Downmodulation of Vaccine-Induced Immunity and Protection against the Intracellular Bacterium Francisella tularensis by the Inhibitory Receptor FcγRIIB by Brian J. Franz, Ying Li, Constantine Bitsaktsis, Bibiana V. Iglesias, Giang Pham, Raju Sunagar, Sudeep Kumar, Edmund J. Gosselin

“…Fc gamma receptor IIB (FcγRIIB) is the only Fc gamma receptor (FcγR) which negatively regulates the immune response, when engaged by antigen- (Ag-) antibody (Ab) complexes. Thus, the generation of Ag-specific IgG in response to infection or immunization has the potential to downmodulate immune protection against infection. …”
Get full text

Geohazard features of the Gulf of Naples and Pontine Islands (Eastern Tyrrhenian Sea) by Francesca Budillon, Eleonora Martorelli, Alessandro Conforti, Giovanni De Falco, Alessandro Bosman, Gabriella Di Martino, Marco Firetto Carlino, Martina Misuraca, Sara Innangi, Martina Pierdomenico, Andrea Sposato, Renato Tonielli, Daniele Casalbore, Roberto Capperucci, Aida Maria Conte, Francesco G. Falese, Michela Ingrassia, Ennio Marsella, Cristian Montanaro, Eleonora Morelli, Roberto Sisinni, Francesco L. Chiocci

“…These include canyon systems, erosive scarps, landslide complexes, fault – and volcanic-related features, such as the products of the volcanic edifices instability, which claim to varying degrees of geo-hazard. …”
Get full text

Sustainable closed-loop supply chain network design: heuristic hybrid approach with considering inflation and carbon emission policies by Saeid Kalantari, Hamed Kazemipoor, Farzad Movahedi Sobhani, Seyyed Mohammad Hadji Molana

“…This study aims to decide on operational and tactical levels to configure the Stable Closed Chain Supply Chain Network (SCLSC) to maximize Net Present Value (NPV) and seek to minimize carbon emissions while maintaining environmentally friendly policies and considering inflation.Methodology: This paper considers a solid Fuzzy Robust Optimization (FRO) approach to deal with stable, closed-loop supply chain uncertainties. Also, due to the complexity of the model and its multi-objective, a new combined method of Heuristic algorithm (HA) and Multi-Choice Goal Programming with Utility Function (MCGP-UF) is used. …”
Get full text

Diversity of frontier processes in Amazonian subnational jurisdictions: Frontier metrics reveal major patterns of human–nature interactions by Guido Briceño, Julie Betbeder, Agnès Bégué, Guillaume Cornu, David Katz-Asprilla, Marie-Gabrielle Piketty, Solen Le Clech, Vinicius Silgueiro, Hélène Dessard, Lilian Blanc

“…Methods for quantitatively characterizing this complexity across large agricultural frontiers are still underdeveloped. …”
Get full text

Neglected Forearm Fractures and Its Outcome Following Mediolateral Plate Osteosynthesis: A Retrospective Case Series by Sitsabesan Chokkalingam, Ashok T Ramanathan, Gopinath Menon

“…Despite the operative complexity of open osteoclasis or the need for bone grafting, the anatomical radial bow can be restored in the absence of forearm cross-union.…”
Get full text

Rapid landslide detection from free optical satellite imagery using a robust change detection technique by Rosa Coluzzi, Angela Perrone, Caterina Samela, Vito Imbrenda, Salvatore Manfreda, Letizia Pace, Maria Lanfredi

“…As a result, nowadays also public institutions dealing with geo-hazard management worldwide regularly use satellite data and products in landslide investigations. Due to the complexity of the phenomenon which might involve the displacement of massive rocks, soil, and both wet and dry vegetation from hillslopes, and the significant impact on the safety of the population and road infrastructure, the development of specific procedures for the rapid detection of landslides is extremely challenging. …”
Get full text

Health and Educational Inequalities among the Third Gender Community in Lahore, Pakistan by Ayesha Humayun, Muhammad Hassan, Hira Ashfaq, Zulqarnain Haider, Nauman Naeem, Mubashar Munir

“…This study aims to explore the educational and healthcare challenges faced by this community, as perceived by its members, to gain deeper insight into the complexities of their lived experiences. Methodology:  This qualitative study conducted in-depth interviews with ten hijra individuals from three areas in Lahore, Pakistan. …”
Get full text

Method for measuring intensity of inhomogeneous electrical fields by average value by S. V. Biryukov, L. V. Tyukina, A. V. Tyukin

“…Existing measurement methods characterized by the complexity of the measurement processes, suitability in some cases, and unsuitability in others, do not provide the desired metrological characteristics. …”
Get full text

Numerical Methodologies for the Analysis of Horizontal-Axis Floating Offshore Wind Turbines (F-HAWTs): A State-of-the-Art Review by Naghmeh Akbari Zadeh, Peter Ryan, David M. Kennedy, Fergal O’Rourke

“…Compared to floating oil and gas platforms, floating wind turbine platforms have a higher centre of gravity, which influences their performance and complexity. The successful large-scale development of floating offshore wind farms will require significant expertise and learning from the onshore wind, oil, and gas sectors. …”
Get full text

Potential Virulence and Survival of Acid-Resistant Bacillus cereus KS100Bc Isolated from Foodservice Establishments in Korea by Seung Min Kim, Daekeun Hwang, Hyun Jung Kim

“…All isolates were positive for genes encoding nonhemolytic enterotoxin complexes, except for one strain that lacked nheC. …”
Get full text

Sustainability in Reconstructive Breast Surgery: An Eco-audit of the Deep Inferior Epigastric Perforator Flap Pathway by Zahra Ahmed, BSc (Hons), Alexander Zargaran, MRCS, David Zargaran, MRCS, Sara Sousi, MRes, Keiron Hakimnia, Sevasti Panagiota Glynou, BSc (Hons), Julie Davies, PhD, Stephen Hamilton, FRCS (Plast), Afshin Mosahebi, FRCS (Plast)

“…The deep inferior epigastric perforator (DIEP) flap provides an effective and popular means for autologous breast reconstruction. However, with the complexity of the pathway, the environmental impact of the pathway has yet to be evaluated. …”
Get full text

Numerical Prediction of Fatigue Life for Landing Gear Considering the Shock Absorber Travel by Haihong Tang, Panglun Liu, Jianbin Ding, Jinsong Cheng, Yiyao Jiang, Bingyan Jiang

“…Due to the complexity of the landing gear’s (LG) structural integrity and its loads under various static or dynamic working conditions, the fatigue life assessment for LG is a highly challenging task. …”
Get full text

Phasor-FSTM: a new paradigm for multicolor super-resolution imaging of living cells based on fluorescence modulation and lifetime multiplexing by Luwei Wang, Yue Chen, Jiaqing Guo, Xiaoyu Weng, Wei Yan, Jun Song, Tong Ye, Junle Qu

“…However, integrating multicolor and super-resolution microscopy into a single method remains challenging due to issues like spectral overlap, crosstalk, photobleaching, phototoxicity, and technical complexity. These challenges arise from the conflicting requirements of using different fluorophores for multicolor labeling and fluorophores with specific properties for super-resolution imaging. …”
Get full text

Case report of the first use of a hydrogel rectal spacer for prostate cancer reirradiation via LDR brachytherapy: applications and technical notes by Amina Lazrek, Sebastiano Finocchi Ghersi, Adeline Petre, Sarah Houabes, Anne-Agathe Serre, Frederic Gassa, Magali Sandt, Cecile Laude, Camille Roukoz, Salvatore Cozzi

“…The patient remains asymptomatic with no urinary or gastrointestinal complications 6 months after the salvage treatment.DiscussionThis case illustrates the complexities in managing recurrent prostate cancer and the evolving role of reirradiation strategies. …”
Get full text

Multifaceted properties of Ni and Zn codoped MgO nanoparticles by A. Chithra Mohan, A. Athira, Bindu P. Nair, G. Sivasubramanian, K. M. Sreekanth, Gopinathan Anoop, Sreeprasanth Pulinthanathu Sree, K. M. Sreedhar

“…By deciphering the complexities of the versatile nanomaterial, MgO, the study aims to deepen our comprehension of the synergistic effects induced by dual doping in MgO, thus propelling the advancement of innovative technologies and materials with broad applications. …”
Get full text

Contemporaneous Emotion Regulation Theoretical Models: A Systematic Review by Camila Florencia Cremades, Cristian Javier Garay, Martín Juan Etchevers, Roberto Muiños, Graciela Mónica Peker, Juan Martín Gómez Penedo

“…The main components found in the definition were the complexity of the construct, goal orientation, intra- or interpersonal regulation, the proposal of moderators, and its voluntary character. …”
Get full text

Design of a humanized CD40 agonist antibody with specific properties using AlphaFold2 and development of an anti-PD-L1/CD40 bispecific antibody for cancer immunotherapy by Kun Du, He Huang

“…It also demonstrates that the current AlphaFold2(AlphaFold2-Multimer) can predict antibody-antigen complexes. Due to the unique epitope, it demonstrates superior activation compared to APX005M (S267E). …”
Get full text

The progress in the field of clinical staging for mental disorders within the last decade: an updated systematic review by Sharon L. Clarke, Sharon L. Clarke, Nicole Soons, Arjan C. Videler, Arjan C. Videler, Sebastiaan P. J. van Alphen, Sebastiaan P. J. van Alphen, Henricus Van, Linda Dil, Laurens Pappijn, Sven Corbeij, Beau Broekhof, Beau Broekhof, Andrew M. Chanen, Andrew M. Chanen, Joost Hutsebaut, Joost Hutsebaut

“…Staging models might need to be better tailored to the complexities of mental disorders to improve their clinical utility.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42021291703.…”
Get full text

MUC2 expression modulates immune infiltration in colorectal cancer by Christophe M. Raynaud, Ayesha Jabeen, Eiman I. Ahmed, Eiman I. Ahmed, Satanay Hubrack, Apryl Sanchez, Shimaa Sherif, Ahmad A. Al-Shaibi, Bernice Lo, Bernice Lo, Jessica Roelands, Davide Bedognetti, Davide Bedognetti, Wouter Hendrickx, Wouter Hendrickx

“…These findings reveal the complexity of mucin biology in CRC and suggest that targeting mucin pathways could be a novel therapeutic approach.…”
Get full text

Altitudinal patterns of bacterial communities across soil layers in the alpine meadows of the Qinghai-Tibet Plateau by Zhiyuan Chen, Yeteng Xu, Xinyue Wang, Tong Ma, Yang Liu, Xiang Qin, Wei Zhang, Tuo Chen, Guangxiu Liu, Binglin Zhang

“…Network analysis revealed that subsurface bacterial networks exhibited greater complexity and a higher prevalence of negative correlations compared to surface soil networks. …”
Get full text