Evaluation of Lyso-Gb1 as a biomarker for Gaucher disease treatment outcomes using data from the Gaucher Outcome Survey by Ari Zimran, Shoshana Revel-Vilk, Tama Dinur, Majdolen Istaiti, Jaco Botha, Elena Lukina, Pilar Giraldo, Patrick Deegan, Stephan vom Dahl

“…Abstract Background Patients with Gaucher disease (GD) require continual monitoring; however, lack of specific disease biomarkers was a significant challenge in the past. …”
Get full text

Secular trends of physical fitness for college students in Anhui Province over the past decade by Jianzhong Sun, Hui Liang, Lei Wang, Zhongju Chen, Cunjian Bi, Feng Zhang

“…In 2024, it is anticipated that the proportion of overweight and obese college students will increase, along with a continued increase in body height and vital capacity. …”
Get full text

Novel image registration algorithm for scene-matching navigation by Hongrui YANG, Qiju ZHU, Peixian CAO, Hao GU, Dongdong ZHAO

“…Compared with traditional simultaneous localization and mapping for visual navigation, which requires extensive computation for continuous point cloud mapping, scene matching ensures real-time performance without such demands. …”
Get full text

Insights in biomarkers complexity and routine clinical practice for the diagnosis of thyroid nodules and cancer by Maria de Lurdes Godinho de Matos, Mafalda Pinto, Ana Gonçalves, Sule Canberk, Maria João Martins Bugalho, Paula Soares

“…Background The differential diagnosis between benign and malignant thyroid nodules continues to be a major challenge in clinical practice. …”
Get full text

The Rearing of Clown Loach (Chromobotia macracanthus) Larvae by Using Enriched Live Foods by . Chumaidi, . Nurhidayat, A. Priyadi

“…The experiment was done indoor by using plastic jars filled 5 L water and aerated continuously.  Twenty clown loach larvae of four days old, 5.58 ± 0.12   mm in average length,  were stocked in plastic jars and  were reared for 28 days. …”
Get full text

An analysis of the Policy of Increasing the Salaries of Government Employees Based on the Framework of Kingdon's Multiple Streams (Case Study of Budget Law 1401) by Seyyed Mojtaba Shahraeini, Heidar Najafi, Seyyedamir Abbaszade, Mahdi Khosravi, Iman Akbari

“…These concerns are also a continuous focus for government employees. Consequently, the mechanism and amount of salary increases for government employees, in a fair and proportionate manner, remain a challenging aspect of the interactions between the government, parliament, and other stakeholders. …”
Get full text

Transprofessional education in the student discourse: Demand, expectations, risks by A. N. Pinchuk, S. G. Karepova, D. A. Tikhomirov

“…The nonlinearity of professional and educational trajectories brings to the fore, and the practice of continuous professional development and retraining becomes particularly important. …”
Get full text

Impact of cariprazine on body weight and blood pressure among adults with bipolar I disorder, schizophrenia, or major depressive disorder in a real-world setting by Christoph U. Correll, Andrew J. Cutler, François Laliberté, Guillaume Germain, Sean D. MacKnight, Julien Boudreau, Sally W. Wade, Nadia Nabulsi, Huy-Binh Nguyen, Mousam Parikh

“…Methods Symphony Health’s Integrated Dataverse® with electronic medical record access (3/1/2015–10/31/2018) was used to identify adults (≥ 18 years) diagnosed with BP-I depression, BP-I mania/mixed, schizophrenia, or MDD, with ≥ 2 cariprazine dispensings (first dispensing = index) and continuous clinical activity for ≥ 12 months pre-index (baseline) and ≥ 3 months post-index. …”
Get full text

Investigating the Asymmetric Relationship between Investor Sentiments and Fluctuations in the Overall Index via the Markov Switching Method by keyvan Shahab Lavasani, Leila Shabani Rezvani, Mohammad Ebrahim Samavi

“…Conclusion As per the research findings, the likelihood of market continuity stands at 41.54% during the boom regime and 58.46% during the recession regime. …”
Get full text

Age-associated microglial transcriptome leads to diminished immunogenicity and dysregulation of MCT4 and P2RY12/P2RY13 related functions by Martin Škandík, Lara Friess, Guillermo Vázquez-Cabrera, Lily Keane, Kathleen Grabert, Mireia Cruz De los Santos, Mercedes Posada-Pérez, Austeja Baleviciute, Mathilde Cheray, Bertrand Joseph

“…However, the specific phenotype adopted by microglia during aging remains a subject of debate and is contingent on the chosen experimental model. To address these unresolved questions, we employed a novel and highly controlled approach utilizing long-term cultivated BV-2 microglia, exempted from additional external stimuli. …”
Get full text

Clinical outcomes of chimeric antigen receptor T-cell therapy following autologous hematopoietic stem cell transplantation in 38 patients with refractory/relapsed primary or second... by Jiaying Wu, Wanying Liu, Yang Cao, Yang Yang, Zhen Shang, Mi Zhou, Yicheng Zhang, Fankai Meng, Xiaojian Zhu, Yi Xiao

“…Group comparisons of continuous variables were tested using the unpaired Student’s t-test or the Mann–Whitney U-test, while categorical variables were analyzed using Fisher's exact test. …”
Get full text

Biologic Therapy and Cardiometabolic Risk in Psoriasis: A Retrospective Review by Annika Smith, Aidin Karahasan, Deborah Yi, Sanjay Yapabandara, James Elhindi, Pablo Fernandez-Penas, Clara Chow, Sarah Zaman

“…This study aimed to assess the change in cardiometabolic risk markers in a cohort of patients with psoriasis treated with 1 year of continuous biologic treatment. Methods A retrospective review was conducted of patients receiving biologic therapy for chronic plaque psoriasis in a single dermatology centre at a major tertiary hospital in Sydney, Australia. …”
Get full text

Effect of miR-144-3p-Targeted Regulation of PTEN on Proliferation, Apoptosis, and Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells under Stretch by Shiyong Ling, Xi Luo, Bo Lv, Hua Wang, Mengzhi Xie, Kai Huang, Jingchuan Sun

“…The BMSCs were then continuously stimulated for 24 h using a Flexercell in vitro cellular mechanics loading device, applying a draft force at a frequency of 1 Hz and a deformation rate of 18%. …”
Get full text

Impact of patient–family physician language concordance on healthcare utilisation and mortality: a retrospective cohort study of home care recipients in Ontario, Canada by Claire Kendall, Sharon Johnston, Michael Reaume, Peter Tanuseputro, Michael Pugliese, Douglas Manuel, Denis Prud'homme, Manish Sood, Ricardo Batista, Ewa Sucha, Rhiannon Roberts, Emily Rhodes, Emily Seale, Lise Bjerre, Louise Bouchard

“…Introduction As the world’s linguistic diversity continues to increase at an unprecedented rate, a growing proportion of patients will be at risk of experiencing language barriers in primary care settings. …”
Get full text

Exzentrisch geformte Klang-Landschaften. Dimensionen des Zyklischen im Lichte von 106 Tonaufnahmen von Schuberts Winterreise aus dem Zeitraum 1928–2020 by Christian Utz

“…This broad view of the cycle’s performance history and its continuously divergent tendencies also suggests the need for a greater diversification of performative approaches in the present.…”
Get full text

Evaluation of processed rubber seed oil Hevea brasiliensis utilization as lipid source in Clarias gariepinus feed by Nuraini Annisa, Muhammad Agus Suprayudi, Mia Setiawati, Ichsan Ahmad Fauzi

“…The price of raw material for the feed lipid source which is currently the main source of fatty acids in freshwater fish feed continues to increase and compete with human needs. …”
Get full text

Codicology in Lithuania in 1918-1990: Between Book History and Palaeography by Rima Cicėnienė

“… The article discusses the development of the discipline of codicology in Lithuania in the period 1918-1990 thus continuing the research carried out from the early 19th century until 1918. …”
Get full text

Convertible metal-backed glenoid in total shoulder arthroplasty: a single-centre case series with minimum 15 years’ follow-up by Riccardo Ranieri, Mario Borroni, Giacomo Delle Rose, Marco Conti, Raffaele Garofalo, Alessandro Castagna

“…These results emphasize the need for continued research into improving TSA outcomes, especially in cases of MBG usage. …”
Get full text

ON THE THIN PRACTICAL RATIONALITY AND ITS THICKENINGS by Zenonas Norkus

“…This theroy conceives practical rationality as maximization of the expected utility defined as the measure of the preferences which satisfy the following conditions: (1) reflexivity; (2) completeness; (3) transitivity; (4) continuity; (5) preference increasing with probability and (6) strong independence. …”
Get full text

Perspektywiczne kierunki rozwoju biologii człowieka w Polsce, ze szczególnym uwzględnieniem auksologii by Napoleon Wolański, Anna Siniarska

“…If science has been interfered in technique continuously, the technical progress which makes our life easier would have been stopped. …”
Get full text