Study insights in the role of PGC-1α in neurological diseases: mechanisms and therapeutic potential by Mi-bo Tang, Yi-xuan Liu, Zheng-wei Hu, Hai-yang Luo, Shuo Zhang, Chang-he Shi, Yu-ming Xu, Yu-ming Xu, Yu-ming Xu

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Polybrominated Dibenzo-p-dioxins/Furans (PBDD/Fs) and Diphenyl Ethers (PBDEs) in the Indoor and Outdoor of Gymnasiums by Ching-Kai Su, Jian-He Lu, How-Ran Chao, Wei-Hsiang Chang, Ming-Hsien Tsai, Chih-Lung Wang, I-Cheng Lu, Yu-Ting Chang, Hsiao-Chi Chuang, Wan-Nurdiyana-Wan Mansor, Yi-Chyun Hsu, Ying-I Tsai, Shang-Ming Ma

“…To assess the risks, the non-dietary daily intakes of PBDEs and PBDD/Fs were estimated as 1.61–2.11 × 10–7 and 4.15–5.42 × 10–13 mg kg b.w.–1 day–1, respectively, in the employees and 5.04–6.58 × 10–8 and 1.29–1.69 × 10–13 mg kg b.w.–1 day–1, respectively, in the gym users. …”
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Comparative studies on physicochemical properties, volatile flavor substances and microbial community of Mianning ham at different altitudes by Qianhui Zeng, Lili Ji, Wei Wang, Jiamin Zhang, Ting Bai, Ling Gan, Lin Chen

“…BackgroundThis study explores the impact of varying altitudes on the quality characteristics of Mianning ham.MethodsBy utilizing Solid-Phase Microextraction—Gas Chromatography–Mass Spectrometry (SPME-GC-MS) technology and high-throughput sequencing techniques, the physicochemical properties, volatile flavor compounds, and shifts in microbial communities of Mianning ham at different altitudes were investigated.ResultsHam’s water content, aw, pH, malondialdehyde content,and nitrite content at high altitudes were higher, while the salt content of ham at low altitudes was higher. 112 volatile compounds were identified in ham fermented for 0, 1, and 2 years at low altitude and high altitude, and the volatile compounds in ham at high altitude were more abundant than those in ham at low altitude. …”
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Formulation Optimization and Quality Analysis of Dendrobium officinale Chewable Tablets by Wenyu ZHANG, Xianshu FU, Xue BAI, Shiwen WU, Jiabin LI, Xiaoping YU, Mingzhou ZHANG, Zihong YE

“…A single-factor experiment was used to study the effects of excipients on the appearance, taste, hardness, and weight difference of chewable tablets, and the optimal formula was selected by combining the response surface optimization and multi-index weight methods. Results showed that the optimal compound ratio of the main ingredients of D. officinale chewable tablets (mass fraction) was D. officinale:P. sibiricum:Z. jujuba=35%:10%:5%, and the corresponding total mass fractions of polysaccharides, flavonoids, and polyphenols were 159.64±0.14, 79.44±0.35, and 78.10±0.28 mg/g, respectively. …”
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Transcriptome analysis and cytochrome P450 monooxygenase reveal the molecular mechanism of Bisphenol A degradation by Pseudomonas putida strain YC-AE1 by Adel, Eltoukhy, Yang, Jia, Imane, Lamraoui, M. A., Abo‑Kadoum, Omar, Mohammad Atta, Ruth, Nahurira, Junhuan, Wang, Yanchun, Yan

“…BPA reported as a prominent endocrine disruptor compound that possesses estrogenic activity and fulminant toxicity. …”
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Ethnobotanical survey of medicinal plants used in management of breast cancers in Qatar by Rasha.S.Abo El Alaa, Hend Al-Jaber, Fatima Al Zahraa Chokor, Abdullah A. Shaito, Layla Al-Mansoori

“…(Black seeds) (habit elbaraka) were the most recommended plants.Literature searches revealed that many of these plants possess compounds with potential anticancer properties as sesquiterpenes, flavonoids, thymoquinone, volatile terpenic compounds and anthocyanin. …”
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Integrated electronic nose and multi-omics reveal changes in flavour characterization of cashmere goats and tan sheep meat by Ju Zhang, Shuang Pang, Ge Yan, Lulu Wang, Yuan Xu, Yuheng Bai, Ran Li, Xihong Wang, Yu Jiang

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Hyssopus cuspidatus volatile oil: a potential treatment for steroid-resistant asthma via inhibition of neutrophil extracellular traps by Xu Wang, Hui-Ming Peng, Meng-Ru Zhang, Jing-Jing Li, Chuan-Peng Zhao, Ya-Li Zhang, Si-Yu Wang, Si-Ying Zhu, Jian-Kang Lu, Hai-Long Yin, Qiang Yin, Jin-Bo Fang

“…Meanwhile, molecular docking results showed that 3-methoxy-4-hydroxy mandelonitrile, 1,2,3,4-tetrahydro-1,5,7-trimethyl-naphthalene, cis-calamenene and aristol-1(10)-en-9-yl isovalerate may be the therapeutic compounds of HVO in treating SRA. …”
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Effects of sodium alginate and calcium on quality attributes of Shepherd’s purse under ultrasound impregnation during blanching processing by Qihui Wu, Zhongyuan Zhang, Yihong Bao, Dajing Li, Xin Wen, Lei Feng, Meimei Nie, Zhuqing Dai, Yayuan Xu

“…The contents of ascorbic acid, phenolic compounds and calcium were determined after blanching for 1 min, and the color, structure and volatile substances were analyzed. …”
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Effects of intramuscular fat on the flavor of fresh sheep and goat meat: Recent insights into pre-mortem and post-mortem factors by Tianyu Su, Yu Fu, Jingjie Tan, Mohammed Gagaoua, Kathrine H. Bak, Olugbenga P. Soladoye, Zhongquan Zhao, Yongju Zhao, Wei Wu

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Comparison of chemical constituents in Lysimachia species and their antimicrobial activity for extending the shelf life of foods by Li-Li Chen, Shuang Long Yang, Ji-Cun Bao, Wei-You Xie, Zhao-Chan Wang, Nian Shi, Zhao-Jie Wang

“…The KBZZC-05, 21, and 23 inhibited both spoilage organisms and foodborne pathogens (MICs = 2–256 μg/mL) better than potassium sorbate (MIC >256 μg/mL). …”
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Optical time-lapsed in situ mechanochemical studies on metal halide perovskite systems by Yonghao Xiao, David G. Bradley, Wei Xin Chan, Xinwen Hu, Lian Xiao, Zhenpeng Liu, Zi Yang Tan, Xin Zhao, Chenfei Li, Mansour Sadek, Vikash Kumar Ravi, Ying Hern Tam, Xiaotao Wang, Felipe García, Handong Sun, Seow Chin Low, Poh Boon Phua, Tze Chien Sum, Xiuwen Zhou, Yee-Fun Lim, John V. Hanna, Han Sen Soo

“…Our work provides insights into the mechanochemistry of compounds with low thermodynamic barriers.…”
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Geographical origin discrimination of Chenpi using machine learning and enhanced mid-level data fusion by Xin Kang Li, Li Jun Tang, Ze Ying Li, Dian Qiu, Zhuo Ling Yang, Xiao Yi Zhang, Xiang-Zhi Zhang, Jing Jing Guo, Bao Qiong Li

“…The results show that data fusion significantly improves Chenpi origin discrimination. …”
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Chemical characterization of Siraitia grosvenorii granules and their efficacy and mechanism of action on PM2.5-induced acute lung injury by Qi Shao, Yan Zhao, YuYu Shi, Fafeng Cheng, ZeHan Zhang, Ying Liu, ChangXiang Li, ZiLin Ren, Hua Bai, Haojie Cheng, Rolando Maddela, Junqiang Tian, Xueqian Wang

“…The chemical composition of SGG, such as wogonin (MOL000173), luteolin (MOL000006), nobiletin (MOL005828), naringenin (MOL004328), acacetin (MOL001689), were identified via ultra-high-performance liquid chromatography-Q Exactive (UHPLC-QE) Orbitrap/MS. …”
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The development and evaluation of a tublysine-based antibody-drug conjugate with enhanced tumor therapeutic efficacy by Huihui Guo, Hongsheng Xie, Yuanyuan Huang, Junxiang Jia, Xiangfei Kong, Qingliang Yang, Shun Gai, Wenjun Li, Lu Bai, Lingli Zhang, Xiaoxiao Chen, Zhicang Ye, Hangbo Ye, Linyao Zhao, Yifang Xu, Yong Du, Xiuzhen Zhang, Miaomiao Chen, Xiaomai Zhou, Robert Y. Zhao

“…DX126-262, incorporating Tub114, a novel Tubulysin B analog, effectively mitigates the inherent hepatotoxicity associated with Tubulysin compounds while maintaining strong antitumor efficacy. …”
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Antifungal activity and biocompatibility assessment with molecular docking and dynamic simulations of new pyrazole derivatives by Basma T. Abd-Elhalim, Ghada G. El-Bana, Ahmed F. El-Sayed, Ghada E. Abdel-Ghani

“…The biocompatibility investigation showed that the 3b compound was completely safe with no IC50 dose obtained. …”
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Efficacy of Chinese traditional quadruple single pill combination versus valsartan/hydrochlorothiazide for the treatment of hypertension (COSPQ-BP): study protocol for randomised c... by Kai Liu, Yu Yan, Xin Zhang, Yanan Li, Yuanyuan Yao, Lu Liu, Runyu Ye, Si Wang, Xiangyu Yang, Xiaoping Chen, Shanshan Jia, Qingtao Meng, Xianghao Zuo

“…Introduction Hypertension constitutes the primary health burden of cardiovascular diseases, and the global control of blood pressure (BP) remains insufficient. Single pill combinations (SPCs) are employed as a means to streamline the management of poor BP control due to non-adherence and treatment inertia. …”
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Flow-based In Vivo Method to Enumerate Translating Ribosomes and Translation Elongation Rate by Mina Seedhom, Devin Dersh, Jonathan Yewdell

“…Here, we detail protocols based on ribosome-mediated nascent chain puromycylation, harringtonine to stall initiating ribosomes while allowing ribosome elongation to continue normally, and cycloheximide to freeze translating ribosomes in place. Each compound is delivered intravenously to mice in the appropriate order, and after ex vivo cell fixation and permeabilization, translating ribosome numbers and transit rates are measured by flow cytometry using a directly conjugated puromycin-specific antibody.…”
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Psilocybin-assisted therapy for reducing alcohol intake in patients with alcohol use disorder: protocol for a randomised, double-blinded, placebo-controlled 12-week clinical trial... by Claus Thorn Ekstrøm, Patrick MacDonald Fisher, Gitte Moos Knudsen, Dea Siggaard Stenbæk, Anders Fink-Jensen, Mathias Ebbesen Jensen, Tobias Søgaard Juul

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Computational Study of Trisindoline 5 Against Overexpressed EGFR Protein on Breast Cancer Stem Cell by Nurhayati A.P.D., Fatoni M., Santoso M., Wati F.A.

“…Trisindoline is an indole trimer alkaloid natural compound that provide a cytotoxic effect on cancer cells. …”
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