Effect of Food on the Steady-State Pharmacokinetics of Tenofovir and Emtricitabine plus Efavirenz in Ugandan Adults by Mohammed Lamorde, Pauline Byakika-Kibwika, William S. Tamale, Francis Kiweewa, Mairin Ryan, Alieu Amara, John Tjia, David Back, Saye Khoo, Marta Boffito, Cissy Kityo, Concepta Merry

“…We investigated the effect of food on the steady-state pharmacokinetics of a proprietary fixed-dose combination (FDC) tablet containing tenofovir disoproxil fumarate (TDF)/emtricitabine/efavirenz. …”
Get full text

Antimicrobial susceptibility of Helicobacter pylori isolates in Smolensk in 2015-2016 by N. N. Dekhnich, N. V. Ivanchik, R. S. Kozlov, A. V. Alimov, A. V. Lukyanova, O. A. Nagaeva, A. S. Steshits, P. G. Bruk

“…So, clarithromycin-containing regimens are recommended for first-line empirical eradication therapy. …”
Get full text

Multiple Immunosuppressive Effects of CpG-c41 on Intracellular TLR-Mediated Inflammation by Wancheng Liu, Xuejiao Yang, Ning Wang, Shijun Fan, Yuanfeng Zhu, Xinchuan Zheng, Yan Li

“…Here, we report the immunomodulatory properties of a nonstimulatory CpG-containing oligodeoxynucleotide (CpG-ODN), CpG-c41, which had previously only been known as a TLR9 antagonist. …”
Get full text

Fabrication and Characterization of Physical, Mechanical, and Wear Characteristics of AA7075/SiC Composites by Floating Die by Ameen Al Njjar, Kamar Mazloum, Amit Sata

“…Regression equations, contour plots, and surface plots generated using the response surface method helped visualize the relationships between these factors. The composite containing 5% SiC demonstrated superior properties, including a substantial increase in compressive strength (20.1%), weight reduction (13.7%), and a significant decrease in wear loss (83.28%), making it highly promising for aerospace, defense, and automotive sectors. …”
Get full text

Tartrazine Removal from Aqueous Solution by HDTMA-Br-Modified Colombian Bentonite by Ronald A. Otavo-Loaiza, Nancy R. Sanabria-González, Gloria I. Giraldo-Gómez

“…The effect of pH, ionic strength (NaCl added), agitation speed, adsorbent mass, and contact time on the removal of tartrazine from an aqueous solution, using an organobentonite, has been studied. …”
Get full text

A multistage drug delivery approach for colorectal primary tumors and lymph node metastases by Yihang Yuan, Quanjun Lin, Hai-Yi Feng, Yunpeng Zhang, Xing Lai, Mao-Hua Zhu, Jue Wang, Jiangpei Shi, Yanhu Huang, Lele Zhang, Qin Lu, Zeli Yuan, Jonathan F. Lovell, Hong-Zhuan Chen, Peng Sun, Chao Fang

“…The liposomal membrane contains 1,2-dipalmitoyl-sn-glycero-3-phospho-rac-(1-glycerol) (DPPG) and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), two phospholipids sensitive to secreted phospholipase A2 in human colorectal tumors. …”
Get full text

PSCA-targeted BPX-601 CAR T cells with pharmacological activation by rimiducid in metastatic pancreatic and prostate cancer: a phase 1 dose escalation trial by Mark N. Stein, Ecaterina E. Dumbrava, Benjamin A. Teply, Usama S. Gergis, Martin E. Guiterrez, Ran Reshef, Sumit K. Subudhi, Céline F. Jacquemont, Joseph H. Senesac, J. Henri Bayle, Charity D. Scripture, Monica S. Chatwal, Mehmet A. Bilen, Walter M. Stadler, Carlos R. Becerra

“…Abstract Here we report results of a phase 1 multi-institutional, open-label, dose-escalation trial (NCT02744287) of BPX-601, an investigational autologous PSCA-directed GoCAR-T® cell product containing an inducible MyD88/CD40 ON-switch responsive to the activating dimerizer rimiducid, in patients with metastatic pancreatic (mPDAC) or castration-resistant prostate cancer (mCRPC). …”
Get full text

Valorization of Olive Pruning Residues through Bioconversion into Edible Mushroom Pleurotus ostreatus (Jacq. Ex Fr.) P. Kumm. (1871) of Improved Nutritional Value by Sami Abou Fayssal, Mohammed A. Alsanad, Zeina El Sebaaly, Ahmed I. H. Ismail, Youssef N. Sassine

“…In several Mediterranean countries, olive pruning residues (OLPRs) are abandoned or burned leading to several environmental problems. …”
Get full text

Lysosphingolipids in ceramide-deficient skin lipid models by Georgios Paraskevopoulos, Lukáš Opálka, Andrej Kováčik, Anna Paraskevopoulou, Eleni Panoutsopoulou, Irene Sagrafena, Petra Pullmannová, Robert Čáp, Kateřina Vávrová

“…When applied topically to human stratum corneum sheets, SPC and GS increased water loss, decreased electrical impedance, and slightly disordered lipid chains. In lipid models containing isolated human stratum corneum ceramides, reducing ceramides by ≥ 30% significantly increased permeability to four markers, likely due to loss of long-periodicity phase (LPP) lamellae and phase separation within the lipid matrix, as revealed by X-ray diffraction and infrared spectroscopy. …”
Get full text

Microbiological Safety and Health Properties of Marketed Fermented Root Vegetables by Eliza Knez, Rafał Hałasa, Katarzyna Turecka, Justyna Ośko, Kornelia Kadac-Czapska, Krzysztof Waleron, Małgorzata Grembecka

“…None of the tested products were contaminated with <i>Bacillus cereus</i>, <i>Salmonella</i> spp., <i>Enterococcus</i> spp., or spore-forming anaerobic bacteria. …”
Get full text

Pan-cancer analysis of the immunological and oncogenic roles of ATAD2 with verification in papillary thyroid carcinoma by Zhecheng Li, Yaxin Zhao, Peng Huang, Zhaoyi Wu, Dengjie Ouyang, Adolphus Osei Nyarko, Lei Ai, Zhejia Zhang, Shi Chang

“…Abstract ATAD2 (ATPase Family AAA Domain-Containing 2) is highly expressed across varies tumor types, yet its common roles in tumor progression and immune interaction remain unclear. …”
Get full text

MONITORING OF CALCIUM CONTENT OF RAW COW MILK by Ye. S. Kandinskaya, S. V. Redkin, G. V. Chebakova

“…Calcium is essential for many metabolic processes and is contained in milk in easily digestible and phosphorus-balanced form. …”
Get full text

The Mosquito Repellent Activity of the Active Component of Air Freshener Gel from Java Citronella Oil (Cymbopogon winterianus) by Willy Tirza Eden, Dante Alighiri, Kasmadi Imam Supardi, Edy Cahyono

“…Java citronella oil, which contains citronellol, citronellal, and geraniol, was isolated by batch vacuum fractional distillation, and their effect was tested against the dengue fever (DF) vector, known as Aedes aegypti. …”
Get full text

Platycodon grandiflorum-derived extracellular vesicles suppress triple-negative breast cancer growth by reversing the immunosuppressive tumor microenvironment and modulating the gu... by Min Yang, Jia Guo, Jinxian Li, Shuyue Wang, Yuan Sun, Ying Liu, Yinghua Peng

“…The PGEVs were isolated by ultracentrifugation and sucrose gradient centrifugation method and contained adequate functional components such as proteins, lipids, RNAs and active molecules. …”
Get full text

A Chemically Defined Serum-Free Culture System for Spontaneous Human Mesenchymal Stem Cell Spheroid Formation by Yajun Zhao, E. Xiao, Wanqi Lv, Xian Dong, Linhai He, Yixiang Wang, Yi Zhang

“…When reseeded in normal serum-containing medium, the expression level of stemness biomarkers was even higher in spheroid-derived ADSCs than monolayer culture. …”
Get full text

Effects of collagen and chondroitin sulfate on relaxation at multiple magnetic field strengths by Olli-Pekka Aro, Victor Casula, Nina E. Hänninen, Jouni Karjalainen, Mikko J. Nissi, Miika T. Nieminen, Henning Henschel

“…Methods: A series of MRI phantoms consisting of gels containing collagen and chondroitin sulfate were prepared with final concentrations of collagen in the range 20-60 mg/g and the CS concentration in the range 0-40 mg/g. …”
Get full text

Brake Drum Temperature Rise and Its Influence on Truck Driving Safety in Tunnel Groups Section by Yunyong He, Enhuai He, Le Zhang, Jianping Gao, Changfeng Yang, Lu Sun, Haotian Yang, Zhen Gong, Ziqiang Liu

“…In this paper, the driving experiments on G350 Gengda-Yingxiu section containing continuous downhill tunnel group. Three-axle trucks under standard load and overload conditions were considered. …”
Get full text

Aloe vera: A promising natural herbal supplement for enhancing growth, physiology, antioxidant activity and immunity in Catla catla by Zeeshan Yousaf, Syed Makhdoom Hussain, Shafaqat Ali, Dariusz Kucharczyk, Joanna Nowosad, Konrad Turkowski, Bilal Ahamad Paray, Adan Naeem

“…The groups fed diets containing equal amounts of canola meal and varying levels of A. vera supplementation (0 %, 1 %, 2 %, 3 %, 4 %, and 5 %). …”
Get full text

Structural, Optical and Electrochromic Properties of Sol–Gel V2O5 Thin Films by M. Benmouss, A. Outzourhit, R. Jourdani, A. Bennouna, E. L. Ameziane

“…The films’ electrochromism is studied using cyclic voltammetry (CV) and chronoamperometry in propylene carbonate solution containing 1 mol/l LiCIO4. The films show reversible multichromism (yellow–green–blue) upon Li+ ion insertion/extraction. …”
Get full text

Microstructural and mechanical responses of Sn58Bi/Cu composite solder joints with 0.1wt.% Ni and carbon fiber addition by Xiangxia Kong, Zuchen Liu, Ruipeng Ma, Junjun Zhai, Zhen Pan, Xuemei Li, Fenglian Sun

“…However, the added materials have a relatively small impact on the melting point of the composite solder. Solder joints containing 0.04wt.% Cf and 0.1 wt.% Ni nanoparticles showed the best performance in all samples. …”
Get full text