FOXA3, a Negative Regulator of Nur77 Expression and Activity in Testicular Steroidogenesis by Hansle Kim, Sudeep Kumar, Keesook Lee

“…The function of Nur77 is modulated through interaction with other proteins. …”
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Altered Coactive Micropattern Connectivity in the Default-Mode Network during the Sleep-Wake Cycle by Yan Cui, Qiao Chen, Yang Xia, Zeru Wang, Yujia Guo, Ge Zhang, Dezhong Yao, Daqing Guo

“…The default-mode network (DMN) is believed to be associated with levels of consciousness, but how the functional connectivity (FC) of the DMN changes across different states of consciousness is still unclear. …”
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Phosphorylation of Bok at Ser-8 blocks its ability to suppress IP3R-mediated calcium mobilization by Caden G. Bonzerato, Katherine R. Keller, Richard J. H. Wojcikiewicz

“…Whether Bok, or phosphorylated Bok, has any direct impact on the Ca2+ mobilizing function of IP3Rs remains to be established. Methods Bok Ser-8 phosphorylation was characterized using purified proteins, G-protein coupled receptor agonists that increase cAMP levels in intact cells, mass spectrometry, and immunoreactivity changes. …”
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Major facility superfamily sugar transporter protein SsMFSST1 regulates Sporisorium scitamineum mating, pathogenicity, and sugar transport/absorption by Yi Zhang, Yongding He, Meixin Yan, Shilong Zhang, Sisi Zhou, Wankuan Shen

“…Therefore, we speculate that the SsMFSST1 gene may regulate the expression of key genes related to the synthesis pathway of the small molecule signaling substance cAMP or tryptophol, affecting the synthesis of the signaling substance cAMP or tryptophol, thereby affecting the sexual mating and pathogenicity of S.scitamineum. …”
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Modulation of Second Messenger Signaling in the Brain Through PDE4 and PDE5 Inhibition: Therapeutic Implications for Neurological Disorders by Min Kyu Park, Hyun Wook Yang, Seo Young Woo, Dong Yeon Kim, Dae-Soon Son, Bo Young Choi, Sang Won Suh

“…This review synthesizes current evidence on the roles of PDE4 and PDE5 in neurological health and disease, focusing on their regulation of second messenger pathways and their implications for brain function. Elevated PDE4 activity impairs synaptic plasticity by reducing cAMP levels and protein kinase A (PKA) activity, contributing to cognitive decline, acute brain injuries, and neuropsychiatric conditions such as bipolar disorder and schizophrenia. …”
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The Influence of Artistic Kitsch on the Formation of Political Memes by Anastasiia Tormakhova, Dmytro Tovmash, Ruslan Grechkosii

“…It was kitsch, which went from ‘low’ art to camp, that initiated the spread of visual forms that perform a powerful communication function. …”
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Caffeine's Vascular Mechanisms of Action by Darío Echeverri, Félix R. Montes, Mariana Cabrera, Angélica Galán, Angélica Prieto

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Warifteine, an Alkaloid Purified from Cissampelos sympodialis, Inhibits Neutrophil Migration In Vitro and In Vivo by Thaline F. A. Lima, Juliana D. B. Rocha, Anderson B. Guimarães-Costa, José M. Barbosa-Filho, Débora Decoté-Ricardo, Elvira M. Saraiva, Luciana B. Arruda, Marcia R. Piuvezam, Ligia M. T. Peçanha

“…In addition, fLMP-induced neutrophil migration in a transwell system was blocked by warifteine; this effect was mimicked by cAMP mimetic/inducing substances, and warifteine increased intracellular cAMP levels in neutrophils. …”
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Exploring Outcome Measures for Exercise Intervention in People with Parkinson’s Disease by L. A. King, A. Salarian, M. Mancini, K. C. Priest, J. Nutt, A. Serdar, J. Wilhelm, J. Schlimgen, M. Smith, F. B. Horak

“…Participants were randomized into either the Agility Boot Camp (ABC) or treadmill training; 4x/week for 4 weeks. …”
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Investigating the Therapeutic Mechanisms of Total Saikosaponins in Alzheimer’s Disease: A Metabolomic and Proteomic Approach by Huiling Wei, Tianyi Du, Weiwei Zhang, Wei Ma, Yao Yao, Juan Li

“…Behavioral tests demonstrated that TSS effectively improved the learning and memory functions of mice. <b>Conclusions</b>: Our findings suggest that TSS ameliorate cognitive decline through regulating neuroinflammatory pathways, cAMP and cGMP signaling, and synaptic plasticity pathways, providing insights into its therapeutic potential in AD.…”
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CREB Regulates Experience-Dependent Spine Formation and Enlargement in Mouse Barrel Cortex by Annabella Pignataro, Antonella Borreca, Martine Ammassari-Teule, Silvia Middei

“…Experience modifies synaptic connectivity through processes that involve dendritic spine rearrangements in neuronal circuits. Although cAMP response element binding protein (CREB) has a key function in spines changes, its role in activity-dependent rearrangements in brain regions of rodents interacting with the surrounding environment has received little attention so far. …”
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Effect of Donepezil on Group II mGlu Receptor Agonist- or Antagonist-Induced Amnesia on Passive Avoidance in Mice by Tomoaki Sato, Koh-ichi Tanaka, Yoshiko Ohnishi, Masahiro Irifune, Takashige Nishikawa

“…The results suggest that activation of group II mGlu receptors and disinhibition of the cAMP/PKA signaling pathway (caused by group II mGlu receptor antagonist) have a negative action on step-through passive avoidance memory performance, and that group II mGlu receptors and ACh interact to modulate learning and memory function.…”
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Differential responses of Bradyrhizobium sp. SUTN9-2 to plant extracts and implications for endophytic interactions within different host plants by Teerana Greetatorn, Pakpoom Boonchuen, Pongdet Piromyou, Pongpan Songwattana, Jenjira Wongdee, Kamonluck Teamtisong, Nantakorn Boonkerd, Shusei Sato, Neung Teaumroong, Panlada Tittabutr

“…The present study reveals that SUTN9-2 can also establish functional endophytic interactions with chili (Capsicum annuum) and tomato (Solanum lycopersicum) plants. …”
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Impact of Disease Activity on the Quality of Life of Crohn’s Disease Patients by T Michael Vallis, Geoffrey K Turnbull

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GABARAPL1 is essential for ACR-induced autophagic cell death of mouse Leydig cells by Jiahui Meng, Linlin Xu, Bingchun Ma, Chaoju Hao, Yanning Guo, Jinglei Wang, Jiaxiang Chen

“…Intriguingly, overexpression of GABARAPL1 significantly induces autophagy, while its knockdown alleviates ACR-induced autophagic responses, underscoring its pivotal function. Furthermore, we demonstrate that transcription factors cAMP response element-binding protein 1 (CREB1) and POZ/BTB and AT-hook-containing zinc finger protein 1 (PATZ1) synergistically enhance Gabarapl1 gene transcription by interacting with its promoter region, contributing to ACR-induced autophagy in mouse Leydig cells. …”
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Bioinformatics Analysis for Identifying Differentially Expressed MicroRNAs Derived from Plasma Exosomes Associated with Radiotherapy Resistance in Non-Small-Cell Lung Cancer by Lirong Zeng, Guilin Zeng, Zhong Ye

“…The miRanda, PITA, and RNAhybrid software were used to identify potential target genes of the DEmiRs. GO function enrichment and KEGG pathway enrichment analyses were performed on the target gene set. …”
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Microenvironmental G protein‐coupled estrogen receptor‐mediated glutamine metabolic coupling between cancer‐associated fibroblasts and triple‐negative breast cancer cells governs t... by Chongwu He, Meixi Peng, Xiaoqiang Zeng, Hanzhi Dong, Zhengkui Sun, Jiawei Xu, Manran Liu, Liyan Liu, Yanxiao Huang, Zhiqiang Peng, Yu‐An Qiu, Chunling Jiang, Bin Xu, Tenghua Yu

“…Key points Estrogen‐activated GPER in CAFs enhances GLUL and LDHB expression via the cAMP/PKA/CREB signalling, facilitating glutamine production and utilization. …”
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The myometrial transcriptome changes in mares with endometrosis by Ewa Monika Drzewiecka, Tomasz Molcan, Agnieszka Sadowska, Katarzyna Piotrowska-Tomala, Magda Słyszewska, Graça Ferreira Dias, Dariusz Jan Skarżyński, Anna Szóstek-Mioduchowska

“…Abstract Mares with endometrosis exhibit histological changes not only in the endometrium but also in the myometrium that suggest possible functional impairment. The molecular background of these changes is not well understood. …”
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CAFs-released exosomal CREB1 promotes cell progression and immune evasion in thyroid cancer via the positive regulation of CCL20 by Chen Zheng, Hu Hei, Yifei Zhai, Wenbo Gong, Runfang Zhang, Songtao Zhang

“…Background Exosomes derived from cancer-associated fibroblasts (CAFs) can affect tumor microenvironment (TME) of thyroid cancer (TC). The cAMP response element binding protein 1 (CREB1) acts as a transcription factor to participate in cancer development. …”
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L’industrie lithique magdalénienne du gisement de plein-air de la Corne-de-Rollay (Couleuvre, Allier) : entre respect des normes et variabilité des chaînes opératoires by Raphaël Angevin

“…La Corne-de-Rollay (Couleuvre, Allier) is a vast open-air camp-site located on the top of a small plateau, between Cher valley and Allier valley. …”
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