CLN6‐related continuum phenotype caused by aberrant splicing by Federica Invernizzi, Barbara Castellotti, Chiara Reale, Celeste Panteghini, Isabel Colangelo, Roberta Solazzi, Francesca Ragona, Lucio Giordano, Jessica Galli, Davide Rossi Sebastiano, Gianluca Marucci, Valeria Cuccarini, Giuseppe Didato, Cinzia Gellera, Barbara Garavaglia, Tiziana Granata, Laura Canafoglia

“…CLN6‐related NCLs include both late‐infantile and adult myoclonic form. We report a 21‐year‐old patient, with mild developmental delay, who developed occipital seizures at 14 years, and subsequently cognitive decline, cortical myoclonus, and photosensitivity at low and higher frequencies. …”
Get full text

Diethyldithiocarbamate-copper complex ignites the tumor microenvironment through NKG2D-NKG2DL axis by Daciana C. Dumut, Daciana C. Dumut, Marian Hajduch, Marian Hajduch, Amanda M. Zacharias, Qingling Duan, Qingling Duan, Ivo Frydrych, Zuzana Rozankova, Zuzana Rozankova, Miroslav Popper, Miroslav Popper, Dusan Garic, Radu Alexandru Paun, Radu Alexandru Paun, Amanda Centorame, Amanda Centorame, Juhi Shah, Martin Mistrik, Martin Mistrik, Petr Dzubak, Petr Dzubak, Juan B. De Sanctis, Juan B. De Sanctis, Danuta Radzioch, Danuta Radzioch, Danuta Radzioch, Danuta Radzioch

“…While the prior represents about 5% of all CRCs, the latter represent 95% and are characterized by low immunogenicity. This study investigates bis-diethyldithiocarbamate (CuET), a novel anticancer compound, and its impact on the colorectal cancer tumor microenvironment (TME). …”
Get full text

Controlled bottom-up synthesis and characterization of crystalline and amorphous lead(II) coordination polymers: Sonochemical methods, structure–property relationship, and photocat... by Saeedeh Ebad Sichani, Mohammad Jaafar Soltanianfard, Alison Zamanpour, Payam Hayati, Jan Janczak, Zahed Karimi-Jaberi

“…The 3D coordination polymers of lead (II) [Pb4(O)(L)3(H2O)]n, where H2L = C6H4(CO2H)2 (benzene-1,3-dicarboxylic acid), were synthesized in crystalline (1(a, b)) and amorphous (2(a, b)) phases. …”
Get full text

DockCADD: A streamlined in silico pipeline for the identification of potent ribosomal S6 Kinase 2 (RSK2) inhibitors by El Mehdi Karim, Meriem Khedraoui, Abdelkbir Errougui, Yasir S. Raouf, Abdelouahid Samadi, Samir Chtita

“…Employing pyran derivatives as the scaffold, top-scoring inhibitors as identified by the pipeline showed scores ranging from -9.46 to -9.89 kcal/mol and binding free energies ranging from -53.731 to -55.193 kcal/mol. …”
Get full text

Role of phytochemicals in cardiovascular disease management: Insights into mechanisms, efficacy, and clinical application by Esther Ugo Alum

“…Background/Objective: New approaches to prevention and treatment are necessary for cardiovascular diseases (CVDs), a major worldwide health issue. …”
Get full text

AI-enhanced 3D-QSAR screening of fragment-based novel designed molecules targeting Phalaris minor ACCase by Bikash Kumar Rajak, Priyanka Rani, Durg Vijay Singh, Nitesh Singh

“…The selected herbicide-like molecules are further processed through fragment-based design to generate a library of new compounds, refined using binding affinity thresholds (-8.5 kcal/mol) and Quantitative Structure-Activity Relationship (QSAR) models. …”
Get full text

Bisphenol B restrains rat leydig cell function via H3K27me3/H3K9me3 histone modifications by Jiayi He, Huiqian Zhang, Hehua Quan, Qingyuan Wang, Congcong Wen, Yiyan Wang, Yang Zhu, Ren-Shan Ge, Xiaoheng Li

“…As an alternative compound of bisphenol A (BPA), bisphenol B (BPB) was widely used in plastic materials. …”
Get full text

Microwave-assisted extraction enhances Aquafaba functionality: A high value-added egg white replacer in vegan meringue production by Zahra Kargar, Abdollah Hematian Sourki

“…X-ray diffraction revealed a reduction in protein crystal size, and FT-IR analysis confirmed the absence of harmful compounds in MAEA. Thermogravimetric analysis (TGA) identified key thermal degradation points. …”
Get full text

Structural evolution characteristics of sulfur in coal during gold-tube thermal simulation by Liping Xue, Yuegang Tang, Shuo Gao

“…At Easy%Ro ≥ 3.64, low and high-organic‑sulfur coals produce elemental sulfur S8 and ester sulfate compounds. …”
Get full text

Study on the Formation of Secondary Organic Aerosol by Ozonolysis of Citral in the Atmosphere by Chenxi Zhang, Xuesong Cao, Xiaomin Sun, Hengjun Peng

“…The low-volatility organic compounds potentially arising from the ozonolysis of citral, including aldehydes (—C(=O)H), ketones (—C(=O)—), alcohols (—OH), and hydroperoxides (—OOH), can form SOA through the nucleation, condensation, and/or partitioning of the condensed and gaseous phases.…”
Get full text

Nutritional contribution of Coula edulis B. and Tetracarpidium conophorum M. A. to the Cameroon food composition table by Talla Tagne Naccis, Kotue Taptue Charles, Fokou Elie

“…TC was separated into two batches: one raw (TCNT) and the other precooked (TCPT) before analysis. …”
Get full text

Predicted thermodynamic structural and elastic properties of SrCuP and SrCuSb for thermoelectric applications by N. Bioud, N. Benchiheub, A. Benamrani, M. A. Ghebouli, M. Fatmi, Faisal Katib Alanazi, R. Yekhlef

“…The vibration energy of phonons is 24.14 kJ/mol and 23.37 kJ/mol for SrCuP and SrCuSb. Our thermodynamic parameters increase monotonically with temperatures for both SrCuP and SrCuSb materials. …”
Get full text

Emission Factors of PAHs Components and Bioreactivity in PM2.5 from Biomass Burning by Xinye Zhu, Kin-Fai Ho, Tzu-Ting Yang, Vincent Laiman, Jian Sun, Zhenxing Shen, Hsiao-Chi Chuang

“…YAP were positively correlated with ANT, PHE, 1-MP, FLU, PYR, 3,6-DP, BaA, CHR, BbF, BkF, BaP, BeP, PER, IcdP, BghiP, and DahA (p < 0.05). …”
Get full text

BIODEGRADABLE POLYMER COMPOSITE BASED ON POLYVINYL CHLORIDE AND WOOD WASTE. DEVELOPMENT AND CHARACTERIZATION by VLAD BARBULESCU, LAURENTIA ALEXANDRESCU, MIHAELA NITUICA, MIHAI GEORGESCU, MARIA SONMEZ, DANIELA-MARIA STELESCU, DANA GURAU

“…The new composite is biodegradable due to the compounding with wood fibers, have low density and implicitly the products made from, a lower weight, reduced costs and recover waste. …”
Get full text

Mycorrhizae: Implications for Environmental Remediation and Resource Conservation by Jyotsna Sharma, Andrew V. Ogram, Abid Al-Agely

“…Al-Agely, describes the symbiotic relationships between plant roots and fungi and how the resulting rhizosphere activity can lead to transformation and removal of polluting compounds from the soil, reduce the need for fertilizer in commercial nurseries, and improve soil structure and health. …”
Get full text

Mycorrhizae: Implications for Environmental Remediation and Resource Conservation by Jyotsna Sharma, Andrew V. Ogram, Abid Al-Agely

“…Al-Agely, describes the symbiotic relationships between plant roots and fungi and how the resulting rhizosphere activity can lead to transformation and removal of polluting compounds from the soil, reduce the need for fertilizer in commercial nurseries, and improve soil structure and health. …”
Get full text

Liposome-like encapsulation of fish oil-based self-nano emulsifying formulation for improved bioavailability by Iqbal Ahmad, Aparana Dogra, Tanya Nagpal, Chandvi Sharma, Sudhakar Singh, Nikhil Shaiva, Gaurav Saini, Kanishk Luhach

“…However, the poor bioavailability of these lipophilic compounds, especially in their ethyl ester form, limits their clinical efficacy. …”
Get full text

Discovery of the bacterial HslV protease activators as lead molecules with novel mode of action by Aurangzeb Sana, Aurongzeb Muhammad, Shamim Shahbaz, Rashid Yasmeen, Khan Khalid Mohammed, Aziz Tariq, Alharbi Metab, Alasmari Abdullah F.

“…Normal mode analysis investigations provided additional confirmation regarding the stability of the conformational interactions between the HslV protease and the active compounds. In addition, the predicted absorption, distribution, metabolism, excretion, and toxicity properties of these lead compounds remarkably demonstrated their considerable drug-like and non-toxic qualities. …”
Get full text

Anthelmintic activity of 1,10-phenanthroline-5,6-dione-based metallodrugs by Maria E. Cirino, Thainá R. Teixeira, Alessandro M. H. Silva, Ana C. C. Borges, Lucas Fukui-Silva, Luis G. Wagner, Christiane Fernandes, Malachy McCann, André L. S. Santos, Josué de Moraes

“…Given the promising biological properties of phendione and its metal complexes, these findings contribute to the growing body of research seeking to address the urgent need for new anthelmintic therapies.…”
Get full text

Pasteur : sous le savant l’artiste by Perrot, Annick

“…As a school boy, Pasteur tried his hand at pastel and lithography with real talent. …”
Get full text