Pathogenic PDE12 variants impair mitochondrial RNA processing causing neonatal mitochondrial disease by Lindsey Van Haute, Petra Páleníková, Jia Xin Tang, Pavel A Nash, Mariella T Simon, Angela Pyle, Monika Oláhová, Christopher A Powell, Pedro Rebelo-Guiomar, Alexander Stover, Michael Champion, Charulata Deshpande, Emma L Baple, Karen L Stals, Sian Ellard, Olivia Anselem, Clémence Molac, Giulia Petrilli, Laurence Loeuillet, Sarah Grotto, Tania Attie-Bitach, Jose E Abdenur, Robert W Taylor, Michal Minczuk

“…Whole exome sequencing of affected probands revealed novel, segregating bi-allelic missense PDE12 variants affecting conserved residues. Patient-derived primary fibroblasts demonstrate diminished steady-state levels of PDE12 protein, whilst mitochondrial poly(A)-tail RNA sequencing (MPAT-Seq) revealed an accumulation of spuriously polyadenylated mitochondrial RNA, consistent with perturbed function of PDE12 protein. …”
Get full text

La actitud hacia los límites sociales de jóvenes de 12 a 20 años de tres religiones by Nadya Luz Velasco Castellón, Luis Antonio Hernández Hernández, Hans Oudhof van Barneveld

“…La muestra fue de 120 jóvenes con edades entre los 12 y 20 años, 50% hombres y 50% mujeres; 40 de cada grupo religioso, a los que se aplicó la versión mexicana de la escala para medir la actitud hacia los límites sociales (Rink, Boersma, Lutje Spelberg y Vos, 2000). …”
Get full text

Serum Asymmetric Dimethylarginine, Nitrate, Vitamin B12, and Homocysteine Levels in Individuals with Pulmonary Embolism by Murat Altuntaş, Figen Atalay, Murat Can, Remzi Altın, Meltem Tor

“…We aimed to analyze the pre- and posttreatment serum asymmetric dimethylarginine (ADMA), nitrate (NO3), vitamin B12 and homocysteine levels in pulmonary embolism (PTE) patients and to determine the prognostic value of these variables in predicting chronic thromboembolic pulmonary hypertension (CTEPH). …”
Get full text

Schenkerian Analysis. Symposium und Workshops. Universität der Künste Berlin, 4. Juni 2004; Gutshof Sauen, 5.–7. Juni 2004; Hochschule für Musik und darstellende Kunst Mannheim, 11.–12. Juni 2004 by Stefan Rohringer

Get full text

Daily time series of 12 human thermal stress indices in Greece, aggregated at commune level (1998–2022)Zenodo by Georgios Charvalis, Michalis Koureas, Chloe Brimicombe, Chara Bogogiannidou, Fani Kalala, Varbara Mouchtouri, Christos Hadjichristodoulou

“…In this paper we present a dataset that contains daily mean, maximum and minimum values of 12 heat stress indices averaged over Greek communes from January 1998 to December 2022. …”
Get full text

LR12 Promotes Liver Repair by Improving the Resolution of Inflammation and Liver Regeneration in Mice with Thioacetamide- (TAA-) Induced Acute Liver Failure by Yongjuan Wang, Xiaoli Xie, Hongqun Liu, Huimin Liu, Huiqing Jiang

“…Triggering receptor expressed on myeloid cells-1 (TREM-1) controls the mobilization of inflammatory cells in response to injury and consequently enhances liver damage. LR12 is a TREM-1 inhibitory peptide. However, the role of LR12 in acute liver failure (ALF) has remained elusive. …”
Get full text

On the Reactivity of N-tert-Butyl-1,2-Diaminoethane: Synthesis of 1-tert-Butyl-2-Imidazoline, Formation of an Intramolecular Carbamate Salt from the Reaction with CO2, and Generation of a Hydroxyalkyl-Substituted Imidazolinium Salt by Kieren J. Evans, Ben Potrykus, Stephen M. Mansell

“…N-tert-Butyl-1,2-diaminoethane was shown to react rapidly with atmospheric carbon dioxide to generate the zwitterionic ammonium carbamate salt CO2N(H)C2H4N(H)2tBu (1). …”
Get full text

Synthesis and crystal structure (E)-1-(4-bromo-2-hydroxyphenyl)-3-(dimethylamino)prop-2-en-1-one, C11H12BrNO2 by Dong Zhang-Chao, Zheng Liang-Liang, Pan Bo-Wen, Shi Yang, Zhou Ying

“…C11H12BrNO2, monoclinic, P21/n (no. 14), a = 7.5143(12) Å, b = 11.8968(15) Å, c = 12.9852(13) Å, β = 105.575(14)°, V = 1118.2(3) Å3, Z = 4, R gt(F) = 0.0607, wR ref(F 2) = 0.1615, T = 293.00(10) K.…”
Get full text

Synthesis of Functional Polyester Based on Polylactic Acid and Its Effect on PC12 Cells after Coupling with Small Peptides by Na Qiang, Shuo Tang, Xiang Liao, Hao Liang, Fang Xie, Ji-xiang Zhu

“…The small peptide was beneficial to the axon growth of PC12 cells.…”
Get full text

Unusual Case of Osseointegrated Dental Implant Migration into Maxillary Sinus Removed 12 Years after Insertion by Mauro Laureti, Nicola Ferrigno, Daniele Rosella, Piero Papi, Francesca Mencio, Francesca De Angelis, Giorgio Pompa, Stefano Di Carlo

“…Postoperative course was uncomplicated and the patient reported no symptoms of sinusitis after 12 months of follow-up.…”
Get full text

Maternal Diet Supplementation with n-6/n-3 Essential Fatty Acids in a 1.2 : 1.0 Ratio Attenuates Metabolic Dysfunction in MSG-Induced Obese Mice by Josiane Morais Martin, Rosiane Aparecida Miranda, Luiz Felipe Barella, Kesia Palma-Rigo, Vander Silva Alves, Gabriel Sergio Fabricio, Audrei Pavanello, Claudinéia Conationi da Silva Franco, Tatiane Aparecida Ribeiro, Jesuí Vergílio Visentainer, Elton Guntendeorfer Banafé, Clayton Antunes Martin, Paulo Cezar de Freitas Mathias, Júlio Cezar de Oliveira

“…The n-6/n-3 essential PUFAs in a ratio of 1.2 : 1.0 supplemented in maternal diet during pregnancy and lactation prevent metabolic dysfunction in MSG-obesity model.…”
Get full text

Crystal structure of catena-poly[(5,5,7,12,12,14-hexamethyl -1,4,8,11-tetraazacyclotetradecane- κ4N,N′,Nʺ,N‴)nickel(II)-(μ2-perchlorato-κ2O:O′)] 3,5-dicarboxybenzoate – methanol (1/2), C27H49ClN4NiO12 by Wang Qiong, Ou Guang-Chuan

“…C27H49ClN4NiO12, triclinic, P1‾$\overline{1}$ (no. 2), a = 11.180(2) Å, b = 12.320(3) Å, c = 12.754(3) Å, α = 98.263(2)°, β = 97.524(2)°, γ = 99.470(2)°, V = 1693.1(6) Å3, Z = 2, Rgt(F) = 0.0423, wRref(F2) = 0.1238, T = 296(2) K.…”
Get full text

Construction of Direct Z-Scheme Photocatalyst by Mg1.2Ti1.8O5 and g-C3N4 Nanosheets toward Photocatalytic H2 Production and Disinfection by Sijia Gu, Dan Zhang, Shirong Luo, Heng Yang

“…Herein, Z-scheme heterojunction composites were successfully fabricated by loading g-C3N4 nanosheets (CN) on the surface of Mg1.2Ti1.8O5 nanoflakes (MT) through a simple sol-gel method followed by the calcination method. …”
Get full text

Real-World Evidence of Clinical Outcomes of the Use of the Adalimumab Biosimilar SB5 in Rheumatic and Gastrointestinal Immune-Mediated Inflammatory Diseases: 12-Month Data from the PERFUSE Study by Bruno Fautrel, Yoram Bouhnik, Carine Salliot, Franck Carbonnel, Mathurin Fumery, Christophe Bernardeau, Yves Maugars, Mathurin Flamant, Fabienne Coury, Ben Braithwaite, Salima Hateb, Janet Addison, the PERFUSE investigators

“…Switched patients’ remission rates remained stable between baseline and month 12 (M12) for all indications (p > 0.05). Persistence (95% CI) at M12 among naïve patients was 59% (46.5, 68.8) for RA, 65% (49.7, 77.1) for PsA, 56% (48.3, 62.6) for AS, 70% (63.0, 75.7) for CD, and 42% (30.7, 53.1) for UC, compared to 60% (42.7, 73.7) for RA, 57% (37.3, 72.1) for PsA, 55% (45.8, 64.0) for AS, 63% (53.4, 71.7) for CD, and 56% (27.2, 77.6) for UC among switched patients. …”
Get full text

Highlighting of Urinary Sodium and Potassium among Indonesian Schoolchildren Aged 9–12 Years: The Contribution of School Food by Farapti Farapti, Muji Sulistyowati, Kurnia Dwi Artanti, Stefania Widya Setyaningtyas, Sri Sumarmi, Bibit Mulyana

“…Indonesian schoolchildren aged 9–12 years are categorized by excessive Na intake and very deficient K intake. …”
Get full text

Association between P2RY12 Gene Polymorphisms and IVIG Resistance in Kawasaki Patients by Zhouping Wang, Yufen Xu, Huazhong Zhou, Yanfei Wang, Wei Li, Zhaoliang Lu, Zhiyong Jiang, Xueping Gu, Hao Zheng, Lanlan Zeng, Ping Huang, Li Zhang, Xiaoqiong Gu

“…Despite the association between Purinergic receptor P2Y12 (P2RY12) polymorphism, KD genetic susceptibility, and CAL complications being proved, few studies have assessed the relationship between P2RY12 polymorphisms and IVIG resistance in patients with KD. …”
Get full text

Effects of a 12-Week Skipping Exercise Program on Leg Endurance in Competitive Badminton Players: A Randomized Controlled Trial by Ririn Irena, Ardila Melati, Vlad Adrian Geanta, ⁠Ayu Mayzura Simbolon, Retha Foret

“…The participants in the intervention cohort undertook a 12-week progressive skipping exercise program in conjunction with their regular badminton training, whereas the control group adhered solely to standard training protocols. …”
Get full text

Prevalence of Asymptomatic Brucellosis in Children 7 to 12 Years Old by Mohammad Aghaali, Siamak Mohebi, Hosein Heydari

“…This study aimed to evaluate the prevalence of brucellosis in asymptomatic children 7 to 12 years old in Kahak, Iran. Methods. In this study, 186 children 7 to 12 years old were evaluated. …”
Get full text

Plasma and Red Cell Reference Intervals of 5-Methyltetrahydrofolate of Healthy Adults in Whom Biochemical Functional Deficiencies of Folate and Vitamin B12 Had Been Excluded by Agata Sobczyńska-Malefora, Dominic J. Harrington, Kieran Voong, Martin J. Shearer

“…The purpose of this study was to establish the reference intervals of 5-MTHF in plasma and red cells of healthy adults who had been prescreened to exclude biochemical evidence of functional deficiency of folate and/or vitamin B12. Functional folate and vitamin B12 status was assessed by respective plasma measurements of homocysteine and methylmalonic acid in 144 healthy volunteers, aged 19–64 years. …”
Get full text

Laxative Effect of Lacticaseibacillus rhamnosus Glory LG12: from the Perspective of the Stem Cell Factor/C-kit Signaling Pathway by XIANG Fangqin, LI Yuxing, LI Bailiang

Subjects: “…lacticaseibacillus rhamnosus glory lg12; constipation; laxative effect; inflammatory cytokines; gastrointestinal regulatory peptides; stem cell factor/c-kit signaling pathway…”
Get full text