Regulation of NK cell development, maturation, and antitumor responses by the nuclear receptor NR2F6 by Johannes Woelk, Florian Hornsteiner, Stephanie Aschauer-Wallner, Patrizia Stoitzner, Gottfried Baier, Natascha Hermann-Kleiter

“…Despite normal NK cell development in the bone marrow, germline Nr2f6-deficient mice exhibit impaired terminal maturation of NK cells in the periphery. …”
Get full text

Spatial-temporal characteristics and influence factors of high-quality development of animal husbandry industry in China. by Tiantian Su, Cuixia Li

“…Regional differences have demonstrated a slight narrowing trend; however, the effect of intra-regional differences on the overall differences has remained relatively stable. …”
Get full text

Analysis of health expenditures in China from 2000 to 2019 compared with the world and upper-middle-income countries by Xindian Zeng, Xindian Zeng, Lijie Chen, Lu Chen

“…The per capita health expenditure in China was $42.11 in 2000 and it's $535.13 in 2019, which rapidly grow to the level of upper-middle-income countries and narrow the gap with the level of the world.ConclusionThe financing structure of THE is increasingly optimized, but the level of financing still needs improvement in China. …”
Get full text

Urban Development and Business Growth: A Case Study of Kabale Municipality. by Natukwatsa, Doreen

“…Some respondents mentioned that high-quality infrastructure that is sustainable increases business activities, creates new employment, narrows income disparities, and empowers gender participation. …”
Get full text

Fast and Slow Roasting of Alcohol- and Honey-infused Coffee Blends: A Comparative Study of PAH and N-PAH Emissions by Hsin-Chieh Kung, Chung-Hsien Hung, Kun-Hui Lin, Bo-Wun Huang, Nicholas Kiprotich Cheruiyot, Guo-Ping Chang-Chien

“…Finally, the emission factors for the fast and slow roasting of green coffee were 1.36 mg kg−1 of coffee (7.49 µg BaP-TEQ kg−1) and 0.483 mg kg−1 (1.35 µg BaP-TEQ kg−1), respectively. These results narrow the research gap on toxic emissions during coffee roasting and would be of particular interest in independent coffee shops where roasting is done in-house.…”
Get full text

Effects of prolonged NaHCO3 exposure on the serum immune function, antioxidant capacity, intestinal tight junctions, microbiota, mitochondria, and autophagy in crucian carp (Carass... by Jia Liu, Faye Zhang, Zihao Yan, Zhengyao Guo, Yuqian Lu, Baolan Yao, Yuehong Li, Wenfa Lv

“…A total of 240 fish (31.19 ± 1.03 g) were randomly allocated to two groups and treated with 0 mmol/L (CK) and 50 mmol/L NaHCO3 (CA) respectively, to simulate the carbonate alkaline water environment. All of the experimental fish were cultured for 8 weeks. …”
Get full text

Detection Rate of Helicobacter Pylori Infection and Atrophic Gastritis Using Serological Markers “GastroPanel®” Among Employees of the National Medical Research Radiological Centre... by A. D. Kaprin, N. S. Sergeeva, S. S. Pirogov, I. I. Alentov, O. К. Yutsevich, V. I. Ryabtseva, G. F. Minibaeva, N. V. Marshutina, T. А. Karmakova

“…Esophagogastroduodenoscopy (EGDS) for suspected atrophic gastritis was performed with an Olympus GIF-HQ190 video endoscope (Japan) in a narrow-spectrum mode with close focus (NBI Dual Focus).Results. …”
Get full text

Quid du port romain estuarien de Barzan (Charente-Maritime) ? by Vivien Mathé, Laurence Tranoy, Marion Druez, François Lévêque, Vincent Miailhe, Frédéric Pouget

“…However, none of the excavations carried out previously made it possible to confirm this hypothesis. …”
Get full text

Diagnostic accuracy of calculated serum osmolarity to predict dehydration in older people: adding value to pathology laboratory reports by Lee Shepstone, John F Potter, Lee Hooper, Asmaa Abdelhamid, Amy Jennings, Paul R Hunter, W Garry John, Neil P Walsh, Adam Ali, Diane K Bunn, Susan Kerry, Gregor Lindner, Carmen A Pfortmueller, Fredrik Sjöstrand, Susan J Fairweather-Tait

“…Two equations were characterised by narrower limits of agreement, low levels of differential bias and good diagnostic accuracy in receiver operating characteristic plots (areas under the curve >0.8). …”
Get full text

MSCs with upregulated lipid metabolism block hematopoietic stem cell differentiation via exosomal CTP-1A in MDS by Chunlai Yin, Xue Yan, Jinyi Ren, Cheng Zhang, Jiaqing Liu, Zilong Wang, Jing Liu, Weiping Li, Xia Li

“…While previous studies have implicated mesenchymal stem cells (MSCs), a principal component of the bone marrow (BM) microenvironment, in the inhibition of normal hematopoiesis, the precise molecular mechanisms have not been fully elucidated. …”
Get full text

Call for Papers: How attractive are political parties and trade unions to young people? by IF and FRFG

“…In: The Journal of Politics, 61 (3), 628–657. Scarrow, Susan E. / Gezgor, Burcu (2010): Declining memberships, changing members? …”
Get full text

The development and evaluation of a tublysine-based antibody-drug conjugate with enhanced tumor therapeutic efficacy by Huihui Guo, Hongsheng Xie, Yuanyuan Huang, Junxiang Jia, Xiangfei Kong, Qingliang Yang, Shun Gai, Wenjun Li, Lu Bai, Lingli Zhang, Xiaoxiao Chen, Zhicang Ye, Hangbo Ye, Linyao Zhao, Yifang Xu, Yong Du, Xiuzhen Zhang, Miaomiao Chen, Xiaomai Zhou, Robert Y. Zhao

“…In cynomolgus monkeys, DX126-262 demonstrated superior hepatotoxic tolerability without significant bone marrow suppression, with an HNSTD of 30 mg/kg. DX126-262, incorporating Tub114, a novel Tubulysin B analog, effectively mitigates the inherent hepatotoxicity associated with Tubulysin compounds while maintaining strong antitumor efficacy. …”
Get full text

Use of Minimal Residual Disease Status to Reduce Uncertainty in Estimating Long-term Survival Outcomes for Newly Diagnosed Multiple Myeloma Patients by Naomi van Hest, Peter Morten, Keith Stubbs, Nicola Trevor

“…It also estimated a narrower interquartile range of LYs in the probabilistic analyses for the majority of parametric extrapolations. …”
Get full text

In vitro antitumor and immunomodulatory activities of 1,2,4-oxadiazole derivatives by Héverton Mendes Araújo, Gabriel Acácio de Moura, Yasmim Mendes Rocha, Cristian Vicson Pinheiro Gomes, Valentina Nascimento e Melo de Oliveira, Ronaldo Nascimento de Oliveira, Larissa Deadame de Figueiredo Nicolete, Emanuel Paula Magalhães, Ramon R.P.P.B. de Menezes, Roberto Nicolete

“…Thus, the present study aims to evaluate the antitumor and immunomodulatory effects of the synthetic derivative 1,2,4-oxadiazole, N-cyclohexyl-3-(3-methylphenyl)-1,2,4-oxadiazole-5-amine (1,2,4-oxadiazole derivative 2), in melanoma cells and murine Bone Marrow-Derived Macrophages (BMDMs). Cytotoxicity in B16–F10 and BMDMs cells was assessed using the (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) MTT method. 1,2,4-oxadiazole derivative 2 exhibited antiproliferative effects on both cell lines, being 2.6 times more selective for B16–F10. …”
Get full text

Joint trajectories of physical activity, health, and income before and after statutory retirement: A 22-year follow-up. by Tea Lallukka, Petteri Kolmonen, Ossi Rahkonen, Eero Lahelma, Jouni Lahti

“…As not all those with a low income had a low level of physical activity or poor general health perceptions, public health interventions should target distinct groups with the most adverse risk factor profiles, to narrow health inequalities during aging.…”
Get full text

A relay race of ESCRT-III paralogs drives cell division in a hyperthermophilic archaeon by Junfeng Liu, Mickaël Lelek, Yunfeng Yang, Audrey Salles, Christophe Zimmer, Yulong Shen, Mart Krupovic

“…Depletion of ESCRT-III-2 leads to the accumulation of cells connected through narrow membrane bridges (“late” stage), consistent with the key role of this protein in the final membrane abscission. …”
Get full text

Combining several indicators to assess the effectiveness of tailor-made health plans in pig farms by Levallois, Pierre, Leblanc-Maridor, Mily, Scollo, Annalisa, Ferrari, Paolo, Belloc, Catherine, Fourichon, Christine

“…An intervention study was carried out in 20 farrow-to-finish pig farms. An initial standardized audit and discussion between the farm veterinarian and the farmer resulted in a specific plan. …”
Get full text

In vitro anticancer effects of frankincense and its nanoemulsions for enhanced cancer cell targeting by Rayya A. Al-Balushi, Aiswarya Chaudhuri, Raghuram Kandimalla, Ashanul Haque, Khalaf M. Alenezi, Mohd. Saeed, Mohammad Changez, Thuraya Al Harthy, Mohammed Al Hinaai, Samra Siddiqui, Ashish Kumar Agrawal, Farrukh Aqil, Farrukh Aqil

“…To address these limitations, this study focuses on developing optimized nanoemulsions (NEs) of Frankincense oil (FO) to enhance its therapeutic efficacy.MethodsFrankincense resins were extracted and characterized using gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS), identifying key metabolites including isopinocarveol, α-thujene, p-cymene, carvone, germacrene A, and various methyl esters. …”
Get full text

Stem Cell Transplantation for Ovarian Cancer Patient with Associated Myelodysplasia After Maintenance Therapy with Olaparib: A Case Report by Linn Z, Gu Z, Wang L, Cai S

“…After two years, she experienced abnormal blood test results, which ultimately led to a diagnosis of myelodysplastic syndrome (MDS), confirmed through a bone marrow biopsy. Despite initial obstacles, the patient underwent stem cell transplantation as a treatment for MDS. …”
Get full text

The position of Lithuanian parties towards Poland in 1920-1926: from modus vivendi to permanent confrontation by Andrius Grodis

“…As the Copenhagen negotiations in the autumn of 1925 illustrated, the Christian Democrats' attempt to reduce the tension between the two small countries by starting economic relations of a narrow nature was met with strong hostility by the opposing Union of Peasants and National Union Parties, as well as by the majority of society supporting them. …”
Get full text