Challenges and opportunities for assessing trends of amphibians with heterogeneous data – a call for better metadata reporting by Klaus Henle, Reinhard A. Klenke, M. Benjamin Barth, Annegret Grimm-Seyfarth, Diana E. Bowler

“…Only for three species (Bufotes viridis, Hyla arborea and Pelophylax esculentus) were the trend results consistent amongst approaches and with expert opinions. …”
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ADAPTATION OF INTERPERSONAL COUNSELLING FOR ADOLESCENTS (IPC-A) FOR FINNISH STUDENT WELFARE SERVICES – RETROSPECTIVE EVALUATION BY USING AN EXPANDED FRAMEWORK FOR REPORTING ADAPTAT... by NOORA SEILO, KRISTIINA MÄMMI, OUTI LINNARANTA

“…The six domains of FRAME used were: 1) what was modified, 2) who made the decision to modify, 3) what was the goal, 4) when did the modification occur, 5) were the modifications fidelity-consistent, and 6) were adaptations planned. Results: The adaptation process of the IPC-A was conducted by several actors in research and healthcare, and it seemed uncoordinated. …”
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Combining Innovative Bioink and Low Cell Density for the Production of 3D-Bioprinted Cartilage Substitutes: A Pilot Study by Christel Henrionnet, Léa Pourchet, Paul Neybecker, Océane Messaoudi, Pierre Gillet, Damien Loeuille, Didier Mainard, Christophe Marquette, Astrid Pinzano

“…The described strategy is very promising for 3D bioprinting by the bioextrusion of an original bioink containing a low concentration of MSCs followed by the culture of the substitutes in hypoxic conditions under the combined influence of TGF-β1 and BMP-2.…”
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Previous treatment decreases efficacy of pralsetinib in RET fusion-positive non-small-cell lung cancer by Lei Wang, Yafei You, Wenzhuo He, Yu Hou, Lan Li, Li Wang, Chang Jiang, Jiahong Yi, Yaoxiong Xia, Liangping Xia

“…The objective response rate and disease control rate of the whole cohort were 57.2% and 71.4%, respectively, and the median PFS and OS were 8.1 months [95% confidence interval (CI), 3.1–13.2] and 13.8 months (95% CI, 2.8–24.8), respectively. …”
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Jackson–Vanik Amendment and Development of Soviet-American Relations in 1972-1975 by V. Yungblyud, D. Ilyin

“…Each of the parties involved regarded the Amendment differently: Soviet leaders saw it as a rude interference in the internal affairs of the USSR; Kissinger saw it as an untimely and too radical in form and methods attempt to transform the Soviet system; Jackson saw it as a good way to increase his popularity by exploiting a popular in the post-Vietnam era theme that was naturally consistent with American national values and traditions. …”
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Spatial analysis of measles cases and vaccination coverage in the Somali region, eastern Ethiopia by Abdilahi Ibrahim Muse, Abdilahi Ibrahim Muse, Mahdi Yonis Kayat, Mohamed Harir Aden, Jemal Beksisa Shuramu, Shikur Mohammed, Musse Ahmed Ibrahim, Musse Ahmed Ibrahim, Binyam Mohammedbirhan Berhe, Ahmed Abdi Kalinle, Sahardiid Ali Abdilahi

“…After the data completeness and consistency were ensured, it was cleaned and recoded. …”
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Helicobacter pylori infection diagnostics and choice of eradication treatment: results of inquiry of doctors from different regions of Russian Federation by N. N. Dekhnich, R. S. Kozlov, O. A. Sablin, Ye. A. Prischepova

“…Data acquisition provided voluntary anonymous application of questionnaire consisting of 12 questions that will allow estimating knowledge of indications to H. pylori testing, diagnostic methods for this infection and utilized antihelicobacter treatment modes. …”
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Environmental awareness factor of used cell phones by N. Wibowo, R. Nurcahyo, D.S. Gabriel

“…The fourth section determined the cell phone consumer behavior. The fifth section consisted of willingness to recycle. …”
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High-throughput untargeted metabolomics reveals metabolites and metabolic pathways that differentiate two divergent pig breeds by S. Bovo, M. Bolner, G. Schiavo, G. Galimberti, F. Bertolini, S. Dall’Olio, A. Ribani, P. Zambonelli, M. Gallo, L. Fontanesi

“…A general correlation network analysis based on Boruta−identified metabolites consisted of 31 singletons and 69 metabolites connected by 141 edges, with two large clusters (> 15 nodes), three medium clusters (3–6 nodes) and eight additional pairs, with most metabolites belonging to the same super pathway. …”
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Synergistic removal of organic and nutrients from landfill leachate using photobioreactor-cultivated microalgae-bacteria consortium by N. Emalya, Y. Yunardi, E. Munawar, S. Suhendrayatna, T. Tarmizi

“…Even with the introduction of carbon dioxide, the pollutant removal remained consistently high, suggesting that the addition of carbon dioxide did not significantly influence the overall process.…”
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Susceptibility to Ventricular Arrhythmias Resulting from Mutations in FKBP1B, PXDNL, and SCN9A Evaluated in hiPSC Cardiomyocytes by Hector Barajas-Martinez, Maya Smith, Dan Hu, Robert J. Goodrow, Colleen Puleo, Can Hasdemir, Charles Antzelevitch, Ryan Pfeiffer, Jacqueline A. Treat, Jonathan M. Cordeiro

“…We report an inherited cardiac arrhythmia syndrome consisting of Brugada and Early Repolarization Syndrome associated with variants in SCN9A, PXDNL, and FKBP1B. …”
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Global, regional, and national burden of young COPD, 1990–2021, with forecasts to 2050: a systematic analysis for the global burden of disease study 2021 by Yi Zhu, Tao Shen, Ruixin Guo, Ke Liu, Xiyu Cao, Xiuli Yang, Chuantao Zhang

“…From 1990 to 2021, both the prevalence and death rates showed a consistent downward trend across all age groups. Joinpoint regression analysis indicated a slight increase in both the ASPR (APC: 0.13; 95% CI: 0.06 to 0.19) and the ASIR (APC: 0.17; 95% CI: 0.10 to 0.24) during the period from 1990 to 1994. …”
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Tick-borne encephalitis: students’ attitude and knowledge analysis by R. Mineikytė, G. Navickaitė, J. Valaikienė

“…The study was conducted using an anonymous questionnaire, which was administered to 404 students studying at I–IV year medical courses (average age 20.7±1.56, range from 17 to 30 years). The questionnaire consisted of 21 semi-closed questions. There were 6 questions about TBE, its incidence, complications and treatment, 9 questions about preventive methods of tick-borne diseases, and 2 questions about information sources and how accessible this information is. …”
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Early experience of Sacubitril–Valsartan in heart failure with reduced ejection fraction in real‐world clinical setting by Charlotte Nordberg Backelin, Michael Fu, Charlotta Ljungman

“…Methods and results This retrospective cohort study consists of two parts. In Part 1 (eligibility study), all patients discharged from Sahlgrenska University Hospital due to HF were consecutively included during 1 year. …”
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Multimodal Pain Recognition in Postoperative Patients: Machine Learning Approach by Ajan Subramanian, Rui Cao, Emad Kasaeyan Naeini, Seyed Amir Hossein Aqajari, Thomas D Hughes, Michael-David Calderon, Kai Zheng, Nikil Dutt, Pasi Liljeberg, Sanna Salanterä, Ariana M Nelson, Amir M Rahmani

“…ResultsThe multimodal pain recognition models achieved an average balanced accuracy of over 80% across the different pain levels. RR models consistently outperformed other single modalities, particularly for lower pain intensities, while facial muscle activity (electromyogram) was most effective for distinguishing higher pain intensities. …”
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KAP of influenza, streptococcal pneumonia, and herpes zoster among community-dwelling older adults with chronic diseases in Nanjing city: a cross-sectional survey by Zhengkai SHEN, Siyu TIAN, Zhiyong WANG, Wenjing ZHU, Lirong DONG, Jinshui XU

“…MethodsThe study population consisted of 7 074 residents aged 60 years and older with hypertension or type 2 diabetes who were recruited through random cluster sampling from 32 community health centers in three districts of Nanjing city, Jiangsu province. …”
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Effectiveness of the BNT162b2 XBB.1.5-adapted vaccine against COVID-19 hospitalization related to the JN.1 variant in Europe: a test-negative case-control study using the id.DRIVE... by Jennifer L. Nguyen, Marianna Mitratza, Hannah R. Volkman, Leonie de Munter, Thao Mai Phuong Tran, Catia Marques, Mustapha Mustapha, Srinivas Valluri, Jingyan Yang, Andrés Antón, Irma Casas, Eduardo Conde-Sousa, Laura Drikite, Beate Grüner, Giancarlo Icardi, Gerrit Luit ten Kate, Charlotte Martin, Ainara Mira-Iglesias, Alejandro Orrico-Sánchez, Susana Otero-Romero, Gernot Rohde, Luis Jodar, John M. McLaughlin, Kaatje Bollaerts

“…Multivariable analyses were adjusted for symptom onset date, age, sex, and number of chronic conditions. Findings: Among 308 test-positive cases and 1117 test-negative controls, BNT162b2 XBB.1.5-adapted VE against hospitalization compared to no vaccination this season was 53.8% (95% CI 38.4–65.4) after a median of 63 days following vaccination. …”
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First-in-human dose escalation trial to evaluate the clinical safety and efficacy of an anti-MAGEA1 autologous TCR-transgenic T cell therapy in relapsed and refractory solid tumors by Ignacio I Wistuba, Mamta Kalra, Linus Backert, Martin Wermke, Edwin R Parra, Jason John Luke, Apostolia M Tsimberidou, Sebastian Bunk, Mohammad B Hossain, Andrea Mayer-Mokler, Arun Satelli, Norbert Hilf, Steffen Walter, Cedrik M Britten, Van K Morris, Tobias A W Holderried, Winfried H Alsdorf, Katrin Wetzko, Borje S Andersson, Sandra Grund-Gröschke, Katrin Aslan, Anantha Marisetty, Swapna Satam, Jens Hukelmann, M Alper Kursunel, Karine Pozo, Andreas Acs, Melissa Baumeister, Claudia Wagner, Oliver Schoor, Ali S Mohamed, Delfi Krishna

“…We investigated the safety and tolerability of IMA202 in a first-in-human, dose escalation basket trial in human leucocyte antigen A*02:01 positive patients with melanoma-associated antigen A1 (MAGEA1)-positive advanced solid tumors.Trial design The 2+2 trial design was an algorithmic design based on a maximally acceptable dose-limiting toxicity (DLT) rate of 25% and the sample size was driven by the algorithmic design with a maximum of 16 patients. IMA202 consists of autologous genetically modified cytotoxic CD8+ T cells expressing a T cell receptor (TCR), which is specific for a nine amino acid peptide derived from MAGEA1. …”
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Digital generation in the context of predicting the professional future by E. F. Zeer, N. G. Tserkovnikova, V. S. Tretyakova

“…The scientific novelty of the work consists in the enrichment of psychological and pedagogical science knowledge about the phenomenological characteristics of the digital generation in the context of vocational education and predicting the professional future.Practical significance. …”
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STING agonist-based treatment promotes vascular normalization and tertiary lymphoid structure formation in the therapeutic melanoma microenvironment by Walter J Storkus, Ronald J Fecek, Manoj Chelvanambi, Jennifer L Taylor

“…Therapeutic responses resulting from intratumoral STING activation were characterized by improved VN, enhanced tumor infiltration by CD8+ T cells and CD11c+ DCs and local TLS neogenesis, all of which were dependent on host expression of STING. Consistent with a central role for DC in TLS formation, ADU S-100-activated mCD11c+ DCs also exhibited upregulated expression of TLS promoting factors including lymphotoxin-α (LTA), interleukin (IL)-36, inflammatory chemokines and type I interferons in vitro and in vivo. …”
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