Effectiveness and safety profile of mesenchymal stem cell secretome as a treatment for severe cases of COVID-19: a randomized controlled trial [version 2; peer review: 1 approved,... by Hary Sakti Muliawan, Erlina Burhan, Mia Elhidsi, Heri Wibowo, Triya Damayanti, Jeanne Adiwinata Pawitan, Isabella Kurnia Liem, Ismail Hadisoebroto Dilogo, Mira Yulianti, Adityo Susilo, Irandi Putra Pratomo, Raden Rara Diah Handayani, Rahyussalim -, Murdani Abdullah, Cosphiadi Irawan, Robert Sinto, Dita Aditianingsih

“…The primary outcome of this study was the changes in inflammatory markers and the ratio of inflammatory to anti-inflammatory markers. …”
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Association of adenylate cyclase activity in vasopressor-type neurally mediated syncope based on the α2b-AR gene. by Tomoyoshi Komiyama, Kengo Ayabe, Kunzo Orita, Ayumi Sasaki, Yuka Kitamura, Hideyuki Matsuzawa, Teppei Yamashita, Eiichiro Nagata, Yasuhiro Kanatani, Koichiro Yoshioka

“…Previous research has shown that variations in the Gi-α signal transduction rate led to changes in adenylate cyclase (AC) activity levels. …”
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Interaction of the gastroenterologist and psychiatrist at management of patient with functional disorder of gastro-intestinal tract by V. T. Ivashkin, Ye. A. Poluektova, A. G. Beniashvili

“…Taking into account patient’s complaints (bloating and abdominal pain relieved after defecation, frequent stool up to 3–5 times per day, incidental imperative urgency to defecation and feeling of incomplete defecation), and long-term benign course of disease, absence of organic changes, according to results of laboratory tests and instrumental investigations irritable bowel syndrome has been diagnosed. …”
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Outcomes after Surgery for Malignant Pancreatic Neuroendocrine Tumors by Omar Hama Ghalib Azeez Hawramy, Karzan Seerwan Abdullah, Barham M.M. Salih, Qalandar Hussein A. Kasnazani, Dana Taib Gharib, Dara Ahmed Mohammed

“…Clinical and pathological factors that changed the outcomes were also analyzed. It is retrospective, case series study. …”
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Innovations and innovative in domestic banking: Theoretical aspect by Natalia Mostovenko

“…The most obvious in this regard is the development of the so-called «product» line of the bank. However, only changing the product line will not be a guarantee of market success. …”
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Lipotoxicity and metabolic disorders at obesity by V. T. Ivashkin, M. V. Mayevskaya

“…New data on pathogenesis of metabolic disorders at obesity assume changes in comprehension of therapeutic actions. In 2008-2009 data on efficacy in treatment of insulin resistance and NAFLD of such pharmacological compounds, as glitazones, metformin, complex silibinin/phosphatidylcholine, ursodeoxycholic acid were published.Conclusion. …”
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“Scarlet Cloak and the Forest Adventure”: a preliminary study of the impact of AI on commonly used writing tools by Barbara Bordalejo, Davide Pafumi, Frank Onuh, A. K. M. Iftekhar Khalid, Morgan Slayde Pearce, Daniel Paul O’Donnell

“…In general, paraphrasing tools score low values in AI detection software, allowing the changes to go mostly unnoticed by the software. However, the use of Microsoft Bing Copilot and Writefull on our selected texts were able to eschew AI detection fairly consistently. …”
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Exposure to triphenyl phosphate during pregnancy: The role of gut-bile acids-liver axis on lipid metabolism in male offspring by Juntong Lin, Fuhui Yan, Longhui Liu, Ganzhong Liao, Yilei Xu, Qian Liu, Miaoliang Wu, Honghui Guo, Bai Zhi, Lianxian Guo, Xiaoshan Liu

“…The expression of lipid metabolism-related genes was significantly changed in the liver and adipose tissue. The gut microbiome of male offspring was also altered, with different profiles between the low and high dose treatment group. …”
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ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI KEDALAMAN JANGKAUAN (DEPTH OF OUTREACH) LEMBAGA KEUANGAN MIKRO (LKM) USAHA EKONOMI DESA SIMPAN PINJAM (UED-SP) DI KECAMATAN KUNTO DARUSSALA... by Dita Putri Nitami, Ahmad Rifai, Roza Yulida

“…Penelitian ini menggunakan pendekatanfixed effect method (FEM) dan alat bantu yang digunakan adalah software Eviews 9.Hasil analisis data menunjukkan bahwa secara bersama-sama (uji F-statistik) hasil estimasi menunjukkan bahwa keenam variabel independen (umur lembaga (AGE) ), return on assets (ROA), rasio pinjaman sektor pertanian (AVL), capital adequacy ratio (CAR), persentase peminjam perempuan (POWB) )dan jumlah peminjam sektor dagang (DAGANG) ) berpengaruh signifikan terhadap kedalaman jangkauan (depth of outreach).Secara parsial (uji t-statistik), dari enam variabel independen yang digunakan dalam penelitian ini, hanya dua variabel independen (umur LKM UED-SP (AGE), dan proporsi jumlah pinjaman sektor pertanian (AVL) ) yang berpengaruh secara signifikan terhadap kedalaman jangkauan (depth of outreach). …”
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Development of a mental health-related structural stigma measurement framework in the healthcare system setting: A modified Delphi study. by Dristy Gurung, Bhawana Subedi, Brandon A Kohrt, Syed Shabab Wahid, Sauharda Rai, Graham Thornicroft, Petra C Gronholm

“…This conceptualization, informed by PWLE and stakeholders in LMICs, makes it easier to measure structural stigma and monitor changes in diverse healthcare settings around the world.…”
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Evolution Characteristics of Soil and Water Conservation Carbon Pool and Its Carbon Sink Potential in Typical Small Watershed of the Loess Plateau by HE Guokai, WANG Kaibo, REN Zongping, XU Guoce, DONG Pengbei, WANG Pu

“…Based on the analysis of the spatio-temporal changes of soil and water conservation measures in the watershed, the evolution law of soil organic carbon (SOC) pool under different soil and water conservation measures was clarified, and the potential of soil carbon sink under different soil and water conservation arrangements was evaluated with scenario analysis. …”
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A clinical study on the efficacy and safety of poly-herbal formulation in managing functional dyspepsia by Debasish Hota, Anand Srinivasan, Manas Kumar Panigrahi, Snigdha Suman Dalua, Poorva Tiwari, Ramachandran Valavan

“…Additionally, the study found no abnormal elevations in liver and renal function parameters in blood or any abnormal changes in hemogram, indicating the safety for use in patients with functional dyspepsia. …”
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Could the Inflation Reduction Act Maximum Fair Price Hurt Patients? by Anne M. Sydor, Esteban Rivera, Robert Popovian

“…Policymakers should closely monitor changes in overall affordability, including all patient out-of-pocket expenditures, for medications in the program. …”
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Describing viewpoints on human‐nature relationships to unveil socio‐environmental conflicts and support community‐based projects by Beatriz Demasi, Nina Garcia de Almeida Prado, Flávia Pereira Lima, Charbel N. El‐Hani, Renata Pardini

“…Abstract Socio‐environmental changes are threatening Indigenous peoples and local communities (IP&LC), hampering conservation efforts, jeopardizing biocultural diversity and escalating environmental injustice. …”
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A dextrorotatory residues-incorporated bioactive dodecapeptide against enterohemorrhagic Escherichia coli by Ping Zeng, Xuemei Yang, Kwok-Yin Wong, Sheng Chen, Kin-Fai Chan, Sharon Shui Yee Leung, Lanhua Yi

“…Thereafter, morphological changes of E. coli O157:H7 cells were monitored by electron microscopy technologies. …”
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The efficacy of neoadjuvant immunotherapy and lymphocyte subset predictors in locally advanced esophageal squamous cell carcinoma: A retrospective study by Ruotong Wang, Shaodi Wen, Xiaoyue Du, Jingwei Xia, Bowen Hu, Yihan Zhang, Guoren Zhou, Feng Jiang, Xiaomin Lu, Miaolin Zhu, Xinyu Xu, Bo Shen

“…Evaluating the differentiation status and dynamic changes of peripheral blood immune cells may provide valuable predictive insights into treatment efficacy and prognosis.…”
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Adaptation of the disease‐related apathy scale in adults with epilepsy into Turkish: A methodological study by Gülcan Bahcecioglu Turan, Zülfünaz Özer, Seda Başak

“…The Turkish form of the 24‐item and 4‐sub‐dimensional scale was validated without any changes to the original scale form. Significance The Turkish adaptation of E‐RAS is a valid and reliable instrument for measuring apathy in adult epilepsy patients. …”
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High-intensity statin therapy in patients with chronic kidney disease: a systematic review and meta-analysis by Jing Wang, Ling Wu, Yu-Ling Yan, Bo Qiu, Song-Bai Deng, Xiao-Dong Jing, Jian-Lin Du, Ya-Jie Liu, Qiang She

“…Objective To evaluate the efficacy and safety of high-intensity statin therapy in patients with chronic kidney disease (CKD).Design A systematic review and meta-analysis.Data sources Randomised controlled trials (RCTs) comparing high-intensity statin therapy (atorvastatin 80 mg or rosuvastatin 20/40 mg) with moderate/mild statin treatment or placebo were derived from the databases (PubMed, Embase, Ovid, the Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library, and ISI Web of Knowledge).Outcome measure Primary end points: clinical events (all-cause mortality, stroke, myocardial infarction and heart failure); secondary end points: serum lipid, renal function changes and adverse events.Results A total of six RCTs with 10 993 adult patients with CKD were included. …”
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Airway microbiota dysbiosis and metabolic disorder in ozone and PM2.5 co-exposure induced lung inflammatory injury in mice by Lin Yang, Fei Xu, Shuaiqi Zhao, Yuling Zeng, Qiong Wu, Ling Zhang, Saige Shi, Fengquan Zhang, Juan Li, Zhen An, Huijun Li, Hui Wu, Jie Song, Weidong Wu

“…The results demonstrated that co-exposure to O3 and PM2.5 exacerbated the pathological changes and inflammatory response induced by O3 or PM2.5. …”
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Impact of telephone follow-up on COPD outcomes in pulmonary rehabilitation patients: A randomized clinical trial by Stefanie Tonguino Rosero, Juan Carlos Ávila Valencia, Jhonatan Betancourt Peña

“…Analysis showed differences between groups for changes in LINQ knowledge domain after intervention, with greater improvement for PRTETFU (*p*=0.018)…”
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