iRGD-Targeted Biosynthetic Nanobubbles for Ultrasound Molecular Imaging of Osteosarcoma by Liu T, Liang X, Liu W, Yang S, Cui T, Yan F, Li Z

“…However, there is a lack of effective means for early diagnosis due to the heterogeneity of tumors and the complexity of tumor microenvironment. αvβ 3 integrin, a crucial role in the growth and spread of tumors, is not only an effective biomarker for cancer angiogenesis, but also highly expressed in many tumor cells. …”
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Active biomonitoring in streams by using multimarker approaches of mussels by T. Ukasha, N.U.H. Faisal, B.K. Adji, A.P. Nugroho

“…The combined effects of the complexity of environmental factors on the biomarkers were analyzed by multiple-factor analysis.FINDINGS: The Code Stream waters at all stations were polluted with microplastics and copper. …”
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L’emploi antique des géomatériaux à Reims/Durocortorum by Gilles Fronteau, Sébastien Laratte, Alain Devos, Claire Pichard

“…In addition, its modest geotechnical qualities exclude it from use in construction of large complexes, which therefore would have required the importation of other materials. …”
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Presenting a Leadership Empowerment Model through Sense-making by Using the Cognitive and Behavioral Scripts by Hamid Zare, Aliasghar Pourezzat, Hasan Zareei Matin, Arezoo Salmani

“…In today’s era, which is characterized by a remarkably rapid pace of information transmission, distinguishing between good and bad decisions becomes particularly challenging, especially in the face of ongoing crises and environmental changes that introduce significant complexity to the process of sense-making. Indeed, in many scenarios, an individual’s perception of reality can hold more significant implications than reality itself. …”
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Identifying and Ranking the Causes of Delay Based on Production Strategies in Manufacturing Projects by Mohsen Rouzbahani, Mohammad Forozandeh

“…Purpose: Today, due to the increase in complexities and uncertainties faced by manufacturing organizations, the production of products faces planned/unplanned events that happen during the production life cycle. …”
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Toward Understanding of Quiet Human Resource Management Theory in Iranian Organizations: Theoretical Origins, Conceptual Narration and its Consequences by Abbas Nargesian, Sajjad Sadpoor

“…The findings of this study offer critical insights for management practitioners navigating the complexities of quiet HRM. By understanding the underlying factors that contribute to quiet HRM practices, organizations can implement strategies to reduce their negative effects and foster a more transparent, just, and supportive work environment. …”
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In silico analysis of the effect of HCV genotype-specific polymorphisms in Core, NS3, NS5A, and NS5B proteins on T-cell epitope processing and presentation by Samina Baig, Samina Baig, Assel Berikkara, Ramsha Khalid, Syed A. Subhan, Tanveer Abbas, Syed Hani Abidi

“…In silico results reveal that epitopes from genotype 6b (NS3), 6d/r (NS5B), 6o and 6 k (NS5A) exhibit higher immunogenicity than other genotypes, forming more energetically stable complexes with host receptors. These epitopes, compared to those from the same positions but different genotypes, showed binding energies of −144.24 kcal/mol, −85.30 kcal/mol, and − 43 kcal/mol, respectively. …”
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Differences in the intrahepatic expression of immune checkpoint molecules on T cells and natural killer cells in chronic HBV patients by Lucile Dumolard, Marie-Noelle Hilleret, Marie-Noelle Hilleret, Charlotte Costentin, Charlotte Costentin, Marion Mercey-Ressejac, Marion Mercey-Ressejac, Nathalie Sturm, Nathalie Sturm, Theophile Gerster, Thomas Decaens, Thomas Decaens, Evelyne Jouvin-Marche, Patrice N. Marche, Zuzana Macek Jilkova, Zuzana Macek Jilkova

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Mass Casualty Incident Training in Immersive Virtual Reality: Quasi-Experimental Evaluation of Multimethod Performance Indicators by Anke Sabine Baetzner, Yannick Hill, Benjamin Roszipal, Solène Gerwann, Matthias Beutel, Tanja Birrenbach, Markus Karlseder, Stefan Mohr, Gabriel Alexander Salg, Helmut Schrom-Feiertag, Marie Ottilie Frenkel, Cornelia Wrzus

“…MethodsA total of 76 participants (mean age 25.54, SD 6.01 y; 45/76, 59% male) with different medical expertise (MFRs: paramedics and emergency physicians; non-MFRs: medical students, in-hospital nurses, and other physicians) participated in 5 virtual MCI scenarios of varying complexity in a randomized order. Tasks involved assessing the situation, triaging virtual patients, and transmitting relevant information to a control center. …”
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Designing a Conceptual model for Evaluating the Performance of Software Developers in Fintech Organizations by Hassan Javadi, Fereshteh Amin

“…ObjectiveSoftware developers occupy top ranks within fintech organizations, representing a significant portion of human capital costs. The complexity of software development tools, the application of specialized knowledge, diverse work attitudes, varying levels of interaction, team distribution, and individual differences in behavior and personality all contribute to making the performance management of software developers a distinct and challenging task in fintech organizations. …”
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Risk barriers and sustainability in payment for ecosystem service implementation in smallholder forestry by A. Ibrahim, S. Withaningsih, R. Kinseng, Parikesit ., D. Muhamad

“…The importance of reliable data is emphasized by technical hurdles like accurate measurement of ecosystem services and monitoring complexities, necessitating innovative solutions and robust methodologies. …”
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Les paysages mémoriels de la Grande Guerre (1914-1918) : un changement de paradigme dans la recherche sur le tourisme de mémoire by Myriam Jansen-Verbeke, Wanda George

“…Seule une étude comparative et équilibrée du point de vue géographique permet de mieux appréhender la relation complexe des nations et des peuples du 21e siècle avec le patrimoine de mémoire, tangible et intangible, du siècle précédent. …”
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Optimization design of liquid crystal-based reconfigurable intelligent surface-assisted indoor visible light communication systems by Lisu YU, Xinxin LÜ, Run ZHONG, Mingli ZHANG, Zhenghai WANG, Yuhao WANG

“…The system performance is evaluated by solving a sum-rate maximization problem that accounts for practical scenarios such as the presence of nonuser-obscured LoS paths between the transmitter and the receiver. A low-complexity algorithm using fractional programming and step-by-step optimization is recommended for managing perfect channel state information. …”
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Ethnobotanical survey of medicinal plants used in management of breast cancers in Qatar by Rasha.S.Abo El Alaa, Hend Al-Jaber, Fatima Al Zahraa Chokor, Abdullah A. Shaito, Layla Al-Mansoori

“…Breast cancer is a global health concern, including in Qatar, where it impacts women significantly. The complexity of breast cancer requires diverse treatment approaches influenced by tumor characteristics and biology. …”
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Prognostic and clinicopathological role of soluble programmed cell death ligand-1 in patients with diffuse large B-cell lymphoma: a meta-analysis by Hongbin Lu, Lulu Luo, Jie Mi, Min Sun, Huaping Wang, Zheng Wang, Wenwen Ding

“…The value of sPD-L1 in predicting the overall survival (OS) and progression-free survival (PFS) of patients with DLBCL was analyzed by computing the combined hazard ratios (HRs) and 95% confidence intervals (CIs). …”
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Global trends and research frontiers on machine learning in sustainable animal production in times of climate change: Bibliometric analysis aimed at insights and orientations for t... by Robson Mateus Freitas Silveira, Concepta Mcmanus, Iran José Oliveira da Siva

“…The main insights generated in the bibliometric analysis were (i) sustainable animal production changed from unidisciplinary science to multidisciplinary science linked to agricultural, environmental and engineering sciences, mainly to genetics and computing; (ii) the concept of sustainable animal production emerged from animal welfare and climate change concepts found in UN's 2030 Agenda; (iii) omics sciences, greenhouse gases, energy efficiency and animal welfare are the main keywords for bibliometric analyses in future studies related to sustainable animal production in the coming centuries; (iii) prediction and classification analyses, i.e., supervised machine learning models used as main tools in animal production; (iv) residual feed intake applied to measure sustainable feed efficiency in animal farming in the past and nowadays; and (v) The United States, China, Brazil and Australia are the main countries publishing studies on sustainability in animal production, but only China has been gaining prominence in publications in this field, in recent years, and it will turn this country into an emerging leader in future publications on this topic. …”
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Elevated miR-221-3p inhibits epithelial–mesenchymal transition and biochemical recurrence of prostate cancer via targeting KPNA2: an evidence-based and knowledge-guided strategy by Dingchao Li, Jingang Jian, Manhong Shi, Zihao Chen, Anguo Zhao, Xuedong Wei, Yuhua Huang, Yalan Chen, Jianquan Hou, Yuxin Lin

“…Finally, a key gene was computationally identified and experimentally validated using cell line and clinical samples through EdU assay, scratch assay, transwell assay, dual-luciferase reporter assay and the epithelial-to-mesenchymal transition (EMT)-related analysis. …”
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Bees on the run: Nosema spp. (Microsporidia) in Apis mellifera and related products, Italy by Giovanni Sgroi, Luigi Jacopo D’Auria, Luigi Jacopo D’Auria, Maria Gabriella Lucibelli, Andrea Mancusi, Yolande Thérèsa Rose Proroga, Mauro Esposito, Mauro Esposito, Simona Rea, Daniel Signorelli, Federica Gargano, Nicola D’Alessio, Ranju Ravindran Santhakumari Manoj, Peyman Khademi, Giuseppe Rofrano, Giuseppe Rofrano

“…Whereas all sequences of N. apis were identical to each other, four sequences types of N. ceranae characterized by single nucleotide polymorphisms (SNPs) were identified. The computation of polymorphisms revealed high haplotype diversity (i.e., Hd = 1.000) and low nucleotide diversity (i.e., Pi = 0.00913) of N. ceranae sequence types.DiscussionThis study reveals a high circulation of N. apis and N. ceranae in Southwestern Italy, indicating the need for improved monitoring of these microsporidia to protect bee welfare and bee industry.…”
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Recombinase-based amplification coupled with lateral flow chromatography for the specific and sensitive detection and identification of Leishmania major in cutaneous leishmaniasis... by Insaf Bel Hadj Ali, Yusr Saadi-Ben Aoun, Imen Khammeri, Hejer Souguir, Emna Harigua-Souiai, Hamed Chouaieb, Ahmed S. Chakroun, Meryem Lemrani, Aicha Kallel, Kalthoum Kallel, Nabil Haddad, Oussaima El Dbouni, Rhea N. Coler, Rhea N. Coler, Rhea N. Coler, Steven G. Reed, Akila Fathallah-Mili, Akila Fathallah-Mili, Ikram Guizani

“…Here, we aimed for a simple and rapid molecular diagnostic test to detect and identify L. major, a predominant CL causal species, which could be prone to become a control tool at the point of care, in endemic areas, using isothermal recombinase DNA amplification (recombinase polymerase amplification, RPA, or recombinase aided amplification, RAA) coupled to detection by the lateral flow (LF) chromatography on a PCRD cassette.MethodsTo develop an L. major species-specific RPA-LF assay, computational analysis of 70 Leishmania DNA targets, identified through bibliography and database searches, selected five targets. …”
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Combinatorial functionomics identifies HDAC6-dependent molecular vulnerability of radioresistant head and neck cancer by Sharon Pei Yi Chan, Celestia Pei Xuan Yeo, Boon Hao Hong, Evelyn Mui Cheng Tan, Chaw Yee Beh, Eugenia Li Ling Yeo, Dennis Jun Jie Poon, Pek Lim Chu, Khee Chee Soo, Melvin Lee Kiang Chua, Edward Kai-Hua Chow

“…Drug combination efficacy was evaluated by computing combination index scores, and by measuring apoptotic response. …”
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