Comprehensive landscape and oncogenic role of extrachromosomal circular DNA in malignant biliary strictures by Zhuo Cheng, Xuanmei Luo, Wenzheng Liu, Xiaofang Lu, Hong Chang, Yingchun Wang, Wei Zheng, Xiue Yan, Yonghui Huang

“…Abstract Background Extrachromosomal circular DNA (eccDNA) is crucial for carcinogenesis and bile has direct contact with malignant biliary strictures, yet eccDNA features in bile and its function in malignant biliary strictures remain underexplored. …”
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A Highly Sensitive and Selective Isobutyraldehyde Sensor Based on Nanosized Sm2O3 Particles by Li Jiang, Yun Wu, Yan Wang, Qin Zhou, Yuguo Zheng, Yafei Chen, Qianchun Zhang

“…The sensor was tested against spiked samples containing IBD, and recoveries between 89.7% and 97.4% were obtained with an RSD of 6.1%–8.6%. …”
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A systematic review of plant-based therapy for the management of diabetes mellitus in the East Africa community by Nancy Bonareri Mitaki, Ilemobayo Victor Fasogbon, Onyinye Vivian Ojiakor, Wusa Makena, Emmanuel O. Ikuomola, Reuben Samson Dangana, Ibe Micheal Usman, Ekom Monday Etukudo, Augustine Oviosun, Swase Dominic Terkimbi, Elizabeth Bessy Umoren, Angela Mumbua Musyoka, Solomon A Mbina, Esther Ugo Alum, Ibrahim Babangida Abubakar, Godson Emeka Anyanwu, Patrick Maduabuchi Aja

“…Conclusion: The phytochemical properties of these medicinal plants, mainly containing alkaloids, tannins, and flavonoids, may contribute to their hypoglycemic effects. …”
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Maternal Fructose Intake Induces Insulin Resistance and Oxidative Stress in Male, but Not Female, Offspring by Lourdes Rodríguez, Paola Otero, María I. Panadero, Silvia Rodrigo, Juan J. Álvarez-Millán, Carlos Bocos

“…However, consumption of beverages containing fructose is allowed during gestation. Recently, we found that an intake of fructose (10% wt/vol) throughout gestation produces an impaired fetal leptin signalling. …”
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PHYTOCHEMICAL, USE IN ETHNOMEDICINE, AND THERAPEUTIC ACTIVITIES OF MARCHANTIA GENUS by Dicki Bakhtiar Purkon, Tonny Cortis Maigoda, Adreanus Andaja Soemardji, Yayat Sudaryat, Faizah Min Fadhlillah, Maria Immaculata Iwo, Ainun Nadhifah

“…Background: Liverworts are a group of plants from the Marchantia genus containing various biologically active compounds and comprised of 65 species worldwide. …”
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Standardization, validation, and comparative evaluation of a convenient surrogate recombinant vesicular stomatitis virus plaque reduction test for quantification of Hantaan orthoha... by Jing Wei, Hui Zhang, Jiawei Pei, Qiqi Yang, Yuan Wang, Xiaolei Jin, He Liu, Liang Zhang, Hongwei Ma, Linfeng Cheng, Yangchao Dong, Yingfeng Lei, Yinlan Bai, Zhikai Xu, Pengbo Yu, Fanglin Zhang, Wei Ye

“…The golden standard for HTNV NAbs measurement is the focus reduction neutralization test (FRNT), which typically requires skilled technicians and is performed under high biosafety containment facility. Here, we established a surrogate NAbs titration method with replication-competent vesicular stomatitis virus (VSV) bearing HTNV glycoprotein (rVSV-HTNV-GP) based plaque reduction neutralization test (PRNT). …”
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Relationship between landscape and river ecosystem services by M. Dede, S. Sunardi, K.C. Lam, S. Withaningsih

“…Landscape dynamics are a consequence of population growth, which can degrade river ecosystem services. Since various countries approved the millennium ecosystem assessment, it has inspired researchers to examine the relationship between landscape and river ecosystem services. …”
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Saprotrophic Wood Decay Ability and Plant Cell Wall Degrading Enzyme System of the White Rot Fungus <i>Crucibulum laeve</i>: Secretome, Metabolome and Genome Investigations by Alexander V. Shabaev, Olga S. Savinova, Konstantin V. Moiseenko, Olga A. Glazunova, Tatyana V. Fedorova

“…The proportion of monosaccharides and polyols in the total pool of identified compounds increased on the sawdust-containing media. Multiple copies of the family AA1_1, AA3_2, AA7 and LPMOs CAZyme genes, as well as eight genes encoding proteins of the YvrE superfamily (COG3386), which includes sugar lactone lactonases, were predicted in the <i>C. laeve</i> genome. …”
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Comprehensive Analysis of <i>Trypoxylus dichotomus</i>: Inorganic Elements, Amino Acids, and Bioactive Compounds and Their Anticancer, Antioxidant, and Neuroprotective Properties by Dongyan Ye, Qianhui Li, Xuwen Liu, Jie Zhou, Shuren Yin, Suyi Zhang, Jing Wang, Kh Ahammad Uz Zaman, Helong Bai, Fanlei Meng

“…GC-MS analysis revealed 37–53 components across different life stages, excluding excessive heavy metals and containing essential trace elements. Amino acid profiling identified 15 types, rich in seven medicinal varieties. …”
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Role of bovine respiratory syncytial virus in etiology of respiratory diseases on milk farms by S. V. Koteneva, A. V. Nefedchenko, T. I. Glotova, A. G. Glotov

“…The number of samples containing simultaneously BRSV and Pasteurellaceae bacteria was 10.8%. …”
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Can geopolymer mixture be a solution for utilizing waste glass and basic oxygen furnace slag as aggregates? by Manap Islambek, Galymzhankyzy Anel, Omarova Zhaniya, Ualiyev Dulat, Temirbekov Doszhan, Shon Chang-Seon, Zhang Dichuan, Kim Jong Ryeol

“…The research includes an experimental program in which geopolymer mixtures were prepared with different combinations of WGS and BOFS contents (0/100, 25/75, 50/50, 75/25, 100/0, respectively) alongside reference OPC samples containing only WGS or BOFS. The samples prepared for testing expansion behavior were cured under 2 conditions: water submersion and 1M NaOH solution submersion, both maintained at 80°C. …”
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Associations of Salivary BPIFA1 Protein in Chronic Periodontitis Patients with Type 2 Diabetes Mellitus by Yue Guo, Lin-Na Guo, Jun-Fei Zhu, Chen-Yi Tang, Yun-Zhi Feng, Hou-De Zhou

“…To explore the differences in salivary BPI fold containing family A, member 1 (BPIFA1) concentration among type 2 diabetes mellitus (T2DM) subjects with various severities of chronic periodontitis and to determine whether BPIFA1 in saliva can be used as a potential biomarker of T2DM. …”
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Cobalt Protoporphyrin Downregulates Hyperglycemia-Induced Inflammation and Enhances Mitochondrial Respiration in Retinal Pigment Epithelial Cells by Peng-Hsiang Fang, Tzu-Yu Lin, Chiu-Chen Huang, Yung-Chang Lin, Cheng-Hung Lai, Bill Cheng

“…ARPE-19 cells were incubated in culture media containing either 5.5 mM (NG) or 25 mM (HG) glucose, with or without the addition of 0.1 µM CoPP. …”
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NRBF2 plays a crucial role in the acquisition process of learning and memory, independent of the Vps34 complex by Songfen Wu, Songfen Wu, Songfen Wu, Haicai Zhuang, Haicai Zhuang, Haicai Zhuang, Xidan Zhou, Kuan Li, Kuan Li, Kuan Li

“…IntroductionNRBF2, a component of autophagy-associated PIK3C3/VPS34-containing phosphatidylinositol 3-kinase complex, plays a crucial role in learning and memory processes, yet its specific impact on memory and the underlying molecular mechanisms remains unclear.MethodsHere, we utilized NRBF2 knockout mice to examine its influence on the time course of fear memory. …”
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The first two mitochondrial genomes for the genus Ramaria reveal mitochondrial genome evolution of Ramaria and phylogeny of Basidiomycota by Qiang Li, Lijiao Li, Ting Zhang, Peng Xiang, Qian Wu, Wenying Tu, Zhijie Bao, Liang Zou, Cheng Chen

“…We further found frequent intron loss/gain and potential intron transfer events in Phallomycetidae mitogenomes during the evolution, and the mitogenomes of R. rubella contained a novel intron P44. Phylogenetic analyses using both Bayesian inference (BI) and Maximum Likelihood (ML) methods based on a combined mitochondrial gene dataset obtained an identical and well-supported phylogenetic tree for Basidiomycota, wherein R. cfr. rubripermanens and Turbinellus floccosus are sister species. …”
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Bioactive Potential of Some <i>Bacillus thuringiensis</i> Strains from Macapá, Amazon, Brazil, Against the Housefly <i>Musca domestica</i> (Diptera: Muscidae) Under Laboratory Cond... by Tatiane Aparecida Nascimento, Maria José Paes, Fernando Hercos Valicente, Margareth Maria de Carvalho Queiroz

“…Six strains exhibited 70 to 100% larval mortality, with five containing <i>cry</i> genes, none harboring <i>cyt</i> genes, and four carrying <i>vip</i> genes. …”
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Multimodal lung cancer theranostics via manganese phosphate/quercetin particle by Chong Qiu, Fei Xia, Qingchao Tu, Huan Tang, Yinan Liu, Hongda Liu, Chen Wang, HaiLu Yao, Linying Zhong, Yuanfeng Fu, Pengbo Guo, Weiqi Chen, Xinyu Zhou, Li Zou, Licheng Gan, Jiawei Yan, Yichong Hou, Junzhe Zhang, Huanhuan Pang, Yuqing Meng, Qiaoli Shi, Guang Han, Xijun Wang, Jigang Wang

“…Here, we present a multifunctional pH-sensitive core-shell nanoparticle containing quercetin (QCT), termed AHA@MnP/QCT NPs, designed for the simultaneous diagnosis and treatment of non-small cell lung cancer. …”
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Estimation of D-dimer, C-reactive protein and ferritin in Covid-19 survivors in a North Indian Hospital, Lucknow, India. by Chetna Singla, Dhananjay Tiwari, Himali Jha, Mohammad Mustufa Khan, Sadaf Parveen, Roshan Alam

“… Background: Novel coronavirus disease (COVID-19), the disease caused by SARS-CoV-2, is a highly contagious disease. COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which was initially thought to affect only the upper respiratory tract, can affect almost all systems. …”
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Effects of Polycarboxylate-Lignosulfonate Superplasticizer on the Engineering Properties and Cementitious Paste Thickness of Pervious Concrete by Ehsan Teymouri, Nurul Noraziemah Mohd Pauzi, Wong Kwong Soon, Mehdi Forouzan, Marjan Salari

“…For this reason, 17 PC mixtures containing different portions of PLS (0.10% to 1.00% of the cement content), water-to-cement ratio (0.30 to 0.40), and cement content (315 to 350 kg/m3) with a constant range aggregate size (4.75 to 9.5 mm) were designed, tested, and analyzed by Design of Expert (DoE). …”
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Binding and cleavage of pro-urokinase by a tegument extract of Fasciola hepatica newly excysted juveniles activate the host fibrinolytic system by Judit Serrat, María Torres-Valle, Carolina De Marco Verissimo, Mar Siles-Lucas, Javier González-Miguel

“…Additionally, our results revealed that the tegument of FhNEJ contains a protease that is capable of cleaving and activating pro-u-PA into its catalytically active form, which positively impacts the capacity of the parasites to generate plasmin from the host PLG. …”
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