Comprehensive safety and toxicity analysis of 2,2’-Bipyridine derivatives in combating MRSA biofilm formation and persistence by Priyanka, Priyanka, Mohini Sharma, Bhavna Vaid, Bhavna Vaid, Ram Bharti, Ram Bharti, Sachin Raut, Sachin Raut, R. S. Jolly, Neeraj Khatri, Neeraj Khatri

“…These factors contribute to the complexity of managing MRSA infections and highlight the urgent need for innovative treatment strategies.ObjectivesThis endeavor aims to evaluate the safety of 2,2’-Bipyridine (2,2’-Bipy) derivatives and their antimicrobial, anti-biofilm, and anti-persister activities in treating MRSA Infections.MethodsSix derivatives were screened for their ADMET properties and tested for minimum inhibitory concentrations against various bacterial strains using agar well diffusion and broth dilution. …”
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Genome-wide transcriptome analysis and drug target discovery reveal key genes and pathways in thyroid cancer metastasis by Minjing Zou, Amal Qattan, Monther Al-Alwan, Hazem Ghebeh, Naif Binjumah, Latifa Al-Haj, Khalid S. A. Khabar, Abdulmohsen Altaweel, Falah Almohanna, Abdullah M. Assiri, Abdelilah Aboussekhra, Ali S. Alzahrani, Ali S. Alzahrani, Yufei Shi

“…Braf-mutant Met cells developed resistance to BRAFV600E inhibitor PLX4720, but remained sensitive to β-catenin inhibitor PKF118-310.ConclusionWe have identified several overexpressed genes/pathways in thyroid cancer metastasis, making them attractive therapeutic targets. Given the complexity of metastasis involving multiple pathways (PD-L1, Mertk, IL6, COX-1/Tbxas1-TXA2), simultaneously targeting more than one of these pathways may be warranted to achieve better therapeutic effect for metastatic thyroid cancer.…”
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Differences in soil Cd immobilization and blockage of rice Cd uptake by biochar derived from crop residue and bone − A 2-year field experiment by Zhongjun Xue, Fengfeng Sui, Yanjie Qi, Siyu Pan, Ning Wang, Rongjun Bian, Stephen Joseph, Xuhui Zhang, Lianqing Li, Genxing Pan

“…Higher Si content in rice root in RHB treatment may promote complexation and deposition of Si hemicellulose-bound Cd in the root cell walls. …”
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Neutrophil extracellular traps as an important part of the pathogenesis of chronic rhinosinusitis without polyps by Valery М. Svistushkin, Galina N. Nikiforova, Boris V. Pinegin, Nina V. Vorobjeva, Artem S. Dekhanov, Yulia A. Dagil, Anna R. Mironova

“…Nasal secretions and venous blood were analyzed in all study participants with the determination of surrogate markers of neutrophil extracellular traps – myeloperoxidase complexes with DNA and the detection of double-stranded DNA (Quant Pico Green dsDNA kit). …”
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Evaluation of nutrient loads conveyed to the deep subalpine lakes of Northern Italy through their main tributaries by Paolo Dezuanni, Paolo Dezuanni, Diego Copetti, Claudia Dresti, Nicolò Pella, Nicolò Pella, Fabio Buzzi, Andrea Fenocchi, Andrea Fenocchi

“…Proper watershed management practices must be put into action to effectively oppose eutrophication. Because of the complexities and the multiple layers of stakeholders involved in this process, the only factual way to evaluate improvements in watershed nutrient management is to directly estimate nutrient loads at watershed closing sections through available data from environmental monitoring. …”
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An EEG-based framework for automated discrimination of conversion to Alzheimer’s disease in patients with amnestic mild cognitive impairment: an 18-month longitudinal study by Yingfeng Ge, Jianan Yin, Caie Chen, Shuo Yang, Yuduan Han, Chonglong Ding, Jiaming Zheng, Yifan Zheng, Jinxin Zhang

“…The performance of each model was assessed using 10-fold cross-validation and evaluated in terms of accuracy (ACC), area under the curve (AUC), sensitivity (SEN), specificity (SPE), positive predictive value (PPV), and F1-score.ResultsCompared to SMCI patients, PMCI patients exhibit a trend of “high to low” frequency shift, decreased complexity, and a disconnection phenomenon in EEG signals. …”
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Research on pipeline-type power frequency electromagnetic heating system and multi-layer winding based power regulation method by Feng Zhou, Longyun Liu, Zixuan Wang, Xin Tong, Yanping Liu

“…Aiming at the issues of complexity, high investment costs, limited heating efficiency improvement, high failure rate, and poor reliability of traditional intermediate and high frequency electromagnetic heating systems, we propose a pipeline-type power-frequency electromagnetic coupling heating device. …”
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Optimized chelator and nanoparticle strategies for high-activity 103Pd-loaded biodegradable brachytherapy seeds by Emanuel Sporer, Claire Deville, Natan J. W. Straathof, Linda M. Bruun, Ulli Köster, Mikael Jensen, Thomas L. Andresen, Paul J. Kempen, Jonas R. Henriksen, Andreas I. Jensen

“…With the second strategy, [103Pd]Pd-SSIB was prepared by conjugating the [16]aneS4 chelator with lipophilic sucrose septaisobutyrate (SSIB) followed by complexation with [103Pd]PdH2Cl4 (RCY = 99%) and mixed with LOIB:EtOH. [103Pd]Pd-SSIB was likewise formulated as injectable liquid forming seeds by mixing with LOIB. …”
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Nanostructured lipid carriers based mRNA vaccine leads to a T cell–inflamed tumour microenvironment favourable for improving PD-1/PD-L1 blocking therapy and long-term immunity in a... by Carole Fournier, Marion Mercey-Ressejac, Valentin Derangère, Amal Al Kadi, David Rageot, Christine Charrat, Alexis Leroy, Julien Vollaire, Véronique Josserand, Marie Escudé, Séverine Escaich, François Ghiringhelli, Thomas Decaens, Fabrice P. Navarro, Evelyne Jouvin-Marche, Patrice N. Marche

“…Methods: We evaluated whether NLC OVA mRNA complexes activate dendritic cells (DCs) in vitro and identified the involved signalling pathways using specific inhibitors. …”
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The effectiveness analysis of traditional and new landscape indexes in indicating flood risk of watersheds from the perspective of source-sink landscapes: A case study of Changsha,... by Lingxuan Zhang, Sheng Jiao, Jie Lu

“…Results showed that over a 40-year period, landscape fragmentation and complexity increased. The source landscapes expanded by 680.84 km2, with significant growth and aggregation, primarily in low-lying areas near watershed outlets, while the sink landscapes evolved in the opposite direction. …”
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A conceptual model and practical guidance for the development, administration, and evaluation of individualized therapies by Lucie Perillat, Lucie Perillat, Andrew McFadyen, Andrew McFadyen, Andrew McFadyen, Patricia Furlong, James Anderson, James Anderson, James Anderson

“…By discussing these stages and parameters in detail, we aim to provide guidance on how to navigate the ethical complexities inherent to individualized interventions and offer a preliminary framework for balancing the interplay between research objectives and patient care needs. …”
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Association between the subclinical level of problematic internet use and habenula volume: a look at mediation effect of neuroticism by Toshiya Murai, Hironobu Fujiwara, Qi Dai, Halwa Zakia, Yusuke Kyuragi, Naoya Oishi, Yuzuki Ishikawa, Lichang Yao, Morio Aki

“…Moreover, neuroticism was shown to mediate the relationship between Hb volume and PIU tendency, offering valuable insight into the complexities of this interaction.…”
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Navigating Patient Satisfaction: A Qualitative Insight into Healthcare Delivery during the COVID-19 Pandemic by Shazina Saeed, Manmohan Singhal, Mohd Shannawaz, Mandeep Kumar Arora

“…Participants expressed a range of emotions, from frustration to gratitude, highlighting the complexities of navigating healthcare during an unprecedented time. …”
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Sediment flow connectivity index data for the Apulia region (Italy): An open-source geodatabase and the innovative CONNECTOSED WebGIS platformZenodo by Alok Kushabaha, Domenico Capolongo, Giovanni Scicchitano, Floriana Rizzo, Marina Zingaro

“…The availability of both input and processed data enables the computation and continuous updating of this applied geomorphological indicator, which is useful for assessing susceptibility to rapid Earth surface changes related to multi-hazard exposure. …”
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From research to practice: bridging the implementation gap on the use of tranexamic acid in total knee arthroplasty by Robin M. Pfister, Benjamin F. Pfister, Ronald L. Hager, Nathan Sandholtz, Daniel Abulafia, David Bradshaw

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Farmers’ Perception about the Use of Sorghum (Sorghum bicolor (L.) Moench) Landraces and Their Genetic Erosion in South Wollo Administrative Zone, Ethiopia by Silamlak Birhanu Abegaz, Faris Hailu Tessema

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Association of a novel nutritional index with cognitive impairment in middle-aged and elderly Chinese adults: a cross-sectional analysis from the China Health and Retirement Longit... by Guotao Liu, Jianyuan Zhang

“…PurposeThe triglyceride-cholesterol-body weight index (TCBI), a novel and easily computable nutritional index, incorporates serum triglyceride (TG), total cholesterol (TC), and body weight (BW). …”
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Design and performance analysis of portable solar powered cooler for vaccine storage by Vicent Marwa, Thomas Kivevele, Baraka Kichonge, Juma Selemani

“…The cooler's performance in terms of temperature distribution, airflow dynamics, and the coefficient of performance (COP) is meticulously examined through computational fluid dynamics (CFD) simulations. The simulated results were validated using experimental data from the open literature, ensuring accuracy and reliability. …”
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Prioritization of genes associated with the pathogenesis of leukosis in cattle by N. S. Yudin, N. L. Podkolodnyy, T. A. Agarkova, E. V. Ignatieva

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Species specificity and specificity diversity (SSD) framework: a novel method for detecting the unique and enriched species associated with disease by leveraging the microbiome het... by Zhanshan Sam Ma

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