To Hemoadsorb or Not to Hemoadsorb—Do We Have the Answer Yet? An Updated Meta-Analysis on the Use of CytoSorb in Sepsis and Septic Shock by Carmen Orban, Angelica Bratu, Mihaela Agapie, Tudor Borjog, Mugurel Jafal, Romina-Marina Sima, Oana Clementina Dumitrașcu, Mihai Popescu

“…Methods: To better understand the clinical effectiveness of hemoadsorption in managing inflammation, we conducted an updated meta-analysis on the effects of CytoSorb in critically ill septic patients. Ten studies containing 715 patients (355 in the interventional group and 360 in the control group) have been included in the final analysis. …”
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A systematic investigation on microstructure evolution, phase transformation and dynamic recrystallization mechanisms of hot isostatic pressed Ti–45Al–2Mn–2Nb–1B alloy during hot d... by Meiyi Ba, Hongkui Tang, Lianxi Hu, Yu Sun, Fei Gao

“…The microstructure after thermal deformation contains true twins (TT) and pseudo twins (PT) and the DRX grains near twin boundaries (TBs) show a peak misorientation angle of 89 ± 3°, driven by high strain energy at twin intersections. …”
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A customizable multiplex protein microarray for antibody testing and its application for tick-borne and other infectious diseases by Hari Krishnan Krishnamurthy, Vasanth Jayaraman, Karthik Krishna, Tianhao Wang, Kang Bei, Chithra Changalath, Shiny Matilda, Alex J. Rai, Renata Welc-Falęciak, Agnieszka Pawełczyk, Lucas S. Blanton, Aleš Chrdle, Andrea Fořtová, Daniel Růžek, Gheyath K. Nasrallah, Laith J. Abu-Raddadi, Duaa W. Al-Sadeq, Marah Abed Alhakim Abdallah, Daniele Lilleri, Chiara Fornara, Piera D’Angelo, Milena Furione, Maria Söderlund-Venermo, Klaus Hedman, Dimosthenis Chochlakis, Eirini Makridaki, Artemis Ntoula, Anna Psaroulaki, Angélica Escárcega-Ávila, John J. Rajasekaran

“…Our microarray in its present form can accommodate 400 antigens (molecules that can bind to specific antibodies) and can multiplex across antigen types, whole cell lysates, recombinant proteins, and peptides. A designed array containing multiple antigens of several microbes including Borrelia burgdorferi, the Lyme disease spirochete, was manufactured and evaluated. …”
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RETRACTED: The Mechanism of Pertussis Cough Revealed by the Mouse-Coughing Model by Yukihiro Hiramatsu, Koichiro Suzuki, Takashi Nishida, Naoki Onoda, Takashi Satoh, Shizuo Akira, Masahito Ikawa, Hiroko Ikeda, Junzo Kamei, Sandra Derouiche, Makoto Tominaga, Yasuhiko Horiguchi

“…ABSTRACT Pertussis, also known as whooping cough, is a contagious respiratory disease caused by the Gram-negative bacterium Bordetella pertussis. …”
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Relationship between Ca2+ and cAMP as second messengers in ACTH-induced cortisol production in bovine adrenal fasciculata cells by Masahiko Kutsukake, Naoko Kuwabara, Yoshikazu Miyate, Kenzo Kudo, Shoko Goto, Eiichi Taira, Eiichi Tachikawa

“…Incubation of the cells with 100 pM ACTH in Ca2+-containing (normal) medium for 1 h increased cortisol production without affecting cAMP content. …”
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Metabolically activated and highly polyfunctional intratumoral VISTA+ regulatory B cells are associated with tumor recurrence in early-stage NSCLC by Domenico Lo Tartaro, Beatrice Aramini, Valentina Masciale, Nikolaos Paschalidis, Francesco Demetrio Lofaro, Anita Neroni, Rebecca Borella, Elena Santacroce, Alin Liviu Ciobanu, Anna Valeria Samarelli, Federica Boraldi, Daniela Quaglino, Alessandra Dubini, Michele Gaudio, Gloria Manzotti, Francesca Reggiani, Federica Torricelli, Alessia Ciarrocchi, Antonino Neri, Federica Bertolini, Massimo Dominici, Pier Luigi Filosso, Franco Stella, Lara Gibellini, Sara De Biasi, Andrea Cossarizza

“…Our analysis revealed that TME contains diverse B cell clusters, including VISTA+ Bregs, with distinct metabolic and functional profiles. …”
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HPLC-MS/MS-Mediated Analysis of the Pharmacokinetics, Bioavailability, and Tissue Distribution of Schisandrol B in Rats by Dahu Liang, Zijing Wu, Yanhao Liu, Chao Li, Xianghong Li, Bin Yang, Haitang Xie, Hua Sun

“…A liquid-liquid extraction (LLE) approach was employed for the preparation of samples that were subsequently separated with an Agilent ZORBAX Eclipse XDB-C18 (4.6 × 150 mm, 5 μm) column with an isocratic mobile phase consisting of methanol and water containing 5 mM ammonium acetate and 0.1% formic acid (90 : 10, v/v). …”
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Aptamer-Conjugated Multi-Quantum Dot-Embedded Silica Nanoparticles for Lateral Flow Immunoassay by Kwanghee Yoo, Hye-Seong Cho, Jaehi Kim, Minsup Shin, Jun-Sik Chu, Sohyeon Jang, Han-Joo Bae, Heung Su Jung, Homan Kang, Bong-Hyun Jun

“…For LFIA optimization, we determined the optimal conditions as a 1.0:2.0 × 10⁻² ratio of polyethylene glycol (PEG) to aptamer by adjusting the amounts of PEG and aptamer, phosphate-buffered saline containing 0.5% Tween^® 20 as a developing solution, and 0.15 μg NPs by setting the NP weight during development. …”
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In Vitro Susceptibility and Florfenicol Resistance in Citrobacter Isolates and Whole-Genome Analysis of Multidrug-Resistant Citrobacter freundii by Wangxiao Zhou, Qianqian Chen, Changrui Qian, Kai Shen, Xinyi Zhu, Danying Zhou, Wei Lu, Zhewei Sun, Hongmao Liu, Kewei Li, Teng Xu, Qiyu Bao, Junwan Lu

“…Sequencing and comparative analysis of the plasmids from a multidrug-resistant C. freundii isolate named R47 showed that the floR-containing region in the plasmid pR47-54 was a truncated transposon-like structure and could be found on both plasmids and chromosomes of bacteria of either animal or human origin. …”
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Mapping QTLs for early leaf spot resistance and yield component traits using an interspecific AB-QTL population in peanut by J. Gomis, J. Gomis, A. Sambou, J. R. Nguepjop, J. R. Nguepjop, J. R. Nguepjop, H. A. Tossim, M. Seye, R. Djiboune, D. Sambakhe, D. Loko, D. Loko, S. Conde, S. Conde, M. H. Alyr, D. J. Bertioli, D. J. Bertioli, S. C. M. Leal-Bertioli, S. C. M. Leal-Bertioli, J. F. Rami, J. F. Rami, A. Kane, D. Fonceka, D. Fonceka, D. Fonceka

“…One genomic region on chromosome A02 contained several relevant QTLs, contributing to ELS resistance, earliness, and increased biomass yield, potentially allowing marker-assisted selection to introduce this region into elite cultivars. …”
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Magnesium extraction of ferronickel slag processed by alkali fusion and hydrochloric acid leaching by Prasetyo A.B., Khaerul A., Mayangsari W., Febriana E., Maksum A., Andinie J., Firdiyono F., Soedarsono J.W.

“…Moreover, the accumulation due to increasing ferronickel demand as well as the environmental contamination due to various potentially toxic elements contained in the ferronickel slag could be prevented. …”
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Characterization of the Phosphotransferase from <i>Bacillus subtilis</i> 1101 That Is Responsible for the Biotransformation of Zearalenone by Yuzhuo Wu, Qiuyu Zhou, Junqiang Hu, Yunfan Shan, Jinyue Liu, Gang Wang, Yin-Won Lee, Jianrong Shi, Jianhong Xu

“…Furthermore, adding 1 mmol/L Fe²⁺ or Fe³⁺ to the reaction system increased the efficiency of ZPH1101 in converting ZEA by 100% relative to the system containing solely 1 mmol/L ATP and 1 mmol/L Mg²⁺, suggesting that low concentrations of Fe²⁺ or Fe³⁺ can improve the ZPH1101-mediated transformation of ZEA. …”
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Birds of a feather? Mis- and dis-information on the social media platform X related to avian influenza by Lauren N. Cooper, Marlon I. Diaz, John J. Hanna, Zachary M. Most, Christoph U. Lehmann, Richard J. Medford

“…A large portion of the tweets contained references to a planned epidemic or “plandemic” to influence the upcoming 2024 US presidential election. …”
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Discovery of 15-deoxynaphthomycins activating the antioxidant NRF2-ARE pathway from Streptomyces sp. N50 via genome mining, global regulator introduction, and molecular networking by Min-Seon Kim, Baskar Selvaraj, Hee-Tae Yeo, Jun-Su Park, Jae Wook Lee, Jin-Soo Park

“…Furthermore, molecular network analysis via MS/MS selectively confirmed the presence of additional sulfur-containing 15-deoxynaphthomycin congeners. Eventually, six new 15-deoxynaphthomycins were isolated and elucidated from the engineered strain N50. …”
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Hydrate-Based Methane Storage in Biodegradable Hydrogels Absorbing Dilute Sodium P-Styrenesulfonate Solution by Fangzheng Hua, Kang Tan, Jingyu Lv, Fei Wang, Mengting Sun

“…In hydrogel-SS hybrid media containing 1, 2, 3 and 4 mmol L⁻¹ of SS solutions, the storage capacity reached 121.2 ± 1.6, 121.5 ± 3.1, 122.6 ± 1.9 and 120.6 ± 1.6 <i>v</i>/<i>v</i>, respectively. …”
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Genomic variation responding to artificial selection on different lines of Pekin duck by Xinye Zhang, Fangxi Yang, Jinxin Zhang, Tao Zhu, Xiurong Zhao, Yuchen Liu, Junhui Wen, Hongchang Gu, Gang Wang, Xufang Ren, Anqi Chen, Lujiang Qu

“…Six regions of interest were identified, containing RPA1, DOT1L, SLC25A42, RALYL, TRPA1, and IGFBP2. …”
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Inhibition of Endothelial–Mesenchymal Transition Mediated by Activin Receptor Type IIA Attenuates Valvular Injury Induced by Group A Streptococcus in Lewis Rats by Zirong Lu, Yuan Li, Chuanghong Lu, Zhongyuan Meng, Ling Bai, Feng Huang, Zhiyu Zeng

“…We constructed a small interfering RNA (ACVR2A-siRNA) by silencing activin receptor type IIA (ACVR2A) and an adeno-associated virus (AAV-ACVR2A) containing a sequence that silenced ACVR2A. The EndMT cell model was established via human umbilical vein endothelial cells (HUVECs), and the RHD animal model was established via female Lewis rats. …”
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Effectiveness and safety of human placenta hydrolysate injection into subacromial space in patients with shoulder impingement syndrome: a single-blind, randomized trial by Du Hwan Kim, Myung Woo Park, Hyun Iee Shin, Byung Chan Lee, Don-Kyu Kim, Chul-Hyun Cho, Ye-Ji Kim

“…Abstract Background Human placental hydrolysate (hPH) contains anti-inflammatory substances. This study aimed to analyze whether injecting hPH into the subacromial space could reduce pain in patients with shoulder impingement syndrome. …”
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NLRP3 deficiency aggravated DNFB-induced chronic itch by enhancing type 2 immunity IL-4/TSLP-TRPA1 axis in mice by Si-Ting Huang, Zuo-Ming Chen, Zhe Peng, Yu Wang, Fan Yang, Yang Tang, Zi Li, Li Wan, Li Wan

“…BackgroundThe nod-like receptor family pyrin domain-containing 3 (NLRP3) has been implicated in various skin diseases. …”
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Milk fat globule membrane supplementation protects against β-lactoglobulin-induced food allergy in mice via upregulation of regulatory T cells and enhancement of intestinal barrier... by Han Gong, Tiange Li, Dong Liang, Jingxin Gao, Xiaohan Liu, Xueying Mao

“…Milk fat globule membrane (MFGM), which contains abundant glycoproteins and phospholipids, exerts beneficial effects on intestinal health and immunomodulation. …”
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