Introducing 3D printed models of fractures in osteology learning improves clinical reasoning skills among first-year medical students: a pilot study by Abhishek Agarwal, Anne D Souza, B. Jyostna, Ashwija Shetty, Nandini Bhat

“…Therefore, this study aims to evaluate the effectiveness of using 3D-printed models of limb bone fractures in routine osteology classes to enhance the clinical reasoning skills of first-year medical undergraduate students. …”
Get full text

Impact of pathogenic mutations of the GLUT1 glucose transporter on solute carrier dynamics using ComDYN enhanced sampling [version 2; peer review: 2 approved, 1 approved with reser... by K. Anton Feenstra, Akiko Higuchi, Kei Yura, Sanne Abeln, Halima Mouhib

“…Background: The solute carrier (SLC) family of membrane proteins is a large class of transporters for many small molecules that are vital for cellular function. …”
Get full text

Methicillin-Resistant Staphylococcus aureus (MRSA): Prevalence and Antimicrobial Sensitivity Pattern among Patients—A Multicenter Study in Asmara, Eritrea by Eyob Yohaness Garoy, Yacob Berhane Gebreab, Oliver Okoth Achila, Daniel Goitom Tekeste, Robel Kesete, Robel Ghirmay, Ruta Kiflay, Thomas Tesfu

“…Data were analyzed using SPSS version 20 software. Results. S. aureus isolation rate from the 130 samples was 82 (63.1%). …”
Get full text

Combining solubilization and controlled release strategies to prepare pH-sensitive solid dispersion loaded with albendazole: in vitro and in vivo studies by Dehai Su, Mingyang Bai, Chaoqun Wei, Xiangyang Long, Xuezhen Liu, Xiangguang Shen, Huanzhong Ding

“…Albendazole (ABZ), classified as a class II basic drug under the Biopharmaceutics Classification System (BCS), is widely recognized for its therapeutic efficacy in treating and preventing trichuriasis. …”
Get full text

Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO by Vidya Narayanaswami PhD, Kenneth Dahl PhD, Vadim Bernard-Gauthier PhD, Lee Josephson PhD, Paul Cumming PhD, Neil Vasdev PhD

“…We provide a brief overview of the cellular expression and function of these targets, noting their selectivity for astrocytes and/or microglia, and highlight the classes of PET radiotracers that have been investigated in early-stage preclinical or clinical research studies of neuroinflammation.…”
Get full text

Genetic potential of quality in spring bread wheat cultivars bred at Kurgan agricultural research institute by A. I. Abugalieva, L. T. Maltsevа, E. A. Filippova, A. I. Morgunov, Y. I. Zelensky, J. Peña

“…In terms of sedimentation, 86% of the genotypes were predicted to belong to the strong and valuable wheat class; according to the composition of HMW glutenin subunits, mixing quality and flour strength (W), 30 – 42% were identified as high-quality genotypes. …”
Get full text

Radiomics for differentiating adenocarcinoma and squamous cell carcinoma in non-small cell lung cancer beyond nodule morphology in chest CT by Minmini Selvam, Abjasree Sadanandan, Anupama Chandrasekharan, Sidharth Ramesh, Arunan Murali, Ganapathy Krishnamurthi

“…The average Area Under the Curve score was 88%, representing good discrimination between the two classes of lung nodules. Radiomics is a powerful non-invasive tool that could potentially add to visual information obtained on CT. …”
Get full text

The impact of temperature on the shear bond strength of conventional multi-step and self-adhesive orthodontic adhesive systems: an in-vitro study by Grėtė Kazlauskaitė, Rytis Vaitiekūnas, Kristina Lopatienė, Audrius Jutas, Benedikta Palesik, Dalia Smailienė

“…The data were analyzed using Student’s t-test, parametric analysis of variance (ANOVA), the intra-class correlation coefficient (ICC), the Kruskal-Wallis test, and the chi-square test. …”
Get full text

Natural science education in the university core curriculum by D. N. Kyrov, N. V. Nesterova, O. A. Prituzhalova, L. D. Cheremnykh

“…The results of a student survey were analysed after completing the course.Results and scientific novelty. In the course of the study, the forms of classes and control were determined that are suitable for joint education of students of natural sciences and humanities in the context of transition to individual educational trajectories. …”
Get full text

Development and evaluation of a deep learning segmentation model for assessing non-surgical endodontic treatment outcomes on periapical radiographs: A retrospective study. by Dennis Dennis, Siriwan Suebnukarn, Sothana Vicharueang, Wasit Limprasert

“…Mask Region-based Convolutional Neural Network (Mask R-CNN) was used to pixel-wise segment the root from other structures in the image and trained to predict class label into healed, healing and disease. Three endodontists annotated 1080 images used for model training, validation, and testing. …”
Get full text

Calm ocean, stormy sea: atmospheric and oceanographic observations of the Atlantic during the Atlantic References and Convection (ARC) ship campaign by L. Köhler, L. Köhler, J. Windmiller, D. Baranowski, M. Brennek, M. Ciuryło, L. Hayo, D. Kȩpski, S. Kinne, B. Latos, B. Lobo, T. Marke, T. Nischik, D. Paul, P. Stammes, A. Szkop, O. Tuinder

“…To this end, we crossed the ITCZ three times in the meridional direction. …”
Get full text

Investigating the Effect of Malocclusion Severity on the Psychological Impact of Dental Aesthetics by Neda Babanouri, Hooman Zarif Najafi, Fatmeh Hosseini, Shabnam Ajami

“…Additionally, the type of malocclusion (e.g., Class I, II, III, open bite, deep bite) and the type of orthodontic treatment (e.g., extraction, nonextraction, and surgery) were documented for case group participants. …”
Get full text

Alcohol, alcoholism and related consequences by M. V. Mayevskaya

“…Pharmaceutical therapy of alcohol-induced dependency made a major step forward as well with introduction of new class of drugs – opioid system modulators represented by nalmefene and naltrexone. …”
Get full text

Effectiveness of lateral femoral cutaneous and femoral nerve block in managing postoperative pain for hemiarthroplasty patients by Kazi Mahzabin Arin, Shofina Sultana, Ayesha Sultana, Abdul Hannan Mohammad, Chandra Shekhar Karmakar, AKM Akhtaruzzaman

“…Adjusted time based on age, sex, body mass index, and Anesthesiologists class for the FIC block group was 6.8 (0.9) hours, while the LFCN plus FN block group recorded 7.5 (0.8) hours (P=0.003). …”
Get full text

A comprehensive investigation of Clerodendrum Infortunatum Linn. using LC-QTOF-MS/MS metabolomics as a promising anti-alzheimer candidate by Fatma Atef, Mostafa A. Abdelkawy, Basma M. Eltanany, Laura Pont, Ahmed M. Fayez, Mohamed F. Abdelhameed, Fernando Benavente, Inas Y. Younis, Asmaa M. Otify

“…A total of 79 metabolites, spanning various chemical classes, such as organic acids, phenolic acids, phenylpropanoids and phenylethanoids, flavonoids, coumarins, other phenolics, and fatty acids and their derivatives, were identified. …”
Get full text

Urinary prostaglandin metabolites evaluation for activity monitoring in inflammatory bowel disease by Renata d’Inca, Hana Manceau, Lucia Zanni, Laura Vernoux, Xavier Treton, Katell Peoc’h

“…Cluster analysis revealed distinct inflammatory patterns with compact and homogenous character, with two endophenotypes based on biomarkers for UC and three for CD showing a between-class variance of 52% and 65%, respectively. PGE-MUM and FC are associated with clinical disease activity in UC and CD. …”
Get full text

Cardiovascular outcomes associated with treatment of type 2 diabetes in patients with ischaemic heart failure by Thomas R. Godec, Daniel I. Bromage, Mar Pujades‐Rodriguez, Antonio Cannatà, Arturo Gonzalez‐Izquierdo, Spiros Denaxas, Harry Hemingway, Ajay M. Shah, Derek M. Yellon, Theresa A. McDonagh

“…Conclusions When considering changes in antidiabetic treatment over time, all drug classes were associated with reduced risk of cardiovascular mortality and HF hospitalization.…”
Get full text

A espacialização da violência criminal na cidade de Santa Maria, RS by Eliane Melara

“…However, many drug dealers and consumers are residents of other parts of the city and are characterized by belonging to different social classes, even if this information does not appear very frequently in the statistics. …”
Get full text

Studies of biological properties of continuous suspension ВНК-21/SUSP/ARRIAH cell line by M. I. Doronin, M. N. Guseva, D. V. Mikhalishin, A. S. Sharypov, N. S. Mudrak, N. Ye. Kamalova, B. L. Manin

“…When cultured in suspension, BHK-21/SUSP/ARRIAH cell subline undergoes selection towards hypoploidy: modal class is represented by cells with 41 chromosomes (32–40% of cells); the share of cells containing 40–42 chromosomes is 78–80%; the share of polyploids averages around 1%; the range of variation in the number of chromosomes is from 36 to 54. …”
Get full text

Magnitude and dynamics of the T-cell response to SARS-CoV-2 infection at both individual and population levels by Thomas M. Snyder, Rachel M. Gittelman, Mark Klinger, Damon H. May, Edward J. Osborne, Ruth Taniguchi, H. Jabran Zahid, Ian M. Kaplan, Jennifer N. Dines, Matthew T. Noakes, Ravi Pandya, Xiaoyu Chen, Summer Elasady, Emily Svejnoha, Peter Ebert, Mitchell W. Pesesky, Patricia De Almeida, Hope O’Donnell, Quinn DeGottardi, Gladys Keitany, Jennifer Lu, Allen Vong, Rebecca Elyanow, Paul Fields, Hussein Al-Asadi, Julia Greissl, Lance Baldo, Simona Semprini, Claudio Cerchione, Fabio Nicolini, Massimiliano Mazza, Ottavia M. Delmonte, Kerry Dobbs, Rocio Laguna-Goya, Gonzalo Carreño-Tarragona, Santiago Barrio, Luisa Imberti, Alessandra Sottini, Eugenia Quiros-Roldan, Camillo Rossi, Andrea Biondi, Laura Rachele Bettini, Mariella D’Angio, Paolo Bonfanti, Miranda F. Tompkins, Camille Alba, Clifton Dalgard, Vittorio Sambri, Giovanni Martinelli, Jason D. Goldman, Jason D. Goldman, James R. Heath, Helen C. Su, Luigi D. Notarangelo, Estela Paz-Artal, Joaquin Martinez-Lopez, Bryan Howie, Jonathan M. Carlson, Harlan S. Robins

“…First, at the individual level, we deeply characterized 3 acutely infected and 58 recovered COVID-19 subjects by experimentally mapping their CD8 T-cell response through antigen stimulation to 545 Human Leukocyte Antigen (HLA) class I presented viral peptides. Then, at the population level, we performed T-cell repertoire sequencing on 1,815 samples (from 1,521 COVID-19 subjects) as well as 3,500 controls to identify shared “public” T-cell receptors (TCRs) associated with SARS-CoV-2 infection from both CD8 and CD4 T cells.ResultsCollectively, our data reveal that CD8 T-cell responses are often driven by a few immunodominant, HLA-restricted epitopes. …”
Get full text