Macrophage heterogeneity and oncogenic mechanisms in lung adenocarcinoma: insights from scRNA-seq analysis and predictive modeling by Han Zhang, Jiaxing Dai, Qiuqiao Mu, Xiaojiang Zhao, Ziao Lin, Ziao Lin, Kai Wang, Meng Wang, Meng Wang, Daqiang Sun

“…Specifically, we used scRNA-seq data processing, intercellular communication analysis, pseudotime trajectory analysis, and transcription factor regulatory analysis to reveal the complexity of macrophage subpopulations. Data from The Cancer Genome Atlas (TCGA) was used to assess the impact of various macrophage subtypes on LUAD prognosis. …”
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Rumen DNA virome and its relationship with feed efficiency in dairy cows by Xiaohan Liu, Yifan Tang, Hongyi Chen, Jian-Xin Liu, Hui-Zeng Sun

“…Conclusions This study constructed a comprehensive rumen DNA virome profile for Holstein dairy cows, elucidating the structural and functional complexity of rumen viruses, the roles of AMGs, and vOTU-hMAG linkages. …”
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Mindfulness Intervention for Health Information Avoidance in Older Adults: Mixed Methods Study by Chenyu Gu, Liquan Qian, Xiaojie Zhuo

“… BackgroundThe global aging population and rapid development of digital technology have made health management among older adults an urgent public health issue. The complexity of online health information often leads to psychological challenges, such as cyberchondria, exacerbating health information avoidance behaviors. …”
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Towards Meaningful Interpretation of Molecular Data: Insights Gained from HMMD Challenges in <i>Salmonella</i> Detection for Future NGS Integration in Clinical Microbiology by Hyunji Kim, Soo Hyun Seo, Jae-Seok Kim, Kwang Jun Lee, Kyoung Un Park

“…As NGS moves toward clinical application, establishing similar interpretive standards will be essential to manage the complexity and volume of molecular data effectively.…”
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Balanced crystalloid versus saline for resuscitation in pediatric septic shock: a systematic review and meta-analysis by Barkhá Vijendra, Ana Beatriz Bertol, Mylena Maria Guedes de Almeida, Pedro Henrique Aquino Gil de Freitas, Áurea Maria Salomão Simão, Bianca Lisa de Faria

“…These results underscore the complexity of fluid management in pediatric septic shock and emphasize the need for further research.…”
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Reflections of Foster Youth Engaging in the Co-Design of Digital Mental Health Technology: Duoethnography Study by Ifunanya Ezimora, Tylia Lundberg, Dylan Miars, Jeruel Trujeque, Ashley Papias, Margareth V Del Cid, Johanna B Folk, Marina Tolou-Shams

“…Discussions pertaining to building community and safe spaces highlighted the positive effect of foster youth communities on co-designers, and discussions related to identity revealed the complexities associated with understanding and embracing foster youth identity. …”
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Hydro-mechanical behavior of two clayey soils in presence of household waste leachates by H. Yonli, B. François, D. Toguyeni, A. Pantet

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Pressurised water flow in fractured permafrost rocks revealed by borehole temperature, electrical resistivity tomography, and piezometric pressure by M. Offer, M. Offer, S. Weber, S. Weber, M. Krautblatter, I. Hartmeyer, M. Keuschnig

“…However, quantifying the role of water flow remains challenging, primarily due to the complexities associated with direct observation and the transient nature of water dynamics in rock slope systems. …”
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Combined multi-scale characterization of pores in ultra-thick coal seams of Jurassic Xishanyao Formation, Tiaohu-Malang sags, Santanghu Basin by Yue CHEN, Qiqi LEI, Dongmin MA, Xin WANG, Xinggang WANG, Diefang HUANG, Gaoxiang RONG

“…For the 9-2 coal sample, the fractal dimensions of micropores and small pores are 2.53 and 2.63, respectively, indicating higher complexity and better permeability connectivity. Multifractal characteristics analysis shows that pores of small diameters exhibit a more concentrated distribution and a narrower range, with stronger heterogeneity. …”
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Transplantation of mitochondria from human malignant tumor cells as a method of tumor growth formation in the lungs of laboratory animals by O. I. Kit, E. M. Frantsiyants, A. I. Shikhlyarova, I. V. Neskubina

“…In addition, signs of adenocarcinoma included glandular and papillary-like structures and cell complexes with large nucleoli. Squamous epithelial cells were characterized by severe atypia and polymorphism. …”
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Management and outcomes of thoracic sarcomas - a collaboration between Orthopaedic Oncology and cardiothoracic surgery: seven-year clinical data from a tertiary referral centre by Zaid Ahmed Shamsi, Vlad Paraoan, Chang Kim, Sarah Raihanah Saifuddin, Thomas D A Cosker, Duncan Whitwell, Christopher L M H Gibbons, Dionisios Stavroulias, Francesco DiChiara

“…Objectives Given the rarity of thoracic sarcomas, and their associated diagnostic and management complexities, our aim is to report on the treatment strategies and outcomes of primary thoracic sarcoma patients treated at the Oxford Sarcoma Service from 2017 to 2023. …”
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Komunikasi Publik Intelijen dalam Mendukung Pemanfaatan Energi Nuklir di Indonesia by Rizkyagi Aanwijzi

“…Qualitative research was chosen as the research method due to complexity of the problems associated with the utilization of nuclear energy in Indonesia, such as public perception, technical challenges, and government policies. government. …”
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The Impact of Carbon on Electronic Structure of N-Doped ZnO Films: Scanning Photoelectron Microscopy Study and DFT Calculations by Elzbieta Guziewicz, Sushma Mishra, Matteo Amati, Luca Gregoratti, Oksana Volnianska

“…The results suggest that interstitial -<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>CH</mi><mi>x</mi></msub></semantics></math></inline-formula> groups facilitate the formation of acceptor complexes due to additional lattice perturbation.…”
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Introducing a Coopetition Model for Domestic Airlines in Iran by Saedeh Ghayourisales, Mohsen Nazari, Mohammadali Shahhoseini

“…As a result of shifts in both internal and external landscapes, along with the swift advancements in technology encapsulated by the term VUCA (signifying volatility, uncertainty, complexity, and ambiguity), the conventional dichotomy of pure competition or complete cooperation has diminished in its efficacy. …”
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Genome drafting of nosocomial infection CRE Klebsiella pneumoniae confirming resistance to colistin and eravacycline, carrying blaNDM-1, mcr-1, and blaKPC-2, in neonatology from No... by Xinlong Zhou, Kailash Wagh, Guizhen Lv, Devender Sharma, Wei Lei

“…Plasmid analysis identified several incompatibility groups (IncFI, IncHI, IncFIB, IncX), indicating the potential for horizontal gene transfer of resistance determinants.ConclusionThis study highlights the complexity of CRKP outbreaks in neonatal care, with isolates exhibiting resistance mechanisms that complicate treatment. …”
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Establishment and application of a rapid new detection method for antimicrobial susceptibility testing of Klebsiella pneumoniae based on MALDI-TOF MS by Yapei Zhang, Fanghua Fan, Xuan Wang, Jie Zhu, Shilei Dong

“…Current rapid AST techniques are hampered by factors such as high costs, technological complexities, and limited detection capabilities. We present a novel rapid method and applied to the determination of the susceptibility of K. pneumoniae to imipenem. …”
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Evaluation of an interprofessional education program involving medical and pharmacy students: a mixed-method study by Josephine F. Mertens, Marleen H. M. Hessel, Thomas G. H. Kempen, Stefan Böhringer, Adriaan F. Norbart, Chris W. Walinga, Teun van Gelder

“…Methods A mixed-method approach was employed to evaluate an IPE program that consisted of three mandatory activities with increased complexity and autonomy, that were integrated into the medical and pharmacy students’ curricula. …”
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6G-oriented cross-modal signal reconstruction technology by Ang LI, Jianxin CHEN, Xin WEI, Liang ZHOU

“…Conclusions: The results of the dataset runs fully demonstrate the practicality of the constructed VisTouch dataset and the accuracy of the video-assisted haptic reconstruction model, while the actual test results of the teleoperated platform indicate that users consider the haptic signals generated by the model to be closer to the actual signals,but are generally satisfied with the running time of the algorithm, i.e. the complexity of this modality needs further optimization.…”
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Explanation and validation of the coordination model of the marketing and sales department in the insurance industry in Iran by Alireza Jahed, Ehsan Abedi, Hamidreza Saeednia

“…The findings showed that the coordination model of the marketing and sales department in the insurance industry is affected by various factors directly and indirectly, and managers' understanding of the complexity of the relationship between these two units is of great importance in the growth of insurance companies and creating a competitive advantage for them. …”
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Identification of natural compound inhibitors for substrate-binding site of MTHFD2 enzyme: Insights from structure-based drug design and biomolecular simulations by Nisarg Rana, Priyanka Solanki, Rukmankesh Mehra, Anu Manhas

“…A computational structure-based drug design approach was employed to identify inhibitors targeting the active site of the MTHFD2 enzyme. …”
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