The Effects of Mesenchymal Stem Cells on Antimelanoma Immunity Depend on the Timing of Their Administration by Dragana Miloradovic, Dragica Miloradovic, Bojana Simovic Markovic, Aleksandar Acovic, Carl Randall Harrell, Valentin Djonov, Nebojsa Arsenijevic, Vladislav Volarevic

“…On the contrary, MSCs, injected 14 days after melanoma induction (B16F10+MSC14d-treated mice), promoted tumor growth by suppressing antigen-presenting properties of tumor-infiltrating dendritic cells (DCs) and macrophages and by reducing tumoricidal capacity of NK cells and T lymphocytes. Significantly higher plasma levels of TGF-β and IL-10, remarkably lower plasma levels of TNF-α and IFN-γ, and significantly reduced number of tumor-infiltrating, I-A-expressing, and IL-12-producing macrophages, CD80- and I-A-expressing DCs, granzyme B-expressing CTLs and NK cells, IFN-γ- and IL-17-producing CTLs, CD4+Th1, and Th17 cells were observed in B16F10+MSC14d-treated animals. …”
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Body image and attitudes toward cosmetic surgeries among female college students in the United Arab Emirates: A cross-sectional study by Ahmad M. Al-Bashaireh, Yousef Aljawarneh, Osama Alkouri, Foad Alzoughool, Amal Alhefeiti, Amnah Aldhuhoori, Amnah Al Kaabi, Aseilah Alkaabi, Fawzia Alnaqbi

“…Moreover, a culturally tailored educational campaign is needed to enhance students' capacity for making informed decisions and instill a conscientious approach to personal health and aesthetic considerations.…”
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Reduction in <i>Aedes aegypti</i> Population After a Year-Long Application of Targeted Sterile Insect Releases in the West Valley Region of Southern California by Solomon Kibret Birhanie, Jacob Hans, Jennifer Thieme Castellon, Ale Macias, Rubi Casas, Huy Hoang, Deanna Mormile, Kecia Pitts-Love, Michelle Q. Brown

“…<i>Aedes aegypti</i> is of great public health concern because of its vectorial capacity to transmit various arboviruses such as Zika, yellow fever, dengue, and chikungunya. …”
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Temperature Sensitivity Response of Soil Enzyme Activity to Simulated Climate Change at Growth Stages of Winter Wheat by Yaokun Jiang, Bingbing Lu, Meng Liang, Yang Wu, Yuanze Li, Ziwen Zhao, Guobin Liu, Sha Xue

“…Different levels of CO₂ concentration (400 and 800 μmol mol⁻¹), temperature conditions (current temperature and 4 °C higher), and water conditions (80% and 60% of field water capacity) were set, and their interactions were examined. …”
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Risk of All-Cause Mortality in Mild Chronic Obstructive Pulmonary Disease: Evidence From the NHANES III and 2007&ndash;2012 by Zou W, Ou J, Wu F, Xiao S, Deng Z, Li H, Wang Z, Tang G, Liu S, Ye D, Zhu D, Hu J, Ran P

“…Mild COPD was defined as prebronchodilator forced expiratory volume in 1 second /forced vital capacity < 0.70 and FEV1 ≥ 80% of the predicted value. …”
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Termination of Repeat Testing in Chemical Laboratories Based on Practice Guidelines: Examining the Effect of Rule-Based Repeat Testing in a Transplantation Center by Neda Soleimani, Amir Azadi, Mohammad Javad Esmaeili, Fatemeh Ghodsi, Reza Ghahramani, Azadeh Hafezi, Tayebeh Hosseyni, Arezoo Arabzadeh, Samira khajeh, Mahsa Farhadi, Sahand Mohammadzadeh

“…., albumin, alkaline phosphatase (ALP), alanine aminotransferase (ALT), amylase, aspartate aminotransferase (AST), bilirubin total (BT), bilirubin direct (BD), blood urea nitrogen (BUN), calcium, chloride (Cl), cholesterol total (CholT), creatine kinase (CK), creatinine (Cr), glucose, gamma-glutamyl transferase (GGT), high-density lipoprotein-cholesterol (HDL-c), iron, lactate dehydrogenase (LDH), LDL-c, lipase, magnesium (Mg), phosphorus (Ph), protein total (ProtT), total iron binding capacity (TIBC), triglyceride (TG), and uric acid) were assessed in both critical and noncritical ranges over two consecutive months (routine subjective test repeats in the first month and rule-based repeats in the second month). …”
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Effectiveness of NSP enzyme and organic chromium supplementation in low-protein feed on carbohydrate utilization in Pomfret Colossoma macropomum by Maihardiyanti Faiqotul Himmah, Ichsan Achmad Fauzi, Julie Ekasari, Muhammad Raditya Gumelar, Muhammad Agus Suprayudi

“…From this research, it can be concluded that supplementation of NSP enzyme and organic chromium at doses of 1 g and 1 mg per kg of feed produces the best growth performance and anti-oxidant capacity in pomfret fish.   Keywords: antioxidant, glycogen, growth performance, postprandial blood glucose   ABSTRAK   Penelitian ini bertujuan untuk mengevaluasi efektivitas suplementasi enzim NSP dan kromium organik pada pakan ikan bawal Colosoma macropomum rendah protein untuk meningkatkan pemanfaatan karbohidrat. …”
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Comprehensive evaluation of physico-chemical, antioxidant, and antimicrobial properties in commercial soaps: A study on bar soaps and liquid hand wash by Jannatul Ferdous Nova, Susmita Zaman Smrity, Mahadi Hasan, Md. Tariquzzaman, Md Al Amin Hossain, Md. Tanvirul Islam, Md. Raysul Islam, Selina Akter, Md. Sifat Rahi, Md. Tuhinur R. Joy, Zannatul Kowser

“…Besides, SN-21 among liquid hand wash soaps possesses overall excellence as it moisturizes skin well (MC-83.75 ± 0.05 %), is almost safe for skin (pH-7.73 ± 0.02, TAC-0.98 ± 0.01 %), has TFM (11.35 %), has good cleansing capacity (FH-22.66 ± 0.58 cm) and bacteria growth inhibiting activity (29.27 ± 0.25 mm/100 % conc.), destroys selected bacteria (MIC – 1.2 × 107 CFU at 1 min and 5.5 × 107 CFU at 10 seconds), and wash away free radicals from skin (420.64 ± 3.62 μg/mL).…”
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Active surveillance of avian influenza in the southwestern Poyang Lake area, China: Analyzing changes in wholesale and frozen fresh retail markets post-policy implementation by Wentao Song, Zhiqiang Deng, Fenglan He, Kang Fang, Lintao Sheng, Jingwen Wu, Junling Tu, Kun Zhou, Xi Wang, Wei Wang, Liu Yi, Kangguo Li, Buasiyamu Abudunaibi, Ping Zhang, Hui Li, Tianmu Chen

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Land use changes, green house gas emissions, and rehabilitation model of native tree species towards sustainable management by W.C. Adinugroho, H.L. Tata, . Darwo, Y. Lisnawati, H.S. Nuroniah, R. Dewi, I. Heriansyah, . Mawazin

“…The findings support potential for wet agroforestry and paludiculture to restore peatlands, mitigate carbón dioxide emissions, and enhance livelihoods while emphasizing the need for inclusive governance and technical capacity.…”
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ELABELA promotes the migration and homing of bone marrow mesenchymal stem cells to myocardial injury sites through the ERK1/2/miR-299a-5p/Exo70 pathway by Jing-Yu Hou, Hao Wu, Shuang-Mei Li, Xiao-Jing Li, Shu-Jun Yang, Xu-Xiang Chen, Chang-Qing Zhou, Hui-Bao Long, Hai-Dong Wu, Jia-Ying Fu, Ya-Jie Guo, Tong Wang

“…ELA pretreatment effectively heightened the homing capacity of BMSCs to the site of myocardial injury and their proficiency in repairing myocardial damage in vivo. …”
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Identification and Classification of Factors Influencing the Regulation of Priority Goods Markets Based on Network Governance with an Interpretive Structural Modeling Approach by sadegh Dadashi, Fattah Sharifzadeh, Reza Vaezi, Hossein Aslipour

“…ObjectiveThe increasing complexity within economies and societies, coupled with the limited capacity of governments to address these challenges, has brought network forms of governance into focus. …”
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The value-added model of the supply chain of petrochemical industries with a sustainable development approach by ali amiri, seyed abbas heydari, vahidreza Mirabi

“…The results of the investigations showed that the excessive increase in the sending capacity, the increase in the volume of orders, and the decrease in the time of sending the orders will have their own positive and negative results; which the creation of a favorable and optimal situation based on the various outputs of the model will be fruitful in the context of the organization's policy adopting. …”
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Designing a Digital Branding Pattern in Healthy Agricultural Products by Abolghasem Mohammadnezhad Ali Zamini, Arezo Ahmadi danyali, Mahmoud Ahmadi Sharif

“…In addition, agriculture plays a major role in shaping the country's export capacity and import substitution program. In recent years, agricultural trade has been developed in most industries in raw materials and feed production.  …”
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A novel ddPCR™ assay for eDNA detection and quantification of Greater Amberjack Seriola dumerilli and three congeners in US waters: challenges and application to fisheries independ... by P. Joana Dias, Ryan Lehman, Bryan L. Huerta-Beltrán, Ana Wheeler, Crystal L. Hightower, Jessica Heise, Theodore Switzer, Clint Rhode, J. Marcus Drymon, Lynne Stokes, Mark A. Albins, Sean Powers, Nicole Phillips

“…In order to groundtruth ddPCR™ data, and explore its capacity to provide abundance estimates, we compared ddPCR™ detections and quantifications to abundance data inferred from multiple camera (ROV, S-BRUV, chevron trap) and acoustic (VPS array) gears deployed during a fisheries research gear-calibration cruise. …”
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Safety, Tolerability, and Immunogenicity of the Invaplex_AR-Detox <i>Shigella</i> Vaccine Co-Administered with the dmLT Adjuvant in Dutch and Zambian Adults: Study Protoc... by Geert V. T. Roozen, Nsofwa Sukwa, Masuzyo Chirwa, Jessica A. White, Marcus Estrada, Nicole Maier, Kevin R. Turbyfill, Renee M. Laird, Akamol E. Suvarnapunya, Aicha Sayeh, Flavia D’Alessio, Candice Marion, Laura Pattacini, Marie-Astrid Hoogerwerf, Rajagopal Murugan, Manuela Terrinoni, Jan R. Holmgren, Sodiomon B. Sirima, Sophie Houard, Michelo Simuyandi, Meta Roestenberg

“…Besides strengthening the vaccine pipeline against a major diarrheal disease, another goal of the ShigaPlexIM project is to stimulate capacity building and strengthen global North-South relations in clinical research. …”
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CAR-CIK vs. CAR-T: benchmarking novel cytokine-induced killer cells as solid tumor immunotherapy in ErbB2+ rhabdomyosarcoma by Laura M. Moser, Laura M. Moser, Laura M. Moser, Laura M. Moser, Laura M. Moser, Catrin Heim, Sebastian E. Koschade, Sebastian E. Koschade, Sebastian E. Koschade, Sebastian E. Koschade, Sebastian E. Koschade, Philipp Wendel, Philipp Wendel, Philipp Wendel, Philipp Wendel, Süleyman Bozkurt, Sabine Harenkamp, Hermann Kreyenberg, Hermann Kreyenberg, Michael Merker, Michael Merker, Christian Münch, Christian Münch, Christian Münch, Elise Gradhand, Meike Vogler, Meike Vogler, Meike Vogler, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Halvard Bönig, Halvard Bönig, Jan-Henning Klusmann, Jan-Henning Klusmann, Jan-Henning Klusmann, Jan-Henning Klusmann, Peter Bader, Peter Bader, Peter Bader, Peter Bader, Peter Bader, Winfried S. Wels, Winfried S. Wels, Winfried S. Wels, Eva Rettinger, Eva Rettinger, Eva Rettinger, Eva Rettinger, Eva Rettinger

“…CIK cells are a heterogenous population of predominantly T cells with a mixed natural killer (NK) phenotype and combine non-MHC-restricted cytotoxicity with potent anti-tumor capacity of the adaptive immune system. Here, we characterize and compare efficacy, phenotypic subpopulations and modes of action of CAR-CIK cells and conventional CAR-T cells from same-donor samples in ErbB2+ rhabdomyosarcoma (RMS).MethodsTo benchmark CAR-CIK against conventional CAR-T cells, effector cells were generated from same-donor samples and lentivirally transduced with a second generation CD28-CD3ζ CAR. …”
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Factors associated with physical fitness and disparities in population segments among older adults: A cross-sectional study by Yuqin Rao, Jingjing Wang, Kai Li, Fanhui Zheng, Ying Chen, Bo Zhai, Jintao Hong, Chen Wang, Bao Liu, Dao Wang

“…Participants completed physical fitness assessments encompassing body fat percentage, lung capacity, high leg raise in place, grip strength, seated forward bending, 30-s sit-to-stand test, single-leg standing with eyes closed, and choice reaction time. …”
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Brucella suis ΔmapB outer membrane vesicles as an acellular vaccine against systemic and mucosal B. suis infection by Florencia Muñoz González, Florencia Muñoz González, Magali G. Bialer, Maria L. Cerutti, Silvia M. Estein, Lila Y. Ramis, Pablo C. Baldi, Pablo C. Baldi, Ángeles Zorreguieta, Ángeles Zorreguieta, Mariana C. Ferrero, Mariana C. Ferrero

“…Immunogenicity was assessed by intramuscular immunization of mice with wt OMVs or ΔmapB OMVs, followed by the measurement of antigen-specific antibody levels and functional assays to evaluate the protective capacity of the antibodies. Cellular immunity was assessed by characterizing cytokine secretion through ELISA after in vitro stimulation of spleen cells with heat-killed B. suis. …”
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Overexpression of the <i>GmPM35</i> Gene Significantly Enhances Drought Tolerance in Transgenic Arabidopsis and Soybean by Xinyu Wang, Yao Sun, Rui Wang, Xinyang Li, Yongyi Li, Tianyu Wang, Zhaohao Guo, Yan Li, Wenxi Qiu, Shuyan Guan, Qi Zhang, Piwu Wang, Mingze Li, Siyan Liu, Xuhong Fan

“…In addition, we found that under drought stress, the MDA content was reduced by an average of 18.8%, and the Pro content was increased by an average of 60.14% in soybean plants overexpressing the <i>GmPM35</i> gene, and the changes in these indexes indicated that the plants had stronger antioxidant and osmoregulatory capacities in response to drought stress. In summary, this experiment demonstrated that the <i>GmPM35</i> gene plays an important role in soybean tolerance to drought stress, and by overexpressing the <i>GmPM35</i> gene, soybean plants can better tolerate drought stress and maintain normal physiological functions.…”
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