Base editing HbS to HbG-Makassar improves hemoglobin function supporting its use in sickle cell disease by Zachary Kostamo, Manuel A. Ortega, Chavonna Xu, Patricia R. Feliciano, Elizabeth Budak, Daisy Lam, Valerie Winton, Rebecca Jenkins, Archita Venugopal, Margaret Zhang, John Jamieson, Brent Coisman, Kennedy Goldsborough, Britney Hernandez, Celeste K. Kanne, Erica N. Evans, Jordan Zgodny, Yankai Zhang, Jawa Darazim, Ashwin Patel, Michael A. Pendergast, John Manis, Adam J. Hartigan, Giuseppe Ciaramella, Seung-Joo Lee, S. Haihua Chu, Vivien A. Sheehan

“…The topology of the hemoglobin fold with the βΕ6Α mutation is similar to HbA in the oxy and deoxy states. However, RBC containing HbGS are dehydrated, showing altered function and increased sickling under hypoxia. …”
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Physicochemical and structural properties of starches from non-traditional sources in China by Yang Jingyi, Chagam Koteswara Reddy, Zhili Fan, Baojun Xu

“…Results demonstrated that the isolated starches contained between 79.82 % to 86.56 % starch, indicating that the isolated starches had high purity. …”
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A step forward in enhancing the health-promoting properties of whole tomato as a functional food to lower the impact of non-communicable diseases by Pier Giorgio Natali, Pier Giorgio Natali, Mauro Piantelli, Alessandra Sottini, Margherita Eufemi, Cristina Banfi, Luisa Imberti

“…In this context, a whole tomato food supplement (WTFS), enriched by 2% olive wastewater containing a complex of healthy nutrients with converging biologic activities, has recently been developed, which is superior to those present in tomato commodities or obtained with whole tomato conventional processing methods. …”
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Effect of genomic regions harboring putative lethal haplotypes on reproductive performance in closed experimental selection lines of Nellore cattle by Gustavo R. D. Rodrigues, Joslaine N. S. G. Cyrillo, Lúcio F. M. Mota, Patrícia I. Schmidt, Júlia P. S. Valente, Eduarda S. Oliveira, Lúcia G. Albuquerque, Luiz F. Brito, Maria E. Z. Mercadante

“…Thus, this study aimed to identify genomic regions containing potential lethal haplotypes in Nellore breed; identify candidate genes located within these regions; and investigate the reproductive performance of heterozygous carriers of lethal haplotypes in Nellore cattle. …”
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Novel Optimized Support Vector Regression Networks for Estimating Fresh and Hardened Characteristics of SCC by Babak Naeim, Ali Javadzade Khiavi, Parisa Dolatimehr, Behnam Sadaghat

“…Fly ash-containing concrete has only been the subject of a small amount of research focused on forecasting the hardened concrete qualities. …”
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hnRNPH1 Inhibits Influenza Virus Replication by Binding Viral RNA by Ruixue Xue, Danqi Bao, Tianxin Ma, Shiqi Niu, Zihua Wu, Xuehua Lv, Yunxiang Zhang, Guanlong Xu, Dawei Yan, Zhifei Zhang, Xue Pan, Minghao Yan, Qiaoyang Teng, Chunxiu Yuan, Zejun Li, Qinfang Liu

“…The results showed that the host hnRNPH1 inhibits the replication of H1N1 and H9N2 influenza viruses by restraining the polymerase activity of viruses. hnRNPH1 contains two RNA recognition motifs (RRM1) and RRM2. …”
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Design Optimization of a Multistage Axial Flow Compressor Based on Full-Blade Surface Parameterization and Phased Strategy by Jinxin Cheng, Shengfeng Zhao, Zhaohui Dong, Chengwu Yang

“…A new design optimization method is proposed for the problem of high-precision aerodynamic design of multistage axial compressors. The method mainly contains three aspects: full-blade surface parametrization can significantly reduce the number of control variables per blade row and increase the degrees of freedom of the leading edge blade angle compared with the traditional semiblade parametric method; secondly, the artificial bee colony algorithm improved initialization and food source exploration and exploitation mechanism to enhance the global optimization ability and convergence speed, and a distributed optimization system is built on the supercomputing platform based on this method; finally, a phased optimization strategy based on the “synchronous change in multirow blades” is proposed, and expert experience is introduced to achieve a better balance between exploration and exploitation. …”
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Acetylcholinesterase Inhibitory and Antioxidant Activity of the Compounds Isolated from Vanda roxburghii by Salim Ahammed, Rejina Afrin, Nasim Uddin, Yusuf Al-Amin, Kamrul Hasan, Uzzal Haque, K. M. Monirul Islam, A. H. M. K. Alam, Toshihisa Tanaka, Golam Sadik

“…These findings revealed that V. roxburghii contained compounds with potential acetylcholinesterase inhibitory and antioxidant activity, which support its traditional use in the treatment of AD.…”
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The Preparation and Performances of Self-Dispersed Nanomicron Emulsified Wax Solid Lubricant Ewax for Drilling Fluids by Feng-shan Zhou, Ting-ting Wang, Zheng-qiang Xiong, Wen-yue Guo, Xi Xiang, Huan-na Wang, Xia-lei Zhu, Fang Liu, Bao-lin Cui

“…At last, a solidified self-dispersed nanomicron emulsified wax named as Ewax, a kind of solid lubricant for water based drilling fluid, was obtained after dried in the special soluble polymer containing emulsifying wax in low temperature. It is shown that the adhesion coefficient reduced rate (ΔKf) is 73.5% and the extreme pressure (E-P) friction coefficient reduced rate (Δf) is 77.6% when the produced Ewax sample was added to fresh water based drilling fluid at dosage 1.0 wt%. …”
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An efficient and environmentally friendly route for PbS crystal recovery from lead ash generated in tin removal section (LATR) via high-speed leaching and recrystallization method by Feng Y., Peng X.-Q., Shi H.-H., Zhang W., Zuo Q.-T.

“…Overall, this method proved to be an efficient and environmental friendly route for synthesis of high quality PbS crystal directly from the common lead containing waste from the lead ore or secondary smelting factory.…”
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Student Engagement Dataset (SED): An Online Learning Activity Dataset by M. S. S. Kassim, Z. H. Azizul, A. A. H. Ahmad Fuaad

“…The dataset consists of 16,609 students and 2,407 courses. It contains information such as grades and daily logged online activities (approximately 12 million data points), including temporal data across four tables. …”
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Pleuroperitoneal Leak Complicating Peritoneal Dialysis: A Case Series by C. Kennedy, C. McCarthy, S. Alken, J. McWilliams, R. k. Morgan, M. Denton, P. J. Conlon, C. Magee

“…Less frequently, a transudative pleural effusion containing dialysate can develop. This phenomenon appears to be due to increased intra-abdominal pressure in the setting of congenital or acquired diaphragmatic defects. …”
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Optimizing photocatalytic degradation of methyl violet dye in a recirculating slurry-type reactor by F. Shokry, M. El-Gedawy, S.A. Nosier, M.H. Abdel-Aziz

“…This study examined the photocatalytic degradation of wastewater containing methyl violet dye in a recirculating slurry-type reactor using commercial TiO2 as the photocatalyst under ultraviolet irradiation. …”
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Single-Round Patterned DNA Library Microarray Aptamer Lead Identification by Jennifer A. Martin, Peter A. Mirau, Yaroslav Chushak, Jorge L. Chávez, Rajesh R. Naik, Joshua A. Hagen, Nancy Kelley-Loughnane

“…A method for identifying an aptamer in a single round was developed using custom DNA microarrays containing computationally derived patterned libraries incorporating no information on the sequences of previously reported thrombin binding aptamers. …”
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A Network-Based Impact Measure for Propagated Losses in a Supply Chain Network Consisting of Resilient Components by Jesus Felix Bayta Valenzuela, Xiuju Fu, Gaoxi Xiao, Rick Siow Mong Goh

“…We obtain an analytical expression for the impact measure under a beta-distributed initial loss (generalizable to any continuous distribution supported on the interval 0,1), under a breakthrough scenario (in which a fraction of the initial production loss reaches a focal company downstream as opposed to containment upstream or at the originating point). Furthermore, we obtain a closed-form solution for a supply chain network with a k-ary tree topology; a numerical study is performed for a scale-free network and a random network. …”
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Nomenclatural standards of oat (<i>Avena sativa</i> L.) cultivars released by the Research Institute of Agriculture for the Northern Trans-Ural Region by M. N. Fomina, Yu. S. Ivanova, N. V. Lebedeva, I. V. Varganova

“…Each herbarium sheet contains an entire plant in the milk-ripeness stage, mature spikes, and grains samples.Results and conclusion. …”
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Amyloid-Beta Induced Changes in Vesicular Transport of BDNF in Hippocampal Neurons by Bianca Seifert, Robert Eckenstaler, Raik Rönicke, Julia Leschik, Beat Lutz, Klaus Reymann, Volkmar Lessmann, Tanja Brigadski

“…Taken together, extracellular cleavage products of APP induced rapid changes in anterograde and retrograde transport of BDNF-containing vesicles while release of BDNF was unaffected by transgenic expression of mutated APP. …”
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Nuclear-Targeting Delivery of CRISPRa System for Upregulation of β-Defensin against Virus Infection by Dexamethasone and Phenylalanine Dual-Modified Dendrimer by Mingxiang Zuo, Xiaoxia Li, Shuang Liu, Bin Chen, Du Cheng

“…The dual-modified dendrimer containing dexamethasone (DET) and phenylalanine (Phe) was prepared to deliver plasmid DNA encoding dCas9 and single-guide RNA (sgRNA) for specific upregulation of β-defensin. …”
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Nonlinear control design of a DC microgrid based on the integral sliding mode controller by Akli Hajar, Abouobaida Hassan, Mchaouar Youssef, Fathelkhair Abdelmoghit, Oualifi Khadija

“…This article is designed to control the stability and the effective operation in a different entity of DC microgrid(MG) under varying climatic and load conditions. The proposed MG contains primarily renewable sources including photovoltaics (PV) commanded by a DC-DC boost converter additionally the wind power conversion system with a turbine wind, a permanent magnet Synchronous Generator (PMSG), a three-phase diode rectifier, and ultimately a DC-DC buck-boost converter. …”
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Monkeypox: a re-emergent virus with global health implications – a comprehensive review by Nourhan G. Naga, Enas A. Nawar, A’laa A. Mobarak, Aya G. Faramawy, Hend M. H. Al-Kordy

“…Abstract Monkeypox virus (MPXV) is an enclosed, double-stranded DNA virus from the Orthopoxvirus genus, which also contains variola, vaccinia, and cowpox. MPXV, which was once confined to West and Central Africa, has recently had a rebound, spreading beyond its original range since 2017. …”
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