Optimal dietary vitamin E level facilitates ovarian development of female largemouth bass (Micropterus salmoides) broodstock by Qiuyu Gao, Qiao Feng, Dong Zhou, Zhili Ding, Changle Qi, Youqin Kong, Qiyou Xu

“…Meanwhile, it was observed that a predominant number of ovarian cells in fish fed 209.31 and 437.77 mg/kg of vitamin E had advanced to maturation, primarily consisting of mature oocytes at stage IV and V. Dietary vitamin E supplementation significantly upregulated the expression of genes involving vitamin E transfer, ovarian development, and hormone, including alpha-tocopherol transfer protein, luteinizing hormone, follicle-stimulating hormone, vitellogenin receptor (vgr), vitellogenin (vg), 17-beta-hydroxysteroid dehydrogenase (17β-hsd), cyclin-dependent kinase 2 (cdk2), and cytochrome P450 family 17 (cyp-17), with the highest expression levels detected in the 209.31 mg/kg group (P < 0.05). …”
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Surgical nonunion treatment of large-sized defects of femur and tibia based on the diamond concept by Sebastian Findeisen, Louis Mennerat, Thomas Ferbert, Lars Helbig, Tim N. Bewersdorf, Tobias Großner, Christian Schamberger, Gerhard Schmidmaier, Michael Tanner

“…Methods: The following retrospective, descriptive analysis consists of patients treated in our department between January 2010 and December 2021. …”
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Predicting bursal-side supraspinatus tendon tears with the acromioclavicular angle by Nadhaporn Saengpetch, Jaturong Bamrungchaowkasem, Niyata Chitrapazt, Pinkawas Kongmalai

“…Group 1 included patients with isolated bursal-side supraspinatus tendon tears confirmed by arthroscopy, while Group 2 consisted of age- and gender-matched controls without rotator cuff pathology. …”
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A generative whole-brain segmentation model for positron emission tomography images by Wenbo Li, Zhenxing Huang, Hongyan Tang, Yaping Wu, Yunlong Gao, Jing Qin, Jianmin Yuan, Yang Yang, Yan Zhang, Na Zhang, Hairong Zheng, Dong Liang, Meiyun Wang, Zhanli Hu

“…Furthermore, the evaluation of the SUV distribution and correlation assessment in the regions of interest demonstrated consistency with the ground truth. Additionally, clinical tolerance rates, which are determined by the tumor background ratio, have confirmed the ability of the method to distinguish highly metabolic regions accurately from normal regions, reinforcing its clinical applicability. …”
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Processing tomato (Lycopersicon esculentum Miller) yield and quality in arid regions through micro-nano aerated drip irrigation coupled with humic acid application by Jiaying Ma, Rui Chen, Yue Wen, Jinzhu Zhang, Feihu Yin, Tehseen Javed, Jiliang Zheng, Zhenhua Wang

“…Multiple regression and spatial analysis of yield, water use efficiency, and lycopene content indicated that, under micro-nano aeration, irrigation volumes between 445.700–446.833 mm, combined with 0.492–0.498 % HA, represent optimal irrigation strategies. These conditions ensured that yield (278.03–281.21 t ha–1), WUE (0.57–0.58 t ha–1 mm–1), lycopene content (56.28–56.76 mg kg–1), and Vc content (56.06–56.19 mg 100 g–1) remained above 95 % of their maximum values.…”
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Development of a horizontal transmission model to assess the effects of exposure to pathogenic E. cecorum during the hatching phase in broiler chickens by James Higuita, Marcela Arango, Aaron Forga, Mitch Rowland, Jundi Liu, Ross Wolfenden, Danielle Graham

“…Seeders were comingled with non-infected embryos, or contacts, for the remainder of embryogenesis. The experiment consisted of 7 treatment groups: (1) non-challenged control (NC), (2) EC5 Contacts, (3) EC5 Seeders, (4) EC7 Contacts, (5) EC7 Seeders, (6) EC11B Contacts, and (7) EC11B Seeders. …”
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A History of The Six-Year Primary Project in the Use of Yoruba as the Medium of Primary Education by Toyin Falola, Michael Oladejo Afolayan

“…In the last half a century or so, researchers have noticed the problem faced especially by developing nations in their language-related educational policies.1 Some countries, like Burundi, for example, have adopted this mentality and made English the official national language, in hopes that encouraging English will stimulate the economy and improve the job prospects of youth.2 However, research consistently shows that focusing entirely on English or any “majority language” at the detriment of one’s native language actually does more harm than good. …”
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Functional Characterization of the SHIP1-Domains Regarding Their Contribution to Inositol 5-Phosphatase Activity by Spike Murphy Müller, Nina Nelson, Manfred Jücker

“…The Src homology 2 domain-containing inositol 5-phosphatase 1 (SHIP1) is a multidomain protein consisting of two protein–protein interaction domains, the Src homology 2 (SH2) domain, and the proline-rich region (PRR), as well as three phosphoinositide-binding domains, the pleckstrin homology-like (PHL) domain, the 5-phosphatase (5PPase) domain, and the C2 domain. …”
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Shaping Administrative Activity (Legal Forms): A Legislative Approach by Sára Hrubešová

“…The paper also includes a case study consisting of a qualitative analysis of the legislative process in a specific case, based on publicly available records of parliamentary debates during the legislative process. …”
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Efficient Method for Robust Backdoor Detection and Removal in Feature Space Using Clean Data by Donik Vrsnak, Marko Subasic, Sven Loncaric

“…Extensive experiments on multiple datasets and attack methods demonstrate that, when compared to state-of-the-art methods such as Neural Cleanse, Neural Attention Distillation, I-BAU, BTI-DBF etc. the FEAT-IN method provides several benefits. It can more consistently detect and mitigate backdoor attacks than similar trigger inversion defense methods that conduct the defense in the input space instead of feature space (where, on average, it achieves approx. 10% higher decrease in attack success rate during mitigation compared to the second-best method). …”
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Characterization of the genomic landscape of canine diffuse large B-cell lymphoma reveals recurrent H3K27M mutations linked to progression-free survival by Anna Darlene van der Heiden, Raphaela Pensch, Sophie Agger, Heather L. Gardner, William Hendricks, Victoria Zismann, Shukmei Wong, Natalia Briones, Bryce Turner, Karin Forsberg-Nilsson, Cheryl London, Kerstin Lindblad-Toh, Maja Louise Arendt

“…We identified 26 recurrently mutated genes, 18 copy number gains, and 8 copy number losses. Consistent with prior studies, the most commonly mutated genes included TRAF3, FBXW7, POT1, TP53, SETD2, DDX3X and TBL1XR1. …”
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TCR-engaging scaffolds selectively expand antigen-specific T-cells with a favorable phenotype for adoptive cell therapy by Marco Donia, Özcan Met, Julie Westerlin Kjeldsen, Sine Reker Hadrup, Inge Marie Svane, Arianna Draghi, Anders Handrup Kverneland, Christina Heeke, Siri Amanda Tvingsholm, Marcus Svensson Frej, Vibeke Mindahl Rafa, Ulla Kring Hansen, Maria Ormhøj, Alexander Tyron, Agnete W P Jensen, Mohammad Kadivar, Amalie Kai Bentzen, Kamilla K Munk, Gitte N Aasbjerg, Jeppe S H Ternander, Tripti Tamhane, Christian Schmess, Samuel A. Funt, Søren Nyboe Jakobsen

“…Here, in this study, we present a novel technology for ex vivo expansion of antigen-specific T-cells; artificial antigen-presenting scaffolds (Ag-scaffolds) consisting of a dextran-polysaccharide backbone, decorated with combinations of peptide-Major Histocompatibility Complex (pMHC), cytokines and co-stimulatory molecules, enabling coordinated stimulation of antigen-specific T-cells.Methods The capacity of Ag-scaffolds to expand antigen-specific T-cells was explored in ex vivo cultures with peripheral blood mononuclear cells from healthy donors and patients with metastatic melanoma. …”
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Non-Alcoholic Fatty Liver Disease in Cardiac Patients with Overweight and Obesity by I. V. Logacheva, T. A. Ryazanova, V. R. Makarova, O. V. Surnina

“…In this research, we set out to study organic changes in the heart and blood vessels of obese men suffering from non-alcoholic fatty liver disease (NAFLD) combined with cardiac pathology in the metabolically unhealthy phenotype (MUHP). Another objective consisted in establishing a relationship between liver damage and the pathology of the heart and blood vessels.Materials and methods. …”
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On the Uniform Projection Problem in Descriptive Set Theory by Vladimir Kanovei, Vassily Lyubetsky

“…There exists a linear <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msubsup><mi>Δ</mi><mrow><mi mathvariant="double-struck">n</mi><mo>+</mo><mn>2</mn></mrow><mn>1</mn></msubsup></semantics></math></inline-formula> set not equal to the projection of any uniform planar <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msubsup><mrow><mi mathvariant="bold">Π</mi></mrow><mrow><mi mathvariant="double-struck">n</mi><mo>+</mo><mn>1</mn></mrow><mn>1</mn></msubsup></semantics></math></inline-formula> set. Ensuing consistency and independence corollaries are discussed.…”
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Medication related osteonecrosis (MRONJ) in the management of CTIBL in breast and prostate cancer patients. Joint report by SIPMO AND SIOMMMS by Francesco Bertoldo, Cristina Eller-Vainicher, Vittorio Fusco, Rodolfo Mauceri, Jessica Pepe, Alberto Bedogni, Andrea Palermo, Umberto Romeo, Giuseppe Guglielmi, Giuseppina Campisi

“…However, there is not clarity about strategies aimed to minimize the MRONJ risk in cancer patients at different conditions as low- vs high-doses of BMA. This joint report from the Italian Societies of Oral Pathology and Medicine (SIPMO) and of Italian Society of Osteoporosis, Mineral Metabolism and Skeletal Diseases (SIOMMMS) aims to define the dental management of breast and prostate cancer patients with CTIBL under LD-BMAs, to reduce their risk to develop MRONJ. …”
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The Topographic Relationships and Geographic Distribution of Prevascular Vitreous Fissures and Cisterns Assessed by Ultrawidefield En Face Vitreous Images by Fei Deng, MD, Mengying Tao, MD, Yanjie Zhu, MD, Xiaoyu Xu, MD, Yue Wu, MD, Lisha Li, Ying Lin, MD, PhD, Yan Luo, MD, PhD

“…Additionally, all preretinal liquefaction spaces, including the PPVP, PVFs, and cisterns, were consistently located overlying the vitreoretinal tightly adhered regions. …”
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Identification of prognostic biomarker of non-small cell lung cancer based on mitochondrial permeability transition-driven necrosis-related genes and determination of anti-tumor ef... by Zhifei Ma, Wen Chen, Aiping Zhang, Xiaokang Shen, Lin Zheng

“…RT-qPCR confirmed that expression levels of three genes in tissues or cells were consistent with the results of bioinformatics analysis. …”
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Effect of trilaciclib administered before chemotherapy in patients with extensive-stage small-cell lung cancer: A pooled analysis of four randomized studies by Ying Liu, Lin Wu, Dingzhi Huang, Qiming Wang, Chen Yang, Li Zhou, Shuguang Sun, Xiaomei Jiang, Ying Cheng

“…General significance of the findings: The consistent efficacy of trilaciclib can be observed from pooled data across different treatment lines. …”
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The mechanism of tea tree oil regulating the damage of hydrogen sulfide to spleen and intestine of chicken by Yachao Wang, Yilei Liang, Yan Huang, Wei wang, Xiaoyan Long, Li Jiang, Tingting Cheng, Jinfeng Du, Xuegang Luo

“…A total of 240 one-day-old Lohmann Brown chicks were randomly divided into three groups: the control group (CON), the H2S exposure group (AVG), and the TTO treatment group (TTG), with four replicates, each consisting of 20 chicks. The experiment lasted 42 days. …”
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Neurotrophin-3 as a mediator in the link between PM2.5 exposure and psychiatric disorders: A Mendelian randomization study by Yuan Zhang, Wei Wang, Xuening Zhang, Ran Jing, Xin Wen, Peng Xiao, Xinjie Liu, Zengle Zhao, Tongmin Chang, Yufei Li, Wen Liu, Chenxi Sun, Xiaorong Yang, Lejin Yang, Ming Lu

“…Results: Our findings indicated that PM2.5 was positively associated with major depressive disorder (odds ratio (OR): 1.33, 95 % confidence interval (CI): 1.11–1.55), anxiety disorder (OR: 2.96, 95 % CI: 2.13–3.79), schizophrenia (OR: 1.55, 95 % CI: 1.29–1.81), and attention deficit hyperactivity disorder (ADHD) (OR: 1.95, 95 % CI: 1.66–2.24). …”
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