Inhibition of Extracellular Calcium Influx Results in Enhanced IL-12 Production in LPS-Treated Murine Macrophages by Downregulation of the CaMKKβ-AMPK-SIRT1 Signaling Pathway by Xin Liu, Ning Wang, Yuanfeng Zhu, Yongjun Yang, Xiaoli Chen, Shijun Fan, Qian Chen, Hong Zhou, Jiang Zheng

“…Activated macrophages are the primary sources of IL-12, a key cytokine bridging innate and adaptive immunity. …”
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Acanthamoeba Keratitis: A 12-Year Experience Covering a Wide Spectrum of Presentations, Diagnoses, and Outcomes by Michael A. Page, William D. Mathers

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ВЛИЯНИЕ ТЕХНОЛОГИЧЕСКИХ ПАРАМЕТРОВ ТЕРМИЧЕСКОЙ ОБРАБОТКИ НА СТРУКТУРУ И СВОЙСТВА ОТВЕТСТВЕННЫХ ДЕТАЛЕЙ ИЗ СТАЛИ Х12МФ by Сергей Геннадьевич Иванов, Михаил Алексеевич Гурьев, Алексей Михайлович Гурьев, Бурьял Дондокович Лыгденов

“… В работе приведены результаты исследования хрупкого разрушения детали из стали Х12МФ. Для этих сталей характерны следующие общие особенности. …”
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Petechiae and Limb Weakness in a 12-Year-Old Boy by Eline Vandersteen, Katrien Smets, Sophie Bravo, Valérie Reynaert, Sherief Janmohammed, Dirk Van Gysel

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Pathogenic PDE12 variants impair mitochondrial RNA processing causing neonatal mitochondrial disease by Lindsey Van Haute, Petra Páleníková, Jia Xin Tang, Pavel A Nash, Mariella T Simon, Angela Pyle, Monika Oláhová, Christopher A Powell, Pedro Rebelo-Guiomar, Alexander Stover, Michael Champion, Charulata Deshpande, Emma L Baple, Karen L Stals, Sian Ellard, Olivia Anselem, Clémence Molac, Giulia Petrilli, Laurence Loeuillet, Sarah Grotto, Tania Attie-Bitach, Jose E Abdenur, Robert W Taylor, Michal Minczuk

“…Whole exome sequencing of affected probands revealed novel, segregating bi-allelic missense PDE12 variants affecting conserved residues. Patient-derived primary fibroblasts demonstrate diminished steady-state levels of PDE12 protein, whilst mitochondrial poly(A)-tail RNA sequencing (MPAT-Seq) revealed an accumulation of spuriously polyadenylated mitochondrial RNA, consistent with perturbed function of PDE12 protein. …”
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La actitud hacia los límites sociales de jóvenes de 12 a 20 años de tres religiones by Nadya Luz Velasco Castellón, Luis Antonio Hernández Hernández, Hans Oudhof van Barneveld

“…La muestra fue de 120 jóvenes con edades entre los 12 y 20 años, 50% hombres y 50% mujeres; 40 de cada grupo religioso, a los que se aplicó la versión mexicana de la escala para medir la actitud hacia los límites sociales (Rink, Boersma, Lutje Spelberg y Vos, 2000). …”
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Editorial - Special Edition: Volume 12, Number 2 by Paul Prinsloo

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Serum Asymmetric Dimethylarginine, Nitrate, Vitamin B12, and Homocysteine Levels in Individuals with Pulmonary Embolism by Murat Altuntaş, Figen Atalay, Murat Can, Remzi Altın, Meltem Tor

“…We aimed to analyze the pre- and posttreatment serum asymmetric dimethylarginine (ADMA), nitrate (NO3), vitamin B12 and homocysteine levels in pulmonary embolism (PTE) patients and to determine the prognostic value of these variables in predicting chronic thromboembolic pulmonary hypertension (CTEPH). …”
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Schenkerian Analysis. Symposium und Workshops. Universität der Künste Berlin, 4. Juni 2004; Gutshof Sauen, 5.–7. Juni 2004; Hochschule für Musik und darstellende Kunst Mannheim, 11.–12. Juni 2004 by Stefan Rohringer

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Daily time series of 12 human thermal stress indices in Greece, aggregated at commune level (1998–2022)Zenodo by Georgios Charvalis, Michalis Koureas, Chloe Brimicombe, Chara Bogogiannidou, Fani Kalala, Varbara Mouchtouri, Christos Hadjichristodoulou

“…In this paper we present a dataset that contains daily mean, maximum and minimum values of 12 heat stress indices averaged over Greek communes from January 1998 to December 2022. …”
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LR12 Promotes Liver Repair by Improving the Resolution of Inflammation and Liver Regeneration in Mice with Thioacetamide- (TAA-) Induced Acute Liver Failure by Yongjuan Wang, Xiaoli Xie, Hongqun Liu, Huimin Liu, Huiqing Jiang

“…Triggering receptor expressed on myeloid cells-1 (TREM-1) controls the mobilization of inflammatory cells in response to injury and consequently enhances liver damage. LR12 is a TREM-1 inhibitory peptide. However, the role of LR12 in acute liver failure (ALF) has remained elusive. …”
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Bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) in treatment-naïve and treatment-experienced people with HIV: 12-month virologic effectiveness and safety outcomes in the BICSTaR Japan cohort by Yoshiyuki Yokomaku, Katsuji Teruya, Dai Watanabe, Tomoyuki Endo, Rumi Minami, Nao Taguchi, Tali Cassidy, Andrea Marongiu, David Thorpe, Takuma Shirasaka, Shinichi Oka

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siRNAs干扰EBNA1下调EBV阳性鼻咽癌细胞内ALOX12的表达

“…【目的】 利用RNA干扰技术抑制C666-1细胞中EB病毒核抗原1(EBNA1)的表达,探索氧化应激与抗氧化相关基因的表达变化65377; 【方法】 采用蛋白质印迹证实了能有效抑制EBNA1表达的干扰序列,使用甲基噻唑基四唑(MTT)方法检测C666-1细胞的存活率,利用实时定量PCR芯片技术探索了氧化应激与抗氧化相关基因的转录谱变化,并通过反转录聚合酶链反应(RT-PCR)和蛋白质印迹进行了验证65377;【结果】 EBNA1-1414和EBNA1-1437干扰序列转染C666-1细胞48 h后,分别可抑制59%和56%的EBNA1蛋白表达,细胞存活率分别降低了33%和24%65377;PCR芯片实验发现干扰EBNA1表达后48 h C666-1细胞中花生四烯酸盐12-脂氧合酶(ALOX12)蛋白表达有下调,谷胱甘肽还原酶(GSR)和过氧化物酶3(PRDX3)在转录水平表达上调65377; 【结论】 EBNA1或许能够通过上调ALOX12的表达间接地发挥促鼻咽癌作用65377;…”
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Editorial do número 12 / Éditorial du numéro 12 by Hervé Théry, Neli Aparecida de Mello-Théry

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2013年12月通信业主要指标完成情况（一）

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On the Reactivity of N-tert-Butyl-1,2-Diaminoethane: Synthesis of 1-tert-Butyl-2-Imidazoline, Formation of an Intramolecular Carbamate Salt from the Reaction with CO2, and Generation of a Hydroxyalkyl-Substituted Imidazolinium Salt by Kieren J. Evans, Ben Potrykus, Stephen M. Mansell

“…N-tert-Butyl-1,2-diaminoethane was shown to react rapidly with atmospheric carbon dioxide to generate the zwitterionic ammonium carbamate salt CO2N(H)C2H4N(H)2tBu (1). …”
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Synthesis and crystal structure (E)-1-(4-bromo-2-hydroxyphenyl)-3-(dimethylamino)prop-2-en-1-one, C11H12BrNO2 by Dong Zhang-Chao, Zheng Liang-Liang, Pan Bo-Wen, Shi Yang, Zhou Ying

“…C11H12BrNO2, monoclinic, P21/n (no. 14), a = 7.5143(12) Å, b = 11.8968(15) Å, c = 12.9852(13) Å, β = 105.575(14)°, V = 1118.2(3) Å3, Z = 4, R gt(F) = 0.0607, wR ref(F 2) = 0.1615, T = 293.00(10) K.…”
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Pendidikan Fithrah dalam Perspektif Hadist (Studi tentang Fithrah Anak Usia 7-12 Tahun) by Siti Aisyah

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Mesleki ve Teknik Anadolu Lisesi Öğrencilerinin Meslek Yüksekokulu Özelinde Yükseköğrenim Tercihlerinin İncelenmesi: Çanakkale İli Mesleki ve Teknik Anadolu Lisesi 12. Sınıf Öğrencileri Üzerine Bir Araştırma by Ümit Demir

“…Bu çalışmada Mesleki ve Teknik Anadolu Lisesi (MTAL) 12. Sınıf öğrencilerinin lise öğrenimleri sonrası meslek yüksekokulu başta olmak üzere yükseköğrenim tercih durumlarının incelenmesi amaçlanmıştır. …”
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Synthesis of Functional Polyester Based on Polylactic Acid and Its Effect on PC12 Cells after Coupling with Small Peptides by Na Qiang, Shuo Tang, Xiang Liao, Hao Liang, Fang Xie, Ji-xiang Zhu

“…The small peptide was beneficial to the axon growth of PC12 cells.…”
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