Single-cell transcriptome-wide Mendelian randomization and colocalization reveals immune-mediated regulatory mechanisms and drug targets for COVID-19Research in context by Hui Ying, Xueyan Wu, Xiaojing Jia, Qianqian Yang, Haoyu Liu, Huiling Zhao, Zhihe Chen, Min Xu, Tiange Wang, Mian Li, Zhiyun Zhao, Ruizhi Zheng, Shuangyuan Wang, Hong Lin, Yu Xu, Jieli Lu, Weiqing Wang, Guang Ning, Jie Zheng, Yufang Bi

“…Summary: Background: COVID-19 continues to show long-term impacts on our health. …”
Get full text

Transcutaneous electrical acupoint stimulation for hypertension complicated by anxiety or sleep disorders: A pilot randomized controlled trial by Xue-Ying Bao, Cun-Zhi Liu, Zi-Tong Qian, Lu Wang, Jian-Feng Tu, Bin-Yan Li, Xiao Wang, Fang Wan, Zhi-Han Li, Zhao-Yi Liu, Liang-Xiao Ma, Li-Qiong Wang

“…Methods: Eligible participants were randomly assigned to the 10 Hz TEAS, 2 Hz TEAS, or routine treatment groups in a 1:1:1 ratio. Participants continued their routine treatment during the trial, while those in the two TEAS groups received 12 sessions of 30-min TEAS treatment with different stimulation frequencies. …”
Get full text

Treatment efficacy for infantile epileptic spasms syndrome in children with trisomy 21 by Henry Chen, Henry Chen, Adam L. Numis, Adam L. Numis, Renée A. Shellhaas, John R. Mytinger, Debopam Samanta, Rani K. Singh, Rani K. Singh, Shaun A. Hussain, Danielle Takacs, Kelly G. Knupp, Li-Rong Shao, Carl E. Stafstrom

“…The overall clinical remission rate after two weeks of treatment was 53% including 13 of 20 (65%) receiving ACTH, three of nine (33%) receiving oral corticosteroids, and two of five (40%) receiving vigabatrin (p = 0.24). The continued clinical response rate at three months was 32% including 8 of 20 (40%) receiving ACTH, two of nine (22%) receiving oral corticosteroids, and one of five (20%) receiving vigabatrin. …”
Get full text

Exposure of wild mammals to glyphosate, AMPA, and glufosinate: a case for “emerging organic contaminants”? by Fritsch, Clémentine, Appenzeller, Brice M. R., Bertrand, Colette, Coeurdassier, Michael, Driget, Vincent, Hardy, Emilie M, Palazzi, Paul, Schaeffer, Charline, Goydadin, Anne-Claude, Gaba, Sabrina, Bretagnolle, Vincent, Pelosi, Céline

“…Glyphosate (GLY) is the most widely used herbicide worldwide, and its use continues to increase. Accumulating evidence shows that GLY and its metabolite aminomethylphosphonic acid (AMPA) are more persistent and toxic than expected, but little is known about the risks to wildlife. …”
Get full text

Healthy food prescription incentive programme for adults with type 2 diabetes who are experiencing food insecurity: protocol for a randomised controlled trial, modelling and implem... by Colleen Norris, Tyler Williamson, Richard Oster, Dana Lee Olstad, Laura White, David J T Campbell, Sharlette Dunn, Kim D Raine, Mary L'Abbé, Richard Lewanczuk, Lorraine L Lipscombe, Eldon Spackman, Reed Beall, Kienan Williams, Sara Scott, Gabrielle L Zimmermann, Kerry A McBrien, Kieran J D Steer, Catherine B Chan, Sheila Tyminski, Seth Berkowitz, Alun L Edwards, Terry Saunders-Smith, Saania Tariq, Naomi Popeski, Sara Nejatinamini, Aruba Naser, Carlota Basualdo-Hammond, Petra O’Connell, Judy Seidel, Jason Cabaj

“…Implementation processes and outcomes will be continuously measured via quantitative and qualitative data.Ethics and dissemination Ethical approval was obtained from the University of Calgary and the University of Alberta. …”
Get full text

Association between glyphosate exposure and cardiovascular health using “Life’s Essential 8” metrics in US adults by Yuankang Zhu, Zhenlin Yang, Yuhao Chen, Lingzi Qian, Changning Hao, Liangshi Hao, Boshen Yang, Junli Duan

“…Results: In fully adjusted models, the total CVH score decreased by 1.33 points for every unit increase in continuous ln-transformed glyphosate [β = -1.33, 95 % confidence interval (CI) (-2.25, −0.41)]. …”
Get full text

Bacteriological Profile of Chronic Suppurative Otitis Media and its Antibiotic Sensitivity Pattern at a Tertiary Care Hospital by Geeta Geeta, Naveen G, Apoorva P, Harish MO, Arathi Nair, Harshitha MC, Kiran Revankar, Girish PB

“…Conclusion Antibiotic sensitivity varies at different geographical areas. Continuous and periodic assessment of microbiological patterns and antibiotic sensitivity of isolates is required to formulate local antibiotic policy so that potential risk of complications can be reduced by early initiation of appropriate therapy. …”
Get full text

Effectiveness and safety of percutaneous endoscopic debridement and drainage for spinal infections: a systematic review and meta-analysis by Guozhong Zhou, Xiaorong Liu, Zhi Liang, Xuesong Chen, Chao Song

“…Erythrocyte sedimentation rate levels decreased significantly at 1-week postoperatively compared with preoperative levels (mean difference [MD] = − 13.48 [95% CI − 15.65 to − 11.31]) and continued to decrease over 3 months. Similarly, the c-reactive protein (CRP), visual analogue scale, and oswestry disability index scores significantly reduced postoperatively. …”
Get full text

Editorial by Editor

“… Dev Sanskriti: Interdisciplinary International Journal, published by Dev Sanskriti Vishwavidyalaya, Haridwar, continues its mission to serve as a platform for research on interdisciplinary subjects, particularly emphasizing the integration of indigenous ancient Indian science with modern scientific inquiry. …”
Get full text

Enhanced preoperative prediction of breast lesion pathology, prognostic biomarkers, and molecular subtypes using multiple models diffusion-weighted MR imaging by Litong He, Feng Li, Yanjin Qin, Yuling Li, Qilan Hu, Zhiqiang Liu, Yunfei Zhang, Tao Ai

“…Abstract This study aims to comprehensively evaluate the clinical utility of five diffusion models, including conventional mono-exponential (Mono), intravoxel incoherent motion (IVIM), diffusion kurtosis imaging (DKI), stretched exponential (SEM), and continuous-time random-walk (CTRW), for preoperatively predicting of breast lesion pathology, prognostic biomarkers, and molecular subtypes. …”
Get full text

Progressive subchondral bone cyst formation following autologous chondrocyte implantation with all-suture anchors: a Case Report with histological evaluation by Takuma Kaibara, Eiji Kondo, Masatake Matsuoka, Koji Iwasaki, Tomohiro Onodera, Daisuke Momma, Zen-Ichi Tanei, Shinya Tanaka, Norimasa Iwasaki

“…Longitudinal radiological assessment revealed bone hole enlargement corresponding to all-suture anchor sites, with one hole continuing to expand up to 15 months postoperatively, reaching a size of 11 × 13 × 13 mm. …”
Get full text

A Comparison of Medial-congruent, Ultracongruent, and Cruciate-retaining Bearings Using a Single Cruciate-retaining Total Knee Design by Alexander V. Strait, MS, Eric J. Wilson, MD, Henry Ho, MS, Kevin B. Fricka, MD, Robert A. Sershon, MD

“…Data analyses utilized analysis of variance tests for continuous data, chi-square tests for categorical data, and Mantel-Cox tests for survivorship analysis. …”
Get full text

The Innovation Intermediaries Role in the Adoption of Emerging Technologies in Iran's Automotive Industry by Ali Maleki, Hadi Nilforoushan

“…Objective The success rate of a type of technology is manifested in its adoption and continued use. In this sense, the condition development, user behavior, and the factors affecting it should be identified. …”
Get full text

Anti-inflammatory treatment using alpha melanocyte stimulating hormone (α-MSH) does not alter osteoblasts differentiation and fracture healing by Johanna Graue, Melanie Timmen, Katharina Schmitz, Daniel Kronenberg, Markus Böhm, Kishor K. Sivaraj, M. Gabriele Bixel, Richard Stange

“…We can conclude from our results, that treatment of inflammatory diseases using α-MSH does not interfere significantly with bone regeneration in a murine fracture model and therefore treatment with α-MSH could be continued without negative effects on bone formation and bone regeneration in patients. …”
Get full text

Changes in Internet Activities and Influencing Factors for Problematic Internet Use During the COVID-19 Pandemic in Korean Adolescents: Repeated Cross-Sectional Study by Sol I Kim, Jae-Chan Jin, Seo-Koo Yoo, Doug Hyun Han

“…Additionally, the rate of problematic internet use was highest for games before COVID-19, but after COVID-19, it was highest for videos, and this trend continued until 2023 (χ23=8.16, P=.04). Furthermore, this study showed that the Young’s Internet Addiction Scale (YIAS) score was highest in the game group in 2018 compared to other groups before COVID-19 (F5=14.63; P<.001). …”
Get full text

Characteristics and Influencing Factors of Soil CH4 and N2O Fluxes in Typical Broad-leaved Forests in the Yangtze River Delta Region, China by JIA Qinqi, XU Fei, CHEN Bingjiang, LU Yanran, CHEN Lihan, HU Jiahao, GUO Na, FANG Shuangxi

“…[Methods] Taking the typical broad-leaved forest soil in Hangzhou, Zhejiang Province as the research object, soil-air interface CH4 and N2O fluxes were continuously measured from November 2022 to November 2023 by the static chamber-gas chromatography method. …”
Get full text

The ground beneath our feet: A critical reflection on 135 years of landscape evolution models for southern Africa by Rivoningo Khosa, Vela Mbele, Kelly Kirsten, Robyn Pickering

“…While the evidence of a homogeneous and stable landscape is continually being challenged through scientific advancement, this terminology is rooted in outdated colonial thinking. …”
Get full text

The Long-term Variations and Influencing Factors of Soil Saturated Hydraulic Conductivity in Terraces on the Loess Plateau by PENG Xin, NI Lingshan, JI Keyan, DAI Wei, WANG Zhuoxiao, CHANG Heng, FANG Nufang

“…The Ks of farmland increased continuously with construction age of 7, 20, 30 and 40 years, increasing from 0.18 mm/min to 0.28 mm/min, with a growth rate of 55.56%. …”
Get full text

Implementasi Algoritma Genetika dalam optimasi Performa Truk Sampah Menggunakan Aplikasi Trash Queen by Arief Kelik Nugroho, Muhammad Naufal Faza

“…Abstract The need for vehicles can be said to be the key in the continuity of the world’s economy. Even so, the efficiency of vehicle design specifications remain a hot topic among automotive designers. …”
Get full text

The search for a blood-based biomarker for Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS): from biochemistry to electrophysiology by Krista S. P. Clarke, Caroline C. Kingdon, Michael Pycraft Hughes, Eliana Mattos Lacerda, Rebecca Lewis, Emily J. Kruchek, Robert A. Dorey, Fatima H. Labeed

“…Without a quantitative biomarker, trivialisation, scepticism, marginalisation, and misunderstanding of ME/CFS continues despite the significant disability for many. …”
Get full text