Proteomics profiling of inflammatory responses to elexacaftor/tezacaftor/ivacaftor in cystic fibrosis by Hazel Ozuna, Hazel Ozuna, Dinesh Bojja, Santiago Partida-Sanchez, Luanne Hall-Stoodley, Amal Amer, Rodney D. Britt, Rodney D. Britt, Shahid Sheikh, David A. Frank, Weiyuan Wang, Bum-Yong Kang, Bum-Yong Kang, Irina Miralda, Irina Miralda, Samantha L. Durfey, Samantha L. Durfey, Benjamin T. Kopp, Benjamin T. Kopp

“…BackgroundCFTR modulator therapies have positive clinical outcomes, yet chronic inflammation and bacterial infections persist in people with CF (pwCF). …”
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Presence of distinct operant phenotypes and transient withdrawal-induced escalation of operant ethanol intake in female rats by Joseph R Pitock, Shannon R Wheeler, Arleen Perez Ayala, Shikun Hou, Nathaly M Arce Soto, Elizabeth J Glover

“…Ethanol intake during home cage drinking was unable to predict future operant phenotype. Relative to controls, Drinkers chronically exposed to ethanol liquid diet exhibited a significant, but transient, escalation in consummatory, but not appetitive, responding during acute withdrawal. …”
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Stroke in the 21st Century: A Snapshot of the Burden, Epidemiology, and Quality of Life by Eric S. Donkor

“…Not only does the burden of stroke lie in the high mortality but the high morbidity also results in up to 50% of survivors being chronically disabled. Thus stroke is a disease of immense public health importance with serious economic and social consequences. …”
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Voices in the Urban Wilderness: Reimagining the Terms of Order in “Renaissance” Boston by Jeffrey Helgeson

“…Suffering both chronic decline and an acute social and economic crisis in the 1960s and 1970s, Boston’s corporate leaders began to create the initiatives that would allow the city to emerge in the succeeding decades as a leader amongst the nation’s newly thriving technology- and professional-service-based urban economies. …”
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Validation of the Food Safe Zone questionnaire for families of individuals with Prader-Willi syndrome by Elisabeth M. Dykens, Elizabeth Roof, Hailee Hunt-Hawkins, Theresa V. Strong

“…Hyperphagic individuals with PWS are chronically hungry yet rarely feel sated, and often engage in food-seeking behaviors. …”
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Uptake and hesitancy of the second booster dose of COVID-19 vaccine among the general population in China after the surge period of the COVID-19 pandemic: a large-scale national st... by Xin Liu, You Xin, Ling Zhang, Yijin Wu, Shu Jing, Zhenwei Dai, Tianrui Ren, Xiaoyang Liu, Jiaqi Fu, Xu Chen, Weijun Xiao, Hao Wang, Yiman Huang, Wenjun Wang, Xiaofen Gu, Li Ma, Shaokai Zhang, Yanqin Yu, Li Li, Tianzuo Gao, Tianyou Zhao, Yimin Qu, Xinyan Liu, Xiaoyou Su, Youlin Qiao

“…The highest hesitancy rate was observed among participants who had not completed primary immunization (71.4%), followed by those with chronic diseases (48.6%) and those aged 60 and above (33.2%). …”
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Changes in donor lymphocyte infusion for relapsed patients post-hematopoietic stem cell transplantation: a 30-year single-center experience by Yusuke Uchibori, Shuhei Kurosawa, Yuho Najima, Kyoko Haraguchi, Daichi Sadato, Chizuko Hirama, Yasutaka Sadaga, Kaori Kondo, Chika Kato, Satoshi Sakai, Yasuhiro Kambara, Fumihiko Ouchi, Masashi Shimabukuro, Atsushi Jinguji, Naoki Shingai, Takashi Toya, Hiroaki Shimizu, Takeshi Kobayashi, Hironori Harada, Hironori Harada, Yuka Harada, Yoshiki Okuyama, Noriko Doki

“…Until 2014, DLI was only performed in patients with AML (n = 14), MDS (n = 2), or chronic myeloid leukemia (n = 5). However, since 2015, patients with various diseases, including lymphoid malignancies, have also undergone DLI. …”
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Geography and age drive racial and ethnic disparities in hospital mortality for paediatric community-acquired pneumonia in the United States: a retrospective population based cohor... by Cody-Aaron L. Gathers, Nadir Yehya, Anireddy Reddy, Paula M. Magee, Vanessa C. Denny, Michelle R. Mayeda, Amanda O’Halloran, Sanjiv D. Mehta, Stephanie Wanamaker, Jessica C. Fowler, Garrett Keim

“…Multivariable logistic regression, clustered by hospital and adjusting for sex, primary insurance payer, median household income quartile, urban identification, and the presence of a complex chronic condition(s), quantified the relationship between the joint exposure and all-cause mortality for paediatric community-acquired pneumonia. …”
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HIV/AIDS prevalence among adolescents in Igbo-Eze South Local Government Area, Enugu State, and the need for faith-based interventions by Favour Chukwuemeka Uroko, Goodness Chimeremma Ike

“…Results further showed that there are adverse effects of HIV/AIDS on adolescents’ futures and well-being, including an increased number of dropouts from school, social isolation as a result of stigmatization, psychological challenges, such as depression and low self-esteem, and susceptibility for contacting other chronic infections. …”
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The impact of long-term care needs on the socio-economic deprivation of older people and their families: A scoping review protocol. by Rossella Martarelli, Georgia Casanova, Giovanni Lamura

“…Major global problems such as population ageing, long-term care and the socio-economic burden of chronically ill older people and their families are urgent issues. …”
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Identifying depression subtypes and investigating their consistency and transitions in a 1-year cohort analysis. by Carolin Oetzmann, Nicholas Cummins, Femke Lamers, Faith Matcham, Sara Siddi, Katie M White, Josep Maria Haro, Srinivasan Vairavan, Brenda W J H Penninx, Vaibhav A Narayan, Matthew Hotopf, Ewan Carr

“…Future work recommendations are made.…”
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Quality of life in children with glaucoma: a qualitative interview study in Australia by Emmanuelle Souzeau, Jamie E Craig, Sandra E Staffieri, Lachlan S W Knight, Bronwyn Ridge, Mallika Prem Senthil

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Self-managed physical activity in breast cancer survivors: A scoping review. by Maria Chiara Bò, Andrea Merlo, Maria Bernadette Ligabue, Maria Chiara Bassi, Mirco Lusuardi, Isabella Campanini

“…We also provided recommendations for future primary studies and secondary synthesis.…”
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A holistic and sustainable approach to public health staffing and workforce development by Paulani Mui, Ruth Maiorana, Beth Resnick

“…This leaves the nation's public health system chronically under-resourced and ill-equipped to respond, resulting in a strained workforce that must remain nimble. …”
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Implementing Practice Guidelines: A Workshop on Guidelines Dissemination and Implementation with a Focus on Asthma and COPD by Louis-Philippe Boulet, Allan Becker, Dennis Bowie, Paul Hernandez, Andrew McIvor, Michel Rouleau, Jean Bourbeau, Ian D Graham, Jo Logan, France Légaré, Thomas F Ward, Robert L Cowie, Denis Drouin, Stewart B Harris, Robyn Tamblyn, Pierre Ernst, Wan C Tan, Martyn R Partridge, Philippe Godard, Carla T Herrerias, John W Wilson, Liz Stirling, Emily-Brynn Rozitis, Nancy Garvey, Diane Lougheed, Manon Labrecque, Renata Rea, Martin C Holroyde, Danielle Fagnan, Eileen Dorval, Lisa Pogany, Alan Kaplan, Lisa Cicutto, Mary L Allen, Serge Moraca, J Mark FitzGerald, Francine Borduas

“…The objectives of this meeting were to examine the optimal implementation of practice guidelines, review current initiatives for the implementation of asthma and chronic obstructive pulmonary disease (COPD) guidelines in Canada and in the rest of the world, and develop an optimal strategy for future guideline implementation. …”
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Factors Contributing to Retention in Care and Treatment Adherence Among People Living With HIV Returning to Care in South-Eastern Tanzania: A Qualitative Study by Matimbwa H, Lolo SA, Matoy LS, Ndaki R, Ngahyoma S, Mollel HA, Luoga E, Vanobberghen F, Vianney JM, Idindili B, Weisser M

“…Factors promoting retention and adherence were improved health through ART, trust in healthcare services, counseling, health education, clinic follow-up, longer drug refill periods, and family support.Conclusion: Our study highlights persisting stigmatization contributing to dropping from care, with strong family and social support improving adherence and clinic attendance. Future interventions should focus on these factors to enhance retention of lifelong treatment adherence. …”
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Milestones and Timescale of Poststroke Recovery: A Cohort Study by Marianna Loi, Alberto Zaliani, Marta Abbamonte, Elena P. Ferrari, Roberto Maestri, Luigi Trojano, Pietro Balbi

“…As many stroke survivors chronically show severe disability, increase in economic, social, and medical burden could be expected in the future. …”
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Against Futility Judgments for Patients with Prolonged Disorders of Consciousness by William Choi

“…However, these beliefs can be predicated on prejudiced perceptions about the quality of life of individuals with disabilities or chronic illnesses, a phenomenon commonly referred to as the disability paradox.[11] The paradox describes the discrepancy between patients with disabilities who report a quality of life much higher than non-disabled individuals would predict their ratings. …”
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A qualitative mystery shopper study that de(codes) the experiences of English and Spanish-speaking patients who call to schedule a first-time primary care appointment in the Los An... by Esmeralda Melgoza, Ahmad Ismail, Lucía Félix-Beltrán, Rosario Majano, Arturo Vargas Bustamante

“…Telehealth for first-time appointments is uncommon and typically available only under special circumstances, including COVID-19, medication refills, test result reviews, and for chronically ill populations. Conclusion: This study shows disparities in access to care between English and Spanish-speaking patients at the time of scheduling a first-time appointment, highlighting an important point for future intervention.…”
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Comparative Ethics of Modern Payment Models by Jacob Riegler

“…Capitated versus fee-for-service reimbursement and quality of care for chronic disease: a US cross-sectional analysis. BMC Health Serv Res. 2022;22(1):1-12. doi:10.1186/s12913-021-07313-3; Emanuel EJ, Mostashari F, Navathe AS. …”
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