Multiomic analysis reveals cellular, transcriptomic and epigenetic changes in intestinal pouches of ulcerative colitis patients by Yu Zhao, Ran Zhou, Bingqing Xie, Cambrian Y. Liu, Martin Kalski, Candace M. Cham, Zhiwei Jiang, Jason Koval, Christopher R. Weber, David T. Rubin, Mitch Sogin, Sean Crosson, Mengjie Chen, Jun Huang, Aretha Fiebig, Sushila Dalal, Eugene B. Chang, Anindita Basu, Sebastian Pott

“…Abstract Total proctocolectomy with ileal pouch anal anastomosis is the standard of care for patients with severe ulcerative colitis. …”
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New Benzoxazole Derivatives as Antiprotozoal Agents: In Silico Studies, Synthesis, and Biological Evaluation by Mohamed A. Abdelgawad, Mohammad M. Al-Sanea, Mohamed A. Zaki, Enas I. A. Mohamed, Shabana I. Khan, Babu L. Tekwani, Amar G Chittiboyina, Ikhlas A Khan, Tarfah Al-Warhi, Nada Aljaeed, Ohoud J. Alotaibi, Abdulsalam A. M. Alkhaldi, Heba A. H. Elshemy

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Phenotypic and Complete Reference Whole Genome Sequence Analyses of Two <i>Paenibacillus</i> spp. Isolates from a Gray Wolf (<i>Canis lupus</i>) Gastrointestinal Tract by Jessika L. Bryant, Jennifer McCabe, C. Cristoph Klews, MiCayla Johnson, Ariel N. Atchley, Thomas W. Cousins, Maya Barnard-Davidson, Kristina M. Smith, Mark R. Ackermann, Michael Netherland, Nur A. Hasan, Peter A. Jordan, Evan S. Forsythe, Patrick N. Ball, Bruce S. Seal

“…Novel probiotic bacteria discovery from free-ranging animals for the treatment of IBD in domestic pets can likely yield promising probiotic candidates. …”
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A Study of Molecular Subtypes (Profile) of Colorectal Cancer and Their Correlation with Clinical and Pathological Profile in a Tertiary Care Center in India by Srujana Joga, Sumit Goyal, Anurag Mehta, Manish Sharma, Venkata Pradeep Babu Koyyala, Pankaj Goyal, Chaturbhuj Aggarwal, M. Shiv Shankara Swamy, Amrith B Patel, Shrinidhi Nathany, Moushumi Suryavanshi, Anurag Sharma, Satya Narayan Saraswat, Satyajeet Soni, Arpit Jain, Pallavi Redhu, Vineet Talwar, D C Doval

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Panitumumab plus 5-fluorouracil and folinic acid or 5-fluorouracil and folinic acid alone as maintenance therapy in RAS wild-type metastatic colorectal cancer (PanaMa, AIO KRK 0212... by Arndt Stahler, Meinolf Karthaus, Stefan Fruehauf, Ullrich Graeven, Lothar Müller, Ludwig Fischer von Weikersthal, Karel Caca, Eray Goekkurt, Alexej Ballhausen, Greta Sommerhäuser, Annabel H.S. Alig, Swantje Held, Armin Jarosch, David Horst, Anke Reinacher-Schick, Stefan Kasper, Volker Heinemann, Sebastian Stintzing, Tanja Trarbach, Dominik P. Modest

“…Interpretation: Panitumumab plus FU/FA might be considered a standard of care maintenance regimen since a potential re-induction therapy with panitumumab cannot be guaranteed at the time of maintenance treatment decision. …”
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Study protocol for a randomized controlled trial: Integrating the 'Time-limited Trial' in the emergency department. by Tadayuki Hashimoto, Rachel K Putman, Anthony F Massaro, Youkie Shiozawa, Katherine McGough, Kerry K McCabe, Judith A Linden, Wei Wang, Shan W Liu, Maura Kennedy, Thanh H Neville, Jacqueline M Kruser, Rebecca L Sudore, Mara A Schonberg, James A Tulsky, Kei Ouchi

“…Some evidence exists that this approach may lead to more patient-centered care in the intensive care unit; however, it has never been evaluated in the emergency department (ED). …”
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Sunlight exposure practice and its associated factors among infants in Ethiopia, systematic review and meta-analysis. by Fanos Yeshanew Ayele, Natnael Kebede, Asnakew Molla Mekonen, Mengistu Mera Mihiretu, Yawkal Tsega, Elsabeth Addisu, Niguss Cherie, Tesfaye Birhane, Chala Daba, Ahmed Hussien Asfaw, Zinet Abegaz, Abel Endawekie, Anissa Mohammed, Dagnachew Melak, Fekade Demeke Bayou, Husniya Yasin, Aregash Abebayehu Zerga, Fikre Bayu Gebeyehu, Birhanu Wagaye

“…<h4>Conclusions</h4>The pooled prevalence of good sunlight exposure practices among infants in Ethiopia is low. Had postnatal care follow-up, being urban residents, mother's employment status, mother's educational status and not fear of sunlight exposure were independent factors of good sunlight exposure practice among infants. …”
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Participatory research towards the control of snakebite envenoming and other illnesses in a riverine community of the Western Brazilian Amazon. by Alícia Patrine Cacau Santos, Evellyn Antonieta Rondon Tomé Silva, Hiran Sátiro Souza da Gama, Jady Shayenne Mota Cordeiro, Ana Paula Silva Oliveira, Jéssica Albuquerque Araújo, Rafaela Nunes Dávila, Hélio Afonso Amazonas Júnior, Altair Seabra Farias, Jacqueline Almeida Gonçalves Sachett, Vinícius Azevedo Machado, Wuelton Marcelo Monteiro, Felipe Leão Gomes Murta

“…<h4>Background</h4>Riverine communities face various health problems, which involve geographical and cultural barriers to accessing care, in addition to a lack of financial investments in services aimed at these communities, resulting in a process of invisibility for the population living in these regions. …”
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Optimizing fodder yield and quality through integrated organic nutrient amendments in multi-crop system by Santosh Onte, Santosh Onte, Vrushabh Vijay Fiskey, Manjunath S. Melavanki, Airadevi P. Angadi, Prasanna S. Pyati, Magan Singh, Dileep Kumar, Sanjivkumar Angadarao Kochewad, Sudhir Kumar, Hari Om, Vijendra Kumar Meena, Kamal Garg, Vetrivel Karunakaran, Manish Kanwat, Babu Lal Meena, Yogananda Shivalli Boregowda, Rahul Bellagi, K. Naveena, Sunil Chandersheker, Elisa Azura Azman, Sanjeev Kumar

“…However, research on integrated organic nutrient management in multi-crop systems remains limited, especially concerning its impact on forage productivity and nutritive value. This study aims to investigate the effects of integrated organic nutrient amendments on the yield and quality of multi-crop system. …”
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Author Correction: Systematic protein-protein interaction mapping for clinically relevant human GPCRs by Kate Sokolina, Saranya Kittanakom, Jamie Snider, Max Kotlyar, Pascal Maurice, Jorge Gandía, Abla Benleulmi-Chaachoua, Kenjiro Tadagaki, Atsuro Oishi, Victoria Wong, Ramy H Malty, Viktor Deineko, Hiroyuki Aoki, Shahreen Amin, Zhong Yao, Xavier Morató, David Otasek, Hiroyuki Kobayashi, Javier Menendez, Daniel Auerbach, Stephane Angers, Natasa Pržulj, Michel Bouvier, Mohan Babu, Francisco Ciruela, Ralf Jockers, Igor Jurisica, Igor Stagljar

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Systematic protein–protein interaction mapping for clinically relevant human GPCRs by Kate Sokolina, Saranya Kittanakom, Jamie Snider, Max Kotlyar, Pascal Maurice, Jorge Gandía, Abla Benleulmi‐Chaachoua, Kenjiro Tadagaki, Atsuro Oishi, Victoria Wong, Ramy H Malty, Viktor Deineko, Hiroyuki Aoki, Shahreen Amin, Zhong Yao, Xavier Morató, David Otasek, Hiroyuki Kobayashi, Javier Menendez, Daniel Auerbach, Stephane Angers, Natasa Pržulj, Michel Bouvier, Mohan Babu, Francisco Ciruela, Ralf Jockers, Igor Jurisica, Igor Stagljar

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Clinical Utility of Combined Tissue and Plasma Next-Generation Sequencing in Patients With Advanced, Treatment-Naïve NSCLC by Helena Bote-de Cabo, MD, Marco Siringo, MD, Esther Conde, MD, PhD, Susana Hernández, PhD, Fernando López-Ríos, MD, PhD, Alicia Castelo-Loureiro, MD, Esther García-Lorenzo, MD, Javier Baena, MD-PhD, Mercedes Herrera, MD, Ana Belén Enguita, MD, Yolanda Ruano, PhD, Jon Zugazagoitia, MD, PhD, Luis Paz-Ares, MD, PhD

“…The addition of orthogonal biopsy (tissue to liquid, or liquid to tissue) offered no relevant clinical value in cases with ESCAT I or II targetable drivers already detected by one method. …”
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Prion protein promotes copper toxicity in Wilson disease by Raffaella Petruzzelli, Federico Catalano, Roberta Crispino, Elena V. Polishchuk, Mariantonietta Elia, Antonio Masone, Giada Lavigna, Anna Grasso, Maria Battipaglia, Lucia Vittoria Sepe, Banu Akdogan, Quirin Reinold, Eugenio Del Prete, Diego Carrella, Annalaura Torella, Vincenzo Nigro, Enrico Caruso, Nicole Innocenti, Emiliano Biasini, Ludmila V. Puchkova, Alessia Indrieri, Ekaterina Y. Ilyechova, Pasquale Piccolo, Hans Zischka, Roberto Chiesa, Roman S. Polishchuk

“…Dysfunction in key components of this network leads to the disruption of Cu homeostasis, resulting in fatal disorders such as Wilson disease, which is caused by mutations in the hepatic Cu efflux transporter ATP7B. …”
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