André, Patrick Gebhard , Matteo Malosio 

“…The embodied covatar (cobot plus its avatar) is introduced to support Flow experiences through co-regulation, interactive emotion regulation guidance. A real-time continuous emotional modeling method and an aligned transparent behavioral model, BASSF (Boredom, Anxiety, Self-efficacy, Self-compassion, Flow) is developed. …”
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The model of intermediate assessment of future teachers’ professional competencies by I. V. Golovina, Kh.-Akh. S. Khaladov, T. Yu. Medvedeva, G. A. Paputkova, A. V. Milekhin

“…The key characteristics of the model are: independence, continuity and consistency, openness, focus on the personal and professional development of the student, focus on the key professional competencies of the teacher, the use of assessment procedures and tools similar to those used in other assessment procedures (Unified State Exam, All-Russian Testing Papers, certification of teaching staff, international comparative studies); the possibility to use the results during the final certification of students. …”
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Analysis of the correlation between the dose exposure intensity and apatinib in advanced gastric cancer: a retrospective cohort study by Xiao Ma, Xiao Ma, Lan Gao, Siying Che, Chaofeng Tao

“…Dose exposure intensity (DEI) was defined as the product of dose and continuous medication time. Patients were assigned to high-dose exposure intensity (HDEI) and low-dose exposure intensity (LDEI) cohorts. …”
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Psychological peculiarities of professional development in late adulthood by E. F. Zeer, E. E. Symanyuk, A. A. Ryabukhina, G. I. Borisov

“…Factor analysis revealed the factors of psychological preparedness for mentoring (“Need for Mentoring”, “Benefits of Mentoring”, “Impact of Mentoring on the Main Place of Work”, “Cons of mentoring”), the factors of self-assessment of work activity (“Social Aspect”, “Professional Aspect”, “Continuation of Work”, “Demand in the Labour Market”) and the factors of psychological difficulties in late adulthood (“Age Changes”, “Impact of Experience”, “Psychophysiological difficulties”, “Cognitive Changes”). …”
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