Natural population cohort study on long-lived adults: West China longevity and ageing procedure (WCLAP) by Li Wang, Yan Zhang, Qiukui Hao, Xiaoyan Chen, Birong Dong, Yan He, Meijuan Chen, Jirong Yue, Xiaochu Wu, Tianyao Zhang, Yan She, Yanling Gao, Yiping Deng

“…Data collection included a comprehensive assessment of the participant’s health (including physical, psychological, social and common chronic disease assessments), instrumental tests (body composition and muscle percentage) and the collection of biomedical-biobank samples (include blood, urine, faeces, hair and urine).Future plans Through the annual cohort follow-up, survival-related information is collected at a group level. …”
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Comparative effectiveness of manual therapy, pharmacological treatment, exercise therapy, and education for neck pain (COMPETE study): protocol of a systematic review with network... by Ana Izabela Sobral de Oliveira-Souza, Jordana Barbosa-Silva, Douglas P. Gross, Bruno R. da Costa, Nikolaus Ballenberger, Tiago V. Pereira, Liz Dennett, Susan Armijo-Olivo

“…., medication) to manage all types of neck pain based on the chronicity of the disease (acute, subacute, and chronic pain). …”
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Geographical distribution of eight neuromuscular disorders in the Netherlands based on a nationwide registry by Johanna C.W. Deenen, André L.M. Verbeek, Pieter A. van Doorn, Catharina G. Faber, Anneke J. van der Kooi, Nicolette C. Notermans, Jan J.G.M. Verschuuren, Baziel G.M. van Engelen, Nicol C. Voermans

“…To address possible outliers due to low population numbers, Bayesian smoothing techniques should be considered in future research.…”
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A Potential Protective Effect of Alcohol Consumption in Male Genital Lichen Sclerosus: A Case-Control Study by Joey El Khoury, Jessica Andraos, Anthony Kanbar, Rami Halabi, Serge Assaf, Anthony Mina, Sabine El Breidi, Charbel Dabal, Charbel El Hachem, Rodrigue Saad, Antoine Kassis, Maher Abdessater, Raghid El Khoury

“…Lichen sclerosus (LSc) is a chronic inflammatory process of the skin characterized by its unique histological features. …”
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Item-level measurement properties of the pediatric awareness and sensory motor assessment in children with medical complexity by Brooke Mulrenin, Bryant A. Seamon, Carrie Cormack, Kimberly Lane Kascak, Cynthia Dodds

“…IntroductionChildren with medical complexity (CMC) are medically fragile with severe brain damage and chronic conditions, necessitating daily care. Their neurological impairments often limit participation in childhood activities, affecting quality of life. …”
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Exploring precision therapeutics: computational design of antisense oligonucleotides targeting AXL gene transcripts in multiple sclerosis treatment management by Bhargav Shreevatsa, Bhargav Shreevatsa, Abhigna Nagaraj, Chandan Dharmashekar, Anisha Jain, Bhavana Harendra, Siddesh V. Siddalingegowda, Haneen A. Al-Mazroua, Sheikh F. Ahmad, Shashanka K. Prasad, Chandrashekar Srinivasa, Chandan Shivamallu, Shiva Prasad Kollur

“…Multiple sclerosis (MS) is a chronic autoimmune illness characterized by demyelination, neurodegeneration, and inflammation in the central nervous system. …”
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An assessment of burden associated with problem joints in children and adults with moderate or severe haemophilia A: analysis of the CHESS-Paediatrics and CHESS II cross-sectional... by Paul McLaughlin, Hortensia De la Corte-Rodriguez, Tom Burke, Francis Nissen, Martynas Aizenas, Katya Moreno, Jamie O’Hara

“…Use of person-centric characterizations of joint morbidity may improve analysis of long-term outcomes and lead to improvements in future haemophilia care.…”
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Metabolite profiling in assessing ulcerative colitis activity: A systematic review by Danyang Cui, Xu Han, Jiazhu Jin, Yanhong Wang, Zijia Chen, Yang Gong, Miao Jiang

“…Background: Ulcerative colitis (UC) is an immune-mediated chronic inflammatory condition of the colon, characterized by defects in the intestinal epithelial barrier, dysbiosis of the microbiota, and immune dysregulation. …”
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Improving Patient Outcomes in mTBI: The Role of Integrated Nursing Interventions in the Emergency Department by Feng T, Zhao P, Wang J, Du X, Ai M, Yang J, Li J

“…The high predictive value of these interventions further underscores their importance in emergency care. Future research should focus on the long-term effects of Integrated Nursing Interventions on patient outcomes across different age groups, particularly in chronic disease management. …”
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Deep learning-based algorithm for classifying high-resolution computed tomography features in coal workers’ pneumoconiosis by Hantian Dong, Biaokai Zhu, Xiaomei Kong, Xuesen Su, Ting Liu, Xinri Zhang

“…Abstract Background Coal workers’ pneumoconiosis is a chronic occupational lung disease with considerable pulmonary complications, including irreversible lung diseases that are too complex to accurately identify via chest X-rays. …”
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Design and psychometric testing of a moral intelligence instrument for pre-hospital emergency medical services personnel: a sequential-exploratory mixed-method study by Fateme Mohammadi, Rasoul Salimi, Salman Khazaei, Mostafa Bijani

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The Role of Neuroglial Crosstalk and Synaptic Plasticity-Mediated Central Sensitization in Acupuncture Analgesia by Zhongxi Lyu, Yongming Guo, Yinan Gong, Wen Fan, Baomin Dou, Ningcen Li, Shenjun Wang, Yuan Xu, Yangyang Liu, Bo Chen, Yi Guo, Zhifang Xu, Xiaowei Lin

“…Pain is a hypersensitivity state caused by peripheral and central sensitization, with the latter considered the culprit for chronic pain. This study summarizes the pathogenesis of central sensitization from the perspective of neuroglial crosstalk and synaptic plasticity and underlines the related analgesic mechanisms of acupuncture. …”
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The role of Akkermansia muciniphila in maintaining health: a bibliometric study by Fangfang Gao, Canyu Cheng, Canyu Cheng, Runwei Li, Zongcun Chen, Zongcun Chen, Ke Tang, Guankui Du, Guankui Du, Guankui Du

“…Therefore, future research should explore its potential further by conducting clinical trials, elucidating its mechanisms of action, and investigating its efficacy and safety in diverse patient populations.…”
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Total Adiponectin Is Inversely Associated with Platelet Activation and CHA2DS2-VASc Score in Anticoagulated Patients with Atrial Fibrillation by Roberto Carnevale, Daniele Pastori, Mariangela Peruzzi, Elena De Falco, Isotta Chimenti, Giuseppe Biondi-Zoccai, Ernesto Greco, Antonino G. M. Marullo, Cristina Nocella, Francesco Violi, Pasquale Pignatelli, Camilla Calvieri, Giacomo Frati

“…Enhancing APN levels may be a future goal to reduce the risk of vascular outcomes in AF patients.…”
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Therapeutic alliance impact on analgesic outcomes in a real-world clinical setting: An observational study by Barrachina Jordi, Margarit César, Andreu Blanca, Zandonai Thomas, Ballester Pura, Muriel Javier, Cutillas Esperanza, Peiró Ana M.

“…A cross-sectional observational study was conducted on outpatients (n = 69) using opioids on a long-term basis for the treatment of chronic non-cancer pain, where clinical pharmacologists and pharmacists advised patients about their opioid treatment. …”
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Healthcare trajectories of aging individuals during their last year of life: application of process mining methods to administrative health databases by Delphine Bosson-Rieutort, Alexandra Langford-Avelar, Juliette Duc, Benjamin Dalmas

“…Abstract Context World is aging and the prevalence of chronic diseases is raising with age, increasing financial strain on organizations but also affecting patients’ quality of life until death. …”
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Exploring Health Educational Interventions for Children With Congenital Heart Disease: Scoping Review by Neda Barbazi, Ji Youn Shin, Gurumurthy Hiremath, Carlye Anne Lauff

“…Despite advances in medical care, CHD is often a chronic condition requiring continuous management and education. …”
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OMIC Technologies and Vaccine Development: From the Identification of Vulnerable Individuals to the Formulation of Invulnerable Vaccines by Nicola Cotugno, Alessandra Ruggiero, Veronica Santilli, Emma Concetta Manno, Salvatore Rocca, Sonia Zicari, Donato Amodio, Manuela Colucci, Paolo Rossi, Ofer Levy, Federico Martinon-Torres, Andrew J. Pollard, Paolo Palma

“…This is also due to the inadequate immune response and paucity of informative correlates of protection upon immunization of vulnerable individuals such as newborns, preterm infants, pregnant women, and elderly individuals as well as those patients affected by chronic and immune compromising medical conditions. …”
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Short- and long-term changes in neurological, behavioural, and blood biomarkers following repeated mild traumatic brain injury in rats—potential biological sex-dependent effects by Rodrigo Moraga-Amaro, Oscar Moreno, Jordi Llop, Marion Bankstahl, Marion Bankstahl, Jens P. Bankstahl

“…IntroductionChronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease resulting from repeated mild traumatic brain injuries (rmTBI). …”
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Risk of SARS-CoV-2 infection before and after the Omicron wave in a cohort of healthcare workers in Ontario, Canada by Jorge L. Martinez-Cajas, Ann Jolly, Yanping Gong, Gerald Evans, Santiago Perez-Patrigeon, Bradley Stoner, T. Hugh Guan, Beatriz Alvarado

“…We compared the contribution of these factors to infection risk and explored the implications for future epidemic preparedness and the protection of HCWs. …”
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