Effectively alleviate rheumatoid arthritis via maintaining redox balance, inducing macrophage repolarization and restoring homeostasis of fibroblast-like synoviocytes by metformin-... by Rui Zhang, Xingyu Lin, Rongjie Lin, Zhenbin Chen, Chenfang Miao, Yao Wang, Xiaoqin Deng, Jianlong Lin, Shishui Lin, Shaohuang Weng, Min Chen

“…In addition, MCDs eliminated the cellular ROS in M1 phenotype macrophages in RA microenvironment through the enzyme-like catalytic activity as well as inhibiting NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome signaling pathway, effectively polarizing them into the M2 phenotype to realize the anti-inflammatory effect. …”
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P-glycoprotein-independent cytotoxic effects of 5-aminopyrazole in L1210 leukemia cells by Lucia Sofrankova, Jana Spaldova, Pavol Stefik, Branislav Pavilek, Dusan Bortnak, Lucia Pavlikova, Ivana Zidekova, Daniel Vegh, Viktor Milata, Albert Breier, Zdena Sulova

“…Five derivatives (A1-A5), each containing perfluorinated methylbenzene at the N3 nitrogen of the pyrazole ring, were tested on murine lymphoblastic cell line variants: parental S cells (P-gp positive), R cells (vincristine-resistant and P-gp positive), and T cells (human P-gp transfected). …”
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Influence of Gd alloying and ultrasonic vibration hybrid treatment on the microstructures, mechanical properties and strengthening mechanisms of Al/Mg interface by compound casting by Qingqing Li, Wenming Jiang, Yuancai Xu, Linghui Yu, Ziwei Peng, Yunchang Xin, Zitian Fan

“…The coherent relationships among Mg2Si, Al12Mg17 and δ-Mg as well as the Gd contained precipitates and Al12Mg17 were revealed. …”
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Improving the Reporting of Primary Care Research: Consensus Reporting Items for Studies in Primary Care—the CRISP Statement by Phillips William R., Sturgiss Elizabeth, Glasziou Paul, olde Hartman Tim C., Orkin Aaron M., Prathivadi Pallavi, Reeve Joanne, Russell Grant M., van Weel Chris

“…The CRISP Checklist contains 24 items that describe the research team, patients, study participants, health conditions, clinical encounters, care teams, interventions, study measures, settings of care, and implementation of findings/results in PC. …”
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Identification and characterization of peat soils using a physiographic approach at semi-detailed scale: a case study in Bangka Belitung Islands Province, Indonesia by Sukarman Sukarman, Yiyi Sulaeman, Edi Yatno, Rachmat Abdul Gani, Budiman Minasny

“…The estimated carbon stock contained in peat is 11.6 million tons C. The peat soils are Organosol Saprik, Organosol Hemik, and Organosol Sulfidik. …”
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Ultrahigh piezoelectric performances of (K,Na)NbO3 based ceramics enabled by structural flexibility and grain orientation by Li-Feng Zhu, Dong Liu, Xiaoming Shi, Shiqing Deng, Jiecheng Liu, Li-Yu Wei, Zi-Qi Yang, Qi Wang, Bo-Ping Zhang, Houbing Huang, Shujun Zhang, Jing-Feng Li

“…Abstract (K,Na)NbO3-based ceramics are deemed among the most promising lead-free piezoelectric materials, though their overall piezoelectric performance still lags behind the mainstream lead-containing counterparts. Here, we achieve an ultrahigh piezoelectric charge coefficient d33 ∼ 807 pC·N−1, along with a high longitudinal electromechanical coupling factor (k33 ∼ 88%) and Curie temperature (Tc ∼ 245 °C) in the (K,Na)(Nb1-x Sb x )O3-Bi0.5Na0.5ZrO3-BiFeO3 (KNN-xSb) system through structural flexibility and grain orientation strategies. …”
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Recovery of Bioactive Constituents from Olive Leaf Pruning Waste of Five Different Cultivars: A Comparison of Green Extraction Techniques to Maximize Health Benefits by Hamid Mushtaq, Simona Piccolella, Jose A. Mendiola, Lidia Montero, Elena Ibáñez, Severina Pacifico

“…PLE extracts showed better antiradical activities, putatively due to a higher content of flavonoids, secoiridoids, and HCA derivatives than UAM-EtOH ones, as these latter also contained 20–40% (cultivar-dependent) of triterpenes. …”
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Novel (Q)SAR models for prediction of reversible and time-dependent inhibition of cytochrome P450 enzymes by Sadegh Faramarzi, Arianna Bassan, Kevin P. Cross, Xinning Yang, Glenn J. Myatt, Donna A. Volpe, Lidiya Stavitskaya

“…The non-proprietary training database for the QSAR models contains data for 10,129 chemicals harvested from FDA drug approval packages and published literature. …”
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Complete genome sequence of Pseudarthrobacter sp. NIBRBAC000502770 from coal mine of Hongcheon on Republic of Korea by Min-Kyu Park, Yeong-Jun Park, Myung-Suk Kang, Min-Ha Kim, Soo-Young Kim, Jae-Ho Shin

“…NIBRBAC000502770, isolated from the rhizosphere of Sasamorpha in a heavy metal-contaminated coal mine in Hongcheon, Republic of Korea. …”
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A Study to Inform the Design of a National Multicentre Randomised Controlled Trial to Evaluate If Reducing Serum Phosphate to Normal Levels Improves Clinical Outcomes including Mor... by Ramya Bhargava, Philip A. Kalra, Paul Brenchley, Helen Hurst, Alastair Hutchison

“…Dual centre prospective parallel group study: 100 dialysis patients randomized to lower (phosphate target 0.8 to 1.4 mmol/L) or higher range group (1.8 to 2.4 mmol/L). Non-calcium-containing phosphate binders and questionnaires will be used to achieve target phosphate. …”
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2-Aminothiophene Derivatives—New Drug Candidates Against Leishmaniasis: Drug Design, Synthesis, Pharmacomodulation, and Antileishmanial Activity by Rodrigo Santos Aquino de Araújo, Vitória Gaspar Bernardo, Robert da Silva Tibúrcio, Danilo Cesar Galindo Bedor, Michel Leandro de Campos, Roberto Pontarolo, Julyanne Maria Saraiva de Sousa, Klinger Antonio da Franca Rodrigues, Marcus Tullius Scotti, Anuraj Nayarisseri, Pascal Marchand, Francisco Jaime Bezerra Mendonça-Junior

“…<b>Background/Objectives</b>: Leishmaniasis is one of the 20 Neglected Tropical Diseases according to the WHO, affecting approximately 12 million people in four continents, generating serious public health problems. …”
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A Hybrid Framework for Detection and Analysis of Leaf Blight Using Guava Leaves Imaging by Sidrah Mumtaz, Mudassar Raza, Ofonime Dominic Okon, Saeed Ur Rehman, Adham E. Ragab, Hafiz Tayyab Rauf

“…Guava is a common fruit found in different countries. It is considered the fourth primary fruit in Pakistan. …”
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Machine Learning Based Method for Insurance Fraud Detection on Class Imbalance Datasets With Missing Values by Ahmed A. Khalil, Zaiming Liu, Ahmed Fathalla, Ahmed Ali, Ahmad Salah

“…The fraud datasets are usually imbalanced, as the number of fraudulent instances is much less than the ligament instances and contains missing values. Prior research has employed machine learning methods to address this class imbalance dataset problem, but there is limited effort handling the class imbalance dataset present in insurance fraud datasets. …”
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Dietary inclusion of African bush mango (Irvingia gabonensis) seed improves sexual performance in sexually inexperienced rats by Olasunkanmi Omojokun, Akindele Famurewa, Ganiyu Oboh, Jemima Enang, Stella Ijeh

“…The group with diet inclusion containing 20% ABM showed an obviously increased sexual behavior similar to the group that received sildenafil. …”
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Different harvesting dates influence the growth, seed yield and quality of two rice varieties in Ghana by Paul Kweku Tandoh, Irene Akua Idun, Philip Amponsah Duodu, Bridget Dwomoh

“…Rice (Oryza sativa L.) is a staple food which contains a high amount of nutrients essential for human nutrition, energy supply, and food security. …”
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General and simple salts-mediating approach enables superior magnesium plating/stripping properties by Ning Yuan, Jing Liu, Wenhao Sun, Min Wang, Changming Mao, Kun Chao, Zhenfang Zhou, Xiaosong Guo, Zhonghua Zhang, Guicun Li

“…In addition, unique MgCl-rich and carbonyl organic compounds-containing interphases are unveiled, which is conducive to active Mg electrodeposition. …”
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Effect of Curry Leaf (Murraya koenigii) as Edwardsiellosis Treatment on Gourami Fish (Osphronemus goramy) by Muyassar H. Abualreesh, Agus Pariawan, Annisa Isti Fauziyyah, Farid Mukhtar Riyadi, Mohammad Fadjar, Arief Prajitno, Arif Syaifurrisal, Muhammad Browijoyo Santanumurti, Suciyono Suciyono

“…The findings revealed that M. koenigii predominantly contains alkaloids, terpenoids, saponins, flavonoids, and tannins, all of which exhibit antibacterial activity. …”
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Natural antifibrosis potential of anthocyanin in Ipomoea batatas against Transforming Growth Factor beta Type II receptor by in silico ADMET and molecular docking study by Evi Lusiana, Ernawati Sinaga, Zen Hafy, Debby Handayati Harahap, Ramzi Amin, Irsan Saleh

“…I. batatas, one of the traditional medicinal plants containing anthocyanins, has the potential to generate effective therapeutic approaches for the treatment of fibrosis. …”
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Performance of twisted tape absorber-based photovoltaic thermal systems in clockwise and counterclockwise configurations by Abdalrahman M.O. Al-Karboly, Adnan Ibrahim, Anas Al-Tarabsheh, Anwer B. Al-Aasam, Ali H.A. Al-Waeli, Ahmad Fazlizan, Kamaruzzaman Sopian

“…Numerous solar irradiance levels (200 W/m2, 400 W/m2, 600 W/m2, 800 W/m2, and 1000 W/m2) were examined using an indoor solar simulator, a nanofluid containing water and 0.5 vol% SiC, and mass flow rates from 0.005 kg/s to 0.04 kg/s. …”
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Effect of the Nitrification Inhibitor 3,4-Dimethylpyrazole Phosphate on the Deep Placement of Nitrogen Fertilizers for Soybean Cultivation by Soshi Hatano, Yoichi Fujita, Yoshifumi Nagumo, Norikuni Ohtake, Kuni Sueyoshi, Yoshihiko Takahashi, Takashi Sato, Sayuri Tanabata, Kyoko Higuchi, Akihiro Saito, Takuji Ohyama

“…The average seed yields were high in LN (464 g·m−2) and DMU (461 g·m−2) and relatively low in CU (405 g·m−2), U (396 g·m−2), and Cont (373 g·m−2) treatments. The accumulations of dry matter and nitrogen in soybean shoots were higher in the plants with deep placement of CU, LN, and DMU than U and Cont. …”
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