Women and birth partners’ experiences of cervical ripening at home and in hospital by Cassandra Yuill, Mairi Harkness, Helen Cheyne, Boo Charkin, Monica Ferreira, Eloise Price, Amarnath Bhide, Mairead Black, Kathleen Boyd, Neelam Heera-Shergill, Neena Modi, John Norrie, Dharmintra Pasupathy, Julia Sanders, Sarah J. Stock, Rosemary Townsend, Linda J. Williams, Christine McCourt

“…The first stage, cervical ripening, traditionally carried out in hospital, is increasingly offered outpatient – or ‘at home’. …”
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Anti-TNBC effects of Lappaol F by targeting epithelial-mesenchymal transition via regulation of GSK-3β/YAP/β-catenin and PI3K/AKT pathways by Qiqi Meng, Qiqi Meng, Zhiping Li, Xiaofeng He, Yuanhao Hu, Guiyun Wu, Jiawen Huang, Zhuohui Luo, Zhuohui Luo, Yingjie Hu, Xiaoling Shen

“…However, the pharmacological mechanism of LAF targeting epithelial-mesenchymal transition (EMT) to inhibit Triple-negative breast cancer (TNBC) growth remains poorly understood. The present study aimed to reveal the potential mechanism of LAF against TNBC by in vivo and in vitro experiments.MethodsIn situ, transplantation-induced MDA-MB-231 solid tumor model in NCG mice and cultured MDA-MB-231 and Hs-578T cells were used to evaluate the anti-TNBC effect of LAF. …”
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Comparative analysis of the primary structure and production of recombinant poly(ADP-ribose)polymerase 1 of long-lived Heterocephalus glaber by K. N. Naumenko, A. R. Nurislamov, K. D. Nazarov, V. S. Fishman, A. A. Popov, I. O. Petruseva, A. N. Evdokimov, O. I. Lavrik

“…The revealed features may be due to the high activity of PARP1 in the cells of the naked mole rat; however, this issue remains poorly understood and, thus, requires more detailed research, including one with the use of isolated protein PARP1 of the naked mole rat, the isolation and characterization of which have not been carried out before. …”
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Baicalin Mitigates Cardiac Hypertrophy and Fibrosis by Inhibiting the p85a Subunit of PI3K by Lu He, Min Zhu, Rui Yin, Liangli Dai, Juan Chen, Jie Zhou

“…Molecular docking was carried out to reveal the effect of baicalin on p85a. …”
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Cellular Cholesterol Loss Impairs Synaptic Vesicle Mobility via the CAMK2/Synapsin-1 Signaling Pathway by Atikam Qurban, Mengqi Zhang, Hengbing Zu, Kai Yao

“…However, the underlying mechanisms remain poorly understood. Intact synaptic vesicle (SV) mobility is crucial for normal synaptic function, whereas disrupted SV mobility can trigger the synaptopathy associated with AD. …”
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Search for and functional annotation of multi-domain PLA2 family proteins in flatworms by M. E. Bocharnikova, I. I. Turnaev, D. A. Afonnikov

“…However, their presence and functional role in non-model organisms is poorly understood. Such poorly studied taxa include flatworms, a number of species of which are human parasites. …”
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Acinetobacter baumannii represses type VI secretion system through a manganese-dependent small RNA-mediated regulation by Somok Bhowmik, Avik Pathak, Shivam Pandey, Kuldip Devnath, Abhiroop Sett, Nishant Jyoti, Timsy Bhando, Jawed Akhter, Saurabh Chugh, Ramandeep Singh, Tarun Kumar Sharma, Ranjana Pathania

“…Acinetobacter baumannii ATCC 17978 utilizes T6SS at the expense of losing pAB3 plasmid to induce contact-dependent killing of competitor microbes, resulting in the loss of antibiotic resistance carried by pAB3. However, the regulatory network associated with T6SS in A. baumannii remains poorly understood. …”
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The role of the Hygiene Department of Stephen Bathory University in the development and promotion of Public Health in Vilnius in the years 1922–1939 by Aistis Žalnora

“…Our study revealed that the significance of the disease prevention in the Faculty of Medicine at the University of Stephen Bathory was well understood. Moreover, the treatment was not segregated from hygiene as strictly as it is today. …”
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L’emploi antique des géomatériaux à Reims/Durocortorum by Gilles Fronteau, Sébastien Laratte, Alain Devos, Claire Pichard

“…Research carried out over the last twenty years on local geomaterials in the Reims region, as well as an important collection of Antiquity period archaeological corpuses, currently make it possible to identify the main characteristics of geomaterial supply and use in the Gallo-Roman city of Reims/Durocortorum. …”
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Is dry needling an effective treatment for tennis elbow? A literature review by Filip Grabowski, Natalia Rulewska, Dagmara Neska, Jakub Siemko, Jakub Chodkowski, Dominika Prystacka-Szar, Justyna Stadler-Szajda, Adrianna Czyżnikiewicz, Wenancjusz Stołowski, Magdalena Bujak, Magdalena Waśniowska

“… Introduction:Tennis elbow, or lateral epicondylitis, affects around 1% to 3% of the population, causing pain and functional limitations, yet its exact causes and degenerative mechanisms are still not fully understood. Research indicates that tendinopathy primarily arises from new blood vessel formation and collagen fiber disruptions, while tennis elbow complicates diagnosis and treatment due to a mix of biomechanics, occupational factors, and individual variations. …”
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Neuropilin1-dependent paracrine signaling of cancer cells mediated by miRNA exosomal cargo by Claudia Palazzo, Roberta Mastrantonio, Noemi Gioelli, Erika Testa, Francesco Recco, Donatella Lucchetti, Giulia Villari, Alessio D’Alessio, Alessandro Sgambato, Flavio Mignone, Guido Serini, Maria Teresa Viscomi, Luca Tamagnone

“…Notably, diffusible forms of NRP1 in the extracellular space have been reported, but their functional role is poorly understood. Methods Extracellular vesicles (EV) were isolated from conditioned media of diverse cancer cells. …”
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Diversity and distribution of nitrifying bacteria play an important role in the nitrogen cycle in mangrove sediments by A. Mubaraq, M. Sembiring, E. Widiastuti, E. Fachrial, B. Utomo, M. Turjaman, F. Sidik, Y.I. Ulumuddin, V.B. Arifanti, E.S. Siregar, T. Kajita, S. Proches, M. Basyuni

“…Nevertheless, the nitrification process and nitrifying bacteria in mangrove areas have yet to be comprehensively understood. The primary objective of this study is to provide comprehensive analysis of nitrifying bacteria in mangrove sediments by conducting a systematic review. …”
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Unveiling the Mechanisms of a Remission in Major Depressive Disorder (MDD)-like Syndrome: The Role of Hippocampal Palmitoyltransferase Expression and Stress Susceptibility by Careen A. Schroeter, Anna Gorlova, Michael Sicker, Aleksei Umriukhin, Alisa Burova, Boris Shulgin, Sergey Morozov, Joao P. Costa-Nunes, Tatyana Strekalova

“…Indeed, molecular changes associated with the application of pharmacotherapy at the remission stage are currently not well understood. Therefore, we used a mouse model of chronic stress to address these questions. …”
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An oligodendrocyte silencer element underlies the pathogenic impact of lamin B1 structural variants by Bruce Nmezi, Guillermo Rodriguez Bey, Talia DeFrancesco Oranburg, Kseniia Dudnyk, Santana M. Lardo, Nathan Herdman, Anastasia Jacko, Sandy Rubio, Emanuel Loeza-Alcocer, Julia Kofler, Dongkyeong Kim, Julia Rankin, Emma Kivuva, Nicholas Gutowski, Katherine Schon, Jelle van den Ameele, Patrick F. Chinnery, Sérgio B. Sousa, Filipe Palavra, Camilo Toro, Filippo Pinto e Vairo, Jonas Saute, Lisa Pan, Murad Alturkustani, Robert Hammond, Francois Gros-Louis, Michael S. Gold, Yungki Park, Geneviève Bernard, Raili Raininko, Jian Zhou, Sarah J. Hainer, Quasar S. Padiath

“…Abstract The role of non-coding regulatory elements and how they might contribute to tissue type specificity of disease phenotypes is poorly understood. Autosomal Dominant Leukodystrophy (ADLD) is a fatal, adult-onset, neurological disorder that is characterized by extensive CNS demyelination. …”
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Le temple polygonal de la rue Lecointre à Reims/Durocortorum by Sébastien Péchart, Frédéric Poupon

“…The northern zone of the ancient city seems to have been understood from the outset as the site of monumental and funerary complexes, even if it also housed spaces devoted to domestic and artisanal activities. …”
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Les aqueducs de Lyon dans la Carte archéologique nationale : une démarche au service de la recherche by Delphine Bellanca-Penel

“…The site is subsequently geolocated as accurately as possible on the land registry.This revision effort was carried out for the 180 archaeological operations related to four aqueducts, which were then integrated into the Patriarche database. …”
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Contaminant-degrading bacteria are super carriers of antibiotic resistance genes in municipal landfills: A metagenomics-based study by Fang-Zhou Gao, Wei-Li Jia, Bing Li, Min Zhang, Liang-Ying He, Hong Bai, You-Sheng Liu, Guang-Guo Ying

“…More concerned, whether there is co-selection or enrichment of antibiotic-resistant bacteria and contaminant-degrading bacteria in these extremely polluted environments is far less understood. Here, we collected metagenomic datasets of 32 raw leachate and 45 solid waste samples in 22 municipal landfills of China. …”
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First microscopic and molecular identification of Cryptosporidium spp. in fat sand rats (Psammomys obesus) in Egypt and their potential zoonotic implications by Sara Abdel-Aal Mohamed, Fatma A. S. Anwar, Ahmed Gareh, Marwa M. I. Ghallab, Remigio Martínez, Asmaa Aboelabbas Gouda, Fatemah Enad Alajmi, Hind Alzaylaee, Ignacio García-Bocanegra, Ignacio García-Bocanegra, Ehab Kotb Elmahallawy, Ehab Kotb Elmahallawy

“…The specific role of fat sand rats (Psammomys obesus) in the transmission of Cryptosporidium spp. in Egypt and the genotypic characteristics of the circulating species in these animals remain poorly understood.MethodsIn this study, a total of 150 individual fat sand rat stool samples were collected from the saline marsh periurban areas of Abu-Rawash, Giza, Egypt. …”
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Preparation of future teachers for innovative activities in pedagogical and technological educational environment by N. I. Naumkin, N. N. Shekshaeva, V. F. Kupryashkin, E. V. Zabrodina

“…The research methodology is based on the following conceptual provisions: 1) innovative activity has arisen together with the formation of human society and has always determined its development; 2) one of the main tasks of each university is the innovative training of students; 3) the training of innovative activity is understood as the formation of students’ competence in innovative activity; 3) the training of innovative activity is most effectively carried out in conditions for the formation of an appropriate educational environment. …”
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Mitigating overconfidence bias: A cross-sectional pilot study of male maintenance workers in the engineering sector by Luca DI GIAMPAOLO, Federica MARINO, Claudia GIURGOLA, Piergiorgio ASTOLFI, Luca COPPETA, Simone DE SIO, Paola BORRELLI, Teresa GALANTI, Laura FORCELLA, Maria Elisa MAIOLO, Kavita BATRA, Murat YILDIRIM, Hicham KHABBACHE, Amelia RIZZO, Mahmood BAHRAMIZADEH, Hiroo WADA, Qiao NIU, Hector NIETO, Francesco CHIRICO

“…Introduction: Overconfidence is understood as the susceptibility to cognitive error caused by overconfidence in one’s own means and a lack of awareness of one’s own limits. …”
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