A Retrospective Claims-Based Study Evaluating Clinical and Economic Burden Among Patients With Moderate to Severe Osteoarthritis Pain in the United States by Patricia B. Schepman, Sheena Thakkar, Rebecca L. Robinson, Craig G. Beck, Deepa Malhotra, Birol Emir, Ryan N. Hansen

“…**Background:** There has been limited evaluation of medication adherence, healthcare resource utilization (HCRU), and healthcare costs over time in patients with osteoarthritis (OA), and stratification by pain severity level has not been reported. …”
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Las cataratas del Lobé, un patrimonio geocultural excepcional en la costa camerunesa, entre el turismo duradero y la conservación de las identidades culturales by Mesmin Tchindjang, Marcel Hugues Etoga

“…Su reconocimiento definitivo como patrimonio tropieza con las vacilaciones de los responsables políticos que privilegian la industrialización frente a la gestión integrada y el turismo sostenible, como recomiendan la OMT y la ONUDI a través del proyecto COAST STEP. El objetivo de este texto es analizar mediante observaciones, trabajos de campo y entrevistas, el fracaso de este proceso teniendo a la vez en cuenta la inserción del turismo sostenible en este espacio de playa, la contribución de los protagonistas y los problemas de desarrollo. …”
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New probabilistic methods for quantitative climate reconstructions applied to palynological data from Lake Kinneret by T. Netzel, A. Miebach, T. Litt, A. Hense

“…In terms of climate ranges, the posterior probability of the Mediterranean biome reveals the greatest change, with an average boreal winter (December–February) temperature of <span class="inline-formula">10^∘C</span> and an annual precipitation of 700 mm for Lake Kinneret during the Holocene. …”
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Genome-wide identification of the Sec14 gene family and the response to salt and drought stress in soybean (Glycine max) by Jinyu Zhang, Liying Zou, Li Wang, Dongchao Zhang, Ao Shen, Yongqi Lei, Maoni Chao, Xinjuan Xu, Zhiwei Xue, Zhongwen Huang

“…Based on the classification method used for Arabidopsis Sec14 members, GmSec14s can be categorized into three classes: GmPITP1 to GmPITP37, GmSFH1 to GmSFH25, and GmPATL1 to GmPATL15. …”
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CD200R1 immune checkpoint blockade by the first-in-human anti-CD200R1 antibody 23ME-00610: molecular mechanism and engineering of a surrogate antibody by Cristina Melero, S. Jimmy Budiardjo, Anahita Daruwalla, Lance Larrabee, Oleg Ganichkin, Alexander J. Heiler, Jill Fenaux, Ben Chung, Germaine Fuh, Yao-Ming Huang

“…Blockade of CD200R1-dependent signaling enhances T cell-mediated antitumor activity in vitro and in vivo. 23ME–00610 is a potential first-in-class, humanized IgG1 investigational antibody that binds hCD200R1 with high affinity. …”
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Evaluation of undergraduate dental students’ awareness, knowledge, and attitudes towards teledentistry: does a course enhance this? by Gökçen Akçiçek, Ezgi Katı, Hatice Yağmur Zengin

“…All analyses were conducted using IBM SPSS Statistics for Windows, Version 23.0 (IBM Corp. …”
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Tousled-like kinase loss confers PARP inhibitor resistance in BRCA1-mutated cancers by impeding non-homologous end joining repair by Min-ah Kim, Banseok Kim, Jihyeon Jeon, Jonghyun Lee, Hyeji Jang, Minjae Baek, Sang-Uk Seo, Dongkwan Shin, Anindya Dutta, Kyung Yong Lee

“…Given that DSBs are highly cytotoxic, PARP inhibitors (PARPi), a prominent class of anticancer drugs, are designed to target tumors with HR deficiency (HRD), such as those harboring BRCA mutations. …”
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Extracellular electron transfer genes expressed by candidate flocking bacteria in cable bacteria sediment by Jamie J. M. Lustermans, Mantas Sereika, Laurine D. W. Burdorf, Mads Albertsen, Andreas Schramm, Ian P. G. Marshall

“…Cable bacteria extend the influence of oxygen to several centimeters, revealing a new class of anaerobic microbial metabolism with cable bacteria as electron acceptors. …”
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Whole-genome analysis of a ST45-SCCmec IVa (2B)-t116 methicillin-resistant Staphylococcus aureus strain isolated from the sputum of a 5-year-old child with pneumonia by Lin Huang, Rui Guo, Jingxian Lin, Xiaowei Li, Zhicong Li, Limei Zhang, Wenting Li, Rui Xue, Cheng Zhang, Xiaosan Feng, Xiaobin Li, Xiaobin Li

“…The SCCmec IVa (2B) carried by SA2107 contained the class B mec gene complex (IS431-mecA-ΔmecR1-IS1272) and type 2 ccr gene complex (ccrA2 and ccrB2). …”
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Adverse events of hepatic anti-fibrotic agents in phase 3 and above clinical trials: a descriptive analysis of the WHO-VigiAccess database by Yuwei Liu, Yuwei Liu, Xu Zhao, Xu Zhao, Xinrui Wang, Xinrui Wang, Qiang Zhou, Qiang Zhou

“…The ADR reports were retrieved from the WHO-VigiAccess database, with data categorized by demographic characteristics, geographic distribution, and System Organ Classes (SOCs). The most frequently reported ADRs were identified through descriptive analysis. …”
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Artificial intelligence-assisted platform performs high detection ability of hepatocellular carcinoma in CT images: an external clinical validation study by Rongxue Shan, Chenhao Pei, Qianrui Fan, Junchuan Liu, Dawei Wang, Shifeng Yang, Ximing Wang

“…The AI-assisted platform is designed based on a two-phase segmentation approach, integrating coarse and fine segmentation techniques to accurately identify and delineate hepatic lesions. …”
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Comparison of Deep-Learning-Based Segmentation Models: Using Top View Person Images by Imran Ahmed, Misbah Ahmad, Fakhri Alam Khan, Muhammad Asif

“…The network consists of a set of max-pooling and convolution layers to identify pixel-wise class labels and prediction of the mask. The second model is based on FCN called U-Net with Encoder-Decoder architecture. …”
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Evaluation of gestational nonpersistent pesticide exposure with newborn size and gestational length in rural Ghana using a novel time-varying extension of multiple informant models by Wylie BJ, Kaali S, Duttweiler L, Ae-Ngibise KA, Mujtaba M, Tawiah C, Gibson E, Calafat AM, Ospina M, Jack DJ, Agyei O, Lee AG, Roberts DJ, Boamah-Kaali EA, Factor-Litvak P, Modest AM, Hauser R, Coull BA, Asante KP

“…Extending multiple informant models to account for the complex data structure allowed us to discern effects in opposing directions by distinct pesticide classes. While estimated effects for a given week were modest, prolonged or repeated exposures could result in larger cumulative impacts.…”
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Le Prince de Miguasha au musée du Parc de Miguasha by Gaëlle Mazé

“…Découverte pour la première fois en 1879 dans la formation géologique d’Escumiac en Gaspésie, Eusthenopteron foordi appartient à la classe des Sarcoptérygiens ou vertébrés à membres charnus1. …”
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Genome-wide identification of the adaptor protein complexes and its expression patterns analysis in foxtail millet (Setaria italica L.) by Dan Wang, Min Su, Jian-Hong Hao, Zi-Dong Li, Shuqi Dong, Xiangyang Yuan, Xiaorui Li, Lulu Gao, Xiaoqian Chu, Guanghui Yang, Jia-Gang Wang, Huiling Du

“…Abstract Backgrounds Adapter proteins (APs) complex is a class of heterotetrameric complexes comprising of 4-subunits with important regulatory functions in eukaryotic cell membrane vesicle trafficking. …”
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Detection and characterization of multidrug resistant Escherichia coli carrying virulence gene isolated from broilers in Bangladesh by Md. Sirazul Islam, Chandan Nath, F. M. Yasir Hasib, Tahia Ahmed Logno, Md. Helal Uddin, Mohammad Mahmudul Hassan, Sharmin Chowdhury

“…A significant percentage (16.38%) of E. coli isolates were MDR to five antimicrobial classes and harboured blaTEM, sul1, ere (A), tetA, tetB and tetC genes. …”
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Fractionation of Rare Earth Elements in Greisen and Hydrothermal Veins Related to A-Type Magmatism by Mikael Tillberg, Olga M. Maskenskaya, Henrik Drake, Johan K. Hogmalm, Curt Broman, Anthony E. Fallick, Mats E. Åström

“…The greisen consists of coarse-grained quartz, muscovite, and fluorite, whereas the veins mainly contain quartz, calcite, epidote, chlorite, and fluorite in order of abundance. …”
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Causal Association Between Skin Microbiota and Malignant Melanoma: Genetic Insights From Mendelian Randomization by Li X, Wu S, Pan Y, Wu Z, Du Z, Xie W, Zhou Q

“…Conversely, genus: Finegoldia and class: Alphaproteobacteria were shown to inhibit the occurrence of MM. …”
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Genetic history of the Koryaks and Evens of the Magadan region based on Y chromosome polymorphism data by B. A. Malyarchuk, M. V. Derenko

“…In order to clarify the history of gene pool formation of the indigenous populations of the Northern Priokhotye (the northern coast of the Sea of Okhotsk), Y-chromosome polymorphisms were studied in the Koryaks and Evens living in the Magadan region. …”
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Vegetation disturbance and regrowth dynamics in shifting cultivation landscapes by Yamini Bhat, Subrata Nandy, Krishna Das, Muna Tamang, Hitendra Padalia, Arun Jyoti Nath, Koushik Majumdar, Rocky Pebam, Pynkhlainbor Thongni, Bandana Kurmi, Ashesh Kumar Das, S. P.S. Kushwaha, R. P. Singh

“…Six land use and land cover classes, viz., forests and trees outside forests, rubber plantation, shifting cultivation, water bodies, agriculture, and settlements, were mapped with an accuracy of 83.08% using a random forest classifier. …”
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