Pulmonary hypertension in Finland 2008-2020: A descriptive real-world cohort study (FINPAH) by Markku Pentikäinen, Piia Simonen, Helena Tuunanen, Pauliina Leskelä, Terttu Harju, Pertti Jääskeläinen, Christian Asseburg, Minna Oksanen, Erkki Soini, Christina Wennerström, Airi Puhakka, Terttu Harju, Elina Heliövaara, Pertti Jääskeläinen, Katriina Kahlos, Pentti Korhonen, Tiina Kyllönen, Pauliina Leskelä, Kirsi Majamaa-Voltti, Piia Simonen, Anu Turpeinen, Helena Tuunanen, Ville Vepsäläinen, Tapani Vihinen

“…Mean age at diagnosis of PAH patients (n = 268) was 57 years, 73% were women, 40% had idiopathic PAH, 28% associated with connective tissue diseases, and 15% with congenital heart disease, 9% had ≥3 cardiovascular comorbidities. …”
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MicroRNA-541-3p/Rac2 signaling bridges radiation-induced lung injury and repair by Jiandong Zhang, Lei Ma, Limin He, Quanxiao Xu, Yan Ding, Lidong Wang

“…We also found that microRNA-541-3p is differentially expressed in radiation-damaged lungs. The connection between microRNA-541-3p, TNFRSF10B signaling, and TGFβ1 signaling is also unclear. …”
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Evolution of artificial intelligence in healthcare: a 30-year bibliometric study by Yaojue Xie, Yuansheng Zhai, Yuansheng Zhai, Guihua Lu, Guihua Lu

“…Additionally, medical artificial intelligence research is dynamically evolving with the advent of new technologies. Moving forward, concerted efforts to bolster international collaboration and enhance comprehension and utilization of AI technologies are imperative for fostering novel innovations in healthcare.…”
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Magnetohydrodynamic nanofluids flow and heat transfer with radiative heat flux and exothermic chemical reactions by Md. Mehedi Hasan, M.J. Uddin, Salah A. Faroughi

“…The results indicate that, for the copper oxide-water nanofluid, both the thermal Rayleigh number and the exothermic chemical reaction parameter significantly impact the convective flow. The average Nusselt number exhibits an increasing trend with rising Frank–Kamenetskii and Rayleigh numbers but follows a decreasing pattern with an increase in the radiation parameter. …”
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Oridonin: A natural terpenoid having the potential to modulate apoptosis and survival signaling in cancer by Abhishek Chauhan, Hemant Joshi, Divya Kandari, Diwakar Aggarwal, Ritu Chauhan, Hardeep Singh Tuli, Arpit Mehrotra, Abhilasha Sood, Ujjawal Sharma, Darin Mansor Mathkor, Shafiul Haque, Naveen Chandra Joshi, Laurent Dufossé

“…It demonstrates efficacy in inducing apoptosis, suppressing cancer cell proliferation, and sensitizing cells to conventional chemotherapeutics by modulating key signaling pathways like PI3K/AKT, MAPKs, and NF-κB. …”
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Carbon Monoxide and Particulate Matter Concentrations inside the Road Tunnels of Guanajuato City, Mexico by Adrián Zamorategui-Molina, Norma L. Gutiérrez-Ortega, Juan Carlos Baltazar-Vera, Julio Del Ángel-Soto, David Tirado-Torres

“…Abstract In the city of Guanajuato, Mexico, road tunnels offer drivers an effective means of avoiding traffic congestion. Additionally, they enable pedestrians to reduce their travel time and distance. …”
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Protective effects of apigenin in neurodegeneration: An update on the potential mechanisms by Ali Mohammadkhanizadeh, Mohammad Sheibani, Soroush Taherkhani, Davood Nourabadi, Seyed Mahdi Mohamadi-Zarch, Farnaz Nikbakht, Yaser Azizi

“…Neurodegenerative diseases (NDs) are characterized by the progressive loss of neurons and neuronal connections, leading to cognitive decline, memory impairment, and motor dysfunction. …”
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Characterizing PM2.5 Secondary Aerosols via a Fusion Strategy of Two-stage Positive Matrix Factorization and Robust Regression by Chun-Sheng Huang, Ho-Tang Liao, Chia-Yang Chen, Li-Hao Young, Ta-Chih Hsiao, Tsung-I Chou, Jyun-Min Chang, Kuan-Lin Lai, Chang-Fu Wu

“…Retrieved factors from PMF were averaged over 24-h intervals and then applied in robust regression analysis to re-apportion the contributions. Comparing with conventional PMF, downweighting the secondary aerosol-related species in the model was more effective in linking them to primary emission sources. …”
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Phase 1 study of safety, tolerability, and efficacy of intradermal DNA vaccine ASP2390 in adults allergic to house dust mites by Thomas Kayser, MD, BS, Ronald Smulders, MD, PhD, Tomohiro Kusawake, PhD, Erik Wambre, PhD, Gurunadh R. Chichili, PhD, Mary B. Blauwet, DrPH, Anna Spence, MS, Melanie Patton, BS, Rima Tabash, PhD, Hannah A. DeBerg, PhD, Sugandhika Khosa, MS, Philipp Badorrek, MD, Jens M. Hohlfeld, MD, Brian C. Ferslew, PharmD, PhD

“…Background: House dust mite (HDM) allergies are prevalent, yet current treatments like allergen avoidance, pharmacotherapy, and conventional allergen immunotherapy present limitations. …”
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Requirements and special considerations for drug trials with children across six jurisdictions: 2. Ethics review in the regulatory approval process by Breanne Stewart, Pirkko Lepola, Gunter F. Egger, Fahimeda Ali, Albert J. Allen, Albert J. Allen, Alysha K. Croker, Andrew J. Davidson, Pamela Dicks, Saul N. Faust, Saul N. Faust, Dionna Green, Collin Hovinga, Collin Hovinga, Agnes V. Klein, Robyn Langham, Hidefumi Nakamura, Laura Pioppo, Shiva Ramroop, Michiyo Sakiyama, Isabel Sanchez Vigil de la Villa, Junko Sato, Donna L. Snyder, Mark A. Turner, Mark A. Turner, Sarah Zaidi, Kanecia Zimmerman, Kanecia Zimmerman, Thierry Lacaze-Masmonteil

“…This work, undertaken by the Working Group (WG) on International Collaborations at the European Network of Pediatric Research at the European Medicines Agency (Enpr-EMA) aims to describe the research ethics review requirements including any pediatric specific requirements, as well as current or upcoming changes across six jurisdictions – the European Union (EU), United Kingdom (UK), United States of America (USA), Canada, Japan, and Australia.MethodsAn open questionnaire developed by the WG and directed at both the Competent Authorities (CA) and the national pediatric clinical trial networks arranged by jurisdictions.ResultsA synopsis of the current regulatory requirements covers centralized versus independent review, comparisons between investigator initiated and industry sponsored clinical trials, timelines, review board members requirements and the consenting/assent process for clinical trial (CT) applications, application submission processes and application requirements for each of the six jurisdictions. …”
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Investigation of the Predictive Factors of Recurrent Ovarian Mucinous Cystadenoma by Aykut Ozcan, Meric Balikoglu, Kaan Okan Alkan, Varol Gulseren

“…CONCLUSION: Unlike conventional ovarian cystadenomas, mucinous cystadenomas should be followed up owing to the possibility of recurrence, especially when detected at an early age. …”
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A Real-Time Human Pose Measurement System for Human-In-The-Loop Dynamic Simulators by Nicola Giulietti, Davide Todesca, Marco Carnevale, Hermes Giberti

“…The YOLOv8x-pose model with four cameras achieves the highest accuracy, with a Mean-Per-Joint Position Error of 18.2 mm and an execution time of 15 ms, outperforming state-of-the-art methods. Converting models to the TensorRT framework reduces execution time by 4.2 ms without significant accuracy loss. …”
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Implementing a rapid geographic range expansion - the role of behavior changes by Logan, Corina, McCune, Kelsey, LeGrande-Rolls, Christa, Marfori, Zara, Hubbard, Josephine, Lukas, Dieter

“…Our findings highlight the value of population studies and of breaking down cognitive concepts into direct measures of individual abilities to better understand how species might adapt to novel circumstances. …”
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Modified Mosquito Programs’ Surveillance Needs and An Image-Based Identification Tool to Address Them by Jewell Brey, Bala Murali Manoghar Sai Sudhakar, Kiley Gersch, Tristan Ford, Margaret Glancey, Jennifer West, Sanket Padmanabhan, Angela F. Harris, Autumn Goodwin

“…Health districts often lack the resources needed to collect essential data, and conventional entomological species identification involves a significant learning curve to produce consistent high accuracy data. …”
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Assessing Medical Students’ Learning Style Preferences at Kabale University Medical School, Uganda. by Muhaise, Hussein, Businge, Phelix Mbabazi, Ssemaluulu, Paul, Kyomugisha, Patricia

“…The study was prompted by a paradigm shift in teaching-learning strategies from the conventional knowledge-based medical curriculum to competency-based medical education (CMBE). …”
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Relationship Between Attitudes, Academic Performance, Gender and Choice of Agricultural Careers Among Secondary School Students in Kanungu District Uganda. by Byaruhanga, Hillary

“…The study focused on specific objectives, including examining the relationship between students' attitudes towards agriculture and their choice of agricultural careers, investigating how agricultural academic performance influences the choice of agricultural careers, and exploring the connection between students' attitudes towards agriculture and their agriculture scores. …”
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Students’ Attitudes and Performance in Mathematics in Secondary Schools in Kakira Town Council in Jinja District. by Kasononta, Ronald

“…The students and teachers responded to the questionnaires and data was collected, calculated, and converted into percentages. The study found out that most students had a positive attitude towards mathematics and that they perceived mathematics as doable, learnable, and important yet this did not translate to good grades. …”
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Impact of Social Classes on Academic Performance of Pupils in Public Primary Schools in Kabale District. by Ampeire, Justus

“…Quantitative data was analyzed using statistics and numerical tools to ensure objectivity, while qualitative data generated concepts and strategies. The findings revealed that age (36.6%) was one of the primary social classes affecting pupils’ academic performance, with age sets influencing the allocation of rewards and status, which, in turn, impacted educational outcomes. …”
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Bee Venom—A Potential Complementary Medicine Candidate for SARS-CoV-2 Infections by Keneth Iceland, Kasozi, Simon Peter, Musinguzi

“…SARS-CoV-2 directly interacts with angiotensin-converting enzyme 2 (ACE-2) receptors in the human body. …”
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Student Engagement and Feedback on Online Learning and Facilitation: A Case Study of the National Open University of Nigeria by Adewale Adesina, Dorothy Ofoha, Olufemi A. Peters, Isaac S. Butswat

“…It is important for NOUN to address these issues by providing more flexible timetables, exploring options for reducing facilitation costs, and ensuring students have access to stable internet connections to improve their engagement in online facilitations. …”
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