RIPK1 expression and inhibition in tauopathies: implications for neuroinflammation and neuroprotection by Ignacio Silva-Llanes, Ignacio Silva-Llanes, Ignacio Silva-Llanes, Enrique Madruga, Enrique Madruga, Ana Martínez, Ana Martínez, Isabel Lastres-Becker, Isabel Lastres-Becker, Isabel Lastres-Becker, Isabel Lastres-Becker

“…These results suggest that although inhibiting RIPK1 activity may help reduce TAU-related astrogliosis in the brain, the complexity of the inflammatory pathways involved could explain the absence of neuroprotective effects against TAU-induced neurodegeneration.…”
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Integrated risk analyses as part of national climate risk assessments: lessons learnt from the climate risk assessment of Germany by Walter Kahlenborn, Maike Voss, Luise Porst, Marc Zebisch, Kathrin Renner, Inke Schauser

“…However, existing CRAs oftentimes do not exploit their full potential by means of an integrated assessment, i.e. to illustrate the complexity of cascading risks, provide cross-sectoral results, integrate adaptive capacity and demonstrate spatial patterns. …”
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Identification and the molecular mechanism of novel duck liver-derived anti-inflammatory peptides in lipopolysaccharide-induced RAW264.7 cell model by Xiankang Fan, Laidi Zhang, Yangying Sun, Changyu Zhou, Qiang Xia, Lihui Du, Zhen Wu, Daodong Pan

“…With binding energies less than –20.93 kJ/mol, molecular docking revealed that they could efficiently bind to the active pockets of tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), cyclooxygenase 2 (COX-2), and nuclear factor κB (NF-κB) proteins with efficiency, indicating that the compounds can spontaneously form complexes through hydrogen bonding and hydrophobic interactions with the protein binding pockets. …”
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The epididymal microenvironment in Akodon cursor (Muridae, Sigmodontinae, Akodontini): The lifetime of spermatozoa from production to maturation by Tatiana Prata Menezes, Fernanda Carolina Ribeiro Dias, Nara Clara Lazaroni e Merchid, Camila Folly Batista, Camilo Jose Ramirez-Lopez, Arabela Guedes de Azevedo Viana, Renner Philipe Rodrigues Carvalho, Adrielli Ribeiro Araújo, José Lino-Neto, Gisele Lessa, Arlindo A. Moura, Mariana Machado-Neves

“…Sperm fertility in mammals depends on the complexity of several physiological events. The male gamete is produced in the testis and matured in the epididymis, which requires an adequate environment for sperm maturation and survival. …”
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Positive real-time PCR in pneumococcal meningitis 12 hours after initiation of antibiotic therapy – case report by Cem Thunstedt, Carla Palleis, Johannes Wischmann, Suzette Heck, Konstantinos Dimitriadis, Matthias Klein

“…This case emphasizes the complexity of bacterial meningitis diagnosis and the utility of multiplex PCR, especially in prolonged antibiotic-treated patients. …”
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Molecular modeling to elucidate the dynamic interaction process and aggregation mechanism between natural organic matters and nanoplastics by Chi Zhang, Zhiyu Zhou, Mengning Xi, Haozhe Ma, Junhao Qin, Hanzhong Jia

“…Their binding and aggregation mechanisms at the molecular level remain elusive due to the high structural complexity of NOMs and aged NPs. Molecular modeling was used to understand the detailed dynamic interaction mechanism between NOMs and NPs. …”
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Inhibitory Effect on the Tyrosinase Activity and Low Cytotoxicity of Monounsaturated Long-Chain Chelating Fatty Ester by ANTONIO SERGIO C. CARVALHO, TATIANA N. PEDROSA, HERONILDES A. DANTAS FILHO, RAQUEL C. MONTENEGRO, EMERSON S. LIMA, MARNE C. DE VASCONCELLOS, ALBERDAN S. SANTOS

“…The IC50 and IC90 values for tyrosinase inhibitory activity for chelating fatty ester and their complexes are values > 400 µM. Finally, the assay with the series showed no hemolytic activity (EC50> 250 μg mL-1), and not cytotoxic to B16F10, ACP-02, and human dermal fibroblast cells at 100 µM and showed no hemolytic potential at the concentration of IC50 250 µM.…”
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Effects of straw amendment on the bioavailability of selenite in soil and its mechanisms by Mingxing Qi, Dan Wang, Hui Zhai, Fei Zhou, Hao Wu, Wanchen Zhao, Rongxin Ren, Jingyi Shi, Dongli Liang

“…Consequently, HA–Se was more likely to form in krasnozems enriched with HA. 2D-COS evidenced that HA mineralization promoted Se bioavailability in krasnozems with high-Se treatment. After selenite complexed with saturated and unsaturated aliphatic carboxyl groups (CO) of DOM, it formed Hy–Se and FA–Se in Lou soil, which could be directly absorbed by wheat roots. …”
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Research on the Rapid Detection of Formaldehyde Emission From Wood-Based Panels Based on the AMSHKELM by Yinuo Wang, Huanqi Zheng, Hua Wang, Yucheng Zhou

“…To enable quick and accurate detection of formaldehyde emissions from wood-based panels and to address the complexities of the full-scale chamber method and the inaccuracy of sensor-based methods, a modified formaldehyde emission model based on AdaBoost-MSBKA-SVMD-HKELM (AMSHKELM) is proposed. …”
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Extent, causes, and consequences of small RNA expression variation in human adipose tissue. by Leopold Parts, Åsa K Hedman, Sarah Keildson, Andrew J Knights, Cei Abreu-Goodger, Martijn van de Bunt, José Afonso Guerra-Assunção, Nenad Bartonicek, Stijn van Dongen, Reedik Mägi, James Nisbet, Amy Barrett, Mattias Rantalainen, Alexandra C Nica, Michael A Quail, Kerrin S Small, Daniel Glass, Anton J Enright, John Winn, MuTHER Consortium, Panos Deloukas, Emmanouil T Dermitzakis, Mark I McCarthy, Timothy D Spector, Richard Durbin, Cecilia M Lindgren

“…This study highlights the similar genetic complexity and shared genetic control of small RNA and mRNA transcripts, and gives a quantitative picture of small RNA expression variation in the human population.…”
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Navigating Translation Rights: Expanding Access to Global Literature in Modern Education by Nodira Rustamova, Dilnoz Ruzieva, Umida Sharaxmetova, Leyla Burxanova, Umida Makhmudxodjayeva, Doniyorbek Imomniyozov, Azimjon Ibrokhimov

“… This study aims to explore the complexities surrounding translation rights in educational contexts, with a focus on finding a balance between copyright protection and the need for greater access to foreign literature for educational purposes. …”
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Modulation of the endocannabinoid system by (S)-ketamine in an animal model of depression by Nicole R. Silva, Shokouh Arjmand, Luana B. Domingos, Adriano M. Chaves-Filho, Melina Mottin, Caroline C. Real, Anna L. Waszkiewicz, Pedro H. Gobira, Alessio Nicola Ferraro, Anne M. Landau, Carolina H. Andrade, Heidi K. Müller, Gregers Wegener, Sâmia R.L. Joca

“…The inability of rimonabant to block the antidepressant effect of S-KET highlights the complexity of its interaction with the ECS, warranting further investigation into the molecular pathways.…”
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Analysis of nanomedicine applications for inflammatory bowel disease: structural and temporal dynamics, research hotspots, and emerging trends by Hong-Yu Jiang, Hong-Yu Jiang, Bo Shao, Bo Shao, Hong-Da Wang, Hong-Da Wang, Wen-Qi Zhao, Shao-Hua Ren, Shao-Hua Ren, Shao-Hua Ren, Yi-Ni Xu, Yi-Ni Xu, Tong Liu, Tong Liu, Cheng-Lu Sun, Cheng-Lu Sun, Yi-Yi Xiao, Yi-Yi Xiao, Yi-Cheng Li, Yi-Cheng Li, Qiang Chen, Qiang Chen, Peng-Yu Zhao, Peng-Yu Zhao, Guang-Mei Yang, Guang-Mei Yang, Xu Liu, Xu Liu, Yu-Fan Ren, Yu-Fan Ren, Hao Wang, Hao Wang, Hao Wang

“…Keyword analysis revealed that current research hotspots include drug delivery, immune cell regulation, antioxidant damage, intestinal microbiota homeostasis, and nanovesicles.ConclusionThis study offers a comprehensive overview of global research landscape, emphasizing the rapid growth and increasing complexity of this field. It identifies key research hotspots and trends, including efforts to enhance the precision, efficacy, and safety of nanomedicine applications. …”
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Non-Anatomic Reconstruction in Multiligament Knee Injuries: A Functional Approach by Mihai Hurmuz, Cătălin-Adrian Miu, Daniel Ceachir, Romulus-Fabian Tatu, Mihai Andrei, Bogdan Andor, Alexandru Catalin Motofelea, Călin Tudor Hozan

“…<i>Conclusions</i>: These findings support the feasibility of non-anatomic reconstructions as a practical solution for patients seeking a return to daily activities and recreational sports without the complexity of full anatomic reconstruction.…”
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(Ph3P)4C4P4: Effect of substitution on the Oligomerization of carbon phosphide radicals by Dr. Moritz Scharnhölz, Dr. Jose Juan Gamboa Carballo, Dr. Nils Trapp, Dr. Rene Verel, Dr. Peter Coburger, Prof. Dr. Hansjörg Grützmacher

“…That a 1,3‐diphosphete type Ph3P→P2C2←PPh3 heterocycle is a short‐lived intermediate in the dehalogenation reaction is indicated by trapping experiments which allowed to isolate and fully characterize the [Fe(CO)4] complexes [Fe(CO)4(κ‐P−P2C2{PPh3}2] and [(Fe(CO)4)2(μ2‐κ‐P−P2C2{PPh3}2]. …”
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Recent Developments in Heavy Metals Detection: Modified Electrodes, Pretreatment Methods, Prediction Models and Algorithms by Yujie Shi, Shijie Zhang, Hang Zhou, Yue Dong, Gang Liu, Wenshuai Ye, Renjie He, Guo Zhao

“…However, challenges such as interference from non-target heavy metal ions and the formation of organometallic complexes with organic compounds can complicate the detection process. …”
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Vascularized composite allograft deceased donation in the United States by Wida S. Cherikh, Samantha M. Noreen, Alexandra Lewis, Sarah E. Booker, Jesse Howell, Erin M. Schnellinger, Jennifer L. Wainright, Christopher C. Curran

“…VCA recovery introduces complexities to conventional solid organ recovery, and there remain concerns regarding the potential impact of VCA recovery on non-VCA organs for transplant. …”
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Construction Management Modeling in Partnership Governance of Laboratory Building Projects by Betty Hariyani, Koespiadi Koespiadi, M. Ikhsan Setiawan

“… Construction management is a crucial aspect in the governance of building construction project partnerships. The complexity and challenges in building construction projects, such as multi-stakeholder involvement, uncertainty, and time and cost pressures, signal the importance of the construction management role. …”
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Empathetic Deep Learning: Transferring Adult Speech Emotion Models to Children With Gender-Specific Adaptations Using Neural Embeddings by Elina Lesyk, Tomás Arias-Vergara, Elmar Nöth, Andreas Maier, Juan Rafael Orozco-Arroyave, Paula Andrea Perez-Toro

“…To tackle this, we perform inference on children’s data to examine how emotional labels in IEMOCAP correspond to those in AIBO, highlighting the complexities of cross-age emotional transfer. This approach achieved F-scores of up to 0.47. …”
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Triple pillars of sustainable finance: The role of green finance, CSR, and digitalization on bank performance in Bangladesh by Shaikh Masrick Hasan, K. M. Anwarul Islam, Tawfiq Taleb Tawfiq, Priya Saha

“…This suggests that higher default rates indicate increased credit risk and financial losses, while larger bank sizes may lead to inefficiencies due to agency costs and organizational complexities.…”
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