Synergistic attenuation of complete freund’s adjuvant-induced inflammation in mice using shinbaro-pelubiprofen: a novel therapeutic complex by Hyunseong Kim, Jin Young Hong, Wan-Jin Jeon, Hyun Kim, Changhwan Yeo, Junseon Lee, Yoon Jae Lee, In-Hyuk Ha

Subjects: “…Complete freund’s adjuvant…”
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Calotropis procera Latex Extract Affords Protection against Inflammation and Oxidative Stress in Freund's Complete Adjuvant-Induced Monoarthritis in Rats by Vijay L. Kumar, Sanjeev Roy

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Metallothionein-3-mediated intracellular zinc mediates antioxidant and anti-inflammatory responses in the complete Freund’s adjuvant-induced inflammatory pain mouse model by Ngoc Buu Tran, Sook-Jeong Lee

“…We investigated the role of metallothionein-3 (MT3) in modulating complete Freund’s adjuvant (CFA)-induced intracellular Zn2+ activity in an MT3 knockout mouse model of inflammatory pain in the hind paw. …”
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Antinociceptive Effect of Tephrosia sinapou Extract in the Acetic Acid, Phenyl-p-benzoquinone, Formalin, and Complete Freund’s Adjuvant Models of Overt Pain-Like Behavior in Mice by Renata M. Martinez, Ana C. Zarpelon, Talita P. Domiciano, Sandra R. Georgetti, Marcela M. Baracat, Isabel C. Moreira, Cesar C. Andrei, Waldiceu A. Verri, Rubia Casagrande

“…T. sinapou extract also inhibited formalin- and complete Freund’s adjuvant- (CFA-) induced flinching/licking at 100 mg/kg dose. …”
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Persistent Suppression of Type 1 Diabetes by a Multicomponent Vaccine Containing a Cholera Toxin B Subunit-Autoantigen Fusion Protein and Complete Freund’s Adjuvant by Béla Dénes, István Fodor, William H. R. Langridge

“…Data presented here demonstrate multifunctional vaccination strategies that harness vaccinia virus mediated delivery of a gene encoding an immunoenhanced diabetes autoantigen in combination with complete Freund’s adjuvant (CFA) that can maintain safe and durable immunologic homeostasis in NOD mice. …”
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The Effect of IFN-γ, Alum and Complete Freund Adjuvant on TNP-KLH Induced Ig.G1, IgE and IgG2a Responses in Mice by R. van Ommen, A. E. C. M. Vredendaal, M. de Gooyer, A. van Oudenaren, H. F. J. Savelkoul

“…This is based on the different cytokine production patterns that were observed after in vitro resttmulation of T cells isolated from mice immunized with antigen either adsorbed on alum or emulsified in complete Freund adjuvant (CFA). However, other studies suggest that primarily the type of antigen determines which isotypes are produced and to what extent. …”
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Potency of Bone Marrow-Derived Mesenchymal Stem Cells and Indomethacin in Complete Freund’s Adjuvant-Induced Arthritic Rats: Roles of TNF-α, IL-10, iNOS, MMP-9, and TGF-β1 by Eman A. Ahmed, Osama M. Ahmed, Hanaa I. Fahim, Tarek M. Ali, Basem H. Elesawy, Mohamed B. Ashour

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The concerted actions of microRNA-29a and interferon-β modulate complete Freund's adjuvant-induced inflammatory pain by regulating the expression of type 1 interferon receptor, interferon-stimulated gene 15, and p-extracellular signal-regulated kinase by Chien-Cheng Liu, Kuo-Chuan Hung, Yu-Yu Li, Eagle Yi-Kung Huang, Chin-Chen Chu, Lok-Hi Chow, Ping-Heng Tan

“…Methods: Inflammatory pain was induced in male rats using complete Freund's adjuvant (CFA). The changes in miR-29a, IFN-ß, and IFNR1 were measured on Days 2, 3, 5, 7, and 10 post-CFA injection and expression of IFNR1, phospho-ERK (phosphorylated extracellular signal-regulated kinase) (p-ERK), extracellular signal-regulated kinase (ERK), and IFN-stimulated gene 15 (ISG15) were measured in rats that received an miR-29a inhibitor or miR-29a mimic. …”
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Inflammation Modulating Activity of the Hydroethanol Stem Bark Extract of Bombax costatum in Murine Models by Meshack Antwi-Adjei, Kofi Oduro Yeboah, James Oppong-Kyekyeku, Newman Osafo

“…Moreover, Bombax costatum extract significantly inhibited joint inflammation and damage following injection of complete Freund’s adjuvant. Treatment with the extract also inhibited the onset of polyarthritis; thus, suppressing the systemic spread of joint inflammation from ipsilateral limbs to contralateral limbs. …”
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Long-Term Provision of Acidified Drinking Water Fails to Influence Autoimmune Diabetes and Encephalomyelitis by Sundararajan Jayaraman, Arathi Jayaraman

“…Interestingly, administration of complete Freund’s adjuvant alone or emulsified with a neuronal peptide to induce neurodegenerative disease during the prediabetic stage completely prevented the onset of diabetes regardless of the pH of the drinking water. …”
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C-Reactive Protein Knockout Attenuates Temporomandibular Joint Inflammation in Rats by Yao He, Mengjiao Zhou, Zixiang Jian, Lingli Fang, Lan Huang, Jinlin Song

“…In this study, we evaluated the biological effect of CRP on temporomandibular joint (TMJ) inflammation. Methods. Freund’s complete adjuvant (CFA) was used to induce TMJ inflammation in CRP-knockout (CRP-/-) and control rats. …”
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IL-6 Promotes Islet β-Cell Dysfunction in Rat Collagen-Induced Arthritis by Huan Jin, Yaogui Ning, Haotong Zhou, Youlian Wang

“…The model of collagen-induced arthritis (CIA) was established by intradermal injection of type II collagen into Wistar rats; complete Freund’s adjuvant injections were used as the control group. …”
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Synthetic Peptides as Potential Antigens for Cutaneous Leishmaniosis Diagnosis by Juliana Seger Link, Silvana Maria Alban, Carlos Ricardo Soccol, Gilberto Vinicius Melo Pereira, Vanete Thomaz Soccol

“…The peptides individually or a mixture of them (MIX) was subsequently emulsified in complete and incomplete Freund’s adjuvant and injected subcutaneously in golden hamsters. …”
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A synthetic cyclic peptide for promoting antigen presentation and immune activation by Jiahui Zhang, Harrison Y. R. Madge, Asmaa Mahmoud, Lantian Lu, Wanyi Wang, Wenbin Huang, Prashamsa Koirala, Jazmina L. Gonzalez Cruz, Wei Yang Kong, Sahra Bashiri, Ahmed O. Shalash, Waleed M. Hussein, Zeinab G. Khalil, James W. Wells, Istvan Toth, Rachel J. Stephenson

“…All vaccine candidates self-assembled into sub-500 nm nanoparticles and induced high antigen-specific systemic IgG titers and opsonic potential compared to the antigen co-administered with a commercial adjuvant, complete Freund’s adjuvant. Notably, presence of the cyclic decapeptide in this vaccine increased accumulation in the draining inguinal lymph nodes, facilitating cellular uptake of peptide antigens. …”
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Identification of CTL Epitopes on Efflux Pumps of the ATP-Binding Cassette and the Major Facilitator Superfamily of Mycobacterium tuberculosis by Yan Lin, Yu Dong, Yanfeng Gao, Ranran Shi, Yubing Li, Xiuman Zhou, Wenwen Liu, Guodong Li, Yuanming Qi, Yahong Wu

“…The immune activities of these two epitopes were improved with the help of complete Freund’s adjuvant (CFA). The epitopes identified here provide a foundation for the diagnosis and treatment of patients infected with drug resistant and the future development of a multiepitope vaccine.…”
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A CFA-Induced Model of Inflammatory Skin Disease in Miniature Swine by Nalú Navarro-Alvarez, Beatriz M. M. Gonçalves, Alec R. Andrews, David H. Sachs, Christene A. Huang

“…Similarities between porcine and human skin make the pig an ideal model for preclinical studies of cutaneous inflammation and wound healing. Complete Freund’s adjuvant (CFA) has been used to induce inflammation and to study inflammatory pain in several animal models. …”
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Comparison of Different Histone Deacetylase Inhibitors in Attenuating Inflammatory Pain in Rats by Yu Mao, Jing Zhou, Xuesheng Liu, Erwei Gu, Zhi Zhang, Wenjuan Tao

“…Persistent inflammatory pain was induced by injecting Complete Freund’s Adjuvant (CFA) into the left hind paw of rats. …”
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Therapeutic Effects of the Superoxide Dismutase Mimetic Compound Me2DO2A on Experimental Articular Pain in Rats by Lorenzo Di Cesare Mannelli, Daniele Bani, Andrea Bencini, Maria Luisa Brandi, Laura Calosi, Miriam Cantore, Anna Maria Carossino, Carla Ghelardini, Barbara Valtancoli, Paola Failli

“…MnL4 (15 mg kg−1) acutely administered, significantly reduced pain induced by carrageenan, complete Freund’s adjuvant (CFA), and sodium monoiodoacetate (MIA). …”
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Sigma-1 Receptor Modulates CFA-Induced Inflammatory Pain via Sodium Channels in Small DRG Neurons by Yuanlong Song, Zifen Xu, Liangpin Zhang, Linlin Gao

“…This study utilized whole-cell patch clamp techniques, single-cell real-time PCR, and immunohistochemistry to examine the influence of Sig-1R on inflammatory pain induced by complete Freund’s adjuvant (CFA) in a rat model. Our results revealed several key findings: (1) The expression of Sig-1R was found to be upregulated during the progression of inflammatory pain, with a notable translocation from the cytoplasm to the membrane; (2) Inhibition of peripheral Sig-1R using S1RA resulted in a reduction of CFA-induced allodynia; (3) Activation of Sig-1R through PRE-084 led to a decrease in the fast sodium current in isolated DRG neurons from CFA-treated rats, which was associated with a diminished action potential (AP) peak and maximum depolarizing rate (MDR), as well as an increased rheobase; (4) Furthermore, PRE-084 was observed to enhance the slow component of the sodium current, resulting in hyperpolarization of the threshold potential and an increase in AP firing frequency, alongside an elevation in the mRNA expression of the slow sodium channel Nav1.9 in CFA-treated rats. …”
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Significant Contribution of Mouse Mast Cell Protease 4 in Early Phases of Experimental Autoimmune Encephalomyelitis by Louisane Desbiens, Catherine Lapointe, Marjan Gharagozloo, Shaimaa Mahmoud, Gunnar Pejler, Denis Gris, Pedro D’Orléans-Juste

“…C57BL/6 wild type (WT) or mMCP-4 knockout (KO) mice were immunized with MOG35–55 plus complete Freund’s adjuvant followed by pertussis toxin. …”
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