Digital tool as speech and language therapy for patients with post-stroke aphasia by Gerardo Ruiz Ares, Marta Martin Alonso, Ricardo Rigual, Carlos Hervás Testal, Gabriel Torres Iglesias, Laura Casado Fernandez, Elena de Celis Ruiz, Jorge Rodríguez Pardo, Jenny Carvajal Muñoz, Laura González Martín, María Alonso de Leciñana, Blanca Fuentes

“…Comfort of use scored 8.8, and complexity 2.2 points. Expectations were exceeded in 61.1%, and impression of improvement in 83.3% of cases. …”
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Key considerations based on pharmacokinetic/pharmacodynamic in the design of antibody-drug conjugates by Yangyang Gao, Yuwei Xia, Yixin Chen, Shiqi Zhou, Yingying Fang, Jieru Yu, Leyin Zhang, Leyin Zhang, Leitao Sun, Leitao Sun, Leitao Sun

“…BackgroundAntibody-drug conjugate (ADC) is an anticancer drug that links toxins to specifically targeted antibodies via linkers, offering the advantages of high target specificity and high cytotoxicity. However, complexity of its structural composition poses a greater difficulty for drug design studies.ObjectivesPharmacokinetic/pharmacodynamic (PK/PD) based consideration of ADCs has increasingly become a hot research topic for optimal drug design in recent years, providing possible ideas for obtaining ADCs with desirable properties.MethodsFrom the assessment of the ADC action process based on PK/PD, we introduce the main research strategies of ADCs. …”
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Dapsone Alters Phenotypical and Functional Properties of Human Neutrophils In Vitro by Sara Rakočević, Vanja Mališ, Ljiljana Kozić, Anđela Dubovina, Marija Drakul, Dejan Bokonjić, Miodrag Čolić, Dušan Mihajlović

“…In conclusion, our results indicate the complexity of dapsone actions on neutrophil functions, extending previous knowledge on the suppression of oxidative burst and IL-8 production upon neutrophils’ activation. …”
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Abnormal ac4C modification in metabolic dysfunction associated steatotic liver cells by Xiqian Zhang, Yaxian Zheng, Jing Yang, Yan Yang, Qin He, Min Xu, Fangyi Long, Yujie Yang

“…Abstract The pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD) remains unclear due to the complexity of its etiology. The emerging field of the epitranscriptome has shown significant promise in advancing the understanding of disease pathogenesis and developing new therapeutic approaches. …”
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Prevalence and Characterization of Psychological Trauma in Patients with Fibromyalgia: A Cross-Sectional Study by Itxaso Gardoki-Souto, Diego Redolar-Ripoll, Marta Fontana, Bridget Hogg, María José Castro, Josep M. Blanch, Fabiola Ojeda, Aleix Solanes, Joaquim Radua, Alicia Valiente-Gómez, Roser Cirici, Víctor Pérez, Benedikt L. Amann, Ana Moreno-Alcázar

“…Our data highlight the clinical complexity of patients with FM and the role of childhood trauma in the onset and maintenance of FM, as well as the high comorbidity between anxiety, depression, somatic symptoms, and FM. …”
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Gas Chromatography Coupled to High Resolution Time-of-Flight Mass Spectrometry as a High-Throughput Tool for Characterizing Geochemical Biomarkers in Sediments by Hector Henrique Ferreira Koolen, Clécio Fernando Klitzke, Joe Binkley, Jeffrey Patrick, Ana Cecília Rizatti de Albergaria-Barbosa, Rolf Roland Weber, Márcia Caruso Bícego, Marcos Nogueira Eberlin, Giovana Anceski Bataglion

“…The high resolving power (m/Δm50% 25,000) and high mass accuracy (error ≤ 1 ppm) offered by the “zig-zag” time-of-flight analyzer were indispensable to resolve the complexity of the total ion chromatograms, representing a high-throughput tool. …”
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Multidimensional features of sporadic Creutzfeldt-Jakob disease in the elderly: a case report and systematic review by Jiangfeng Liao, Jiangfeng Liao, Wenming Hu, Wenming Hu, Shiheng Chen, Chunyu Huang, Chunyu Huang, Senwei Dong, Senwei Dong, Wanjin Chen, Wanjin Chen, Xiaochun Chen, Longfei Chen, Longfei Chen

“…Restricted hyperintensities were reported in 60.0% cases on DWI, periodic sharp wave complexes in 73.3% cases on electroencephalogram, and cerebral hypoperfusion/hypometabolism in 26.7% cases on molecular imaging. …”
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Chemical Composition and Antimicrobial Activity of Subcritical CO2 Extract of Lepidium latifolium L. (Brassicaceae) by Balzhan B. Azimkhanova, Gulbaram O. Ustenova, Kamalidin O. Sharipov, Kayrolla D. Rakhimov, Galiya M. Sayakova, Ardak B. Jumagaziyeva, Elena V. Flisyuk, Nadezhda G. Gemejiyeva

“…The technology of carbon dioxide extraction has undoubted advantages over traditional methods of extraction: it has a controlled selectivity in relation to groups of biologically active substances, allows deep extraction, and maximizes the release of rich complexes of compounds contained in plants. In this study, firstly, the CO2 extract was obtained under subcritical conditions from the aerial part of L. latifolium L., and the composition was determined. …”
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Segmented evolution and exploration targets of the Cambrian platform margin in the Manxi area, Tarim Basin by Zongquan Hu, Fan Feng, Chengming Fang, Zicheng Cao, Tieyi Wang, Kangkang Guo, Yang Li, Shi Wang

“…In this segment, the Shayilike Formation transgressive deposits and the high-energy mound-shoal complexes along the platform margin of the Wusonggeer Formation constitute the optimal reservoir - cap rock assemblage, establishing this segment as the most promising target for hydrocarbon exploration in the platform margin.…”
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Enhancing chemotherapy response prediction via matched colorectal tumor-organoid gene expression analysis and network-based biomarker selection by Wei Zhang, Chao Wu, Hanchen Huang, Paulina Bleu, Wini Zambare, Janet Alvarez, Lily Wang, Philip B. Paty, Paul B. Romesser, J. Joshua Smith, X. Steven Chen

“…Current methods often fail to account for the complexity and variability inherent in individual tumors. …”
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A Refined Terrace Extraction Method Based on a Local Optimization Model Using GF-2 Images by Guobin Kan, Jie Gong, Bao Wang, Xia Li, Jing Shi, Yutao Ma, Wei Wei, Jun Zhang

“…However, the extraction of terrace patches faces challenges due to the complexity of the terrain and limitations in remote sensing (RS) data. …”
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The role of oxidized non-coding RNAs of the epigenome in the development of human diseases (literature review) by S.S. Ostrovska, Ye.N. Dychko, T.Ye. Shumna, G.I. Titov, O.S. Trushenko, P.G. Gerasymchuk, I.Y. Burega

“…The results of the study showed that cadmium manifests its toxicity by oxidizing micro RNAs and long RNAs that regulate gene expression without changing DNA/histone complexes. It has been shown that epigenetic disorders under the influence of cadmium-induced oxidative stress can be transmitted to offspring without changing the genotype, and these aberrant changes in non-coding RNA expression patterns are associated with aging, cancer, neurodegenerative, cardiovascular diseases, etc. …”
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Residency training programs to support residents working in First Nations, Inuit, and Métis communities by Marghalara Rashid, Julie Nguyen, Wayne Clark, Jessica L. Foulds, Ida John, Ming-Ka Chan, Molly Whalen-Browne, Pamela Roach, Melanie Morris, Sarah Forgie

“…Results Our data analysis revealed five themes: Five themes were generated: Complexity of voluntourism as a concept; Diversity of knowledge representation required for developing curriculum; Effective models of care for First Nations, Inuit and/or Métis health; Essential traits that residents should have for working in First Nations, Inuit and/or Métis communities; and Building relationships and trust by engaging the community. …”
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Correlation Between <i>Cryptococcus</i> Infection and the Nasal Mycobiota in a Population of Free-Ranging Koalas (<i>Phascolarctos cinereus</i>) in New South Wales, Australia by Andrew S. McPherson, Sophie L. Haworth, Alex Kan, Luisa Monteiro de Miranda, Mark B. Krockenberger

“…Cryptococcosis is a fungal disease in humans and animals, caused by the <i>Cryptococcus neoformans</i> and <i>Cryptococcus gattii</i> species complexes. Clinical cryptococcosis primarily manifests as upper respiratory tract disease; however, dissemination to other organs, particularly the brain, can occur. …”
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Investigation of Novel Aronia Bioactive Fraction-Alginic Acid Nanocomplex on the Enhanced Modulation of Neuroinflammation and Inhibition of Aβ Aggregation by Bong-Keun Jang, Soo Jung Shin, Hyun Ha Park, Vijay Kumar, Yong Ho Park, Jeom-Yong Kim, Hye-Yeon Kang, Sunyoung Park, Youngsun Kwon, Sang-Eun Shin, Minho Moon, Beom-Jin Lee

“…The AANCP exhibited better stability in four plasma samples (human, dog, rat, and mouse) and was slowly released in different pH conditions (pH 2.0, 7.4, and 8.0) compared with non-complexedABF. In vitro studies on microglial cells treated with AANCPs revealed a suppression of inflammatory cytokines (tumor necrosis factor-alpha and interleukin-6) induced by LPS. …”
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In-silico study of E169G and F242K double mutations in leucine-rich repeats (LRR) polygalacturonase inhibiting protein (PGIP) of Gossypium barbadense and associated defense mechani... by Sneha Murmu, Mayank Rashmi, Dipak T. Nagrale, Tejasman Kour, Mahender Kumar Singh, Anurag Chaurasia, Santosh Kumar Behera, Raja Shankar, Rajiv Ranjan, Girish Kumar Jha, Shailesh P. Gawande, Neelakanth S. Hiremani, Y. G. Prasad, Sunil Kumar

“…The molecular dynamics simulation studies provide insights into the dynamic behaviour and stability of the PGIP-PG complexes, shedding light on the intricate details of the inhibitory and exhibitory mechanism against the major fungal and bacterial pathogens of G. barbadense, respectively. …”
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A new multi-grid bathymetric dataset of the Gulf of Naples (Italy) from complementary multi-beam echo sounders by F. Foglini, M. Rovere, R. Tonielli, G. Castellan, G. Castellan, M. Prampolini, M. Prampolini, F. Budillon, M. Cuffaro, G. Di Martino, V. Grande, S. Innangi, M. F. Loreto, L. Langone, F. Madricardo, A. Mercorella, P. Montagna, C. Palmiotto, C. Pellegrini, A. Petrizzo, L. Petracchini, A. Remia, M. Sacchi, D. Sanchez Galvez, A. N. Tassetti, F. Trincardi

“…This area is particularly vulnerable to abrupt changes driven by the dynamics of several volcanic complexes, active in the area, and by human-induced impacts reflecting the proximity to the highly populated and touristic coastal area of Naples and nearby famous islands. …”
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Effect of Colloidal Silicate on the Migration Behaviour of Strontium in Groundwater Environment of Geological Disposal Candidate Site by Rui Zuo, Kexue Han, Rongtao Shi, Fei Ding, Li Liu, Jinsheng Wang, Yanguo Teng, Jie Yang, Xin Liu

“…It was inferred that strong chemical interactions and/or surface complexation contributed primarily to Sr(II) sorption, and the process was on the monolayer adsorption of the outer surface. …”
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Integrative deep immune profiling of the elderly reveals systems-level signatures of aging, sex, smoking, and clinical traitsResearch in context by Lennart Riemann, Rodrigo Gutierrez, Ivan Odak, Joana Barros-Martins, Lennart M. Roesner, Ximena Leon Lara, Christine Falk, Thomas F. Schulz, Gesine Hansen, Thomas Werfel, Reinhold Förster, Berislav Bošnjak, Felix Jenniches, Norman Klopp, Till Robin Lesker, Martin Stangel

“…Studying the human immune system, however, remains challenging due to its complexity and significant inter-individual variability. …”
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Single-cell multiomics reveal divergent effects of DNMT3A- and TET2-mutant clonal hematopoiesis in inflammatory response by Wazim Mohammed Ismail, Jenna A. Fernandez, Moritz Binder, Terra L. Lasho, Minsuk Kim, Susan M. Geyer, Amelia Mazzone, Christy M. Finke, Abhishek A. Mangaonkar, Jeong-Heon Lee, Liguo Wang, Kwan Hyun Kim, Vernadette A. Simon, Fariborz Rakhshan Rohakthar, Amik Munankarmy, Seul Kee Byeon, Susan M. Schwager, Jonathan J. Harrington, Melissa R. Snyder, Keith D. Robertson, Akhilesh Pandey, Eric D. Wieben, Nicholas Chia, Alexandre Gaspar-Maia, Mrinal M. Patnaik

“…Although individual impacts on the epigenome have been described using different model systems, the phenotypic complexity in humans remains to be elucidated. Here, we make use of a natural inflammatory response occurring during coronavirus disease 2019 (COVID-19), to understand the association of these mutations with inflammatory morbidity (acute respiratory distress syndrome [ARDS]) and mortality. …”
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